Supplemental Table S8						
						
# Significantly enriched GO terms (FDR 0.1%)						
# P-value - uncorrected P value						
# P-value adjusted - P value corrected for 20 tests for testis dataset and for 122 test for liver dataset (Benjamini-Hochberg method)						
						
Species	Tissue, ages	GO Term	Description	P-value	P-value adjusted	Enrichment
Human	Testis, primates-mammals	GO:0048387	negative regulation of retinoic acid receptor signaling pathway	1.93E-12	3.86E-11	15.22
Human	Testis, primates-mammals	GO:0048385	regulation of retinoic acid receptor signaling pathway	1.40E-10	1.40E-09	11.84
Human	Testis, primates-mammals	GO:0007283	spermatogenesis	4.50E-09	2.60E-08	3.40
Human	Testis, primates-mammals	GO:0048232	male gamete generation	5.19E-09	2.60E-08	3.38
Human	Testis, primates-mammals	GO:0007276	gamete generation	3.90E-08	1.56E-07	3.10
Human	Testis, primates-mammals	GO:0048609	multicellular organismal reproductive process	2.67E-06	8.90E-06	2.50
Human	Testis, primates-mammals	GO:0042742	defense response to bacterium	1.96E-05	5.60E-05	4.53
Human	Testis, primates-mammals	GO:0018149	peptide cross-linking	2.73E-05	6.83E-05	7.14
Human	Testis, primates-mammals	GO:0009617	response to bacterium	3.12E-05	6.93E-05	4.01
Human	Testis, primates-mammals	GO:0050911	detection of chemical stimulus involved in sensory perception of smell	1.37E-04	2.74E-04	19.37
Human	Testis, primates-mammals	GO:0000042	protein targeting to Golgi	2.10E-04	3.82E-04	8.07
Human	Testis, primates-mammals	GO:0072600	establishment of protein localization to Golgi	3.26E-04	5.15E-04	7.45
Human	Testis, primates-mammals	GO:0030216	keratinocyte differentiation	3.35E-04	5.15E-04	5.02
Human	Testis, primates-mammals	GO:0050907	detection of chemical stimulus involved in sensory perception	4.15E-04	5.93E-04	9.68
Human	Testis, primates-mammals	GO:0000301	retrograde transport, vesicle recycling within Golgi	4.86E-04	6.19E-04	6.92
Human	Testis, primates-mammals	GO:0098543	detection of other organism	5.26E-04	6.19E-04	14.53
Human	Testis, primates-mammals	GO:0016045	detection of bacterium	5.26E-04	6.19E-04	14.53
Human	Testis, primates-mammals	GO:0008544	epidermis development	6.72E-04	7.17E-04	4.52
Human	Testis, primates-mammals	GO:0002437	inflammatory response to antigenic stimulus	7.17E-04	7.17E-04	8.61
Human	Testis, primates-mammals	GO:0031424	keratinization	7.17E-04	7.17E-04	8.61
Human	Liver, mammals	GO:0006805	xenobiotic metabolic process	3.52E-27	4.29E-25	9.80
Human	Liver, mammals	GO:0008202	steroid metabolic process	6.12E-16	3.73E-14	6.00
Human	Liver, mammals	GO:0019369	arachidonic acid metabolic process	1.23E-14	5.00E-13	13.71
Human	Liver, mammals	GO:0019373	epoxygenase P450 pathway	8.75E-14	2.67E-12	20.10
Human	Liver, mammals	GO:0006690	icosanoid metabolic process	3.23E-13	6.57E-12	10.50
Human	Liver, mammals	GO:1901568	fatty acid derivative metabolic process	3.23E-13	6.57E-12	10.50
Human	Liver, mammals	GO:0032787	monocarboxylic acid metabolic process	6.01E-13	1.05E-11	3.86
Human	Liver, mammals	GO:0001676	long-chain fatty acid metabolic process	1.01E-12	1.54E-11	9.06
Human	Liver, mammals	GO:0017144	drug metabolic process	6.65E-12	9.01E-11	15.64
Human	Liver, mammals	GO:0033559	unsaturated fatty acid metabolic process	9.69E-12	1.18E-10	8.71
