Supplemental Table S12: # Neural tissue-specific human genes # Mean of cortex and cerebellum expression values was used to estimate gene expression in both tissues. "# Tissue specificity was defined as ""twice uniform expression"", see Methods" # Significantly enriched GO terms (FDR 0.1%) # P-value - uncorrected P value "# P-value adjusted - P value corrected (Benjamini-Hochberg method) for 263 tests for the combined dataset of neural tissues, for 206 tests in brain-specific genes, and for 107 tests in cerebellum-specific genes" Neural_tissues_combined GO Term Description P-value P-value adjusted Enrichment Neural_tissues_combined GO:0098916 anterograde trans-synaptic signaling 6.54E-28 4.30E-26 3.84 Neural_tissues_combined GO:0007268 chemical synaptic transmission 3.27E-28 3.05E-26 3.84 Neural_tissues_combined GO:0099536 synaptic signaling 3.48E-28 3.05E-26 3.82 Neural_tissues_combined GO:0099537 trans-synaptic signaling 2.61E-28 3.05E-26 3.82 Neural_tissues_combined GO:0050804 modulation of synaptic transmission 3.81E-23 2.00E-21 3.71 Neural_tissues_combined GO:0023052 signaling 5.19E-23 2.27E-21 2.64 Neural_tissues_combined GO:0044700 single organism signaling 7.72E-23 2.90E-21 2.64 Neural_tissues_combined GO:0007267 cell-cell signaling 4.19E-22 1.38E-20 2.68 Neural_tissues_combined GO:0007399 nervous system development 1.13E-19 3.30E-18 3.34 Neural_tissues_combined GO:0051960 regulation of nervous system development 2.16E-19 5.68E-18 2.37 Neural_tissues_combined GO:0007154 cell communication 6.42E-17 1.53E-15 2.24 Neural_tissues_combined GO:0007610 behavior 1.68E-16 3.68E-15 2.63 Neural_tissues_combined GO:0098660 inorganic ion transmembrane transport 3.64E-16 7.36E-15 2.45 Neural_tissues_combined GO:0044708 single-organism behavior 5.85E-16 1.10E-14 2.91 Neural_tissues_combined GO:0006811 ion transport 6.38E-16 1.12E-14 1.9 Neural_tissues_combined GO:0034220 ion transmembrane transport 9.67E-16 1.59E-14 2.15 Neural_tissues_combined GO:0043269 regulation of ion transport 1.13E-15 1.75E-14 2.48 Neural_tissues_combined GO:0048167 regulation of synaptic plasticity 4.88E-14 7.13E-13 3.98 Neural_tissues_combined GO:0050877 neurological system process 6.16E-14 8.31E-13 2.16 Neural_tissues_combined GO:0050767 regulation of neurogenesis 6.32E-14 8.31E-13 2.23 Neural_tissues_combined GO:0048731 system development 3.19E-13 4.00E-12 2.16 Neural_tissues_combined GO:0045664 regulation of neuron differentiation 4.10E-13 4.90E-12 2.32 Neural_tissues_combined GO:0001505 regulation of neurotransmitter levels 1.00E-12 1.14E-11 3.76 Neural_tissues_combined GO:0050807 regulation of synapse organization 5.79E-12 6.34E-11 3.97 Neural_tissues_combined GO:0010975 regulation of neuron projection development 6.66E-12 6.37E-11 2.48 Neural_tissues_combined GO:0099531 presynaptic process involved in chemical synaptic transmission 6.60E-12 6.37E-11 4.22 Neural_tissues_combined GO:0051962 positive regulation of nervous system development 6.74E-12 6.37E-11 2.41 Neural_tissues_combined GO:0055085 transmembrane transport 6.78E-12 6.37E-11 1.84 Neural_tissues_combined GO:0099643 signal release from synapse 7.20E-12 6.53E-11 4.66 Neural_tissues_combined GO:0030001 metal ion transport 7.89E-12 6.77E-11 2.19 Neural_tissues_combined GO:0060284 regulation of cell development 7.98E-12 6.77E-11 2.05 Neural_tissues_combined GO:0050890 cognition 8.87E-12 7.29E-11 3.03 Neural_tissues_combined GO:0034765 regulation of ion transmembrane transport 2.34E-11 1.86E-10 2.61 Neural_tissues_combined GO:0042391 regulation of membrane potential 2.88E-11 2.23E-10 2.6 Neural_tissues_combined GO:0006812 cation transport 4.78E-11 3.59E-10 1.98 Neural_tissues_combined GO:0051963 regulation of synapse assembly 5.12E-11 3.74E-10 4.5 Neural_tissues_combined GO:0060078 regulation of postsynaptic membrane potential 8.07E-11 5.74E-10 5.89 Neural_tissues_combined GO:0098662 inorganic cation transmembrane transport 9.70E-11 6.54E-10 2.29 Neural_tissues_combined GO:0051049 regulation of transport 9.48E-11 6.54E-10 1.63 Neural_tissues_combined GO:0098655 cation transmembrane transport 1.19E-10 7.63E-10 2.18 Neural_tissues_combined GO:0007611 learning or memory 1.19E-10 7.63E-10 3.07 Neural_tissues_combined GO:0023061 signal release 1.24E-10 7.76E-10 3.61 Neural_tissues_combined GO:0034762 regulation of transmembrane transport 2.82E-10 1.72E-09 2.47 Neural_tissues_combined GO:0031344 regulation of cell projection organization 3.48E-10 2.08E-09 2.15 Neural_tissues_combined GO:0051588 regulation of neurotransmitter transport 6.16E-10 3.60E-09 4.85 Neural_tissues_combined GO:0051234 establishment of localization 1.06E-09 6.06E-09 1.37 Neural_tissues_combined GO:0006810 transport 1.32E-09 7.39E-09 1.37 Neural_tissues_combined GO:0007270 neuron-neuron synaptic transmission 2.23E-09 1.22E-08 5.43 Neural_tissues_combined GO:0050806 positive regulation of synaptic transmission 2.82E-09 1.51E-08 3.94 Neural_tissues_combined GO:0007626 locomotory behavior 4.30E-09 2.26E-08 3.05 Neural_tissues_combined GO:0006813 potassium ion