Gene_Set	Direction	Enrichment	n	b	N	B	p.value	Driver_Genes	adj.p.val
HALLMARK_MYOGENESIS	DOWN	4.450887956	190	12	11487	12	0.000402747	"SSPN,HRC,MEF2A,COX7A1,EIF4A2,ENO3,SPEG,CRAT,PKIA,NAV2,SYNGR2,CDH13,HDAC5,PYGM,SGCG,AK1,PDE4DIP,ADCY9,MEF2D,ACSL1,MYH11,SGCA,SH3BGR,COX6A2,REEP1,ITGB1,DMD,AGL,PFKM,ABLIM1,LAMA2,CKMT2,RIT1,RB1,NCAM1,ITGA7,BAG1,LPIN1,PDLIM7,CD36,AKT2,FXYD1,ST5,CKM,SVIL,CASQ1,KCNH2,FOXO4,APLNR,MYL2,MYH8,DTNA,STC2,CAV3,MEF2C,SORBS1,TAGLN,TSC2,CSRP3,DMPK,CHRNB1,MYOM2,MYOM1,SH2B1,MRAS,IFRD1,TCAP,MYH2,PTP4A3,IGFBP3,PSEN2,MYLK,MB,FDPS,GADD45B,PGAM2,ERBB3,ITGB4,TNNT2,HSPB8,LDB3,FABP3,PLXNB2,SIRT2,COL4A2,OCEL1,NOTCH1,CRYAB,FLII,MAPRE3,MYH1,HSPB2,MYL3,PICK1,CACNA1H,WWTR1,SGCD,EPHB3,CASQ2,TEAD4,CTF1,ACTC1,HBEGF,MYH4,SORBS3,DAPK2,MYBPC3,TNNT1,CNN3,LARGE,SMTN,CLU,SPARC,ATP6AP1,GAA,GJA5,FGF2,KIFC3,PPP1R3C,MAPK12,COL15A1,PTGIS,CAMK2B,ACTN2,CKB,DES,LSP1,TNNC1,ITGB5,GABARAPL2,CDKN1A,MYO1C,GNAO1,BHLHE40,TNNI2,AGRN,TGFB1,IGF1,TPM2,GSN,SOD3,VIPR1,SLC6A8,COL6A2,MYH7,TPM3,BIN1,NQO1,COL6A3,TPD52L1,COL3A1,FHL1,PRNP,APP,COL1A1,APOD,MYH9,MYL1,AEBP1,IGFBP7,GPX3,ACTA1,RYR1"	0.001917845
HALLMARK_UV_RESPONSE_UP	UP	1.367574977	5551	76	11487	76	0.001668599	"GPX3,TAP1,ICAM1,EPHX1,MMP14,PRKCD,SLC6A8,SQSTM1,JUNB,CCND3,IL6ST,TCHH,FMO1,MAOA,ARRB2,HSPA2,RAB27A,RRAD,CYB5R1,HMOX1,PDAP1,FOS,ASNS,OLFM1,CNP,GRINA,SPR,SIGMAR1,BAK1,ATP6V1F,NR4A1,E2F5,CLTB,MSX1,ALAS1,IRF1,NXF1,CREG1,DDX21,GGH,TGFBRAP1,LYN,TFRC,TUBA4A,MRPL23,MGAT1,FEN1,PARP2,DLG4,PDLIM3,YKT6,DNAJA1,EIF2C2,POLE3,H2AFX,POLR2H,TARS,CDK2,ATF3,SEPW1,CDC34,ALDOA,DNAJB1,STK25,PPP1R2,NFKBIA,BTG2,RET,GRPEL1,PSMC3,WIZ,EIF5,DGAT1,TST,CDC5L,RHOB,STARD3,ATP6V1C1,PPAT,PRPF3,RXRB,PPT1,PRKACA,HSPA13,HNRNPU,TMBIM6,MARK2,GCH1,SULT1A1,CYB5B,NUPL1,BSG,STIP1,HYAL2,CEBPG,AP2S1,BTG1,RPN1,CHKA,KLHDC3,BCL2L11,FGF18,KCNH2,NKX2-5,PLCL1,RFC4,FURIN,UROD,PTPRD,CDKN1C,SLC25A4,GLS,PPIF,SOD2,FKBP4"	0.007584543
HALLMARK_P53_PATHWAY	UP	1.333466173	5158	97	11487	97	0.001761075	"TAP1,ABAT,APP,EPHX1,TPD52L1,INHBB,IFI30,DRAM1,NUPR1,CCND2,RPS12,ZMAT3,CCND3,TRAFD1,CASP1,TCHH,TGFB1,EPS8L2,NINJ1,F2R,CDKN1A,RRAD,HMOX1,DDIT3,RNF19B,S100A10,PRMT2,PPP1R15A,SAT1,AEN,HSPA4L,PLK2,FUCA1,APAF1,FOS,VWA5A,IP6K2,KLF4,GNB2L1,POM121,RPS27L,SP1,TM4SF1,CD82,SLC19A2,BAK1,SFN,RRP8,XPC,UPP1,CTSD,IER3,PERP,NDRG1,STOM,CEBPA,LRMP,RAB40C,HBEGF,TAX1BP3,PCNA,DCXR,IER5,TM7SF3,DNTTIP2,HINT1,HIST3H2A,MXD1,BAIAP2,FDXR,EPHA2,STEAP3,MXD4,PMM1,SLC3A2,CCNK,RPL18,ZFP36L1,TPRKB,TOB1,KIF13B,TXNIP,ATF3,NOTCH1,JAG2,PLXNB2,RHBDF2,RALGDS,PTPN14,MKNK2,HEXIM1,CD81,ITGB4,BTG2,MDM2,POLH,OSGIN1,PPM1D,ISCU,JUN,H2AFJ,ABCC5,HDAC3,TSPYL2,TCN2,CDKN2AIP,SLC35D1,SEC61A1,HIST1H1C,VAMP8,RAP2B,DDIT4,RCHY1,GM2A,KLK8,PTPRE,ERCC5,WWP1,PDGFA,DGKA,FAM162A,ABHD4,TRAF4,IKBKAP,NOL8,PHLDA3,BTG1,DEF6,FOXO3,ACVR1B,GADD45A,NUDT15,TRIAP1,ANKRA2,BAX,RXRA,RPL36,CTSF,ZBTB16,SERTAD3,CGRRF1,FAS,CSRNP2,RB1,BLCAP,CCNG1,FBXW7,PRKAB1,CYFIP2,MAPKAPK3,LDHB,RETSAT,IRAK1,AK1,ADCK3,EI24,SDC1,TSC22D1,SESN1,CDH13,PITPNC1,FGF13"	0.007656847
HALLMARK_XENOBIOTIC_METABOLISM	UP	2.110661204	1148	27	11487	27	0.002663509	"APOE,CFB,TGFB2,PSMB10,EPHX1,SLC6A6,VTN,TNFRSF1A,IGFBP4,NQO1,SERPINE1,COMT,FAH,PROS1,TMEM176B,IRF8,IGF1,ID2,FMO1,MAOA,PTGDS,NINJ1,PDLIM5,FBLN1,CNDP2,HMOX1,ATOH8,LPIN2,ITIH4,GSS,ARPP19,ANGPTL3,ACP2,ENPEP,CAT,UPP1,CSAD,DDAH2,ALAS1,GSR,GCNT2,ELOVL5,UGDH,ETS2,IL1R1,AHCY,DCXR,GSTO1,NMT1,PAPSS2,TPST1,ASL,EPHA2,ABCD2,HSD11B1,PMM1,GSTA3,CBR1,PGRMC1,ACP1,DHPS,RAP1GAP,POR,SLC1A5,PGD,ACOX1,ALDH2,DHRS1,XDH,GSTM4,CYP27A1,HACL1,SPINT2,BCAR1,MTHFD1,BLVRB,SLC35D1,LONP1,SLC12A4,MPP2,ALDH9A1,TMBIM6,DAK,CASP6,GCH1,SLC46A3,PTS,PTGES3,HES6,BPHL,AP4B1,CROT,PPARD,GABARAPL1,DHRS7,GART,GCLC,JUP,SERTAD1,DDT,NFS1,KARS,SSR3,SHMT2,ADH5,SAR1B,SLC35B1,ACOX3,FAS,CD36,ABHD6,IDH1,GSTT2,SMOX,CYFIP2,NPC1,ETFDH,AOX1,RETSAT,ENTPD5,PDK4,ACO2,ECH1,MARCH6,MCCC2,PINK1,NDRG2,ATP2A2"	0.011097953
