Supplemental Table S5 # Significantly enriched GO terms (FDR 0.1%) # Gene category - signifies dN- and ED-biased genes and the age category, either "lineage-specific and young" or "old and ancient" # P-value - uncorrected P value # P-value adjusted - P value corrected for 667 tests (Benjamini-Hochberg method) Gene category GO Term Description P-value P-value adjusted Enrichment dN-biased lineage-specific and young GO:0006351 "transcription, DNA-templated" 7.70E-61 2.57E-58 2.52 dN-biased lineage-specific and young GO:0097659 nucleic acid-templated transcription 7.70E-61 2.57E-58 2.52 dN-biased lineage-specific and young GO:0032774 RNA biosynthetic process 7.30E-60 1.62E-57 2.5 dN-biased lineage-specific and young GO:0034654 nucleobase-containing compound biosynthetic process 1.50E-59 1.67E-57 2.48 dN-biased lineage-specific and young GO:0018130 heterocycle biosynthetic process 1.50E-59 1.67E-57 2.48 dN-biased lineage-specific and young GO:0019438 aromatic compound biosynthetic process 1.50E-59 1.67E-57 2.48 dN-biased lineage-specific and young GO:0044271 cellular nitrogen compound biosynthetic process 4.49E-59 4.28E-57 2.47 dN-biased lineage-specific and young GO:1901362 organic cyclic compound biosynthetic process 2.58E-56 2.15E-54 2.42 dN-biased lineage-specific and young GO:0034645 cellular macromolecule biosynthetic process 1.10E-55 8.15E-54 2.41 dN-biased lineage-specific and young GO:0051252 regulation of RNA metabolic process 1.82E-55 1.21E-53 2.28 dN-biased lineage-specific and young GO:2001141 regulation of RNA biosynthetic process 2.10E-55 1.27E-53 2.3 dN-biased lineage-specific and young GO:0016070 RNA metabolic process 3.52E-55 1.96E-53 2.39 dN-biased lineage-specific and young GO:0006355 "regulation of transcription, DNA-templated" 8.94E-55 4.26E-53 2.29 dN-biased lineage-specific and young GO:1903506 regulation of nucleic acid-templated transcription 8.94E-55 4.26E-53 2.29 dN-biased lineage-specific and young GO:2000112 regulation of cellular macromolecule biosynthetic process 2.24E-54 9.96E-53 2.28 dN-biased lineage-specific and young GO:0090304 nucleic acid metabolic process 7.13E-54 2.97E-52 2.34 dN-biased lineage-specific and young GO:0009059 macromolecule biosynthetic process 1.66E-53 6.51E-52 2.37 dN-biased lineage-specific and young GO:0010556 regulation of macromolecule biosynthetic process 4.87E-53 1.80E-51 2.25 dN-biased lineage-specific and young GO:0031326 regulation of cellular biosynthetic process 3.81E-51 1.34E-49 2.21 dN-biased lineage-specific and young GO:0019219 regulation of nucleobase-containing compound metabolic process 6.71E-51 2.24E-49 2.13 dN-biased lineage-specific and young GO:0009889 regulation of biosynthetic process 2.09E-50 6.64E-49 2.2 dN-biased lineage-specific and young GO:0051171 regulation of nitrogen compound metabolic process 1.91E-49 5.79E-48 2.16 dN-biased lineage-specific and young GO:0044260 cellular macromolecule metabolic process 1.05E-46 3.05E-45 2 dN-biased lineage-specific and young GO:0010468 regulation of gene expression 8.22E-45 2.19E-43 2.05 dN-biased lineage-specific and young GO:0006139 nucleobase-containing compound metabolic process 2.22E-44 5.70E-43 2.02 dN-biased lineage-specific and young GO:0044249 cellular biosynthetic process 6.15E-43 1.52E-41 2.13 dN-biased lineage-specific and young GO:1901576 organic substance biosynthetic process 1.33E-42 3.17E-41 2.12 dN-biased lineage-specific and young GO:0046483 heterocycle metabolic process 8.60E-42 1.98E-40 1.97 dN-biased lineage-specific and young GO:0006725 cellular aromatic compound metabolic process 1.92E-41 4.27E-40 1.96 dN-biased lineage-specific and young GO:0009058 biosynthetic process 2.80E-41 6.02E-40 2.09 dN-biased lineage-specific and young GO:0060255 regulation of macromolecule metabolic process 5.43E-41 1.13E-39 1.95 dN-biased lineage-specific and young GO:0080090 regulation of primary metabolic process 7.31E-40 1.48E-38 1.94 dN-biased lineage-specific and young GO:0031323 regulation of cellular metabolic process 4.43E-38 8.69E-37 2.1 dN-biased lineage-specific and young GO:0034641 cellular nitrogen compound metabolic process 4.87E-38 9.28E-37 1.99 dN-biased lineage-specific and young GO:0043170 macromolecule metabolic process 7.26E-36 1.24E-34 1.73 dN-biased lineage-specific and young GO:0019222 regulation of metabolic process 7.73E-35 1.29E-33 1.64 dN-biased lineage-specific and young GO:1901360 organic cyclic compound metabolic process 3.08E-34 5.01E-33 1.83 dN-biased lineage-specific and young GO:0006807 nitrogen compound metabolic process 1.02E-31 1.58E-30 1.84 dN-biased lineage-specific and young GO:0050794 regulation of cellular process 4.39E-28 6.51E-27 1.45 dN-biased lineage-specific and young GO:0050789 regulation of biological process 3.85E-26 5.46E-25 1.39 dN-biased lineage-specific and young GO:0044237 cellular metabolic process 1.60E-22 2.13E-21 1.79 dN-biased lineage-specific and young GO:0065007 biological regulation 4.62E-22 6.04E-21 1.33 dN-biased lineage-specific and young GO:0071704 organic substance metabolic process 1.15E-18 1.22E-17 1.63 dN-biased lineage-specific and young GO:0044238 primary metabolic process 2.93E-18 3.01E-17 1.66 dN-biased lineage-specific and young GO:0008152 metabolic process 1.56E-13 1.18E-12 1.49 dN-biased lineage-specific and young GO:0009987 cellular process 2.70E-08 1.01E-07 1.18 dN-biased lineage-specific and young GO:0051253 negative regulation of RNA metabolic process 7.14E-06 1.58E-05 2.12 dN-biased lineage-specific and young GO:0006366 transcription from RNA polymerase II promoter 9.32E-06 2.00E-05 9.39 dN-biased lineage-specific and young GO:1902679 negative regulation of RNA biosynthetic process 9.66E-06 2.07E-05 3.25 dN-biased lineage-specific and young GO:0045892 "negative regulation of transcription, DNA-templated" 1.28E-05 2.62E-05 3.32 dN-biased lineage-specific and young GO:2000113 negative regulation of cellular macromolecule biosynthetic process 1.28E-05 2.62E-05 3.32 dN-biased lineage-specific and young GO:0016998 cell wall macromolecule catabolic process 1.38E-05 2.79E-05 79.07 dN-biased lineage-specific and young GO:0045934 negative regulation of nucleobase-containing compound metabolic process 2.00E-05 3.90E-05 1.92 dN-biased lineage-specific and young GO:0051172 negative regulation of nitrogen compound metabolic process 2.00E-05 3.90E-05 1.92 dN-biased lineage-specific and young GO:1903507 negative regulation of nucleic acid-templated transcription 2.06E-05 3.98E-05 3.23 dN-biased lineage-specific and young GO:0010558 negative regulation of macromolecule biosynthetic process 2.34E-05 4.45E-05 3.1 dN-biased lineage-specific and young GO:0044036 cell wall macromolecule metabolic process 2.51E-05 4.70E-05 69.19 dN-biased lineage-specific and young GO:0031327 negative regulation of cellular biosynthetic process 3.62E-05 6.42E-05 3.04 dN-biased lineage-specific and young GO:0009890 negative regulation of biosynthetic process 5.54E-05 9.38E-05 2.97 dN-biased lineage-specific and young GO:0007339 binding of sperm to zona pellucida 2.76E-04 0.000356678 110.7 dN-biased lineage-specific and young GO:0000122 negative regulation of transcription from RNA polymerase II promoter 5.08E-04 0.000580199 5.24 dN-biased lineage-specific and young GO:0006952 defense response 5.77E-04 0.000646822 1.19 dN-biased lineage-specific and young GO:0010927 cellular component assembly involved in morphogenesis 5.87E-04 0.000652548 88.56 dN-biased lineage-specific and young GO:0001675 acrosome assembly 5.87E-04 0.000652548 88.56 dN-biased lineage-specific and young GO:0033363 secretory granule organization 5.87E-04 0.000652548 88.56 dN-biased lineage-specific and young GO:0035036 sperm-egg recognition 5.87E-04 0.000652548 88.56 dN-biased lineage-specific and young GO:0070925 organelle assembly 5.87E-04 0.000652548 88.56 dN-biased lineage-specific and young GO:0048387 negative regulation of retinoic acid receptor signaling pathway 7.82E-04 0.000822703 23.72 dN-biased lineage-specific and young GO:0016050 vesicle organization 9.53E-04 0.000961205 73.8 dN-biased old and ancient GO:0044260 cellular macromolecule metabolic process 1.74E-16 1.61E-15 1.39 dN-biased old and ancient GO:0090304 nucleic acid