transport 7.12E-09 3.62E-08 3.05 Neural_tissues_combined GO:0051179 localization 7.15E-09 3.62E-08 1.33 Neural_tissues_combined GO:0050808 synapse organization 8.77E-09 4.35E-08 3.52 Neural_tissues_combined GO:0051965 positive regulation of synapse assembly 9.10E-09 4.43E-08 4.54 Neural_tissues_combined GO:0007165 signal transduction 1.00E-08 4.78E-08 1.32 Neural_tissues_combined GO:0071805 potassium ion transmembrane transport 1.18E-08 5.44E-08 3.15 Neural_tissues_combined GO:0071804 cellular potassium ion transport 1.16E-08 5.44E-08 3.15 Neural_tissues_combined GO:0007186 G-protein coupled receptor signaling pathway 1.87E-08 8.34E-08 1.91 Neural_tissues_combined GO:0046928 regulation of neurotransmitter secretion 1.86E-08 8.34E-08 4.97 Neural_tissues_combined GO:1902578 single-organism localization 2.00E-08 8.77E-08 1.5 Neural_tissues_combined GO:0016079 synaptic vesicle exocytosis 2.36E-08 1.02E-07 5.39 Neural_tissues_combined GO:0015672 monovalent inorganic cation transport 3.64E-08 1.54E-07 2.25 Neural_tissues_combined GO:0030534 adult behavior 3.91E-08 1.63E-07 3.41 Neural_tissues_combined GO:0017156 calcium ion regulated exocytosis 6.67E-08 2.74E-07 4.7 Neural_tissues_combined GO:0007612 learning 9.16E-08 3.71E-07 3.39 Neural_tissues_combined GO:2000026 regulation of multicellular organismal development 1.18E-07 4.70E-07 1.54 Neural_tissues_combined GO:0048812 neuron projection morphogenesis 1.33E-07 5.22E-07 2.74 Neural_tissues_combined GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 1.55E-07 5.99E-07 3.25 Neural_tissues_combined GO:0032879 regulation of localization 1.87E-07 7.13E-07 1.43 Neural_tissues_combined GO:1903530 regulation of secretion by cell 1.97E-07 7.40E-07 1.96 Neural_tissues_combined GO:0045595 regulation of cell differentiation 2.64E-07 9.78E-07 1.56 Neural_tissues_combined GO:0048858 cell projection morphogenesis 3.44E-07 1.26E-06 2.66 Neural_tissues_combined GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway 3.60E-07 1.30E-06 4.35 Neural_tissues_combined GO:0006836 neurotransmitter transport 3.65E-07 1.30E-06 3.45 Neural_tissues_combined GO:0097479 synaptic vesicle localization 4.47E-07 1.56E-06 3.98 Neural_tissues_combined GO:0044765 single-organism transport 4.52E-07 1.56E-06 1.48 Neural_tissues_combined GO:0051952 regulation of amine transport 1.10E-06 3.71E-06 3.97 Neural_tissues_combined GO:0099003 vesicle-mediated transport in synapse 1.09E-06 3.71E-06 3.7 Neural_tissues_combined GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 1.19E-06 3.96E-06 2.7 Neural_tissues_combined GO:0017158 regulation of calcium ion-dependent exocytosis 2.48E-06 8.15E-06 4.13 Neural_tissues_combined GO:0014059 regulation of dopamine secretion 2.93E-06 9.51E-06 6.13 Neural_tissues_combined GO:0017157 regulation of exocytosis 3.07E-06 9.73E-06 2.9 Neural_tissues_combined GO:0032990 cell part morphogenesis 3.07E-06 9.73E-06 2.47 Neural_tissues_combined GO:0045666 positive regulation of neuron differentiation 3.31E-06 1.04E-05 2.24 Neural_tissues_combined GO:0051046 regulation of secretion 3.60E-06 1.11E-05 1.83 Neural_tissues_combined GO:0010769 regulation of cell morphogenesis involved in differentiation 3.88E-06 1.17E-05 2.34 Neural_tissues_combined GO:0048168 regulation of neuronal synaptic plasticity 3.86E-06 1.17E-05 4.63 Neural_tissues_combined GO:0051648 vesicle localization 4.17E-06 1.25E-05 3.04 Neural_tissues_combined GO:0050433 regulation of catecholamine secretion 5.00E-06 1.48E-05 4.83 Neural_tissues_combined GO:0048489 synaptic vesicle transport 6.01E-06 1.74E-05 3.78 Neural_tissues_combined GO:0097480 establishment of synaptic vesicle localization 5.95E-06 1.74E-05 3.78 Neural_tissues_combined GO:0050769 positive regulation of neurogenesis 6.32E-06 1.81E-05 2.06 Neural_tissues_combined GO:0003008 system process 7.05E-06 1.99E-05 1.56 Neural_tissues_combined GO:0006821 chloride transport 9.85E-06 2.76E-05 3.15 Neural_tissues_combined GO:0010720 positive regulation of cell development 1.06E-05 2.93E-05 1.96 Neural_tissues_combined GO:0051650 establishment of vesicle localization 1.09E-05 2.99E-05 3.05 Neural_tissues_combined GO:1902476 chloride transmembrane transport 1.15E-05 3.12E-05 3.21 Neural_tissues_combined GO:0051961 negative regulation of nervous system development 1.75E-05 4.70E-05 2.25 Neural_tissues_combined GO:0010976 positive regulation of neuron projection development 1.83E-05 4.86E-05 2.35 Neural_tissues_combined GO:0008344 adult locomotory behavior 1.94E-05 5.10E-05 3.55 Neural_tissues_combined GO:0007269 neurotransmitter secretion 2.09E-05 5.44E-05 3.99 Neural_tissues_combined GO:0060291 long-term synaptic potentiation 2.14E-05 5.52E-05 4.68 Neural_tissues_combined GO:0007214 gamma-aminobutyric acid signaling pathway 3.36E-05 8.58E-05 5.21 Neural_tissues_combined GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway 3.49E-05 8.83E-05 2.83 Neural_tissues_combined GO:0009581 detection of external stimulus 3.90E-05 9.77E-05 3.02 Neural_tissues_combined GO:0050773 regulation of dendrite development 