HALLMARK_HEDGEHOG_SIGNALING	UP	3.416309779	1401	10	11487	10	0.00294783	"MYH9,AMOT,PML,DPYSL2,TLE3,THY1,L1CAM,GPR56,HEY1,NF1,ETS2,RTN1,VEGFA,NRP1,NRP2,RASA1,LDB1,OPHN1,PTCH1,TLE1,HEY2,CDK6,CELSR1,VLDLR"	0.011791319
HALLMARK_ANDROGEN_RESPONSE	UP	1.66796969	3153	38	11487	38	0.004188898	"AKAP12,B2M,CCND1,ACTN1,RRP12,FADS1,DHCR24,MAF,PMEPA1,TPD52,UAP1,CCND3,ADAMTS1,PDLIM5,SGK1,SAT1,MERTK,AKT1,SRF,ADRM1,RAB4A,CDC14B,STEAP4,HOMER2,SLC26A2,SEC24D,GNAI3,ARID5B,INPP4B,GSR,NDRG1,ELOVL5,ZMIZ1,PTPN21,PTK2B,CAMKK2,XRCC5,SRP19,PPAP2A,GUCY1A3,IDI1,HPGD,UBE2J1,ITGAV,SPCS3,PGM3,UBE2I,B4GALT1,PA2G4,HMGCR,IQGAP2,TMEM50A,SORD,NCOA4,FKBP5,ELK4,INSIG1,SLC38A2,XRCC6,ABHD2,H1F0,SEPP1,GPD1L,ELL2,NGLY1,HERC3,RPS6KA3,LMAN1,DBI,ABCC4,PIAS1,VAPA,ACSL3,CDK6,APPBP2,SMS,LIFR,HMGCS1,STK39,DNAJB9,TNFAIP8,TSC22D1,ZBTB10"	0.015695996
HALLMARK_UV_RESPONSE_DN	DOWN	5.703574975	106	7	11487	7	0.004237919	"TFPI,VLDLR,TGFBR3,NFIB,CDKN1B,SPOP,BCKDHB,LPHN2,SYNJ2,ARHGEF9,PTPRM,PTEN,MRPS31,ATRX,CDK13,SLC7A1,BMPR1A,LTBP1,CAP2,ATXN1,NR1D2,IRS1,APBB2,ATP5S,GJA1,F3,WDR37,PHF3,MAPK14,MAGI2,ADD3,PRDM2,RND3,RXRA,CDON,PRKCE,IGF1R,NIPBL,YTHDC1,PPAP2B,SNAI2,RBPMS,BDNF,MGMT,NEK7,DLG1,INSIG1,SCAF8,KALRN,AGGF1,DUSP1,VAV2,CELF2,ACVR2A,ABCC1,TJP1,LDLR,ATP2B1,ATRN,DBP,ATP2B4,ERBB2,PLCB4,MET,CDC42BPA,FHL2,DYRK1A,NR3C1,FAM179B,CAV1,RGS4,SMAD3,NRP1,MIOS,MAP2K5,CITED2,RASA2,PRKCA,SYNE1,LAMC1,PAPD7,FYN,SFMBT1,FBLN5,PIAS3,KIT,ID1,MGLL,PTPN21,ZMIZ1,ICA1,AKT3,PTGFR,NOTCH2,ATP2C1,INPP4B,AMPH,NFKB1,PEX14,CACNA1A,MYC,DDAH1,PIK3R3,MTA1,CYR61,PPARG,FZD2,DLC1,COL1A2,SIPA1L1,PDLIM5,BHLHE40,ANXA4,SRI,SMAD7,PIK3CD,LPAR1,PRKAR2B,RUNX1,EFEMP1,GRK5,PDGFRB,COL5A2,SERPINE1,SDC2,DAB2,ITGB3,IGFBP5,COL3A1,GCNT1,COL1A1,TGFBR2,ANXA2"	0.015695996
HALLMARK_APICAL_SURFACE	UP	7.073275862	290	5	11487	5	0.006390583	"CX3CL1,APP,AIM1,ATP8B1,SULF2,THY1,IL2RG,RTN4RL1,SRPX,MAL,LYN,AFAP1L2,GAS1,TMEM8B,ADIPOR2,B4GALT1,ADAM10,DCBLD2,EPHB4,MDGA1,CROCC,HSPB1,EFNA5,SHROOM2,NCOA6,FLOT2,AKAP7,SLC2A4"	0.022823509
HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY	UP	4.663283651	401	7	11487	7	0.00792238	"GPX3,PDLIM1,PRNP,PFKP,NQO1,MBP,SBNO2,JUNB,MGST1,LSP1,FES,TXNRD1,CAT,SRXN1,GSR,HMOX2,CDKN2D,PPP2R4,PRDX4,ATOX1,STK25,GLRX,NDUFA6,PRDX2,SCAF4,HBXIP,EGLN2,GPX4,GLRX2,HHEX,ABCC1,PRDX6,ERCC2,TXNRD2,MSRA,GCLC,NDUFB4,SOD1,GCLM,OXSR1,PRDX1,NDUFS2,SOD2"	0.02731855
HALLMARK_HYPOXIA	DOWN	10.84190656	26	4	11487	4	0.008366606	"PHKG1,HSPA5,KLHL24,VLDLR,CDKN1B,ENO3,HDLBP,GPC3,PYGM,IDS,CDKN1C,HK2,GYS1,EXT1,PPARGC1A,CCNG2,PGF,PGM2,SELENBP1,F3,AK4,PIM1,GPC1,P4HA2,SLC37A4,VHL,DPYSL4,AMPD3,TES,ANGPTL4,DTNA,FOXO3,GBE1,STC2,BTG1,EFNA1,CCRN4L,SIAH2,PRDX5,PDK1,HS3ST1,RRAGD,FAM162A,GPC4,NDST2,CASP6,DUSP1,KDM3A,GALK1,TIPARP,KDELR3,ATP7A,DDIT4,PDK3,SCARB1,ISG20,ADM,CXCR7,PGK1,MIF,IGFBP3,RORA,SLC2A1,NR3C1,JUN,CAV1,MXI1,NDST1,PGAM2,GLRX,BNIP3L,KLF6,PFKL,ZFP36,ERO1L,SLC25A1,CITED2,ILVBL,CHST2,NFIL3,TPST2,PRKCA,STC1,RBPJ,ALDOA,NAGK,ATF3,VEGFA,PGM1,SDC4,PFKFB3,LXN,FOSL2,CSRP2,IRS2,WSB1,ETS1,KLF7,CHST3,EGFR,NEDD4L,LDHA,GCNT2,PTRF,NDRG1,IER3,STBD1,SAP30,CXCR4,LARGE,HEXA,GAA,COL5A1,XPNPEP1,GAPDH,ANKZF1,PPP1R3C,ALDOB,MAFF,ERRFI1,B3GALT6,SRPX,CYR61,JMJD6,FOS,TGFB3,HK1,PPP1R15A,DDIT3,HMOX1,WISP2,PRKCDBP,TPI1,CDKN1A,GCK,BHLHE40,UGP2,P4HA1,PNRC1,GRHPR,MAP3K1,TPD52,LOX,CTGF,PDGFB,TNFAIP3,SERPINE1,SDC2,BCL2,PLIN2,DCN,PFKP,SDC3,SLC6A6,PAM,KIF5A,TGM2,MYH9,TGFBI,ANXA2,AKAP12,CP,BGN"	0.027888688