metabolic process 4.46E-15 3.81E-14 1.89 dN-biased old and ancient GO:0043170 macromolecule metabolic process 9.83E-15 8.30E-14 1.42 dN-biased old and ancient GO:0044237 cellular metabolic process 1.50E-13 1.16E-12 1.31 dN-biased old and ancient GO:0046483 heterocycle metabolic process 4.62E-13 3.35E-12 1.6 dN-biased old and ancient GO:0016070 RNA metabolic process 5.92E-13 4.25E-12 1.55 dN-biased old and ancient GO:0044238 primary metabolic process 7.45E-13 5.29E-12 1.3 dN-biased old and ancient GO:0006725 cellular aromatic compound metabolic process 9.04E-13 6.35E-12 1.59 dN-biased old and ancient GO:0006139 nucleobase-containing compound metabolic process 9.20E-13 6.39E-12 1.65 dN-biased old and ancient GO:1901360 organic cyclic compound metabolic process 1.52E-11 1.01E-10 1.52 dN-biased old and ancient GO:0071704 organic substance metabolic process 2.52E-11 1.66E-10 1.27 dN-biased old and ancient GO:0034641 cellular nitrogen compound metabolic process 3.99E-11 2.58E-10 1.52 dN-biased old and ancient GO:0045184 establishment of protein localization 1.89E-10 9.85E-10 2.19 dN-biased old and ancient GO:0009059 macromolecule biosynthetic process 3.70E-10 1.75E-09 1.58 dN-biased old and ancient GO:0006807 nitrogen compound metabolic process 9.03E-10 4.02E-09 1.43 dN-biased old and ancient GO:0015031 protein transport 1.67E-09 7.28E-09 2.18 dN-biased old and ancient GO:0019219 regulation of nucleobase-containing compound metabolic process 2.64E-09 1.12E-08 1.33 dN-biased old and ancient GO:0006396 RNA processing 3.34E-09 1.36E-08 4.34 dN-biased old and ancient GO:0008152 metabolic process 9.08E-09 3.60E-08 1.21 dN-biased old and ancient GO:0034645 cellular macromolecule biosynthetic process 9.40E-09 3.71E-08 1.57 dN-biased old and ancient GO:0019058 viral life cycle 1.18E-08 4.58E-08 69.35 dN-biased old and ancient GO:0051171 regulation of nitrogen compound metabolic process 1.19E-08 4.59E-08 1.31 dN-biased old and ancient GO:0009057 macromolecule catabolic process 2.01E-08 7.57E-08 2.22 dN-biased old and ancient GO:0034654 nucleobase-containing compound biosynthetic process 3.05E-08 1.11E-07 1.54 dN-biased old and ancient GO:0008104 protein localization 4.67E-08 1.67E-07 2.17 dN-biased old and ancient GO:0033036 macromolecule localization 5.61E-08 1.99E-07 2.16 dN-biased old and ancient GO:0006281 DNA repair 6.64E-08 2.34E-07 7.9 dN-biased old and ancient GO:0018130 heterocycle biosynthetic process 6.89E-08 2.42E-07 1.52 dN-biased old and ancient GO:0044265 cellular macromolecule catabolic process 8.46E-08 2.94E-07 2.35 dN-biased old and ancient GO:0070647 protein modification by small protein conjugation or removal 1.03E-07 3.54E-07 2.07 dN-biased old and ancient GO:0019438 aromatic compound biosynthetic process 1.42E-07 4.69E-07 1.51 dN-biased old and ancient GO:0032774 RNA biosynthetic process 1.90E-07 6.18E-07 1.54 dN-biased old and ancient GO:1902583 multi-organism intracellular transport 2.05E-07 6.48E-07 90.88 dN-biased old and ancient GO:1902579 multi-organism localization 2.05E-07 6.48E-07 90.88 dN-biased old and ancient GO:0044766 multi-organism transport 2.05E-07 6.48E-07 90.88 dN-biased old and ancient GO:0075733 intracellular transport of virus 2.05E-07 6.48E-07 90.88 dN-biased old and ancient GO:0046794 transport of virus 2.05E-07 6.48E-07 90.88 dN-biased old and ancient GO:0006397 mRNA processing 2.47E-07 7.73E-07 4.72 dN-biased old and ancient GO:2000112 regulation of cellular macromolecule biosynthetic process 4.52E-07 1.36E-06 1.4 dN-biased old and ancient GO:0016197 endosomal transport 5.23E-07 1.56E-06 4.97 dN-biased old and ancient GO:0034660 ncRNA metabolic process 5.34E-07 1.59E-06 3.26 dN-biased old and ancient GO:0006355 "regulation of transcription, DNA-templated" 5.62E-07 1.66E-06 1.41 dN-biased old and ancient GO:1903506 regulation of nucleic acid-templated transcription 5.63E-07 1.66E-06 1.41 dN-biased old and ancient GO:0006351 "transcription, DNA-templated" 5.87E-07 1.72E-06 1.54 dN-biased old and ancient GO:0097659 nucleic acid-templated transcription 5.87E-07 1.72E-06 1.54 dN-biased old and ancient GO:0044249 cellular biosynthetic process 5.98E-07 1.74E-06 1.44 dN-biased old and ancient GO:1901362 organic cyclic compound biosynthetic process 6.03E-07 1.75E-06 1.52 dN-biased old and ancient GO:2001141 regulation of RNA biosynthetic process 6.63E-07 1.90E-06 1.41 dN-biased old and ancient GO:0051252 regulation of RNA metabolic process 6.72E-07 1.91E-06 1.4 dN-biased old and ancient GO:0031329 regulation of cellular catabolic process 6.72E-07 1.91E-06 1.69 dN-biased old and ancient GO:0043412 macromolecule modification 7.12E-07 2.00E-06 1.38 dN-biased old and ancient GO:0044271 cellular nitrogen compound biosynthetic process 7.37E-07 2.06E-06 1.47 dN-biased old and ancient GO:0016482 cytoplasmic transport 1.09E-06 2.96E-06 2.74 dN-biased old and ancient GO:0010556 regulation of macromolecule biosynthetic process 1.32E-06 3.54E-06 1.38 dN-biased old and ancient GO:0019222 regulation of metabolic process 1.69E-06 4.40E-06 1.21 dN-biased old and ancient GO:0046907 intracellular transport 1.82E-06 4.72E-06 1.95 dN-biased old and ancient GO:0044267 cellular protein metabolic process 2.28E-06 5.83E-06 1.35 dN-biased old and ancient GO:0031323 regulation of cellular metabolic process 2.50E-06 6.36E-06 1.22 dN-biased old and ancient GO:1901576 organic substance biosynthetic process 2.56E-06 6.49E-06 1.41 dN-biased old and ancient GO:0006259 DNA metabolic process 2.63E-06 6.64E-06 4.77 dN-biased old and ancient GO:0016071 mRNA metabolic process 3.24E-06 8.06E-06 2.4 dN-biased old and ancient GO:0009058 biosynthetic process 3.26E-06 8.08E-06 1.4 dN-biased old and ancient GO:0010468 regulation of gene expression 3.90E-06 9.53E-06 1.34 dN-biased old and ancient GO:0009894 regulation of catabolic process 4.23E-06 1.03E-05 1.6 dN-biased old and ancient GO:0016032 viral process 4.58E-06 1.09E-05 7.12 dN-biased old and ancient GO:0044764 multi-organism cellular process 4.58E-06 1.09E-05 7.12 dN-biased old and ancient GO:0044403 "symbiosis, encompassing mutualism through parasitism" 4.58E-06 1.09E-05 7.12 dN-biased old and ancient GO:0080090 regulation of primary metabolic process 4.59E-06 1.09E-05 1.22 dN-biased old and ancient GO:0008380 RNA splicing 5.12E-06 1.19E-05 5.89 dN-biased old and ancient GO:0006886 intracellular protein transport 5.81E-06 1.32E-05 2.41 dN-biased old and ancient GO:0044248 cellular catabolic process 8.15E-06 1.78E-05 1.55 dN-biased old and ancient GO:0031331 positive regulation of cellular catabolic process 9.70E-06 2.07E-05 1.67 dN-biased old and ancient GO:0043632 modification-dependent macromolecule catabolic process 1.22E-05 2.53E-05 2.36 dN-biased old and ancient GO:0051603 proteolysis involved in cellular protein catabolic process 1.34E-05 2.72E-05 2.29 dN-biased old and ancient GO:0009896 positive regulation of catabolic process 1.44E-05 2.90E-05 1.64 dN-biased old and ancient GO:0006974 cellular response to DNA damage stimulus 2.02E-05 3.92E-05 4.35 dN-biased old and ancient GO:0009056 catabolic process 2.15E-05 4.13E-05 1.46 dN-biased old and ancient GO:0006307 DNA dealkylation involved in DNA repair 2.35E-05 4.45E-05 42.98 dN-biased old and ancient GO:0060255 regulation of macromolecule metabolic process 2.51E-05 4.70E-05 1.27 dN-biased old and ancient GO:0019941 modification-dependent protein catabolic process 2.84E-05 5.25E-05 2.31 dN-biased old and ancient GO:1902582 single-organism intracellular transport 2.84E-05 5.25E-05 1.97 dN-biased old and ancient GO:0044419 interspecies interaction between organisms 3.06E-05 5.59E-05 5.89 dN-biased old and ancient GO:0070646 protein modification by small protein removal 3.34E-05 6.00E-05 5.18 dN-biased old and ancient GO:0071897 DNA biosynthetic process 3.59E-05 6.40E-05 6.95 dN-biased old and ancient GO:0006464 cellular protein modification process 3.87E-05 6.83E-05 1.33 dN-biased old and ancient GO:0036211 protein modification process 3.87E-05 6.83E-05 1.33 dN-biased old and ancient GO:0006511 ubiquitin-dependent protein catabolic process 5.08E-05 8.67E-05 2.29 dN-biased old and ancient GO:0031326 regulation of cellular biosynthetic process 5.63E-05 9.48E-05 1.38 dN-biased