4.17E-05 1.03E-04 2.94 Neural_tissues_combined GO:0007409 axonogenesis 4.34E-05 1.06E-04 2.86 Neural_tissues_combined GO:0031346 positive regulation of cell projection organization 4.35E-05 1.06E-04 2.1 Neural_tissues_combined GO:0051094 positive regulation of developmental process 4.86E-05 1.17E-04 1.54 Neural_tissues_combined GO:0009582 detection of abiotic stimulus 5.05E-05 1.21E-04 2.98 Neural_tissues_combined GO:0050768 negative regulation of neurogenesis 5.49E-05 1.30E-04 2.23 Neural_tissues_combined GO:0098656 anion transmembrane transport 6.00E-05 1.41E-04 2.17 Neural_tissues_combined GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 7.62E-05 1.77E-04 5.31 Neural_tissues_combined GO:0060079 excitatory postsynaptic potential 7.81E-05 1.80E-04 5.79 Neural_tissues_combined GO:1902803 regulation of synaptic vesicle transport 9.03E-05 2.07E-04 4.52 Neural_tissues_combined GO:0006820 anion transport 9.76E-05 2.21E-04 1.78 Neural_tissues_combined GO:0007215 glutamate receptor signaling pathway 1.07E-04 0.000240521 4.2 Neural_tissues_combined GO:0050793 regulation of developmental process 1.25E-04 0.000276261 1.35 Neural_tissues_combined GO:0007218 neuropeptide signaling pathway 1.24E-04 0.000276261 3.3 Neural_tissues_combined GO:0051966 "regulation of synaptic transmission, glutamatergic" 1.75E-04 0.000382545 4.06 Neural_tissues_combined GO:0010721 negative regulation of cell development 1.76E-04 0.000382545 2.09 Neural_tissues_combined GO:0007416 synapse assembly 1.78E-04 0.000383721 3.83 Neural_tissues_combined GO:0048814 regulation of dendrite morphogenesis 2.02E-04 0.000431919 3.33 Neural_tissues_combined GO:0051239 regulation of multicellular organismal process 2.14E-04 0.000453887 1.31 Neural_tissues_combined GO:0098661 inorganic anion transmembrane transport 2.39E-04 0.000498865 2.68 Neural_tissues_combined GO:1900452 regulation of long term synaptic depression 2.37E-04 0.000498648 8.69 Neural_tissues_combined GO:0007187 "G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger" 2.44E-04 0.000505291 2.47 Neural_tissues_combined GO:0097485 neuron projection guidance 3.07E-04 0.000630789 2.29 Neural_tissues_combined GO:0051656 establishment of organelle localization 3.33E-04 0.000678907 2.14 Neural_tissues_combined GO:0060627 regulation of vesicle-mediated transport 3.64E-04 0.0007364 1.86 Neural_tissues_combined GO:0032989 cellular component morphogenesis 4.28E-04 0.000859267 1.92 Neural_tissues_combined GO:0070588 calcium ion transmembrane transport 4.96E-04 0.000988242 2.35 Neural_tissues_combined GO:0006816 calcium ion transport 6.77E-04 0.001338729 2.16 Neural_tissues_combined GO:0007411 axon guidance 6.93E-04 0.001360142 2.24 Neural_tissues_combined GO:0045665 negative regulation of neuron differentiation 7.28E-04 0.001418252 2.21 Neural_tissues_combined GO:0007417 central nervous system development 8.20E-04 0.001574161 2.69 Neural_tissues_combined GO:0010959 regulation of metal ion transport 8.18E-04 0.001574161 1.98 Neural_tissues_combined GO:0015698 inorganic anion transport 8.62E-04 0.001624964 2.36 Neural_tissues_combined GO:0032940 secretion by cell 8.61E-04 0.001624964 1.78 Neural_tissues_combined GO:0030030 cell projection organization 8.65E-04 0.001624964 1.6 Neural_tissues_combined GO:0043524 negative regulation of neuron apoptotic process 1.24E-03 0.00229662 2.56 Neural_tissues_combined GO:0048666 neuron development 1.23E-03 0.002294255 2.56 Neural_tissues_combined GO:1903305 regulation of regulated secretory pathway 1.31E-03 0.002392569 2.85 Neural_tissues_combined GO:0051932 "synaptic transmission, GABAergic" 1.31E-03 0.002392569 7.45 Neural_tissues_combined GO:0051640 organelle localization 1.35E-03 0.002448621 1.94 Neural_tissues_combined GO:0022604 regulation of cell morphogenesis 1.56E-03 0.00279102 1.72 Neural_tissues_combined GO:0046903 secretion 1.56E-03 0.00279102 1.67 Neural_tissues_combined GO:0007420 brain development 1.61E-03 0.002841812 2.32 Neural_tissues_combined GO:0048169 regulation of long-term neuronal synaptic plasticity 1.61E-03 0.002841812 4.89 Neural_tissues_combined GO:0050770 regulation of axonogenesis 1.73E-03 0.003013179 2.27 Neural_tissues_combined GO:0000160 phosphorelay signal transduction system 1.73E-03 0.003013179 8.69 Neural_tissues_combined GO:0070838 divalent metal ion transport 1.80E-03 0.003114474 1.97 Neural_tissues_combined GO:0006814 sodium ion transport 1.89E-03 0.003248824 2.3 Neural_tissues_combined GO:2001257 regulation of cation channel activity 2.06E-03 0.003495355 2.84 Neural_tissues_combined GO:0035235 ionotropic glutamate receptor signaling pathway 2.05E-03 0.003495355 4.35 Neural_tissues_combined GO:1904062 regulation of cation transmembrane transport 2.22E-03 0.003742692 2.17 Neural_tissues_combined GO:0007631 feeding behavior 2.43E-03 0.004070637 3.02 Neural_tissues_combined GO:0072511 divalent inorganic cation transport 2.63E-03 0.004377785 1.94 Neural_tissues_combined GO:0044057 regulation of system process 2.73E-03 0.00451566 1.7 Neural_tissues_combined GO:0043523 