Human	Liver, mammals	GO:0006954	inflammatory response	3.01E-11	3.34E-10	4.49
Human	Liver, mammals	GO:0009812	flavonoid metabolic process	1.17E-10	1.19E-09	17.71
Human	Liver, mammals	GO:0006629	lipid metabolic process	1.76E-10	1.65E-09	2.51
Human	Liver, mammals	GO:0044281	small molecule metabolic process	2.06E-10	1.80E-09	1.98
Human	Liver, mammals	GO:0070098	chemokine-mediated signaling pathway	2.87E-10	2.33E-09	10.59
Human	Liver, mammals	GO:0042737	drug catabolic process	1.00E-09	7.63E-09	22.39
Human	Liver, mammals	GO:0034754	cellular hormone metabolic process	2.75E-09	1.97E-08	7.31
Human	Liver, mammals	GO:0052696	flavonoid glucuronidation	4.35E-09	2.79E-08	19.90
Human	Liver, mammals	GO:0009813	flavonoid biosynthetic process	4.35E-09	2.79E-08	19.90
Human	Liver, mammals	GO:0006063	uronic acid metabolic process	5.34E-09	3.10E-08	15.75
Human	Liver, mammals	GO:0019585	glucuronate metabolic process	5.34E-09	3.10E-08	15.75
Human	Liver, mammals	GO:0052695	cellular glucuronidation	1.40E-08	7.76E-08	17.91
Human	Liver, mammals	GO:0055114	oxidation-reduction process	1.53E-08	8.12E-08	2.53
Human	Liver, mammals	GO:0006631	fatty acid metabolic process	1.60E-08	8.13E-08	4.05
Human	Liver, mammals	GO:0010817	regulation of hormone levels	3.76E-08	1.83E-07	4.65
Human	Liver, mammals	GO:0048247	lymphocyte chemotaxis	4.82E-08	2.26E-07	12.79
Human	Liver, mammals	GO:0042445	hormone metabolic process	6.60E-08	2.96E-07	5.41
Human	Liver, mammals	GO:0043436	oxoacid metabolic process	6.79E-08	2.96E-07	2.34
Human	Liver, mammals	GO:0006082	organic acid metabolic process	8.66E-08	3.57E-07	2.32
Human	Liver, mammals	GO:0097267	omega-hydroxylase P450 pathway	8.85E-08	3.57E-07	19.19
Human	Liver, mammals	GO:0006720	isoprenoid metabolic process	9.06E-08	3.57E-07	6.82
Human	Liver, mammals	GO:0006721	terpenoid metabolic process	1.25E-07	4.77E-07	7.41
Human	Liver, mammals	GO:0060326	cell chemotaxis	1.43E-07	5.29E-07	5.12
Human	Liver, mammals	GO:0042180	cellular ketone metabolic process	1.68E-07	6.03E-07	7.22
Human	Liver, mammals	GO:0019752	carboxylic acid metabolic process	3.02E-07	1.05E-06	2.37
Human	Liver, mammals	GO:0072676	lymphocyte migration	4.11E-07	1.39E-06	10.24
Human	Liver, mammals	GO:0042738	exogenous drug catabolic process	5.11E-07	1.68E-06	21.32
Human	Liver, mammals	GO:0006952	defense response	6.02E-07	1.93E-06	2.17
Human	Liver, mammals	GO:0019748	secondary metabolic process	6.42E-07	2.01E-06	9.75
Human	Liver, mammals	GO:0010951	negative regulation of endopeptidase activity	1.95E-06	5.56E-06	4.22
Human	Liver, mammals	GO:0030595	leukocyte chemotaxis	2.06E-06	5.56E-06	5.74
Human	Liver, mammals	GO:0002526	acute inflammatory response	2.10E-06	5.56E-06	8.53
Human	Liver, mammals	GO:0016098	monoterpenoid metabolic process	2.28E-06	5.56E-06	25.59
Human	Liver, mammals	GO:1901523	icosanoid catabolic process	2.28E-06	5.56E-06	25.59
Human	Liver, mammals	GO:1901569	fatty acid derivative catabolic process	2.28E-06	5.56E-06	25.59
Human	Liver, mammals	GO:0036101	leukotriene B4 catabolic process	2.28E-06	5.56E-06	25.59
Human	Liver, mammals	GO:0036100	leukotriene catabolic process	2.28E-06	5.56E-06	25.59
Human	Liver, mammals	GO:0036102	leukotriene B4 metabolic process	2.28E-06	5.56E-06	25.59