old and ancient GO:0009889 regulation of biosynthetic process 7.37E-05 0.000121678 1.38 dN-biased old and ancient GO:0009451 RNA modification 8.45E-05 0.000137133 6.94 dN-biased old and ancient GO:0032446 protein modification by small protein conjugation 9.49E-05 0.000151794 1.95 dN-biased old and ancient GO:0032479 regulation of type I interferon production 1.06E-04 0.000164807 3.25 dN-biased old and ancient GO:0072594 establishment of protein localization to organelle 1.07E-04 0.000165206 3.82 dN-biased old and ancient GO:0010467 gene expression 1.14E-04 0.0001748 2.49 dN-biased old and ancient GO:1901575 organic substance catabolic process 1.17E-04 0.000178989 1.45 dN-biased old and ancient GO:1903507 negative regulation of nucleic acid-templated transcription 1.18E-04 0.000179694 1.62 dN-biased old and ancient GO:0001522 pseudouridine synthesis 1.18E-04 0.000179694 5.76 dN-biased old and ancient GO:0032321 positive regulation of Rho GTPase activity 1.29E-04 0.000195109 2.19 dN-biased old and ancient GO:0035511 oxidative DNA demethylation 1.30E-04 0.000196176 122.33 dN-biased old and ancient GO:0043547 positive regulation of GTPase activity 1.32E-04 0.000197852 1.63 dN-biased old and ancient GO:0033126 positive regulation of GTP catabolic process 1.32E-04 0.000197852 1.63 dN-biased old and ancient GO:0006457 protein folding 1.37E-04 0.000204886 3.02 dN-biased old and ancient GO:0006399 tRNA metabolic process 1.46E-04 0.000215967 6.33 dN-biased old and ancient GO:0006607 NLS-bearing protein import into nucleus 1.50E-04 0.00021989 10.17 dN-biased old and ancient GO:0032318 regulation of Ras GTPase activity 1.61E-04 0.000232944 1.76 dN-biased old and ancient GO:1902679 negative regulation of RNA biosynthetic process 1.64E-04 0.000236771 1.61 dN-biased old and ancient GO:0019082 viral protein processing 1.68E-04 0.000240981 29.82 dN-biased old and ancient GO:0006470 protein dephosphorylation 1.75E-04 0.000248351 2.16 dN-biased old and ancient GO:0051253 negative regulation of RNA metabolic process 1.88E-04 0.000262885 1.6 dN-biased old and ancient GO:0071826 ribonucleoprotein complex subunit organization 1.88E-04 0.000262885 216.86 dN-biased old and ancient GO:0022618 ribonucleoprotein complex assembly 1.88E-04 0.000262885 216.86 dN-biased old and ancient GO:0045892 "negative regulation of transcription, DNA-templated" 1.96E-04 0.000271228 1.61 dN-biased old and ancient GO:0032319 regulation of Rho GTPase activity 2.23E-04 0.000303553 2.08 dN-biased old and ancient GO:0051172 negative regulation of nitrogen compound metabolic process 2.26E-04 0.00030701 1.44 dN-biased old and ancient GO:0031123 RNA 3'-end processing 2.28E-04 0.000307846 6.8 dN-biased old and ancient GO:0045934 negative regulation of nucleobase-containing compound metabolic process 2.28E-04 0.000307846 1.45 dN-biased old and ancient GO:0016567 protein ubiquitination 2.30E-04 0.000309919 1.92 dN-biased old and ancient GO:0034340 response to type I interferon 2.31E-04 0.000310639 4.31 dN-biased old and ancient GO:0048193 Golgi vesicle transport 2.35E-04 0.000315382 3.4 dN-biased old and ancient GO:0051649 establishment of localization in cell 2.45E-04 0.000328143 1.59 dN-biased old and ancient GO:0043087 regulation of GTPase activity 2.48E-04 0.000330832 1.59 dN-biased old and ancient GO:0033124 regulation of GTP catabolic process 2.48E-04 0.000330832 1.59 dN-biased old and ancient GO:0017038 protein import 2.54E-04 0.000335473 4.89 dN-biased old and ancient GO:0043038 amino acid activation 2.67E-04 0.00034783 6.98 dN-biased old and ancient GO:0043039 tRNA aminoacylation 2.67E-04 0.00034783 6.98 dN-biased old and ancient GO:0051704 multi-organism process 2.95E-04 0.000374078 3.69 dN-biased old and ancient GO:0006420 arginyl-tRNA aminoacylation 2.99E-04 0.000378431 57.48 dN-biased old and ancient GO:0019538 protein metabolic process 3.01E-04 0.000380241 1.23 dN-biased old and ancient GO:0016579 protein deubiquitination 3.04E-04 0.000383304 5.05 dN-biased old and ancient GO:0006308 DNA catabolic process 3.13E-04 0.000392206 16.31 dN-biased old and ancient GO:0098506 polynucleotide 3' dephosphorylation 3.14E-04 0.000392206 56.13 dN-biased old and ancient GO:0098501 polynucleotide dephosphorylation 3.14E-04 0.000392206 56.13 dN-biased old and ancient GO:2000113 negative regulation of cellular macromolecule biosynthetic process 3.27E-04 0.000405407 1.45 dN-biased old and ancient GO:0016311 dephosphorylation 3.27E-04 0.000405407 1.92 dN-biased old and ancient GO:0006401 RNA catabolic process 3.38E-04 0.000414423 3.76 dN-biased old and ancient GO:0034470 ncRNA processing 3.38E-04 0.000414423 2.95 dN-biased old and ancient GO:0031124 mRNA 3'-end processing 3.53E-04 0.000430441 7.62 dN-biased old and ancient GO:0000377 "RNA splicing, via transesterification reactions with bulged adenosine as nucleophile" 3.58E-04 0.000434156 3.63 dN-biased old and ancient GO:0000375 "RNA splicing, via transesterification reactions" 3.58E-04 0.000434156 3.63 dN-biased old and ancient GO:0000398 "mRNA splicing, via spliceosome" 3.58E-04 0.000434156 3.63 dN-biased old and ancient GO:0070989 oxidative demethylation 3.68E-04 0.000443863 81.56 dN-biased old and ancient GO:0090503 "RNA phosphodiester bond hydrolysis, exonucleolytic" 3.96E-04 0.000474205 9.12 dN-biased old and ancient GO:0030813 positive regulation of nucleotide catabolic process 4.04E-04 0.000482054 1.57 dN-biased old and ancient GO:0033123 positive regulation of purine nucleotide catabolic process 4.04E-04 0.000482054 1.57 dN-biased old and ancient GO:0030488 tRNA methylation 4.11E-04 0.00048953 99.4 dN-biased old and ancient GO:0045979 positive regulation of nucleoside metabolic process 4.63E-04 0.000541791 1.56 dN-biased old and ancient GO:0006996 organelle organization 4.68E-04 0.000546683 1.47 dN-biased old and ancient GO:0010558 negative regulation of macromolecule biosynthetic process 5.47E-04 0.000617342 1.52 dN-biased old and ancient GO:0042147 "retrograde transport, endosome to Golgi" 5.96E-04 0.000661451 6.88 dN-biased old and ancient GO:0001731 formation of translation preinitiation complex 6.29E-04 0.000687775 1�590.33 dN-biased old and ancient GO:0032481 positive regulation of type I interferon production 6.39E-04 0.000696426 3.47 dN-biased old and ancient GO:0043631 RNA polyadenylation 7.28E-04 0.000778167 74.55 dN-biased old and ancient GO:0006378 mRNA polyadenylation 7.28E-04 0.000778167 74.55 dN-biased old and ancient GO:0090305 nucleic acid phosphodiester bond hydrolysis 7.74E-04 0.000815573 5.14 dN-biased old and ancient GO:0006895 Golgi to endosome transport 7.74E-04 0.000815573 21.05 dN-biased old and ancient GO:0043414 macromolecule methylation 7.93E-04 0.000831653 2.88 dN-biased old and ancient GO:0030811 regulation of nucleotide catabolic process 8.38E-04 0.000862571 1.53 dN-biased old and ancient GO:0033121 regulation of purine nucleotide catabolic process 8.38E-04 0.000862571 1.53 dN-biased old and ancient GO:0000387 spliceosomal snRNP assembly 8.38E-04 0.000862571 1�192.75 dN-biased old and ancient GO:0006606 protein import into nucleus 8.71E-04 0.000891038 5.54 dN-biased old and ancient GO:1902593 single-organism nuclear import 8.71E-04 0.000891038 5.54 dN-biased old and ancient GO:0051170 nuclear import 8.71E-04 0.000891038 5.54 dN-biased old and ancient GO:0071357 cellular response to type I interferon 9.14E-04 0.000927912 4.13 dN-biased old and ancient GO:0060337 type I interferon signaling pathway 9.14E-04 0.000927912 4.13 dN-biased old and ancient GO:0006418 tRNA aminoacylation for protein translation 9.45E-04 0.000955023 7.26 dN-biased old and ancient GO:0033554 cellular response to stress 9.71E-04 0.000974461 1.97 ED-biased lineage-specific and young GO:0006805 xenobiotic metabolic process 1.05E-10 6.04E-10 1.92 ED-biased lineage-specific and young GO:0044699 single-organism process 1.77E-10 9.37E-10 1.16 ED-biased lineage-specific and young GO:0055114 oxidation-reduction process 3.38E-10 1.63E-09 1.94 ED-biased lineage-specific and young GO:0044710 single-organism metabolic process 3.50E-10 1.68E-09 1.25 ED-biased lineage-specific and young GO:0044763 single-organism cellular process 6.36E-10 2.88E-09 1.24 ED-biased lineage-specific and