regulation of neuron apoptotic process 2.80E-03 0.0046025 2.21 Neural_tissues_combined GO:0007613 memory 3.23E-03 0.005276335 2.59 Neural_tissues_combined GO:0006865 amino acid transport 3.26E-03 0.005292469 2.41 Neural_tissues_combined GO:0007600 sensory perception 3.49E-03 0.005631104 1.7 Neural_tissues_combined GO:1903421 regulation of synaptic vesicle recycling 4.15E-03 0.006575 6.52 Neural_tissues_combined GO:0050805 negative regulation of synaptic transmission 4.15E-03 0.006575 3.32 Neural_tissues_combined GO:0030182 neuron differentiation 4.14E-03 0.006575 2 Neural_tissues_combined GO:0031644 regulation of neurological system process 5.27E-03 0.008299461 2.96 Neural_tissues_combined GO:0010977 negative regulation of neuron projection development 5.77E-03 0.009032798 2.32 Neural_tissues_combined GO:0045597 positive regulation of cell differentiation 6.04E-03 0.009399527 1.49 Neural_tissues_combined GO:0032412 regulation of ion transmembrane transporter activity 6.18E-03 0.009449651 2.27 Neural_tissues_combined GO:0023051 regulation of signaling 6.18E-03 0.009449651 1.23 Neural_tissues_combined GO:0010646 regulation of cell communication 6.16E-03 0.009449651 1.23 Neural_tissues_combined GO:0031345 negative regulation of cell projection organization 6.46E-03 0.009820694 2.22 Neural_tissues_combined GO:0043576 regulation of respiratory gaseous exchange 6.87E-03 0.010383966 4.63 Neural_tissues_combined GO:0050789 regulation of biological process 7.91E-03 0.011680726 1.09 Neural_tissues_combined GO:0032409 regulation of transporter activity 7.89E-03 0.011680726 2.15 Neural_tissues_combined GO:0051954 positive regulation of amine transport 7.95E-03 0.011680726 4.12 Neural_tissues_combined GO:0061001 regulation of dendritic spine morphogenesis 7.91E-03 0.011680726 4.12 Neural_tissues_combined GO:0065008 regulation of biological quality 7.95E-03 0.011680726 1.22 Neural_tissues_combined GO:0008306 associative learning 8.35E-03 0.012200278 2.97 Neural_tissues_combined GO:0002087 regulation of respiratory gaseous exchange by neurological system process 1.02E-02 0.014820994 5.79 Neural_tissues_combined GO:0001764 neuron migration 1.08E-02 0.015606593 2.38 Neural_tissues_combined GO:0015813 L-glutamate transport 1.17E-02 0.01645508 4.35 Neural_tissues_combined GO:0015800 acidic amino acid transport 1.17E-02 0.01645508 4.35 Neural_tissues_combined GO:0007628 adult walking behavior 1.16E-02 0.01645508 4.35 Neural_tissues_combined GO:0022898 regulation of transmembrane transporter activity 1.16E-02 0.01645508 2.17 Neural_tissues_combined GO:0046834 lipid phosphorylation 1.16E-02 0.01645508 2.31 Neural_tissues_combined GO:0021953 central nervous system neuron differentiation 1.39E-02 0.019445213 2.62 Neural_tissues_combined GO:0060359 response to ammonium ion 1.42E-02 0.019655789 2.83 Neural_tissues_combined GO:0015807 L-amino acid transport 1.41E-02 0.019620635 2.72 Neural_tissues_combined GO:0031175 neuron projection development 1.53E-02 0.021067539 2.17 Neural_tissues_combined GO:0045596 negative regulation of cell differentiation 1.54E-02 0.021094792 1.53 Neural_tissues_combined GO:0051968 "positive regulation of synaptic transmission, glutamatergic" 1.62E-02 0.021627411 4.68 Neural_tissues_combined GO:0045956 positive regulation of calcium ion-dependent exocytosis 1.61E-02 0.021603571 4.68 Neural_tissues_combined GO:1901385 regulation of voltage-gated calcium channel activity 1.60E-02 0.021603571 4.68 Neural_tissues_combined GO:0048488 synaptic vesicle endocytosis 1.60E-02 0.021603571 4.68 Neural_tissues_combined GO:0044087 regulation of cellular component biogenesis 1.61E-02 0.021603571 1.48 Neural_tissues_combined GO:0009583 detection of light stimulus 1.63E-02 0.02165101 3.07 Neural_tissues_combined GO:0030817 regulation of cAMP biosynthetic process 1.80E-02 0.023788945 2.41 Neural_tissues_combined GO:0090659 walking behavior 1.83E-02 0.0240645 4.09 Neural_tissues_combined GO:0014048 regulation of glutamate secretion 2.07E-02 0.02695099 5.21 Neural_tissues_combined GO:0044065 regulation of respiratory system process 2.06E-02 0.02695099 5.21 Neural_tissues_combined GO:0071420 cellular response to histamine 2.21E-02 0.028491667 6.21 Neural_tissues_combined GO:0060012 "synaptic transmission, glycinergic" 2.20E-02 0.028491667 6.21 Neural_tissues_combined GO:0048856 anatomical structure development 2.28E-02 0.029250732 1.2 Neural_tissues_combined GO:0051129 negative regulation of cellular component organization 2.33E-02 0.029747087 1.55 Neural_tissues_combined GO:0065007 biological regulation 2.64E-02 0.033542029 1.07 Neural_tissues_combined GO:0060998 regulation of dendritic spine development 2.66E-02 0.033633654 3.08 Neural_tissues_combined GO:2000463 positive regulation of excitatory postsynaptic potential 2.70E-02 0.033976077 4.35 Neural_tissues_combined GO:1900449 regulation of glutamate receptor signaling pathway 2.82E-02 0.034141743 3.86 Neural_tissues_combined GO:0098815 modulation of excitatory postsynaptic potential 2.80E-02 0.034092593 3.86 