Human	Liver, mammals	GO:0042758	long-chain fatty acid catabolic process	2.28E-06	5.56E-06	25.59
Human	Liver, mammals	GO:0051410	detoxification of nitrogen compound	2.28E-06	5.56E-06	25.59
Human	Liver, mammals	GO:0051186	cofactor metabolic process	2.40E-06	5.74E-06	3.28
Human	Liver, mammals	GO:0010466	negative regulation of peptidase activity	2.59E-06	6.08E-06	4.13
Human	Liver, mammals	GO:0006953	acute-phase response	2.84E-06	6.42E-06	9.95
Human	Liver, mammals	GO:1901661	quinone metabolic process	2.84E-06	6.42E-06	9.95
Human	Liver, mammals	GO:0006935	chemotaxis	1.69E-05	3.68E-05	3.38
Human	Liver, mammals	GO:0042330	taxis	1.69E-05	3.68E-05	3.38
Human	Liver, mammals	GO:1901616	organic hydroxy compound catabolic process	2.28E-05	4.86E-05	6.40
Human	Liver, mammals	GO:0045861	negative regulation of proteolysis	2.31E-05	4.86E-05	3.30
Human	Liver, mammals	GO:0050907	detection of chemical stimulus involved in sensory perception	3.22E-05	6.44E-05	17.06
Human	Liver, mammals	GO:0044598	doxorubicin metabolic process	3.22E-05	6.44E-05	17.06
Human	Liver, mammals	GO:0044597	daunorubicin metabolic process	3.22E-05	6.44E-05	17.06
Human	Liver, mammals	GO:0044710	single-organism metabolic process	3.71E-05	7.28E-05	1.39
Human	Liver, mammals	GO:0006790	sulfur compound metabolic process	3.76E-05	7.28E-05	2.83
Human	Liver, mammals	GO:0071395	cellular response to jasmonic acid stimulus	5.91E-05	1.08E-04	25.59
Human	Liver, mammals	GO:0003095	pressure natriuresis	5.91E-05	1.08E-04	25.59
Human	Liver, mammals	GO:0009804	coumarin metabolic process	5.91E-05	1.08E-04	25.59
Human	Liver, mammals	GO:0009753	response to jasmonic acid	5.91E-05	1.08E-04	25.59
Human	Liver, mammals	GO:0030638	polyketide metabolic process	7.28E-05	1.29E-04	14.62
Human	Liver, mammals	GO:0030647	aminoglycoside antibiotic metabolic process	7.28E-05	1.29E-04	14.62
Human	Liver, mammals	GO:0006766	vitamin metabolic process	8.12E-05	1.41E-04	4.34
Human	Liver, mammals	GO:0009593	detection of chemical stimulus	8.23E-05	1.41E-04	7.68
Human	Liver, mammals	GO:0030593	neutrophil chemotaxis	9.60E-05	1.60E-04	6.18
Human	Liver, mammals	GO:1990266	neutrophil migration	9.60E-05	1.60E-04	6.18
Human	Liver, mammals	GO:0006955	immune response	1.19E-04	1.94E-04	1.93
Human	Liver, mammals	GO:1901615	organic hydroxy compound metabolic process	1.20E-04	1.94E-04	2.45
Human	Liver, mammals	GO:0001523	retinoid metabolic process	1.21E-04	1.94E-04	5.97
Human	Liver, mammals	GO:0002548	monocyte chemotaxis	1.32E-04	2.04E-04	9.14
Human	Liver, mammals	GO:0008210	estrogen metabolic process	1.32E-04	2.04E-04	9.14
Human	Liver, mammals	GO:0044255	cellular lipid metabolic process	1.34E-04	2.04E-04	1.99
Human	Liver, mammals	GO:0051346	negative regulation of hydrolase activity	1.34E-04	2.04E-04	2.75
Human	Liver, mammals	GO:0043252	sodium-independent organic anion transport	1.41E-04	2.10E-04	12.79
Human	Liver, mammals	GO:0070989	oxidative demethylation	1.41E-04	2.10E-04	12.79
Human	Liver, mammals	GO:0034308	primary alcohol metabolic process	1.48E-04	2.17E-04	6.98
Human	Liver, mammals	GO:0071621	granulocyte chemotaxis	1.51E-04	2.17E-04	5.78
Human	Liver, mammals	GO:0097530	granulocyte migration	1.51E-04	2.17E-04	5.78
Human	Liver, mammals	GO:0016101	diterpenoid metabolic process	1.87E-04	2.65E-04	5.60