young GO:0044281 small molecule metabolic process 1.37E-09 6.01E-09 1.58 ED-biased lineage-specific and young GO:0032787 monocarboxylic acid metabolic process 9.74E-08 3.37E-07 2.53 ED-biased lineage-specific and young GO:0019752 carboxylic acid metabolic process 1.12E-07 3.79E-07 1.94 ED-biased lineage-specific and young GO:0006082 organic acid metabolic process 1.13E-07 3.81E-07 1.33 ED-biased lineage-specific and young GO:0043436 oxoacid metabolic process 6.55E-07 1.88E-06 1.33 ED-biased lineage-specific and young GO:0031424 keratinization 7.22E-07 2.02E-06 10.48 ED-biased lineage-specific and young GO:0032501 multicellular organismal process 1.49E-06 3.96E-06 2.29 ED-biased lineage-specific and young GO:0008544 epidermis development 3.81E-06 9.38E-06 4.8 ED-biased lineage-specific and young GO:0006690 icosanoid metabolic process 4.90E-06 1.14E-05 3.23 ED-biased lineage-specific and young GO:0001676 long-chain fatty acid metabolic process 4.90E-06 1.14E-05 3.23 ED-biased lineage-specific and young GO:0033559 unsaturated fatty acid metabolic process 4.90E-06 1.14E-05 3.23 ED-biased lineage-specific and young GO:1901568 fatty acid derivative metabolic process 4.90E-06 1.14E-05 3.23 ED-biased lineage-specific and young GO:0048856 anatomical structure development 6.12E-06 1.39E-05 2.01 ED-biased lineage-specific and young GO:0015671 oxygen transport 1.03E-05 2.17E-05 19.77 ED-biased lineage-specific and young GO:0015669 gas transport 1.03E-05 2.17E-05 19.77 ED-biased lineage-specific and young GO:0030216 keratinocyte differentiation 1.24E-05 2.55E-05 11.53 ED-biased lineage-specific and young GO:0009913 epidermal cell differentiation 1.24E-05 2.55E-05 11.53 ED-biased lineage-specific and young GO:0006790 sulfur compound metabolic process 1.54E-05 3.08E-05 1.87 ED-biased lineage-specific and young GO:0009888 tissue development 1.71E-05 3.38E-05 3.69 ED-biased lineage-specific and young GO:0006749 glutathione metabolic process 1.90E-05 3.73E-05 4.61 ED-biased lineage-specific and young GO:0060429 epithelium development 2.01E-05 3.91E-05 6.08 ED-biased lineage-specific and young GO:0006631 fatty acid metabolic process 2.14E-05 4.13E-05 2.58 ED-biased lineage-specific and young GO:0030855 epithelial cell differentiation 2.35E-05 4.45E-05 7.69 ED-biased lineage-specific and young GO:0044707 single-multicellular organism process 2.38E-05 4.50E-05 2.84 ED-biased lineage-specific and young GO:0044272 sulfur compound biosynthetic process 2.78E-05 5.17E-05 3.11 ED-biased lineage-specific and young GO:0065008 regulation of biological quality 3.43E-05 6.15E-05 1.34 ED-biased lineage-specific and young GO:0016311 dephosphorylation 3.95E-05 6.95E-05 9.07 ED-biased lineage-specific and young GO:0006691 leukotriene metabolic process 4.23E-05 7.39E-05 12.55 ED-biased lineage-specific and young GO:0019369 arachidonic acid metabolic process 4.61E-05 7.97E-05 3.23 ED-biased lineage-specific and young GO:0042180 cellular ketone metabolic process 5.56E-05 9.39E-05 2.97 ED-biased lineage-specific and young GO:0019373 epoxygenase P450 pathway 6.51E-05 0.0001091 4.83 ED-biased lineage-specific and young GO:0044711 single-organism biosynthetic process 7.59E-05 0.000125001 1.78 ED-biased lineage-specific and young GO:0006629 lipid metabolic process 8.62E-05 0.000139552 1.29 ED-biased lineage-specific and young GO:0006518 peptide metabolic process 9.18E-05 0.000148187 4.19 ED-biased lineage-specific and young GO:0044282 small molecule catabolic process 9.22E-05 0.000148187 2.75 ED-biased lineage-specific and young GO:0008202 steroid metabolic process 9.90E-05 0.000157006 2.83 ED-biased lineage-specific and young GO:0044255 cellular lipid metabolic process 1.13E-04 0.000174067 1.98 ED-biased lineage-specific and young GO:0003014 renal system process 1.32E-04 0.000197852 14.28 ED-biased lineage-specific and young GO:0002718 regulation of cytokine production involved in immune response 1.47E-04 0.000215967 110.7 ED-biased lineage-specific and young GO:0002720 positive regulation of cytokine production involved in immune response 1.47E-04 0.000215967 110.7 ED-biased lineage-specific and young GO:0002700 regulation of production of molecular mediator of immune response 1.47E-04 0.000215967 110.7 ED-biased lineage-specific and young GO:0002702 positive regulation of production of molecular mediator of immune response 1.47E-04 0.000215967 110.7 ED-biased lineage-specific and young GO:0051186 cofactor metabolic process 1.65E-04 0.0002377 2.15 ED-biased lineage-specific and young GO:0032502 developmental process 1.73E-04 0.00024709 1.61 ED-biased lineage-specific and young GO:0044283 small molecule biosynthetic process 1.74E-04 0.000247458 2.24 ED-biased lineage-specific and young GO:0016054 organic acid catabolic process 1.91E-04 0.00026541 7.05 ED-biased lineage-specific and young GO:0046395 carboxylic acid catabolic process 1.91E-04 0.00026541 7.05 ED-biased lineage-specific and young GO:0045103 intermediate filament-based process 2.05E-04 0.000281348 4.03 ED-biased lineage-specific and young GO:0045104 intermediate filament cytoskeleton organization 2.05E-04 0.000281348 4.03 ED-biased lineage-specific and young GO:1901566 organonitrogen compound biosynthetic process 2.50E-04 0.000332171 2.05 ED-biased lineage-specific and young GO:0042181 ketone biosynthetic process 2.55E-04 0.000335473 6.59 ED-biased lineage-specific and young GO:0008217 regulation of blood pressure 2.76E-04 0.000356678 9.92 ED-biased lineage-specific and young GO:0043603 cellular amide metabolic process 2.78E-04 0.000357184 3.66 ED-biased lineage-specific and young GO:0097267 omega-hydroxylase P450 pathway 3.27E-04 0.000405407 4.83 ED-biased lineage-specific and young GO:0010043 response to zinc ion 3.28E-04 0.000405892 9.3 ED-biased lineage-specific and young GO:0017144 drug metabolic process 3.50E-04 0.000427564 2.44 ED-biased lineage-specific and young GO:1901685 glutathione derivative metabolic process 3.62E-04 0.000437417 4.48 ED-biased lineage-specific and young GO:1901687 glutathione derivative biosynthetic process 3.62E-04 0.000437417 4.48 ED-biased lineage-specific and young GO:0006766 vitamin metabolic process 3.88E-04 0.00046546 2.62 ED-biased lineage-specific and young GO:0042737 drug catabolic process 4.63E-04 0.000541791 10.67 ED-biased lineage-specific and young GO:0042738 exogenous drug catabolic process 4.63E-04 0.000541791 10.67 ED-biased lineage-specific and young GO:0032313 regulation of Rab GTPase activity 5.00E-04 0.00057401 61.5 ED-biased lineage-specific and young GO:0032851 positive regulation of Rab GTPase activity 5.00E-04 0.00057401 61.5 ED-biased lineage-specific and young GO:0048731 system development 5.13E-04 0.000584908 3.81 ED-biased lineage-specific and young GO:0022610 biological adhesion 7.20E-04 0.00077209 1.39 ED-biased lineage-specific and young GO:0007155 cell adhesion 7.20E-04 0.00077209 1.39 ED-biased lineage-specific and young GO:0006636 unsaturated fatty acid biosynthetic process 7.55E-04 0.000798074 50.32 ED-biased lineage-specific and young GO:0006633 fatty acid biosynthetic process 7.55E-04 0.000798074 50.32 ED-biased lineage-specific and young GO:0019370 leukotriene biosynthetic process 7.55E-04 0.000798074 50.32 ED-biased lineage-specific and young GO:1901570 fatty acid derivative biosynthetic process 7.55E-04 0.000798074 50.32 ED-biased lineage-specific and young GO:0046456 icosanoid biosynthetic process 7.55E-04 0.000798074 50.32 ED-biased lineage-specific and young GO:0032259 methylation 7.92E-04 0.000831653 2.68 ED-biased old and ancient GO:0007268 synaptic transmission 2.95E-46 8.20E-45 6.53 ED-biased old and ancient GO:0007267 cell-cell signaling 1.78E-37 3.30E-36 4.64 ED-biased old and ancient GO:0044700 single organism signaling 1.95E-36 3.42E-35 4.53 ED-biased old and ancient GO:0023052 signaling 1.95E-36 3.42E-35 4.53 ED-biased old and ancient GO:0007154 cell communication 1.82E-33 2.89E-32 3.99 ED-biased old and ancient GO:0034220 ion transmembrane transport 5.45E-29 8.26E-28 3.61 ED-biased old and ancient GO:0098660 inorganic ion transmembrane transport 1.04E-27 1.51E-26 4.28 ED-biased old and ancient GO:0006811 ion transport 5.54E-25 7.70E-24 2.77 ED-biased old and ancient