HALLMARK_ESTROGEN_RESPONSE_EARLY	UP	1.734483135	1679	36	11487	36	0.009021753	"ABAT,TGM2,CCND1,RRP12,OLFML3,MYOF,TPD52L1,INHBB,IGFBP4,NBL1,SLC7A2,BCL2,ENDOD1,FLNB,ADCY1,MYBL1,IL6ST,BCL11B,FRK,JAK2,BHLHE40,WISP2,CD44,CXCL12,DLC1,TIAM1,ALDH3B1,RPS6KA2,FOS,KLF4,ABCA3,FAM102A,OLFM1,RAB31,SYBU,SYT12,SLC26A2,SLC19A2,PODXL,MYC,SFN,SLC39A6,RARA,MYBBP1A,AR,DEPTOR,SLC9A3R1,SEMA3B,ELOVL5,SLC37A1,SLC7A5,RBBP8,GAB2,TBC1D30,FARP1,PDLIM3,CANT1,PAPSS2,KAZN,ISG20L2,ELF1,AMFR,TOB1,FAM63A,NCOR2,SLC1A1,SYNGR1,THSD4,HES1,SLC24A3,P2RY2,UNC119,HSPB8,MREG,KLF10,RET,PEX11A,UGCG,B4GALT1,NRIP1,SLC2A1,FHL2,SLC16A1,FDFT1,BLVRB,SNX24,TUBB2B,SH3BP5,MAPT,INPP5F,DHCR7,SCARB1,NADSYN1,DHRS3,ITPK1,NXT1,TIPARP,ASB13,FKBP5,PRSS23,FOXC1,GFRA1,DYNLT3,ABHD2,AFF1,OPN3,ARL3,SIAH2,HR,STC2,CISH,IGF1R,SVIL,CBFA2T3,RHOBTB3,ADD3,TMEM164,MED24,SLC22A5,KDM4B,BAG1,CYP26B1,LRIG1,GJA1,FASN,ABLIM1,MED13L,CHPT1,PLA2G16,WFS1,MAST4,REEP1,XBP1,FAM134B,CELSR1,ADCY9,CELSR2,AKAP1,MPPED2,PPIF,NAV2,FKBP4"	0.029102429
HALLMARK_BILE_ACID_METABOLISM	DOWN	2.467139175	970	15	11487	15	0.011632891	"NR3C2,ISOC1,ABCD3,PHYH,PEX7,PXMP2,PEX13,GSTK1,MLYCD,RETSAT,ACSL1,NPC1,PNPLA8,GNPAT,PEX1,IDH1,PFKM,ATXN1,EPHX2,RXRG,GCLM,SLC23A2,RXRA,SOD1,SLC29A1,PEX26,CROT,PRDX5,PEX6,NEDD4,LIPE,ACSL5,ABCA6,ABCA4,NUDT12,ALDH9A1,PEX19,HSD17B4,HACL1,CYP27A1,NR0B2,PEX12,CYP39A1,PEX16,BCAR3,PEX11A,IDI1,ABCA9,LONP2,BMP6,ABCD1,SLC35B2,ABCD2,FADS2,FDXR,AMACR,ABCA1,IDH2,ABCA5,ABCA2,AR,SCP2,CAT,PECR,ALDH1A1,ABCA3,HSD17B11,HSD3B7,DHCR24,FADS1,OPTN,RBP1"	0.036352783
HALLMARK_SPERMATOGENESIS	DOWN	1.418799386	5741	39	11487	39	0.015636046	"TNNI3,MLF1,YBX2,ART3,BRAF,IFT88,TALDO1,NF2,PSMG1,STRBP,SHE,IP6K1,RFC4,CLPB,LPIN1,EZH2,GMCL1,CHFR,CSNK2A2,PRKAR2A,RAD17,TSN,PHF7,ZC3H14,SPATA6,TLE4,VDAC3,TOPBP1,ARL4A,PIAS2,SLC12A2,NPHP1,HSPA1L,MLLT10,MAST2,GPR182,FAM164C,SIRT1,SEPT4,COIL,SNAP91,JAM3,STAM2,PARP2,AGFG1,PHKG2,NCAPH,DBF4,PEBP1,HSPA4L,HSPA2,PGS1,MTOR,ACE,IDE"	0.045996044
HALLMARK_UV_RESPONSE_DN	UP	2.040929391	931	22	11487	22	0.015638655	"ANXA2,TGFBR2,COL1A1,GCNT1,COL3A1,IGFBP5,ITGB3,DAB2,SDC2,SERPINE1,COL5A2,PDGFRB,GRK5,EFEMP1,RUNX1,PRKAR2B,LPAR1,PIK3CD,SMAD7,SRI,ANXA4,BHLHE40,PDLIM5,SIPA1L1,COL1A2,DLC1,FZD2,PPARG,CYR61,MTA1,PIK3R3,DDAH1,MYC,CACNA1A,PEX14,NFKB1,AMPH,INPP4B,ATP2C1,NOTCH2,PTGFR,AKT3,ICA1,ZMIZ1,PTPN21,MGLL,ID1,KIT,PIAS3,FBLN5,SFMBT1,FYN,PAPD7,LAMC1,SYNE1,PRKCA,RASA2,CITED2,MAP2K5,MIOS,NRP1,SMAD3,RGS4,CAV1,FAM179B,NR3C1,DYRK1A,FHL2,CDC42BPA,MET,PLCB4,ERBB2,ATP2B4,DBP,ATRN,ATP2B1,LDLR,TJP1,ABCC1,ACVR2A,CELF2,VAV2,DUSP1,AGGF1,KALRN,SCAF8,INSIG1,DLG1,NEK7,MGMT,BDNF,RBPMS,SNAI2,PPAP2B,YTHDC1,NIPBL,IGF1R,PRKCE,CDON,RXRA,RND3,PRDM2,ADD3,MAGI2,MAPK14,PHF3,WDR37,F3,GJA1,ATP5S,APBB2,IRS1,NR1D2,ATXN1,CAP2,LTBP1,BMPR1A,SLC7A1,CDK13,ATRX,MRPS31,PTEN,PTPRM,ARHGEF9,SYNJ2,LPHN2,BCKDHB,SPOP,CDKN1B,NFIB,TGFBR3,VLDLR,TFPI"	0.045996044