Neural_tissues_combined GO:2000300 regulation of synaptic vesicle exocytosis 2.79E-02 0.034092593 3.86 Neural_tissues_combined GO:0050974 detection of mechanical stimulus involved in sensory perception 2.78E-02 0.034092593 3.86 Neural_tissues_combined GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway 2.76E-02 0.034092593 3.86 Neural_tissues_combined GO:0051899 membrane depolarization 2.76E-02 0.034092593 2.9 Neural_tissues_combined GO:0035725 sodium ion transmembrane transport 2.76E-02 0.034092593 2.38 Neural_tissues_combined GO:0001508 action potential 2.77E-02 0.034092593 2.76 Neural_tissues_combined GO:0030802 regulation of cyclic nucleotide biosynthetic process 2.83E-02 0.034141743 2.2 Neural_tissues_combined GO:0051240 positive regulation of multicellular organismal process 2.94E-02 0.035306849 1.32 Neural_tissues_combined GO:0044763 single-organism cellular process 3.04E-02 0.036341818 1.09 Neural_tissues_combined GO:0006835 dicarboxylic acid transport 3.20E-02 0.03790991 2.51 Neural_tissues_combined GO:0031279 regulation of cyclase activity 3.18E-02 0.037843439 2.51 Neural_tissues_combined GO:0035556 intracellular signal transduction 3.45E-02 0.040688341 1.3 Neural_tissues_combined GO:0045761 regulation of adenylate cyclase activity 3.49E-02 0.040976339 2.69 Neural_tissues_combined GO:0021549 cerebellum development 3.61E-02 0.042126549 3.4 Neural_tissues_combined GO:0016048 detection of temperature stimulus 3.66E-02 0.042218421 4.74 Neural_tissues_combined GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity 3.64E-02 0.042172687 4.74 Neural_tissues_combined GO:0035249 "synaptic transmission, glutamatergic" 3.62E-02 0.042126549 4.74 Neural_tissues_combined GO:0008277 regulation of G-protein coupled receptor protein signaling pathway 3.81E-02 0.043756769 2.15 Neural_tissues_combined GO:1901215 negative regulation of neuron death 3.94E-02 0.044106226 2.02 Neural_tissues_combined GO:0009584 detection of visible light 3.98E-02 0.044106226 3.66 Neural_tissues_combined GO:0030072 peptide hormone secretion 4.10E-02 0.044106226 3.1 Neural_tissues_combined GO:0007602 phototransduction 4.08E-02 0.044106226 3.1 Neural_tissues_combined GO:1903831 signal transduction involved in cellular response to ammonium ion 4.07E-02 0.044106226 4.06 Neural_tissues_combined GO:0095500 acetylcholine receptor signaling pathway 4.05E-02 0.044106226 4.06 Neural_tissues_combined GO:0032502 developmental process 4.24E-02 0.044106226 1.15 Neural_tissues_combined GO:0030814 regulation of cAMP metabolic process 4.23E-02 0.044106226 2.17 Neural_tissues_combined GO:0045980 negative regulation of nucleotide metabolic process 4.33E-02 0.044139147 2.74 Neural_tissues_combined GO:1900543 negative regulation of purine nucleotide metabolic process 4.31E-02 0.044106226 2.74 Neural_tissues_combined GO:0031281 positive regulation of cyclase activity 4.29E-02 0.044106226 2.74 Neural_tissues_combined GO:0042552 myelination 4.28E-02 0.044106226 2.74 Neural_tissues_combined GO:0051349 positive regulation of lyase activity 4.26E-02 0.044106226 2.74 Neural_tissues_combined GO:0032291 axon ensheathment in central nervous system 4.25E-02 0.044106226 6.95 Neural_tissues_combined GO:0099612 protein localization to axon 4.23E-02 0.044106226 6.95 Neural_tissues_combined GO:2000809 positive regulation of synaptic vesicle clustering 4.21E-02 0.044106226 6.95 Neural_tissues_combined GO:0001941 postsynaptic membrane organization 4.20E-02 0.044106226 6.95 Neural_tissues_combined GO:0022010 central nervous system myelination 4.18E-02 0.044106226 6.95 Neural_tissues_combined GO:0033603 positive regulation of dopamine secretion 4.16E-02 0.044106226 6.95 Neural_tissues_combined GO:0038003 opioid receptor signaling pathway 4.15E-02 0.044106226 6.95 Neural_tissues_combined GO:0021902 commitment of neuronal cell to specific neuron type in forebrain 4.13E-02 0.044106226 6.95 Neural_tissues_combined GO:0034776 response to histamine 4.31E-02 0.044106226 5.43 Neural_tissues_combined GO:0097090 presynaptic membrane organization 4.29E-02 0.044106226 5.43 Neural_tissues_combined GO:0033605 positive regulation of catecholamine secretion 4.28E-02 0.044106226 5.43 Neural_tissues_combined GO:0050961 detection of temperature stimulus involved in sensory perception 4.26E-02 0.044106226 5.43 Neural_tissues_combined GO:0050965 detection of temperature stimulus involved in sensory perception of pain 4.24E-02 0.044106226 5.43 Neural_tissues_combined GO:0007210 serotonin receptor signaling pathway 4.23E-02 0.044106226 5.43 Neural_tissues_combined GO:0051589 negative regulation of neurotransmitter transport 4.21E-02 0.044106226 5.43 Neural_tissues_combined GO:0051339 regulation of lyase activity 4.24E-02 0.044106226 2.41 Neural_tissues_combined GO:1902580 single-organism cellular localization 4.48E-02 0.045071374 1.48 Neural_tissues_combined GO:0051931 regulation of sensory perception 4.49E-02 0.045071374 3.26 Neural_tissues_combined GO:0051930 regulation of sensory perception of pain 4.47E-02 0.045071374 3.26 