GO:0055085 transmembrane transport 5.56E-24 7.57E-23 2.06 ED-biased old and ancient GO:0043269 regulation of ion transport 7.56E-22 9.70E-21 3.58 ED-biased old and ancient GO:0034765 regulation of ion transmembrane transport 2.52E-21 3.17E-20 4.58 ED-biased old and ancient GO:0006812 cation transport 3.71E-21 4.58E-20 2.17 ED-biased old and ancient GO:0030001 metal ion transport 3.58E-20 4.34E-19 2.33 ED-biased old and ancient GO:0051049 regulation of transport 1.35E-19 1.61E-18 2.39 ED-biased old and ancient GO:0044765 single-organism transport 1.59E-19 1.86E-18 1.6 ED-biased old and ancient GO:0051234 establishment of localization 1.84E-19 2.12E-18 1.96 ED-biased old and ancient GO:0034762 regulation of transmembrane transport 1.94E-19 2.19E-18 4.25 ED-biased old and ancient GO:0051179 localization 1.99E-19 2.21E-18 1.92 ED-biased old and ancient GO:0006810 transport 5.08E-19 5.55E-18 1.97 ED-biased old and ancient GO:0006821 chloride transport 5.33E-19 5.73E-18 16.99 ED-biased old and ancient GO:0015672 monovalent inorganic cation transport 1.75E-18 1.82E-17 2.65 ED-biased old and ancient GO:1902476 chloride transmembrane transport 3.66E-18 3.70E-17 17.22 ED-biased old and ancient GO:1902578 single-organism localization 6.50E-18 6.47E-17 1.56 ED-biased old and ancient GO:0098662 inorganic cation transmembrane transport 8.04E-18 7.89E-17 2.53 ED-biased old and ancient GO:0098655 cation transmembrane transport 9.93E-18 9.60E-17 2.36 ED-biased old and ancient GO:0006184 GTP catabolic process 1.50E-16 1.41E-15 5.69 ED-biased old and ancient GO:1901069 guanosine-containing compound catabolic process 1.50E-16 1.41E-15 5.69 ED-biased old and ancient GO:1901068 guanosine-containing compound metabolic process 1.91E-16 1.75E-15 5.35 ED-biased old and ancient GO:0006813 potassium ion transport 3.28E-16 2.96E-15 5.85 ED-biased old and ancient GO:0015698 inorganic anion transport 8.73E-16 7.76E-15 12.55 ED-biased old and ancient GO:0098661 inorganic anion transmembrane transport 9.53E-16 8.36E-15 13.59 ED-biased old and ancient GO:0046039 GTP metabolic process 9.90E-16 8.58E-15 12.76 ED-biased old and ancient GO:0071805 potassium ion transmembrane transport 1.48E-14 1.22E-13 6.01 ED-biased old and ancient GO:0071804 cellular potassium ion transport 1.48E-14 1.22E-13 6.01 ED-biased old and ancient GO:0032879 regulation of localization 1.80E-14 1.46E-13 2.08 ED-biased old and ancient GO:0007214 gamma-aminobutyric acid signaling pathway 4.22E-14 3.39E-13 28.03 ED-biased old and ancient GO:0048856 anatomical structure development 5.26E-14 4.18E-13 1.48 ED-biased old and ancient GO:0098656 anion transmembrane transport 1.49E-13 1.16E-12 2.93 ED-biased old and ancient GO:0065007 biological regulation 1.54E-13 1.18E-12 1.22 ED-biased old and ancient GO:0044763 single-organism cellular process 2.70E-13 2.02E-12 1.31 ED-biased old and ancient GO:0044707 single-multicellular organism process 3.29E-13 2.44E-12 1.55 ED-biased old and ancient GO:0006820 anion transport 3.89E-13 2.85E-12 5.79 ED-biased old and ancient GO:0032501 multicellular organismal process 1.32E-12 9.08E-12 1.53 ED-biased old and ancient GO:0044699 single-organism process 4.60E-12 3.13E-11 1.14 ED-biased old and ancient GO:0003008 system process 5.83E-12 3.93E-11 1.95 ED-biased old and ancient GO:0065008 regulation of biological quality 3.95E-11 2.58E-10 1.48 ED-biased old and ancient GO:0009203 ribonucleoside triphosphate catabolic process 4.44E-11 2.79E-10 7.15 ED-biased old and ancient GO:0009207 purine ribonucleoside triphosphate catabolic process 4.44E-11 2.79E-10 7.15 ED-biased old and ancient GO:0009146 purine nucleoside triphosphate catabolic process 4.44E-11 2.79E-10 7.15 ED-biased old and ancient GO:0006152 purine nucleoside catabolic process 4.99E-11 3.06E-10 7.1 ED-biased old and ancient GO:0046130 purine ribonucleoside catabolic process 4.99E-11 3.06E-10 7.1 ED-biased old and ancient GO:0042278 purine nucleoside metabolic process 5.04E-11 3.06E-10 3.07 ED-biased old and ancient GO:0046128 purine ribonucleoside metabolic process 5.04E-11 3.06E-10 3.07 ED-biased old and ancient GO:0009143 nucleoside triphosphate catabolic process 5.76E-11 3.46E-10 7.05 ED-biased old and ancient GO:0009150 purine ribonucleotide metabolic process 6.06E-11 3.61E-10 2.96 ED-biased old and ancient GO:0006163 purine nucleotide metabolic process 7.12E-11 4.20E-10 2.95 ED-biased old and ancient GO:0009205 purine ribonucleoside triphosphate metabolic process 8.34E-11 4.88E-10 3.2 ED-biased old and ancient GO:0042454 ribonucleoside catabolic process 9.35E-11 5.42E-10 6.87 ED-biased old and ancient GO:0009144 purine nucleoside triphosphate metabolic process 1.06E-10 6.04E-10 3.18 ED-biased old and ancient GO:0009164 nucleoside catabolic process 1.34E-10 7.56E-10 6.74 ED-biased old and ancient GO:1901361 organic cyclic compound catabolic process 1.35E-10 7.56E-10 2.83 ED-biased old and ancient GO:0050877 neurological system process 1.36E-10 7.56E-10 1.97 ED-biased old and ancient GO:0006195 purine nucleotide catabolic process 1.49E-10 8.15E-10 6.7 ED-biased old and ancient GO:0009154 purine ribonucleotide catabolic process 1.49E-10 8.15E-10 6.7 ED-biased old and ancient GO:0009199 ribonucleoside triphosphate metabolic process 1.62E-10 8.78E-10 3.14 ED-biased old and ancient GO:0072523 purine-containing compound catabolic process 1.69E-10 9.02E-10 6.66 ED-biased old and ancient GO:0009261 ribonucleotide catabolic process 1.69E-10 9.02E-10 6.66 ED-biased old and ancient GO:1901658 glycosyl compound catabolic process 1.89E-10 9.85E-10 6.62 ED-biased old and ancient GO:0046700 heterocycle catabolic process 1.95E-10 1.01E-09 2.88 ED-biased old and ancient GO:0009259 ribonucleotide metabolic process 2.51E-10 1.28E-09 2.86 ED-biased old and ancient GO:0019693 ribose phosphate metabolic process 2.51E-10 1.28E-09 2.86 ED-biased old and ancient GO:0009166 nucleotide catabolic process 2.64E-10 1.33E-09 6.5 ED-biased old and ancient GO:0072521 purine-containing compound metabolic process 2.93E-10 1.45E-09 2.84 ED-biased old and ancient GO:0042391 regulation of membrane potential 2.94E-10 1.45E-09 3.41 ED-biased old and ancient GO:0044270 cellular nitrogen compound catabolic process 2.94E-10 1.45E-09 2.85 ED-biased old and ancient GO:1901292 nucleoside phosphate catabolic process 3.31E-10 1.62E-09 6.42 ED-biased old and ancient GO:0050789 regulation of biological process 3.35E-10 1.63E-09 1.21 ED-biased old and ancient GO:0009141 nucleoside triphosphate metabolic process 3.61E-10 1.72E-09 3.07 ED-biased old and ancient GO:0034655 nucleobase-containing compound catabolic process 3.77E-10 1.77E-09 5.74 ED-biased old and ancient GO:0019439 aromatic compound catabolic process 3.93E-10 1.83E-09 2.87 ED-biased old and ancient GO:0050794 regulation of cellular process 4.02E-10 1.86E-09 1.22 ED-biased old and ancient GO:0043279 response to alkaloid 4.65E-10 2.13E-09 6.51 ED-biased old and ancient GO:0046434 organophosphate catabolic process 4.66E-10 2.13E-09 6.02 ED-biased old and ancient GO:0009119 ribonucleoside metabolic process 6.40E-10 2.88E-09 2.86 ED-biased old and ancient GO:0048666 neuron development 7.52E-10 3.37E-09 3.19 ED-biased old and ancient GO:0009116 nucleoside metabolic process 1.06E-09 4.68E-09 2.82 ED-biased old and ancient GO:0009117 nucleotide metabolic process 1.98E-09 8.58E-09 2.63 ED-biased old and ancient GO:1901657 glycosyl compound metabolic process 2.16E-09 9.29E-09 2.76 ED-biased old and ancient GO:0032502 developmental process 2.21E-09 9.45E-09 1.29 ED-biased old and ancient GO:1903530 regulation of secretion by cell 2.66E-09 1.12E-08 2.19 ED-biased old and ancient GO:0006753 nucleoside phosphate metabolic process 2.92E-09 1.22E-08 2.6 ED-biased old and ancient GO:0048704 embryonic skeletal system morphogenesis 2.99E-09 1.25E-08 4.27 ED-biased old and ancient GO:0051046 regulation of secretion 3.05E-09 1.26E-08 2.1 ED-biased old and ancient GO:0006836 neurotransmitter transport 3.18E-09 1.31E-08 3.33 ED-biased old and ancient GO:0055086 nucleobase-containing small molecule metabolic process 3.28E-09 1.34E-08 2.54 ED-biased old and ancient GO:0048731 system development 4.45E-09 1.80E-08 2.29 ED-biased old and ancient GO:1901136 