HALLMARK_PEROXISOME	DOWN	2.618739478	704	13	11487	13	0.01639986	"SOD2,CRAT,ISOC1,ABCD3,SLC25A4,ECH1,CNBP,PRDX1,PEX13,GSTK1,MLYCD,RETSAT,ACSL1,GNPAT,CLN8,MSH2,IDH1,EHHADH,ATXN1,CDK7,EPHX2,ECI2,RXRG,SLC23A2,SOD1,PEX11B,FIS1,RDH11,SLC25A19,PRDX5,PEX6,ACOT8,PEX5,CTBP1,ACSL5,DHRS3,ALDH9A1,HSD17B4,HMGCL,ABCC5,FDPS,CADM1,SLC25A17,PEX11A,ABCB9,NUDT19,SEMA3C,ACOX1,ACSL4,IDI1,ABCC8,ERCC3,ITGB1BP1,LONP2,VPS4B,ABCD1,SLC35B2,ABCD2,SMARCC1,BCL10,CLN6,DLG4,IDH2,ELOVL5,YWHAH,SCP2,PEX14,CAT,TSPO,ERCC1,ALDH1A1,PABPC1,CTPS,HSD17B11,ABCB4,HSD3B7,TOP2A,DHCR24,FADS1,MVP,IDE"	0.046856742
HALLMARK_APICAL_JUNCTION	UP	7.17594532	193	17	11487	17	1.17E-08	"VCAN,ACTA1,VWF,ACTB,PTPRC,FBN1,LIMA1,TGFBI,MYH9,CX3CL1,ACTG1,NRAP,FLNC,LAYN,ICAM1,ACTN1,SKAP2,CD274,SDC3,ZYX,PFN1,RAC2,GNAI2,THY1,MSN,ARPC2,LAMC2,BMP1,THBS3,CAP1,COL16A1,VCAM1,PKD1,CNN2,ADAM15,ACTN2,RRAS,AMIGO1,MYH10,ACTN4,MYL12B,NF1,ADAM23,TAOK2,DHX16,LDLRAP1,ADAM9,PIK3R3,MYL9,PVRL1,GTF2F1,PCDH1,PECAM1,CD86,ITGA9,CDH4,VASP,CD34,NLGN2,YWHAH,CDK8,SGCE,CLDN5,CADM3,SORBS3,AMIGO2,AKT3,EGFR,ICAM2,ACTC1,FSCN1,MAPK11,LAMA3,SIRPA,BAIAP2,SRC,RSU1,NRXN2,PARD6G,TMEM8B,TIAL1,CLDN15,ITGB4,JAM3,B4GALT1,PLCG1,PARVA,RASA1,ADAMTS5,TUBG1,CD276,NEGR1,TSC1,MAP4K2,TJP1,VAV2,NEXN,LAMB3,MVD,WASL,INSIG1,DLG1,ARHGEF6,SYMPK,INPPL1,MMP9,PBX2,IKBKG,CDH11,TSPAN4,PTK2,VCL,CTNND1,SHROOM2,MPP5,NRTN,EXOC4,JUP,PVRL3,KCNH2,PVRL2,SHC1,MAPK14,AKT2,WNK4,IRS1,MPZL1,NF2,SLIT2,ITGB1,ACTG2,PIK3CB,GNAI1,HADH,PTEN,EVL,ITGA3,CTNNA1,ADRA1B,CRAT,SPEG"	9.79E-08
HALLMARK_APOPTOSIS	UP	2.91208234	1141	35	11487	35	1.19E-07	"BGN,EMP1,GPX3,DAP,TGFB2,TAP1,IFITM3,CCND1,APP,LUM,LMNA,ANXA1,LGALS3,DCN,HMGB2,TNFRSF12A,CCND2,TOP2A,SQSTM1,PDGFRB,CASP8,IGF2R,GSN,CASP1,SMAD7,PLAT,GPX1,F2R,CDKN1A,IGFBP6,BIRC3,IFNGR1,CD44,HMOX1,DDIT3,SAT1,DPYD,PSEN1,TIMP2,FEZ1,TNFSF10,ADD1,TSPO,RNASEL,CLU,GSR,IER3,IRF1,RARA,CDC25B,CFLAR,BCL10,XIAP,DNAJA1,FDXR,RELA,NEDD9,SATB1,CD14,PDCD4,CDK2,TXNIP,CASP4,ATF3,CTH,DFFA,EBP,BTG2,ERBB3,DNAJC3,VDAC2,BNIP3L,GADD45B,PPP2R5B,SLC20A1,CAV1,JUN,RHOB,PSEN2,CD38,ERBB2,MCL1,CASP2,ISG20,GPX4,PPT1,HSPB1,BCAP31,CASP6,WEE1,GCH1,MADD,GSTM1,ETF1,CASP7,DIABLO,RHOT2,H1F0,MGMT,CASP9,PTK2,CYLD,GADD45A,BMF,BCL2L11,DAP3,CREBBP,SOD1,BAX,BCL2L1,BCL2L2,FAS,PPP3R1,TIMP3,RETSAT,CTNNB1,ROCK1,DNM1L,CDKN1B,SOD2,TGFBR3"	8.48E-07
HALLMARK_ANGIOGENESIS	UP	5.879257398	796	11	11487	11	1.20E-05	"VCAN,FSTL1,POSTN,APP,LUM,COL3A1,VTN,CCND2,COL5A2,FGFR1,PF4,THBD,MSX1,VEGFA,JAG2,STC1,ITGAV,NRP1,LRPAP1,SLCO2A1,VAV2,PDGFA,KCNJ8,JAG1,PTK2,TNFRSF21,LPL"	6.31E-05
HALLMARK_TNFA_SIGNALING_VIA_NFKB	UP	2.573252688	1302	42	11487	42	1.46E-07	"PLEK,IFIT2,DDX58,TAP1,CCND1,ICAM1,IFIH1,TNIP1,RCAN1,DRAM1,TUBB2A,PLAU,BCL3,TLR2,SERPINE1,SQSTM1,TNFAIP3,LITAF,JUNB,PMEPA1,SOCS3,NFKBIE,PNRC1,IL6ST,CEBPD,ID2,BHLHE40,NINJ1,PTGER4,NR4A3,CDKN1A,PDLIM5,SGK1,BIRC3,RIPK2,EGR1,CD44,RNF19B,PPP1R15A,SAT1,PHLDA1,PLK2,FOS,KLF4,KLF2,CYR61,B4GALT5,NFE2L2,IER2,CSF1,MAFF,MYC,NR4A1,TNIP2,NFKB1,NFKB2,IER3,IRF1,SLC16A6,BCL6,HBEGF,GFPT2,CFLAR,ETS2,ABCA1,EDN1,MARCKS,DUSP5,RELB,IER5,IRS2,MXD1,FOSL2,SIK1,PFKFB3,CCNL1,RELA,NFAT5,TNC,SDC4,VEGFA,ATF3,HES1,NFIL3,ZC3H12A,TGIF1,MAP3K8,NFKBIA,KLF10,BTG2,GEM,ZFP36,KLF6,B4GALT1,G0S2,GADD45B,SMAD3,CCRL2,JUN,RHOB,EHD1,PDE4B,TRIP10,MCL1,CXCR7,DUSP4,SNN,ATP2B1,LDLR,TIPARP,PTPRE,DUSP1,LAMB3,GCH1,TANK,CD83,STAT5A,PPAP2B,YRDC,JAG1,EFNA1,BTG1,DENND5A,GADD45A,REL,EIF1,MAP2K3,DNAJB4,PER1,F3,CEBPB,TRIB1,IL15RA,SPSB1,KDM6B,TNFAIP2,BIRC2,TNFAIP8,NAMPT,TSC22D1,ZBTB10,SOD2,IFNGR2,KLF9"	9.76E-07