Human	Liver, mammals	GO:0050900	leukocyte migration	2.28E-04	3.04E-04	3.14
Human	Liver, mammals	GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib	2.29E-04	3.04E-04	19.19
Human	Liver, mammals	GO:0048007	antigen processing and presentation, exogenous lipid antigen via MHC class Ib	2.29E-04	3.04E-04	19.19
Human	Liver, mammals	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste	2.29E-04	3.04E-04	19.19
Human	Liver, mammals	GO:0042447	hormone catabolic process	2.29E-04	3.04E-04	19.19
Human	Liver, mammals	GO:0009698	phenylpropanoid metabolic process	2.29E-04	3.04E-04	19.19
Human	Liver, mammals	GO:0043207	response to external biotic stimulus	2.38E-04	3.12E-04	2.34
Human	Liver, mammals	GO:0006749	glutathione metabolic process	2.50E-04	3.24E-04	6.40
Human	Liver, mammals	GO:0002376	immune system process	2.57E-04	3.30E-04	1.66
Human	Liver, mammals	GO:0006775	fat-soluble vitamin metabolic process	2.69E-04	3.42E-04	8.00
Human	Liver, mammals	GO:0019221	cytokine-mediated signaling pathway	3.04E-04	3.82E-04	2.42
Human	Liver, mammals	GO:0052548	regulation of endopeptidase activity	3.16E-04	3.93E-04	2.66
Human	Liver, mammals	GO:0071346	cellular response to interferon-gamma	3.69E-04	4.46E-04	7.53
Human	Liver, mammals	GO:1901685	glutathione derivative metabolic process	3.69E-04	4.46E-04	7.53
Human	Liver, mammals	GO:1901687	glutathione derivative biosynthetic process	3.69E-04	4.46E-04	7.53
Human	Liver, mammals	GO:0006544	glycine metabolic process	3.98E-04	4.76E-04	10.24
Human	Liver, mammals	GO:0009607	response to biotic stimulus	4.25E-04	5.03E-04	2.24
Human	Liver, mammals	GO:0044248	cellular catabolic process	5.17E-04	6.06E-04	1.75
Human	Liver, mammals	GO:0034310	primary alcohol catabolic process	5.57E-04	6.12E-04	15.35
Human	Liver, mammals	GO:0002475	antigen processing and presentation via MHC class Ib	5.57E-04	6.12E-04	15.35
Human	Liver, mammals	GO:0071276	cellular response to cadmium ion	5.57E-04	6.12E-04	15.35
Human	Liver, mammals	GO:0098581	detection of external biotic stimulus	5.57E-04	6.12E-04	15.35
Human	Liver, mammals	GO:0050912	detection of chemical stimulus involved in sensory perception of taste	5.57E-04	6.12E-04	15.35
Human	Liver, mammals	GO:0042178	xenobiotic catabolic process	5.57E-04	6.12E-04	15.35
Human	Liver, mammals	GO:0042373	vitamin K metabolic process	5.57E-04	6.12E-04	15.35
Human	Liver, mammals	GO:0052547	regulation of peptidase activity	5.98E-04	6.49E-04	2.51
Human	Liver, mammals	GO:0006706	steroid catabolic process	6.06E-04	6.49E-04	9.30
Human	Liver, mammals	GO:0016137	glycoside metabolic process	6.06E-04	6.49E-04	9.30
Human	Liver, mammals	GO:0008209	androgen metabolic process	6.51E-04	6.85E-04	6.73
Human	Liver, mammals	GO:0009056	catabolic process	6.51E-04	6.85E-04	1.61
Human	Liver, mammals	GO:0097529	myeloid leukocyte migration	6.77E-04	7.06E-04	4.59
Human	Liver, mammals	GO:0005996	monosaccharide metabolic process	6.95E-04	7.19E-04	2.95
Human	Liver, mammals	GO:0051707	response to other organism	7.80E-04	8.00E-04	2.54
Human	Liver, mammals	GO:0050729	positive regulation of inflammatory response	7.93E-04	8.06E-04	4.48
Human	Liver, mammals	GO:0002704	negative regulation of leukocyte mediated immunity	8.81E-04	8.81E-04	8.53
Human	Liver, mammals	GO:1901623	regulation of lymphocyte chemotaxis	8.81E-04	8.81E-04	8.53