carbohydrate derivative catabolic process 4.99E-09 2.01E-08 5.31 ED-biased old and ancient GO:0048598 embryonic morphogenesis 8.50E-09 3.39E-08 2.35 ED-biased old and ancient GO:0051899 membrane depolarization 9.53E-09 3.74E-08 6.68 ED-biased old and ancient GO:0048562 embryonic organ morphogenesis 1.09E-08 4.25E-08 3.41 ED-biased old and ancient GO:0060341 regulation of cellular localization 1.60E-08 6.13E-08 1.81 ED-biased old and ancient GO:0009987 cellular process 1.66E-08 6.33E-08 1.09 ED-biased old and ancient GO:0060359 response to ammonium ion 1.69E-08 6.40E-08 7.17 ED-biased old and ancient GO:0048705 skeletal system morphogenesis 2.78E-08 1.04E-07 3.78 ED-biased old and ancient GO:0097485 neuron projection guidance 2.84E-08 1.05E-07 2.07 ED-biased old and ancient GO:0007411 axon guidance 2.84E-08 1.05E-07 2.07 ED-biased old and ancient GO:1901698 response to nitrogen compound 3.03E-08 1.11E-07 2.57 ED-biased old and ancient GO:0009887 organ morphogenesis 3.77E-08 1.37E-07 2.22 ED-biased old and ancient GO:0042221 response to chemical 3.87E-08 1.40E-07 1.53 ED-biased old and ancient GO:0010038 response to metal ion 5.53E-08 1.97E-07 3.24 ED-biased old and ancient GO:0010035 response to inorganic substance 7.71E-08 2.69E-07 2.79 ED-biased old and ancient GO:0010243 response to organonitrogen compound 1.04E-07 3.56E-07 2.54 ED-biased old and ancient GO:0071300 cellular response to retinoic acid 1.10E-07 3.74E-07 4.34 ED-biased old and ancient GO:0034776 response to histamine 1.27E-07 4.24E-07 41.06 ED-biased old and ancient GO:0071420 cellular response to histamine 1.27E-07 4.24E-07 41.06 ED-biased old and ancient GO:0051716 cellular response to stimulus 1.34E-07 4.45E-07 1.33 ED-biased old and ancient GO:0006816 calcium ion transport 1.64E-07 5.39E-07 2.64 ED-biased old and ancient GO:0001505 regulation of neurotransmitter levels 1.74E-07 5.69E-07 3.32 ED-biased old and ancient GO:1901565 organonitrogen compound catabolic process 2.03E-07 6.48E-07 4.29 ED-biased old and ancient GO:0070838 divalent metal ion transport 2.27E-07 7.14E-07 2.5 ED-biased old and ancient GO:0014070 response to organic cyclic compound 2.61E-07 8.13E-07 1.95 ED-biased old and ancient GO:0009719 response to endogenous stimulus 2.67E-07 8.28E-07 1.75 ED-biased old and ancient GO:0048489 synaptic vesicle transport 2.85E-07 8.76E-07 3.93 ED-biased old and ancient GO:0097480 establishment of synaptic vesicle localization 2.85E-07 8.76E-07 3.93 ED-biased old and ancient GO:0010033 response to organic substance 2.95E-07 9.03E-07 1.56 ED-biased old and ancient GO:0032412 regulation of ion transmembrane transporter activity 3.91E-07 1.19E-06 4.41 ED-biased old and ancient GO:0072511 divalent inorganic cation transport 4.34E-07 1.32E-06 2.45 ED-biased old and ancient GO:0006091 generation of precursor metabolites and energy 4.64E-07 1.39E-06 2.73 ED-biased old and ancient GO:0044057 regulation of system process 6.07E-07 1.75E-06 2.26 ED-biased old and ancient GO:0050807 regulation of synapse organization 6.95E-07 1.96E-06 4.24 ED-biased old and ancient GO:0042472 inner ear morphogenesis 9.10E-07 2.53E-06 4.7 ED-biased old and ancient GO:0017157 regulation of exocytosis 9.76E-07 2.70E-06 4.4 ED-biased old and ancient GO:0007600 sensory perception 9.89E-07 2.73E-06 2.17 ED-biased old and ancient GO:0007610 behavior 1.04E-06 2.84E-06 2.05 ED-biased old and ancient GO:0070887 cellular response to chemical stimulus 1.04E-06 2.84E-06 1.58 ED-biased old and ancient GO:0022898 regulation of transmembrane transporter activity 1.06E-06 2.89E-06 4.18 ED-biased old and ancient GO:0070588 calcium ion transmembrane transport 1.23E-06 3.32E-06 2.96 ED-biased old and ancient GO:0050896 response to stimulus 1.32E-06 3.54E-06 1.26 ED-biased old and ancient GO:0035094 response to nicotine 1.41E-06 3.76E-06 8.55 ED-biased old and ancient GO:0044767 single-organism developmental process 1.52E-06 4.02E-06 1.25 ED-biased old and ancient GO:0071310 cellular response to organic substance 1.56E-06 4.11E-06 1.62 ED-biased old and ancient GO:0032409 regulation of transporter activity 1.60E-06 4.20E-06 3.91 ED-biased old and ancient GO:0007165 signal transduction 1.69E-06 4.40E-06 1.49 ED-biased old and ancient GO:0030182 neuron differentiation 1.86E-06 4.81E-06 2.46 ED-biased old and ancient GO:0007186 G-protein coupled receptor signaling pathway 2.01E-06 5.18E-06 2.99 ED-biased old and ancient GO:0071242 cellular response to ammonium ion 2.10E-06 5.39E-06 28.74 ED-biased old and ancient GO:1901700 response to oxygen-containing compound 2.69E-06 6.77E-06 1.56 ED-biased old and ancient GO:1901701 cellular response to oxygen-containing compound 2.88E-06 7.22E-06 1.64 ED-biased old and ancient GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity 3.23E-06 8.06E-06 10.15 ED-biased old and ancient GO:0035295 tube development 3.77E-06 9.31E-06 2.9 ED-biased old and ancient GO:1901135 carbohydrate derivative metabolic process 3.84E-06 9.42E-06 3.33 ED-biased old and ancient GO:0009628 response to abiotic stimulus 4.17E-06 1.02E-05 1.56 ED-biased old and ancient GO:0035095 behavioral response to nicotine 4.25E-06 1.03E-05 15.19 ED-biased old and ancient GO:0051650 establishment of vesicle localization 4.53E-06 1.09E-05 3.23 ED-biased old and ancient GO:0055082 cellular chemical homeostasis 4.79E-06 1.13E-05 1.83 ED-biased old and ancient GO:0051259 protein oligomerization 5.22E-06 1.21E-05 2.61 ED-biased old and ancient GO:0019637 organophosphate metabolic process 5.35E-06 1.23E-05 1.98 ED-biased old and ancient GO:0050801 ion homeostasis 5.54E-06 1.27E-05 1.77 ED-biased old and ancient GO:0048697 positive regulation of collateral sprouting in absence of injury 5.80E-06 1.32E-05 397.58 ED-biased old and ancient GO:0048696 regulation of collateral sprouting in absence of injury 5.80E-06 1.32E-05 397.58 ED-biased old and ancient GO:0003002 regionalization 6.50E-06 1.47E-05 2.08 ED-biased old and ancient GO:0071705 nitrogen compound transport 6.71E-06 1.51E-05 1.94 ED-biased old and ancient GO:0051952 regulation of amine transport 6.81E-06 1.53E-05 6.61 ED-biased old and ancient GO:1901385 regulation of voltage-gated calcium channel activity 6.83E-06 1.53E-05 9.34 ED-biased old and ancient GO:0032526 response to retinoic acid 7.01E-06 1.56E-05 3.08 ED-biased old and ancient GO:0009581 detection of external stimulus 7.14E-06 1.58E-05 2.36 ED-biased old and ancient GO:0007269 neurotransmitter secretion 7.28E-06 1.61E-05 3.61 ED-biased old and ancient GO:0060627 regulation of vesicle-mediated transport 7.32E-06 1.61E-05 2.9 ED-biased old and ancient GO:0001508 action potential 7.81E-06 1.71E-05 9.43 ED-biased old and ancient GO:0007270 neuron-neuron synaptic transmission 7.95E-06 1.74E-05 9.79 ED-biased old and ancient GO:0048468 cell development 8.21E-06 1.78E-05 1.75 ED-biased old and ancient GO:0051932 "synaptic transmission, GABAergic" 8.78E-06 1.90E-05 57.48 ED-biased old and ancient GO:0006090 pyruvate metabolic process 8.95E-06 1.93E-05 3.74 ED-biased old and ancient GO:0008016 regulation of heart contraction 9.20E-06 1.98E-05 3.03 ED-biased old and ancient GO:0051960 regulation of nervous system development 9.75E-06 2.07E-05 1.67 ED-biased old and ancient GO:0045595 regulation of cell differentiation 1.05E-05 2.21E-05 1.6 ED-biased old and ancient GO:0006139 nucleobase-containing compound metabolic process 1.11E-05 2.33E-05 1.3 ED-biased old and ancient GO:0042592 homeostatic process 1.15E-05 2.40E-05 1.55 ED-biased old and ancient GO:0006725 cellular aromatic compound metabolic process 1.20E-05 2.50E-05 1.29 ED-biased old and ancient GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste 1.21E-05 2.51E-05 70.16 ED-biased old and ancient GO:0006814 sodium ion transport 1.29E-05 2.63E-05 2.35 ED-biased old and ancient GO:0006112 energy reserve metabolic process 1.34E-05 2.72E-05 3.13 ED-biased old and ancient GO:0009653 anatomical structure morphogenesis 1.54E-05 3.08E-05 1.56 ED-biased old and ancient GO:0048878 chemical homeostasis 1.64E-05 3.28E-05 1.61 ED-biased old and ancient GO:0060429 epithelium development 1.65E-05 3.29E-05 2.12 ED-biased old and ancient GO:1990267 response to transition metal nanoparticle 1.69E-05 