HALLMARK_MYOGENESIS	UP	2.358438638	1255	42	11487	42	2.39E-06	"RYR1,ACTA1,GPX3,IGFBP7,AEBP1,MYL1,MYH9,APOD,COL1A1,APP,PRNP,FHL1,COL3A1,TPD52L1,COL6A3,NQO1,BIN1,TPM3,MYH7,COL6A2,SLC6A8,VIPR1,SOD3,GSN,TPM2,IGF1,TGFB1,AGRN,TNNI2,BHLHE40,GNAO1,MYO1C,CDKN1A,GABARAPL2,ITGB5,TNNC1,LSP1,DES,CKB,ACTN2,CAMK2B,PTGIS,COL15A1,MAPK12,PPP1R3C,KIFC3,FGF2,GJA5,GAA,ATP6AP1,SPARC,CLU,SMTN,LARGE,CNN3,TNNT1,MYBPC3,DAPK2,SORBS3,MYH4,HBEGF,ACTC1,CTF1,TEAD4,CASQ2,EPHB3,SGCD,WWTR1,CACNA1H,PICK1,MYL3,HSPB2,MYH1,MAPRE3,FLII,CRYAB,NOTCH1,OCEL1,COL4A2,SIRT2,PLXNB2,FABP3,LDB3,HSPB8,TNNT2,ITGB4,ERBB3,PGAM2,GADD45B,FDPS,MB,MYLK,PSEN2,IGFBP3,PTP4A3,MYH2,TCAP,IFRD1,MRAS,SH2B1,MYOM1,MYOM2,CHRNB1,DMPK,CSRP3,TSC2,TAGLN,SORBS1,MEF2C,CAV3,STC2,DTNA,MYH8,MYL2,APLNR,FOXO4,KCNH2,CASQ1,SVIL,CKM,ST5,FXYD1,AKT2,CD36,PDLIM7,LPIN1,BAG1,ITGA7,NCAM1,RB1,RIT1,CKMT2,LAMA2,ABLIM1,PFKM,AGL,DMD,ITGB1,REEP1,COX6A2,SH3BGR,SGCA,MYH11,ACSL1,MEF2D,ADCY9,PDE4DIP,AK1,SGCG,PYGM,HDAC5,CDH13,SYNGR2,NAV2,PKIA,CRAT,SPEG,ENO3,EIF4A2,COX7A1,MEF2A,HRC,SSPN"	1.41E-05
HALLMARK_IL2_STAT5_SIGNALING	UP	2.034814956	2621	65	11487	65	2.44E-08	"EMP1,TGM2,IFITM3,ECM1,PRNP,PLIN2,CKAP4,AKAP2,BCL2,CCND2,NFKBIZ,FGL2,ITIH5,FAH,IRF4,IGF2R,COL6A1,TNFRSF1B,GBP4,CTSZ,CAPN3,CCND3,CAPG,IRF8,P4HA1,ANXA4,BHLHE40,MYO1C,IFNGR1,CD44,ST3GAL4,ITGA6,PHLDA1,GLIPR2,TIAM1,NOP2,LRRC8C,APLP1,TLR7,SOCS2,TNFSF10,CSF1,MAFF,SYT11,POU2F1,SNX9,AHNAK,CD86,MYC,PENK,SH3BGRL2,CDC42SE2,PNP,SPRY4,RNH1,ODC1,S100A1,SLC39A8,UCK2,SWAP70,IL18R1,SLC29A2,NDRG1,PRAF2,MYO1E,CYFIP1,PTH1R,PLSCR1,PRKCH,ENPP1,AHCY,AMACR,GSTO1,N6AMT2,MXD1,PDCD2L,PPAP2A,IL10RA,TTC39B,NFIL3,SLC1A5,PUS1,MAP3K8,CD81,ITGAV,PTRH2,NRP1,KLF6,DCPS,GADD45B,ADAM19,GUCY1B3,BMPR2,RHOB,RORA,NCOA3,P2RX4,MAPKAPK2,GPX4,DHRS3,SMPDL3A,PLAGL1,ARL4A,NCS1,CD83,LCLAT1,RRAGD,IL2RA,AHR,PTCH1,SNX14,GABARAPL1,GALM,CISH,DENND5A,IGF1R,BCL2L1,HIPK2,SPRED2,UMPS,TNFRSF21,PIM1,IKZF2,PLEC,LRIG1,SHE,WLS,HUWE1,FAM126B,FURIN,XBP1,HK2,TWSG1,NT5E,CDKN1C,HOPX,PHTF2,RABGAP1L,SYNGR2,ENO3"	1.88E-07
HALLMARK_INTERFERON_ALPHA_RESPONSE	UP	2.251091825	4230	63	11487	63	3.26E-09	"IFIT3,PARP14,IFI44,C1S,IFIT2,SAMD9L,TAP1,B2M,IFITM3,DDX60,IFIH1,SP110,LY6E,IRF9,PARP9,HERC6,EIF2AK2,IFI30,CD74,RSAD2,DHX58,BST2,NCOA7,USP18,ADAR,STAT2,CASP8,RTP4,MOV10,GBP4,UBE2L6,CMPK2,ISG15,TRAFD1,CASP1,EPSTI1,TRIM25,PSMB9,PSMB8,RIPK2,TDRD7,FTSJD2,IFI35,PARP12,CNP,CSF1,IRF2,NMI,LAP3,OGFR,WARS,IRF1,TRIM14,UBA7,PLSCR1,TMEM140,TRIM26,PSME1,TRIM21,CD47,IFITM2,ELF1,TXNIP,FAM46A,NUB1,CCRL2,PSME2,LPAR6,ISG20,RNF31,GMPR,PNPT1,FAM125A,PSMA3,SLC25A28,IL15"	4.95E-08
HALLMARK_ALLOGRAFT_REJECTION	UP	4.34107453	1079	42	11487	42	3.70E-09	"ITGB2,PTPRC,CTSS,TGFB2,HCLS1,TAP1,B2M,PSMB10,ICAM1,FCGR2B,GCNT1,LCP2,FLNA,CCR2,ITGAL,INHBB,TAPBP,CD74,TAP2,BCL3,PTPN6,TLR2,CCND2,THY1,ELF4,RPS9,IRF4,TPD52,CCND3,CAPG,IRF8,PRKCB,AARS,PF4,CCR5,IGSF6,TGFB1,JAK2,F2R,GLMN,CSK,RIPK2,STAB1,IFNGR1,IFNAR2,IL2RG,EIF3D,AKT1,CSF1,CFP,CD86,CXCL9,WARS,TLR3,RPS19,DARS,IL16,CD28,EGFR,LYN,SRGN,HIF1A,NOS2,ETS1,CCL11,RARS,BCL10,C2,NME1,EIF3A,CD47,RPL39,CXCL13,RPS3A,TRAF2,MAP3K7,NCK1,IKBKB,EIF3J,NPM1,LY75,MRPL3,RPL9,ACVR2A,DEGS1,EIF5A,ST8SIA4,SOCS5,IL2RA,GALNT1,MMP9,MTIF2,EIF4G3,HDAC9,ABI1,FAS,ABCE1,UBE2N,APBB1,UBE2D1,RPL3L,IL15,IFNGR2"	4.95E-08
HALLMARK_FATTY_ACID_METABOLISM	DOWN	3.794438256	1025	43	11487	43	3.86E-09	"SUCLA2,ACSS1,ENO3,BCKDHB,ECHS1,PDHA1,SDHA,CRAT,SDHD,IDH3B,SERINC1,SDHC,HADHB,HSDL2,ACOT2,PDHB,ACADVL,IDH3G,CPT2,ECH1,HMGCS1,MDH1,ACADS,ACAA2,ACO2,HADH,ACADM,DLST,MLYCD,RETSAT,D2HGDH,SMS,ACSL1,SUCLG2,SUCLG1,ETFDH,NBN,UROD,MDH2,DECR1,GPD2,ECI1,AUH,ACADL,IDH1,FASN,EHHADH,CRYZ,DLD,CD36,SLC22A5,MCEE,ECI2,NTHL1,HCCS,PPARA,HSPH1,ALAD,GCDH,HSD17B10,HIBCH,GABARAPL1,AOC3,RDH11,ME1,BPHL,GLUL,ACOT8,PTS,RAP1GDS1,PRDX6,ACSL5,NSDHL,ALDH9A1,CPT1A,ACAT2,HMGCS2,MIF,PTPRG,REEP6,CPOX,HSD17B4,HMGCL,OSTC,METAP1,G0S2,CCDC58,ADIPOR2,ACOX1,ALDH3A2,ALDOA,ACSL4,GSTZ1,HPGD,IDI1,CBR1,UROS,CIDEA,ADSL,INMT,SETD8,MGLL,APEX1,PSME1,UGDH,ELOVL5,H2AFZ,LDHA,BLVRA,AQP7,YWHAH,NCAPH2,ODC1,ALDH1A1,HSP90AA1,S100A10,MAOA,HSD17B11,LGALS1,ERP29,FMO1,UBE2L6,GRHPR,GPD1,DHCR24,HSD17B7,EPHX1"	4.95E-08