Neural_tissues_combined GO:0072583 clathrin-dependent endocytosis 4.45E-02 0.045071374 3.26 Neural_tissues_combined GO:1900371 regulation of purine nucleotide biosynthetic process 4.62E-02 0.0462 2.09 Brain-specific GO:0098916 anterograde trans-synaptic signaling 2.21E-14 1.14E-12 3.57 Brain-specific GO:0007268 chemical synaptic transmission 1.11E-14 7.62E-13 3.57 Brain-specific GO:0099536 synaptic signaling 9.59E-15 7.62E-13 3.55 Brain-specific GO:0099537 trans-synaptic signaling 7.19E-15 7.62E-13 3.55 Brain-specific GO:0051960 regulation of nervous system development 1.02E-13 4.20E-12 2.44 Brain-specific GO:0050804 modulation of synaptic transmission 1.01E-12 3.47E-11 3.51 Brain-specific GO:0007610 behavior 5.84E-12 1.72E-10 2.75 Brain-specific GO:0007186 G-protein coupled receptor signaling pathway 7.88E-11 2.00E-09 2.33 Brain-specific GO:0006811 ion transport 9.69E-11 2.00E-09 1.92 Brain-specific GO:0050767 regulation of neurogenesis 9.07E-11 2.00E-09 2.36 Brain-specific GO:0023052 signaling 1.80E-10 3.37E-09 2.36 Brain-specific GO:0010975 regulation of neuron projection development 2.02E-10 3.47E-09 2.76 Brain-specific GO:0045664 regulation of neuron differentiation 2.33E-10 3.69E-09 2.47 Brain-specific GO:0044700 single organism signaling 2.72E-10 3.86E-09 2.35 Brain-specific GO:0044708 single-organism behavior 2.81E-10 3.86E-09 2.91 Brain-specific GO:0007267 cell-cell signaling 9.61E-10 1.24E-08 2.36 Brain-specific GO:0098660 inorganic ion transmembrane transport 1.13E-09 1.37E-08 2.39 Brain-specific GO:0034220 ion transmembrane transport 1.45E-09 1.66E-08 2.11 Brain-specific GO:0050877 neurological system process 2.09E-09 2.15E-08 2.18 Brain-specific GO:0031344 regulation of cell projection organization 2.01E-09 2.15E-08 2.41 Brain-specific GO:0010769 regulation of cell morphogenesis involved in differentiation 1.35E-08 1.26E-07 3.08 Brain-specific GO:0060284 regulation of cell development 1.31E-08 1.26E-07 2.12 Brain-specific GO:0048167 regulation of synaptic plasticity 1.61E-08 1.44E-07 3.91 Brain-specific GO:0001505 regulation of neurotransmitter levels 3.75E-08 3.22E-07 3.78 Brain-specific GO:0030001 metal ion transport 4.80E-08 3.80E-07 2.22 Brain-specific GO:0007399 nervous system development 4.78E-08 3.80E-07 2.82 Brain-specific GO:0007626 locomotory behavior 5.87E-08 4.42E-07 3.45 Brain-specific GO:0006812 cation transport 6.01E-08 4.42E-07 2.04 Brain-specific GO:0007165 signal transduction 9.14E-08 6.33E-07 1.37 Brain-specific GO:0050770 regulation of axonogenesis 9.22E-08 6.33E-07 3.55 Brain-specific GO:0030534 adult behavior 1.18E-07 7.84E-07 4.03 Brain-specific GO:0007154 cell communication 1.26E-07 8.11E-07 2.01 Brain-specific GO:0099531 presynaptic process involved in chemical synaptic transmission 2.08E-07 1.30E-06 4.2 Brain-specific GO:0099643 signal release from synapse 3.68E-07 2.23E-06 4.59 Brain-specific GO:0051962 positive regulation of nervous system development 6.20E-07 3.65E-06 2.34 Brain-specific GO:0048731 system development 7.22E-07 4.13E-06 2.03 Brain-specific GO:0055085 transmembrane transport 1.04E-06 5.79E-06 1.78 Brain-specific GO:0051963 regulation of synapse assembly 2.23E-06 1.21E-05 4.37 Brain-specific GO:0050890 cognition 4.23E-06 2.23E-05 2.82 Brain-specific GO:0007611 learning or memory 5.67E-06 2.92E-05 2.94 Brain-specific GO:0023061 signal release 7.61E-06 3.65E-05 3.44 Brain-specific GO:0007612 learning 7.57E-06 3.65E-05 3.66 Brain-specific GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway 7.44E-06 3.65E-05 3.54 Brain-specific GO:0098662 inorganic cation transmembrane transport 8.58E-06 4.02E-05 2.18 Brain-specific GO:0007218 neuropeptide signaling pathway 9.36E-06 4.20E-05 4.41 Brain-specific GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway 9.38E-06 4.20E-05 4.89 Brain-specific GO:2000026 regulation of multicellular organismal development 1.15E-05 5.04E-05 1.58 Brain-specific GO:1902578 single-organism localization 1.40E-05 6.01E-05 1.51 Brain-specific GO:0044765 single-organism transport 1.92E-05 8.07E-05 1.53 Brain-specific GO:0051961 negative regulation of nervous system development 2.06E-05 8.49E-05 2.59 Brain-specific GO:0006813 potassium ion transport 2.17E-05 8.77E-05 3.01 Brain-specific GO:0006810 transport 2.35E-05 9.31E-05 1.35 Brain-specific GO:0022604 regulation of cell morphogenesis 2.63E-05 0.000101474 2.14 Brain-specific GO:0007187 "G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger" 2.66E-05 0.000101474 3.12 Brain-specific GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 2.71E-05 0.000101502 3.39 Brain-specific GO:0098655 cation transmembrane transport 2.94E-05 0.000106253 2.03 Brain-specific GO:0051234 establishment of localization 2.94E-05 0.000106253 1.33 Brain-specific GO:0008344 adult locomotory behavior 3.28E-05 0.000114522 4.25 Brain-specific GO:0043269 regulation of ion transport 3.26E-05 0.000114522 2.03 Brain-specific GO:0050768 negative regulation of neurogenesis 3.61E-05 0.000123943 2.6 Brain-specific GO:0006836 neurotransmitter transport 5.65E-05 