3.35E-05 4.63 ED-biased old and ancient GO:0045921 positive regulation of exocytosis 1.74E-05 3.43E-05 5.8 ED-biased old and ancient GO:0006796 phosphate-containing compound metabolic process 1.84E-05 3.62E-05 1.49 ED-biased old and ancient GO:2001257 regulation of cation channel activity 2.19E-05 4.20E-05 4.37 ED-biased old and ancient GO:0060119 inner ear receptor cell development 2.30E-05 4.40E-05 29 ED-biased old and ancient GO:0009582 detection of abiotic stimulus 2.39E-05 4.50E-05 2.28 ED-biased old and ancient GO:0009888 tissue development 2.66E-05 4.97E-05 1.61 ED-biased old and ancient GO:1900449 regulation of glutamate receptor signaling pathway 2.76E-05 5.14E-05 7.28 ED-biased old and ancient GO:0050773 regulation of dendrite development 2.85E-05 5.25E-05 4.45 ED-biased old and ancient GO:0023061 signal release 2.95E-05 5.42E-05 2.99 ED-biased old and ancient GO:0033993 response to lipid 3.05E-05 5.59E-05 1.77 ED-biased old and ancient GO:0042220 response to cocaine 3.08E-05 5.61E-05 4.76 ED-biased old and ancient GO:0010770 positive regulation of cell morphogenesis involved in differentiation 3.13E-05 5.67E-05 36.98 ED-biased old and ancient GO:0044248 cellular catabolic process 3.13E-05 5.67E-05 2.78 ED-biased old and ancient GO:0051606 detection of stimulus 3.15E-05 5.69E-05 2.12 ED-biased old and ancient GO:0006793 phosphorus metabolic process 3.33E-05 6.00E-05 1.47 ED-biased old and ancient GO:0009725 response to hormone 3.50E-05 6.26E-05 1.72 ED-biased old and ancient GO:0002026 regulation of the force of heart contraction 3.62E-05 6.42E-05 7.52 ED-biased old and ancient GO:0051705 multi-organism behavior 4.05E-05 7.11E-05 4.92 ED-biased old and ancient GO:0048513 organ development 4.17E-05 7.30E-05 1.57 ED-biased old and ancient GO:0019725 cellular homeostasis 4.28E-05 7.45E-05 1.69 ED-biased old and ancient GO:0071396 cellular response to lipid 4.36E-05 7.57E-05 2.21 ED-biased old and ancient GO:0046483 heterocycle metabolic process 4.41E-05 7.64E-05 1.27 ED-biased old and ancient GO:0071407 cellular response to organic cyclic compound 4.70E-05 8.10E-05 2.29 ED-biased old and ancient GO:0060080 regulation of inhibitory postsynaptic membrane potential 4.81E-05 8.26E-05 15.39 ED-biased old and ancient GO:0090102 cochlea development 4.82E-05 8.26E-05 16.43 ED-biased old and ancient GO:0032892 positive regulation of organic acid transport 4.93E-05 8.43E-05 13.87 ED-biased old and ancient GO:0032870 cellular response to hormone stimulus 5.27E-05 8.97E-05 1.98 ED-biased old and ancient GO:0051963 regulation of synapse assembly 5.37E-05 9.11E-05 4.3 ED-biased old and ancient GO:0051649 establishment of localization in cell 5.65E-05 9.49E-05 1.5 ED-biased old and ancient GO:0001823 mesonephros development 6.69E-05 0.000111556 8.24 ED-biased old and ancient GO:0070509 calcium ion import 6.69E-05 0.000111556 7.67 ED-biased old and ancient GO:0035107 appendage morphogenesis 7.09E-05 0.000117638 2.94 ED-biased old and ancient GO:0035108 limb morphogenesis 7.09E-05 0.000117638 2.94 ED-biased old and ancient GO:0030534 adult behavior 7.30E-05 0.000120821 4.2 ED-biased old and ancient GO:0071229 cellular response to acid chemical 7.69E-05 0.000126025 2.24 ED-biased old and ancient GO:2000543 positive regulation of gastrulation 7.69E-05 0.000126025 8.58 ED-biased old and ancient GO:1902582 single-organism intracellular transport 8.16E-05 0.0001334 1.78 ED-biased old and ancient GO:0043623 cellular protein complex assembly 8.19E-05 0.000133563 29.41 ED-biased old and ancient GO:0046928 regulation of neurotransmitter secretion 8.32E-05 0.000135352 5.74 ED-biased old and ancient GO:0007389 pattern specification process 9.21E-05 0.000148187 1.76 ED-biased old and ancient GO:0051258 protein polymerization 9.48E-05 0.000151794 62.23 ED-biased old and ancient GO:0071495 cellular response to endogenous stimulus 9.60E-05 0.000153187 1.69 ED-biased old and ancient GO:0051260 protein homooligomerization 9.89E-05 0.000157006 2.82 ED-biased old and ancient GO:0007626 locomotory behavior 9.91E-05 0.000157006 2.45 ED-biased old and ancient GO:0048672 positive regulation of collateral sprouting 9.98E-05 0.000157683 198.79 ED-biased old and ancient GO:0008150 biological_process 1.00E-04 0.000157683 1.04 ED-biased old and ancient GO:0072073 kidney epithelium development 1.01E-04 0.000158884 3.27 ED-biased old and ancient GO:0051965 positive regulation of synapse assembly 1.03E-04 0.00016127 4.77 ED-biased old and ancient GO:0048793 pronephros development 1.03E-04 0.00016127 12.83 ED-biased old and ancient GO:0006865 amino acid transport 1.05E-04 0.000163633 2.38 ED-biased old and ancient GO:0051084 'de novo' posttranslational protein folding 1.05E-04 0.000163633 22.45 ED-biased old and ancient GO:0090257 regulation of muscle system process 1.07E-04 0.000165206 2.76 ED-biased old and ancient GO:0046907 intracellular transport 1.07E-04 0.000165206 1.67 ED-biased old and ancient GO:0044712 single-organism catabolic process 1.14E-04 0.0001748 2.9 ED-biased old and ancient GO:0009952 anterior/posterior pattern specification 1.19E-04 0.000180804 2.16 ED-biased old and ancient GO:0051962 positive regulation of nervous system development 1.25E-04 0.000189489 1.97 ED-biased old and ancient GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation 1.40E-04 0.000208904 83.7 ED-biased old and ancient GO:0006937 regulation of muscle contraction 1.43E-04 0.000212904 2.87 ED-biased old and ancient GO:0050767 regulation of neurogenesis 1.44E-04 0.000213915 1.62 ED-biased old and ancient GO:0051094 positive regulation of developmental process 1.51E-04 0.000220387 1.6 ED-biased old and ancient GO:0006096 glycolytic process 1.51E-04 0.000220387 7.53 ED-biased old and ancient GO:0050954 sensory perception of mechanical stimulus 1.55E-04 0.000225731 4.74 ED-biased old and ancient GO:1901019 regulation of calcium ion transmembrane transporter activity 1.58E-04 0.0002291 4.4 ED-biased old and ancient GO:1903169 regulation of calcium ion transmembrane transport 1.58E-04 0.0002291 4.4 ED-biased old and ancient GO:1901575 organic substance catabolic process 1.66E-04 0.000238625 2.52 ED-biased old and ancient GO:0006458 'de novo' protein folding 1.71E-04 0.000244758 20.41 ED-biased old and ancient GO:0050793 regulation of developmental process 1.74E-04 0.000247458 1.44 ED-biased old and ancient GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway 1.76E-04 0.00024924 2.71 ED-biased old and ancient GO:0010043 response to zinc ion 1.78E-04 0.000251538 6.95 ED-biased old and ancient GO:0001657 ureteric bud development 1.82E-04 0.000256647 3.89 ED-biased old and ancient GO:0050912 detection of chemical stimulus involved in sensory perception of taste 1.87E-04 0.000262885 40.09 ED-biased old and ancient GO:0044070 regulation of anion transport 1.91E-04 0.00026541 4.26 ED-biased old and ancient GO:0071294 cellular response to zinc ion 1.96E-04 0.000271228 10.87 ED-biased old and ancient GO:0016079 synaptic vesicle exocytosis 1.99E-04 0.000274242 10.91 ED-biased old and ancient GO:0034341 response to interferon-gamma 1.99E-04 0.000274242 22.8 ED-biased old and ancient GO:0048670 regulation of collateral sprouting 2.06E-04 0.00028214 159.03 ED-biased old and ancient GO:0007399 nervous system development 2.16E-04 0.00029523 2.34 ED-biased old and ancient GO:0086010 membrane depolarization during action potential 2.18E-04 0.000297354 5.28 ED-biased old and ancient GO:0048869 cellular developmental process 2.27E-04 0.000307742 1.43 ED-biased old and ancient GO:0050433 regulation of catecholamine secretion 2.49E-04 0.000331503 6.67 ED-biased old and ancient GO:0051656 establishment of organelle localization 2.53E-04 0.000335473 2.48 ED-biased old and ancient GO:1901360 organic cyclic compound metabolic process 2.54E-04 0.000335473 1.24 ED-biased old and ancient GO:0005513 detection of calcium ion 2.55E-04 0.000335473 19.63 ED-biased old and ancient GO:0050796 regulation of insulin secretion 2.59E-04 0.000340065 2.18 ED-biased old and ancient GO:0071248 cellular response to metal ion 2.65E-04 0.000347259 3.35 ED-biased old and ancient GO:0010470 regulation of gastrulation 2.66E-04 0.00034783 4.52 ED-biased old and