HALLMARK_KRAS_SIGNALING_UP	UP	3.435060963	1074	44	11487	44	4.07E-09	"CFB,EMP1,ITGB2,CTSS,AKAP12,CFH,APOD,ACE,ITGBL1,IL33,GPNMB,LCP1,LAPTM5,C3AR1,F13A1,DOCK2,ENG,FCER1G,SPARCL1,PLAU,CCND2,KIF5C,TNFAIP3,TOR1AIP2,SCN1B,GABRA3,TNFRSF1B,TMEM176B,MAP3K1,PPBP,IRF8,SOX9,CSF2RA,TMEM176A,PLAT,ID2,PLVAP,MYCN,GNG11,STRN,CMKLR1,GADD45G,PSMB8,BIRC3,IL2RG,FGF9,PPP1R15A,FUCA1,VWA5A,GPRC5B,KLF4,SLMO2,ANO1,MAFB,PECAM1,CBR4,DNMBP,GPR124,IKZF1,CXCR4,NGF,ETV5,TLR8,ALDH1A2,RELN,SEMA3B,DUSP6,USH1C,HBEGF,GFPT2,ETS1,HIST1H2BB,AVL9,HSD11B1,IL10RA,CIDEA,MMP11,GUCY1A3,MMD,SATB1,CBX8,EVI5,BPGM,FLT4,BTC,TMEM100,TNNT2,ST6GAL1,NIN,ERO1L,SNAP91,NRP1,GLRX,ADAM17,MALL,G0S2,NR0B2,ATG10,DCBLD2,IGFBP3,IGF2,CAB39L,GYPC,USP12,TSPAN13,PTCD2,CDADC1,BTBD3,RBM4,SDCCAG8,SPRY2,MMP9,PRDM1,YRDC,CROT,CBL,FBXO4,WDR33,TRIB2,SPON1,JUP,ANGPTL4,MTMR10,HDAC9,CPE,AMMECR1,AKT2,PTPRR,PTBP2,ELTD1,TSPAN7,TRIB1,ETV1,RABGAP1L,PRRX1,PEG3,TFPI"	4.95E-08
HALLMARK_COMPLEMENT	UP	1.964623076	3455	78	11487	78	4.08E-09	"C3,LRP1,CFB,F5,CP,PLEK,C1S,C1QC,CTSS,CFH,ITGAM,C1QA,SERPING1,FN1,LCP2,MMP14,LGALS3,FCER1G,PFN1,PIK3R5,PRKCD,SERPINE1,GNAI2,TNFAIP3,PDGFB,RNF4,CASP1,PLAT,PCLO,CD55,JAK2,PSMB9,SPOCK2,PREP,ANXA5,CTSH,RCE1,ACTN2,CSRP1,PSEN1,CALM1,ZEB1,TIMP2,CPM,LGMN,DOCK10,ADAM9,MAFF,PIK3CG,GNG2,S100A13,USP16,USP15,XPNPEP1,GNAI3,CLU,IRF2,CTSD,LAP3,F8,SIRT6,IRF1,PRSS36,USP14,CTSB,GNB2,DUSP6,PLSCR1,LYN,GNGT2,RHOG,DGKH,DUSP5,CALM3,PPP4C,ZFYVE20,C2,PRCP,SRC,HSPA1A,FYN,ATOX1,PLA2G7,CASP4,LIPA,RABIF,COL4A2,DOCK9,DPP4,SEPX1,PRDM4,NOTCH4,PLA2G4A,LTA4H,EHD1,LAMP2,PPP2CB,CTSO,GNB4,BRPF3,PGCP,GRB2,CBLB,VCPIP1,AKAP10,SH2B3,USP8,KCNIP3,GMFB,CTSC,CASP7,KIF2A,ME1,DOCK4,CASP9,GCA,DYRK2,PDP1,PIK3CA,FDX1,PIM1,ANG,CD36,F3,CEBPB,GPD2,ZFPM2,RAF1,KCNIP2,MMP15,CDH13,HSPA5"	4.95E-08
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	UP	3.287888756	1520	67	11487	67	4.14E-09	"THBS1,BGN,LRP1,MGP,VCAN,FSTL1,POSTN,FBLN2,FBN1,VIM,LOXL2,TGFBI,TGM2,SFRP1,COL1A1,SERPINE2,ECM1,PCOLCE,FN1,LUM,FLNA,COL3A1,MMP14,LOXL1,IGFBP4,DCN,COL6A3,ITGB3,DAB2,TNFRSF12A,TPM4,COL6A2,SERPINE1,SLC6A8,THY1,COL5A2,PDGFRB,TNFAIP3,COL12A1,NID2,CTGF,SLIT3,LOX,TPM2,PMEPA1,LAMC2,BMP1,EMP3,CAPG,MATN2,COL16A1,ID2,LGALS1,TGFB1,VCAM1,CALD1,FBLN1,ITGB5,FSTL3,CD44,COL4A1,COL1A2,CXCL12,EFEMP2,SAT1,FUCA1,APLP1,CYR61,ANPEP,MYL9,MFAP5,FGF2,QSOX1,COL5A1,SPARC,WNT5A,THBS2,MSX1,NOTCH2,WIPF1,BASP1,MAGEE1,PCOLCE2,COL5A3,PPIB,ABI3BP,LAMA3,SGCD,FBLN5,TNC,SDC4,FMOD,GAS1,VEGFC,VEGFA,LAMC1,COL4A2,CALU,FZD8,ITGAV,GEM,PDLIM4,GLT25D1,GADD45B,RGS4,CADM1,JUN,TPM1,MCM7,RHOB,FAP,GPX7,MYLK,IGFBP3,PLOD3,PLOD2,MEST,ITGA5,ELN,PVR,PLOD1,SGCB,BDNF,SNAI2,TAGLN,CDH11,SERPINH1,CDH2,ECM2,FBN2,GADD45A,COPA,ACTA2,DST,FERMT2,PFN2,GPC1,FAS,DPYSL3,GJA1,SNTB1,LAMA2,TIMP3,CAP2,SLIT2,LEPRE1,ITGB1,NT5E,SGCG,SDC1,HTRA1,PRRX1,IL15,TGFBR3"	4.95E-08