0.000190803 3.6 Brain-specific GO:0051179 localization 5.80E-05 0.00019271 1.31 Brain-specific GO:0010721 negative regulation of cell development 6.35E-05 0.000207635 2.46 Brain-specific GO:0050807 regulation of synapse organization 6.46E-05 0.000207931 3.32 Brain-specific GO:0071805 potassium ion transmembrane transport 8.74E-05 0.000272794 3 Brain-specific GO:0071804 cellular potassium ion transport 8.60E-05 0.000272554 3 Brain-specific GO:0048812 neuron projection morphogenesis 8.95E-05 0.000275179 2.73 Brain-specific GO:0007269 neurotransmitter secretion 1.05E-04 0.000318088 4.63 Brain-specific GO:0015672 monovalent inorganic cation transport 1.09E-04 0.00032542 2.18 Brain-specific GO:0050808 synapse organization 1.61E-04 0.000466361 3.25 Brain-specific GO:0007409 axonogenesis 1.59E-04 0.000466361 3.25 Brain-specific GO:0048858 cell projection morphogenesis 1.63E-04 0.000466361 2.65 Brain-specific GO:0051965 positive regulation of synapse assembly 1.84E-04 0.000519233 4.17 Brain-specific GO:0050773 regulation of dendrite development 2.09E-04 0.000574053 3.31 Brain-specific GO:0007600 sensory perception 2.09E-04 0.000574053 2.05 Brain-specific GO:0051049 regulation of transport 3.00E-04 0.000813158 1.49 Brain-specific GO:0006820 anion transport 3.61E-04 0.000941342 1.93 Brain-specific GO:0061387 regulation of extent of cell growth 3.60E-04 0.000941342 3.44 Brain-specific GO:0050806 positive regulation of synaptic transmission 3.55E-04 0.000941342 3.44 Brain-specific GO:0098656 anion transmembrane transport 4.65E-04 0.001197375 2.35 Brain-specific GO:0042391 regulation of membrane potential 5.16E-04 0.001312296 2.16 Brain-specific GO:0000160 phosphorelay signal transduction system 5.73E-04 0.001439488 12.24 Brain-specific GO:0030516 regulation of axon extension 5.86E-04 0.00145441 3.63 Brain-specific GO:0007270 neuron-neuron synaptic transmission 6.18E-04 0.001515571 4.59 Brain-specific GO:0032990 cell part morphogenesis 6.43E-04 0.001558329 2.46 Brain-specific GO:0051588 regulation of neurotransmitter transport 6.67E-04 0.001597698 3.98 Brain-specific GO:0032879 regulation of localization 6.94E-04 0.001643264 1.38 Brain-specific GO:0045665 negative regulation of neuron differentiation 7.23E-04 0.001692477 2.54 Brain-specific GO:0010771 negative regulation of cell morphogenesis involved in differentiation 8.82E-04 0.002041483 3.36 Brain-specific GO:0006821 chloride transport 1.01E-03 0.002311778 3.19 Brain-specific GO:0034765 regulation of ion transmembrane transport 1.03E-03 0.002331648 2.11 Brain-specific GO:0050805 negative regulation of synaptic transmission 1.18E-03 0.002642174 4.32 Brain-specific GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 1.23E-03 0.002724516 2.57 Brain-specific GO:0045595 regulation of cell differentiation 1.32E-03 0.002892766 1.49 Brain-specific GO:0007631 feeding behavior 1.47E-03 0.003187579 3.72 Brain-specific GO:0003008 system process 1.55E-03 0.003258163 1.54 Brain-specific GO:0007214 gamma-aminobutyric acid signaling pathway 1.54E-03 0.003258163 5.51 Brain-specific GO:0021954 central nervous system neuron development 1.52E-03 0.003258163 5.51 Brain-specific GO:1902476 chloride transmembrane transport 1.59E-03 0.003308485 3.2 Brain-specific GO:0051966 "regulation of synaptic transmission, glutamatergic" 1.70E-03 0.003502 4.49 Brain-specific GO:0050771 negative regulation of axonogenesis 1.73E-03 0.003528515 3.88 Brain-specific GO:0048814 regulation of dendrite morphogenesis 1.80E-03 0.003635294 3.64 Brain-specific GO:0045666 positive regulation of neuron differentiation 2.00E-03 0.004 2.14 Brain-specific GO:0050769 positive regulation of neurogenesis 2.10E-03 0.004159615 2 Brain-specific GO:0099003 vesicle-mediated transport in synapse 2.21E-03 0.00433581 3.4 Brain-specific GO:0060291 long-term synaptic potentiation 2.45E-03 0.004716822 4.71 Brain-specific GO:1900452 regulation of long term synaptic depression 2.45E-03 0.004716822 10.2 Brain-specific GO:0010976 positive regulation of neuron projection development 2.53E-03 0.004825741 2.32 Brain-specific GO:0034762 regulation of transmembrane transport 3.02E-03 0.005707523 2 Brain-specific GO:0051239 regulation of multicellular organismal process 3.07E-03 0.005749273 1.34 Brain-specific GO:0009581 detection of external stimulus 3.31E-03 0.006142883 3.01 Brain-specific GO:0031345 negative regulation of cell projection organization 3.87E-03 0.007118036 2.62 Brain-specific GO:0009582 detection of abiotic stimulus 3.97E-03 0.007237345 2.97 Brain-specific GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 4.58E-03 0.00827614 5.44 Brain-specific GO:0030030 cell projection organization 5.52E-03 0.009802759 1.67 Brain-specific GO:0030817 regulation of cAMP biosynthetic process 5.48E-03 0.009802759 3.01 Brain-specific GO:0010977 negative regulation of neuron projection development 5.58E-03 0.009824615 2.7 Brain-specific GO:0030802 regulation of cyclic nucleotide biosynthetic process 5.64E-03 0.009846102 2.79 Brain-specific GO:0051952 regulation of amine transport 5.78E-03 