ancient GO:0015980 energy derivation by oxidation of organic compounds 2.75E-04 0.000356678 2.57 ED-biased old and ancient GO:0043270 positive regulation of ion transport 2.77E-04 0.000356678 3.54 ED-biased old and ancient GO:0002087 regulation of respiratory gaseous exchange by neurological system process 2.77E-04 0.000356678 9.62 ED-biased old and ancient GO:0044065 regulation of respiratory system process 2.77E-04 0.000356678 9.62 ED-biased old and ancient GO:0030326 embryonic limb morphogenesis 2.79E-04 0.000357184 2.56 ED-biased old and ancient GO:0035113 embryonic appendage morphogenesis 2.79E-04 0.000357184 2.56 ED-biased old and ancient GO:0071822 protein complex subunit organization 2.83E-04 0.000361611 1.76 ED-biased old and ancient GO:1901699 cellular response to nitrogen compound 2.88E-04 0.000367296 2.47 ED-biased old and ancient GO:0055080 cation homeostasis 2.90E-04 0.000369141 1.66 ED-biased old and ancient GO:0007271 "synaptic transmission, cholinergic" 2.92E-04 0.000370979 9.5 ED-biased old and ancient GO:0050907 detection of chemical stimulus involved in sensory perception 3.11E-04 0.000390653 35.08 ED-biased old and ancient GO:0034622 cellular macromolecular complex assembly 3.11E-04 0.000390653 21.42 ED-biased old and ancient GO:0006461 protein complex assembly 3.26E-04 0.000405407 1.88 ED-biased old and ancient GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway 3.38E-04 0.000414423 149.09 ED-biased old and ancient GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 3.38E-04 0.000414423 149.09 ED-biased old and ancient GO:1901186 positive regulation of ERBB signaling pathway 3.38E-04 0.000414423 149.09 ED-biased old and ancient GO:0006936 muscle contraction 3.45E-04 0.000422229 2.46 ED-biased old and ancient GO:0044708 single-organism behavior 3.82E-04 0.000459917 1.76 ED-biased old and ancient GO:0051588 regulation of neurotransmitter transport 3.83E-04 0.00046029 2.99 ED-biased old and ancient GO:0050804 regulation of synaptic transmission 4.12E-04 0.000489847 2.9 ED-biased old and ancient GO:0060284 regulation of cell development 4.15E-04 0.000492536 1.52 ED-biased old and ancient GO:0072163 mesonephric epithelium development 4.18E-04 0.000494337 3.65 ED-biased old and ancient GO:0072164 mesonephric tubule development 4.18E-04 0.000494337 3.65 ED-biased old and ancient GO:0021533 cell differentiation in hindbrain 4.28E-04 0.000505267 31.39 ED-biased old and ancient GO:0031290 retinal ganglion cell axon guidance 4.43E-04 0.000522051 5.28 ED-biased old and ancient GO:0042538 hyperosmotic salinity response 4.49E-04 0.000528189 66.26 ED-biased old and ancient GO:0060070 canonical Wnt signaling pathway 4.73E-04 0.000551558 2.73 ED-biased old and ancient GO:0071417 cellular response to organonitrogen compound 4.78E-04 0.000556415 2.45 ED-biased old and ancient GO:0006972 hyperosmotic response 4.82E-04 0.000560094 28.4 ED-biased old and ancient GO:0060037 pharyngeal system development 4.87E-04 0.000564118 6.58 ED-biased old and ancient GO:0022400 regulation of rhodopsin mediated signaling pathway 4.88E-04 0.000564118 10.65 ED-biased old and ancient GO:0016056 rhodopsin mediated signaling pathway 4.88E-04 0.000564118 10.65 ED-biased old and ancient GO:0071241 cellular response to inorganic substance 4.94E-04 0.000570066 3.18 ED-biased old and ancient GO:1903522 regulation of blood circulation 4.98E-04 0.000573689 2.29 ED-biased old and ancient GO:0006208 pyrimidine nucleobase catabolic process 5.06E-04 0.000578906 5.9 ED-biased old and ancient GO:0046113 nucleobase catabolic process 5.06E-04 0.000578906 5.9 ED-biased old and ancient GO:0007601 visual perception 5.17E-04 0.000588462 2.32 ED-biased old and ancient GO:0016055 Wnt signaling pathway 5.21E-04 0.000592005 2.06 ED-biased old and ancient GO:0097104 postsynaptic membrane assembly 5.27E-04 0.000597804 15.39 ED-biased old and ancient GO:0007417 central nervous system development 5.29E-04 0.000599054 2.78 ED-biased old and ancient GO:0060084 synaptic transmission involved in micturition 5.35E-04 0.000604822 15.19 ED-biased old and ancient GO:0007605 sensory perception of sound 5.57E-04 0.000627566 4.48 ED-biased old and ancient GO:0009755 hormone-mediated signaling pathway 5.63E-04 0.000633256 2.83 ED-biased old and ancient GO:0009593 detection of chemical stimulus 5.71E-04 0.000641173 7.36 ED-biased old and ancient GO:0090276 regulation of peptide hormone secretion 6.08E-04 0.000673648 2.22 ED-biased old and ancient GO:0060158 phospholipase C-activating dopamine receptor signaling pathway 6.10E-04 0.000674717 19.45 ED-biased old and ancient GO:0071702 organic substance transport 6.12E-04 0.000674717 1.36 ED-biased old and ancient GO:0060078 regulation of postsynaptic membrane potential 6.12E-04 0.000674717 5.91 ED-biased old and ancient GO:0060272 embryonic skeletal joint morphogenesis 6.18E-04 0.000680208 10.29 ED-biased old and ancient GO:0042474 middle ear morphogenesis 6.21E-04 0.000682359 8.04 ED-biased old and ancient GO:0045664 regulation of neuron differentiation 6.22E-04 0.000682359 2.07 ED-biased old and ancient GO:0045666 positive regulation of neuron differentiation 6.25E-04 0.000684524 2.1 ED-biased old and ancient GO:0018209 peptidyl-serine modification 6.38E-04 0.000696426 17.59 ED-biased old and ancient GO:0021527 spinal cord association neuron differentiation 6.46E-04 0.000702907 27.9 ED-biased old and ancient GO:0048485 sympathetic nervous system development 6.51E-04 0.000707194 7.36 ED-biased old and ancient GO:0046549 retinal cone cell development 6.58E-04 0.000713636 6.62 ED-biased old and ancient GO:0014706 striated muscle tissue development 6.69E-04 0.000724388 2.6 ED-biased old and ancient GO:0060081 membrane hyperpolarization 7.10E-04 0.000767536 7.79 ED-biased old and ancient GO:0051602 response to electrical stimulus 7.12E-04 0.000768126 3.34 ED-biased old and ancient GO:0015849 organic acid transport 7.14E-04 0.000768126 1.89 ED-biased old and ancient GO:0046942 carboxylic acid transport 7.14E-04 0.000768126 1.89 ED-biased old and ancient GO:0060048 cardiac muscle contraction 7.48E-04 0.000798074 8.95 ED-biased old and ancient GO:0048843 negative regulation of axon extension involved in axon guidance 7.51E-04 0.000798074 99.4 ED-biased old and ancient GO:0050953 sensory perception of light stimulus 7.97E-04 0.000834535 2.27 ED-biased old and ancient GO:0021954 central nervous system neuron development 8.06E-04 0.000842636 4.57 ED-biased old and ancient GO:0032890 regulation of organic acid transport 8.18E-04 0.000853844 6.77 ED-biased old and ancient GO:0030878 thyroid gland development 8.21E-04 0.000855048 5.61 ED-biased old and ancient GO:0045924 regulation of female receptivity 8.23E-04 0.000855048 10.46 ED-biased old and ancient GO:0060180 female mating behavior 8.23E-04 0.000855048 10.46 ED-biased old and ancient GO:0051924 regulation of calcium ion transport 8.29E-04 0.000858607 2.34 ED-biased old and ancient GO:0050885 neuromuscular process controlling balance 8.29E-04 0.000858607 4.64 ED-biased old and ancient GO:0006333 chromatin assembly or disassembly 8.38E-04 0.000862571 17.45 ED-biased old and ancient GO:0051047 positive regulation of secretion 8.46E-04 0.000869464 2.93 ED-biased old and ancient GO:0010769 regulation of cell morphogenesis involved in differentiation 8.87E-04 0.000906017 16.4 ED-biased old and ancient GO:0060384 innervation 8.92E-04 0.000909731 11.81 ED-biased old and ancient GO:0016572 histone phosphorylation 9.04E-04 0.000920562 11.08 ED-biased old and ancient GO:0060021 palate development 9.17E-04 0.000929543 2.94 ED-biased old and ancient GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 9.33E-04 0.000944326 95.42 ED-biased old and ancient GO:0035136 forelimb morphogenesis 9.54E-04 0.000961205 3.02 ED-biased old and ancient GO:0043933 macromolecular complex subunit organization 9.66E-04 0.000971828 1.55 ED-biased old and ancient GO:0032305 positive regulation of icosanoid secretion 9.73E-04 0.000974461 16.64 ED-biased old and ancient GO:0032308 positive regulation of prostaglandin secretion 9.73E-04 0.000974461 16.64 ED-biased old and ancient GO:0051239 regulation of multicellular organismal process 9.91E-04 0.000991 1.37