HALLMARK_INTERFERON_GAMMA_RESPONSE	UP	2.836296296	2484	92	11487	92	4.15E-09	"IFIT3,CFB,IFIT1,GBP6,STAT3,PARP14,IFI44,C1S,IFIT2,CFH,DDX58,SAMD9L,TAP1,B2M,PSMB10,IFITM3,ICAM1,PTPN1,SERPING1,DDX60,IFIH1,OAS2,SP110,ZNFX1,LY6E,IRF9,CD274,LCP2,HERC6,EIF2AK2,XAF1,PML,PFKP,IFI30,TAPBP,NLRC5,MVP,CD74,RSAD2,DHX58,BST2,USP18,ADAR,PTPN6,STAT2,FGL2,CASP8,RTP4,IRF4,TNFAIP3,SOCS3,GBP4,UBE2L6,CMPK2,IRF8,ISG15,TRAFD1,CASP1,IRF5,EPSTI1,TRIM25,SRI,JAK2,PSMB9,VCAM1,CMKLR1,CDKN1A,PSMB8,RIPK2,TDRD7,IFNAR2,FTSJD2,IFI35,PARP12,TNFSF10,SAMHD1,CD86,PNP,MTHFD2,TOR1B,ARID5B,CIITA,NFKB1,UPP1,IRF2,CXCL9,NMI,LAP3,OGFR,WARS,MARCH1,IRF1,NUP93,TRIM14,PLSCR1,HIF1A,TRIM26,IL18BP,PSME1,TRIM21,MX2,P2RY14,IFITM2,CSF2RB,IL10RA,RBCK1,BANK1,ST3GAL5,BPGM,TXNIP,CASP4,VAMP5,LATS2,NFKBIA,PLA2G4A,PSMB2,RIPK1,MYD88,NCOA3,CD38,PSME2,PDE4B,ISG20,PTPN2,VAMP8,PSMA2,LYSMD2,EIF4E3,RNF31,NOD1,ARL4A,ST8SIA4,GCH1,CASP7,PELI1,PNPT1,BTG1,PSMA3,SLC25A28,PIM1,RAPGEF6,FAS,IL15RA,TNFAIP2,NAMPT,ISOC1,AUTS2,IL15,SOD2,SSPN"	4.95E-08
HALLMARK_OXIDATIVE_PHOSPHORYLATION	DOWN	4.060223447	1452	97	11487	97	4.45E-09	"NDUFS1,SUCLA2,CS,ALDH6A1,ATP5F1,ATP5C1,ATP5A1,ECHS1,ATP5H,PDHA1,SDHA,BCKDHA,VDAC1,ATP5J,SDHD,LRPPRC,DLAT,IDH3B,HADHA,SDHC,ETFA,NDUFB8,HSPA9,HADHB,ACADSB,ETFB,UQCRC1,COX6C,IDH3A,SDHB,NDUFS2,PHYH,MGST3,IMMT,PDHB,UQCRB,NDUFV2,ACADVL,IDH3G,NDUFC1,SLC25A4,ECH1,NDUFV1,PRDX3,SLC25A3,MDH1,CYCS,UQCRQ,ACAA2,ACO2,COX5A,MRPS22,PDK4,ACADM,CYC1,ATP6V0B,FXN,DLST,MRPL15,RETSAT,NDUFA8,UQCRC2,ACAT1,MRPS15,LDHB,SUCLG1,NDUFA9,GOT2,ATP5G2,ETFDH,COX5B,COX7B,ATP5G1,ABCB7,COX7C,MDH2,OGDH,DECR1,NDUFC2,NDUFB6,ATP5B,ECI1,UQCRFS1,ATP5E,AIFM1,IDH1,BRP44L,PMPCA,SLC25A11,SLC25A20,NDUFB5,NDUFA4,ATP5O,COX15,MFN2,NDUFS7,NDUFA5,NDUFAB1,SLC25A12,TOMM70A,DLD,MRPL35,OPA1,NDUFS4,NQO2,FDX1,COX7A2,ISCA1,NNT,TIMM50,HCCS,NDUFB7,PDP1,BAX,COX10,HSD17B10,ATP5L,NDUFB4,UQCR10,NDUFA7,MRPL11,NDUFB2,NDUFS3,MTRF1,MTX2,NDUFA2,ATP5G3,MRPL34,GLUD1,TIMM13,RHOT2,COX6B1,ATP5J2,PDHX,CASP7,ATP5D,OAT,NDUFS6,NDUFS8,COX8A,UQCR11,VDAC3,AFG3L2,TIMM17A,POLR2F,UQCRH,NDUFB3,ATP6V1G1,COX7A2L,RHOT1,ATP1B1,ATP6V1E1,MRPS30,GPX4,CPT1A,MAOB,NDUFA3,TIMM10,NDUFA1,ATP6V1C1,MRPS11,COX6A1,NDUFA6,ISCU,VDAC2,GRPEL1,SURF1,TIMM8B,TIMM9,POR,MTRR,HTRA2,OXA1L,SLC25A5,MRPS12,ATP6V1D,PHB2,IDH2,LDHA,ALAS1,COX11,ATP6AP1,SUPV3L1,COX17,ATP6V1F,TOMM22,ATP6V1H,CYB5R3,TCIRG1"	4.95E-08
HALLMARK_ADIPOGENESIS	DOWN	2.95409541	1111	54	11487	54	4.46E-09	"SSPN,DBT,CS,REEP5,ADCY6,ECHS1,CRAT,BCKDHA,DLAT,CMBL,SDHC,AGPAT3,SLC27A1,ETFB,UQCRC1,IDH3A,SDHB,PHYH,MGST3,IMMT,PIM3,DNAJB9,MCCC1,IDH3G,CPT2,ECH1,PRDX3,DRAM2,UQCRQ,ACADS,ACAA2,ACO2,HADH,LIFR,CHUK,ACADM,CYC1,COQ3,MRPL15,RETSAT,SUCLG1,COX7B,RNF11,TALDO1,CCNG2,LPCAT3,MDH2,DECR1,PTCD3,GPD2,LPL,COQ9,RREB1,AIFM1,ACADL,IDH1,GPAM,ATP5O,NDUFA5,ATL2,NDUFAB1,VEGFB,ITGA7,DLD,ABCB8,PPP1R15B,CD36,EPHX2,FAM82A2,NDUFB7,GHITM,SAMM50,SOD1,ANGPTL4,DDT,FZD4,SDPR,RIOK3,UQCR10,ELMOD3,GADD45A,HIBCH,OBFC2A,GBE1,CHCHD10,DHRS7,ESRRA,NDUFS3,COQ5,SQRDL,SORBS1,ME1,ANKRD57,QDPR,FAM73B,UCP2,STAT5A,SULT1A1,COX8A,UQCR11,TANK,LIPE,BCL2L13,ARL4A,PHLDB1,AGPAT6,UCK1,CDKN2C,G3BP2,DNAJC15,PREB,MTCH2,DHRS7B,GPX4,SCARB1,RAB34,DHCR7,MRAP,SLC5A6,NKIRAS1,ANGPT1,REEP6,GPHN,JAGN1,MYLK,TST,COX6A1,DGAT1,SLC25A10,PFKL,GRPEL1,CMPK1,SLC25A1,ADIPOR2,MAP4K3,ALDH2,ACOX1,HSPB8,SLC1A5,POR,BAZ2A,YWHAG,PPM1B,ACLY,ALDOA,PGM1,PDCD4,TOB1,RTN3,AK2,ATP1B3,ARAF,CIDEA,UBQLN1,PFKFB3,CYP4B1,NMT1,MGLL,ABCA1,FABP4,UBC,BCL6,PTRF,STOM,CD302,SCP2,PEX14,CAT,TKT,MOSC2,ITSN1,PPARG,LAMA4,APLP2,COL15A1,COL4A1,IFNGR1,PQLC3,ENPP2,CD151,SNCG,FAH,ESYT1,ITIH5,SPARCL1,PLIN2,GPX3,APOE,C3"	4.95E-08
HALLMARK_COAGULATION	UP	2.376125591	2913	47	11487	47	5.39E-09	"C3,THBS1,LRP1,CFB,VWF,PLEK,C1S,FBN1,CFH,C1QA,SERPING1,FN1,DCT,MMP14,ANXA1,ITGB3,PLAU,SERPINE1,PDGFB,GSN,PROS1,BMP1,PF4,PLAT,PREP,GDA,CTSH,CSRP1,LGMN,ADAM9,MAFF,S100A13,PECAM1,SPARC,CLU,S100A1,THBD,F8,RAC1,CTSK,CTSB,GNB2,CD9,DUSP6,WDR1,CAPN5,KLF7,RAPGEF3,C2,CAPN2,FYN,MMP11,RABIF,SIRT2,DPP4,ISCU,GNG12,LTA4H,LAMP2,MSRB2,CTSO,PEF1,HMGCS2,PGCP,KLK8,ARF4,PRSS23,MMP9,CASP9,USP11,ANG,F3,TIMP3,FURIN,CRIP2,MMP15,HTRA1,P2RY1"	5.39E-08
HALLMARK_IL6_JAK_STAT3_SIGNALING	UP	3.667198746	1168	22	11487	22	6.66E-07	"STAT3,PTPN1,IRF9,TNFRSF1A,ITGB3,TNFRSF12A,PIK3R5,TLR2,STAT2,OSMR,ITGA4,TNFRSF1B,SOCS3,IL6ST,ACVRL1,PF4,CSF2RA,TGFB1,IFNGR1,CD44,HMOX1,IL2RG,IFNAR1,TYK2,CSF1,BAK1,IL17RA,CXCL9,IRF1,IL18R1,CRLF2,CD9,LEPR,IL13RA1,IL1R1,PDGFC,CSF2RB,HAX1,CD14,CXCL13,STAM2,LTBR,PTPN11,MAP3K8,JUN,MYD88,CD38,PTPN2,GRB2,IL2RA,CBL,ACVR1B,IL10RB,TNFRSF21,PIM1,FAS,CD36,IL15RA,IFNGR2"	4.16E-06
HALLMARK_INFLAMMATORY_RESPONSE	UP	2.059094168	3138	63	11487	63	7.10E-09	"CX3CL1,ICAM1,C3AR1,CYBB,LY6E,LCP2,MMP14,EIF2AK2,TAPBP,ITGB3,BST2,SLC7A2,C5AR1,EMR1,PIK3R5,AXL,TLR2,MSR1,SERPINE1,OSMR,RTP4,SCN1B,TNFRSF1B,LPAR1,EMP3,CD55,SRI,CLEC5A,PTGER4,CMKLR1,CDKN1A,RIPK2,STAB1,P2RX7,IFNAR1,PSEN1,SLC11A2,ADRM1,PDPN,SLC4A4,PTAFR,TNFSF10,CSF1,CD82,MYC,GNAI3,SGMS2,NFKB1,CXCL9,NMI,SLC31A2,ATP2C1,TLR3,IRF1,IL18R1,HBEGF,LYN,HIF1A,ABCA1,IL1R1,RHOG,PTGIR,EDN1,SCARF1,MXD1,IL10RA,RELA,CD14,SLC28A2,IRAK2,P2RY2,CHST2,NFKBIA,BTG2,KLF6,CCRL2,DCBLD2,ITGB8,MET,PDE4B,P2RX4,ADM,NOD2,ATP2B1,LDLR,PTPRE,ACVR2A,ITGA5,GCH1,SEMA4D,PVR,AHR,KIF1B,GABBR1,SLC31A1,RNF144B,ACVR1B,CALCRL,APLNR,FZD5,ABI1,F3,IL15RA,SLC7A1,RAF1,KCNJ2,NAMPT,GPC3,PCDH7,IL15,ATP2A2,IFNGR2"	6.45E-08
HALLMARK_ESTROGEN_RESPONSE_LATE	UP	2.216523908	1660	41	11487	41	9.28E-06	"CCND1,FABP5,MYOF,TPD52L1,IGFBP4,NBL1,CXCL14,BCL2,FLNB,PTPN6,PRLR,TOP2A,LAMC2,PRKAR2B,CACNA2D2,IL6ST,KIF20A,ID2,FRK,JAK2,FGFR3,SGK1,WISP2,TNNC1,CD44,ASS1,IGSF1,CXCL12,SNX10,CKB,HSPA4L,TIAM1,ALDH3B1,ST6GALNAC2,RPS6KA2,FOS,KLF4,ABCA3,FAM102A,OLFM1,RAB31,HOMER2,SLC26A2,SFN,JAK1,LARGE,NAB2,DLG5,PERP,DNAJC12,TSTA3,SLC9A3R1,SEMA3B,CD9,ELOVL5,IDH2,UGDH,SLC7A5,RBBP8,UNC13B,DCXR,FARP1,PDLIM3,PAPSS2,AMFR,TOB1,PDCD4,NCOR2,SLC2A8,ALDH3A2,PLK4,SLC24A3,HSPB8,ZFP36,RET,CAV1,NRIP1,TST,MOCS2,SLC16A1,FDFT1,BLVRB,HMGCS2,MAPT,ATP2B4,DHCR7,ISG20,SCARB1,SORD,ITPK1,TSPAN13,MEST,METTL3,NXT1,FKBP5,RABEP1,PRSS23,FOXC1,DYNLT3,ABHD2,AFF1,OPN3,ARL3,SIAH2,IMPA2,HR,CISH,SLC29A1,DNAJC1,EMP2,CPE,SCUBE2,ADD3,SLC22A5,BAG1,CYP26B1,CHPT1,PLA2G16,WFS1,XBP1,LLGL2,PLXNB1,CELSR2,RNASEH2A,PPIF,COX6C,ETFB,FKBP4"	5.15E-05
HALLMARK_HYPOXIA	UP	1.771912828	2267	57	11487	57	9.29E-05	"BGN,CP,AKAP12,ANXA2,TGFBI,MYH9,TGM2,KIF5A,PAM,SLC6A6,SDC3,PFKP,DCN,PLIN2,BCL2,SDC2,SERPINE1,TNFAIP3,PDGFB,CTGF,LOX,TPD52,MAP3K1,GRHPR,PNRC1,P4HA1,UGP2,BHLHE40,GCK,CDKN1A,TPI1,PRKCDBP,WISP2,HMOX1,DDIT3,PPP1R15A,HK1,TGFB3,FOS,JMJD6,CYR61,SRPX,B3GALT6,ERRFI1,MAFF,ALDOB,PPP1R3C,ANKZF1,GAPDH,XPNPEP1,COL5A1,GAA,HEXA,LARGE,CXCR4,SAP30,STBD1,IER3,NDRG1,PTRF,GCNT2,LDHA,NEDD4L,EGFR,CHST3,KLF7,ETS1,WSB1,IRS2,CSRP2,FOSL2,LXN,PFKFB3,SDC4,PGM1,VEGFA,ATF3,NAGK,ALDOA,RBPJ,STC1,PRKCA,TPST2,NFIL3,CHST2,ILVBL,CITED2,SLC25A1,ERO1L,ZFP36,PFKL,KLF6,BNIP3L,GLRX,PGAM2,NDST1,MXI1,CAV1,JUN,NR3C1,SLC2A1,RORA,IGFBP3,MIF,PGK1,CXCR7,ADM,ISG20,SCARB1,PDK3,DDIT4,ATP7A,KDELR3,TIPARP,GALK1,KDM3A,DUSP1,CASP6,NDST2,GPC4,FAM162A,RRAGD,HS3ST1,PDK1,PRDX5,SIAH2,CCRN4L,EFNA1,BTG1,STC2,GBE1,FOXO3,DTNA,ANGPTL4,TES,AMPD3,DPYSL4,VHL,SLC37A4,P4HA2,GPC1,PIM1,AK4,F3,SELENBP1,PGM2,PGF,CCNG2,PPARGC1A,EXT1,GYS1,HK2,CDKN1C,IDS,PYGM,GPC3,HDLBP,ENO3,CDKN1B,VLDLR,KLHL24,HSPA5,PHKG1"	0.0004647