0.010005714 3.46 Brain-specific GO:0070838 divalent metal ion transport 5.89E-03 0.010111167 2.13 Brain-specific GO:0007215 glutamate receptor signaling pathway 6.44E-03 0.010963967 4.22 Brain-specific GO:0097485 neuron projection guidance 6.70E-03 0.011313115 2.35 Brain-specific GO:0009584 detection of visible light 6.81E-03 0.011313387 5.15 Brain-specific GO:0006816 calcium ion transport 6.78E-03 0.011313387 2.26 Brain-specific GO:0046928 regulation of neurotransmitter secretion 7.09E-03 0.01168432 3.85 Brain-specific GO:0008306 associative learning 7.24E-03 0.011836825 3.58 Brain-specific GO:0098661 inorganic anion transmembrane transport 7.44E-03 0.012068031 2.72 Brain-specific GO:0010720 positive regulation of cell development 7.58E-03 0.012168372 1.84 Brain-specific GO:0072511 divalent inorganic cation transport 7.62E-03 0.012168372 2.1 Brain-specific GO:0070588 calcium ion transmembrane transport 7.68E-03 0.012169846 2.43 Brain-specific GO:0048168 regulation of neuronal synaptic plasticity 8.28E-03 0.013020458 4.08 Brain-specific GO:1902803 regulation of synaptic vesicle transport 9.46E-03 0.014652331 4.41 Brain-specific GO:0030800 negative regulation of cyclic nucleotide metabolic process 9.39E-03 0.014652331 4.41 Brain-specific GO:1900371 regulation of purine nucleotide biosynthetic process 9.87E-03 0.015060889 2.65 Brain-specific GO:0006865 amino acid transport 9.80E-03 0.015060889 2.65 Brain-specific GO:0030814 regulation of cAMP metabolic process 1.00E-02 0.015147059 2.74 Brain-specific GO:0060078 regulation of postsynaptic membrane potential 1.08E-02 0.016239416 3.95 Brain-specific GO:0030808 regulation of nucleotide biosynthetic process 1.13E-02 0.016627143 2.62 Brain-specific GO:0042752 regulation of circadian rhythm 1.12E-02 0.016598561 3.06 Brain-specific GO:0048638 regulation of developmental growth 1.12E-02 0.016598561 2.08 Brain-specific GO:0015813 L-glutamate transport 1.30E-02 0.018727273 5.35 Brain-specific GO:0015800 acidic amino acid transport 1.29E-02 0.018714085 5.35 Brain-specific GO:0007628 adult walking behavior 1.28E-02 0.018700709 5.35 Brain-specific GO:0048666 neuron development 1.33E-02 0.019026389 2.67 Brain-specific GO:0017157 regulation of exocytosis 1.37E-02 0.019198639 2.5 Brain-specific GO:0007411 axon guidance 1.37E-02 0.019198639 2.27 Brain-specific GO:0031346 positive regulation of cell projection organization 1.37E-02 0.019198639 1.97 Brain-specific GO:0050433 regulation of catecholamine secretion 1.67E-02 0.023244595 4.08 Brain-specific GO:0030799 regulation of cyclic nucleotide metabolic process 1.79E-02 0.024211688 2.45 Brain-specific GO:0032291 axon ensheathment in central nervous system 1.80E-02 0.024211688 9.79 Brain-specific GO:0022010 central nervous system myelination 1.79E-02 0.024211688 9.79 Brain-specific GO:0031279 regulation of cyclase activity 1.78E-02 0.024211688 3.06 Brain-specific GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway 1.77E-02 0.024211688 3.06 Brain-specific GO:0015698 inorganic anion transport 1.81E-02 0.024211688 2.38 Brain-specific GO:0030803 negative regulation of cyclic nucleotide biosynthetic process 1.83E-02 0.02432129 4.45 Brain-specific GO:0014059 regulation of dopamine secretion 1.86E-02 0.024405096 5.04 Brain-specific GO:0090659 walking behavior 1.85E-02 0.024405096 5.04 Brain-specific GO:0048489 synaptic vesicle transport 1.94E-02 0.025134591 3.19 Brain-specific GO:0097480 establishment of synaptic vesicle localization 1.93E-02 0.025134591 3.19 Brain-specific GO:0051650 establishment of vesicle localization 2.06E-02 0.026357764 2.65 Brain-specific GO:0032989 cellular component morphogenesis 2.06E-02 0.026357764 1.87 Brain-specific GO:0017158 regulation of calcium ion-dependent exocytosis 2.08E-02 0.026449383 3.37 Brain-specific GO:0030815 negative regulation of cAMP metabolic process 2.48E-02 0.030962424 4.26 Brain-specific GO:0050919 negative chemotaxis 2.47E-02 0.030962424 4.26 Brain-specific GO:0051339 regulation of lyase activity 2.46E-02 0.030962424 2.95 Brain-specific GO:0060627 regulation of vesicle-mediated transport 2.56E-02 0.031768675 1.8 Brain-specific GO:0016079 synaptic vesicle exocytosis 2.72E-02 0.033552096 3.8 Brain-specific GO:1900542 regulation of purine nucleotide metabolic process 2.80E-02 0.033929412 2.19 Brain-specific GO:0015807 L-amino acid transport 2.80E-02 0.033929412 3.06 Brain-specific GO:0097479 synaptic vesicle localization 2.78E-02 0.033929412 3.06 Brain-specific GO:0051094 positive regulation of developmental process 2.90E-02 0.034935673 1.44 Brain-specific GO:0050793 regulation of developmental process 2.93E-02 0.03509186 1.3 Brain-specific GO:0031175 neuron projection development 2.99E-02 0.035603468 2.39 Brain-specific GO:0045761 regulation of adenylate cyclase activity 3.08E-02 0.036464368 3.2 Brain-specific GO:1900372 negative regulation of purine nucleotide biosynthetic process 3.22E-02 0.037265169 4.08 Brain-specific GO:0051931 regulation of sensory perception 3.20E-02 0.037242938 4.08 Brain-specific GO:0051930 regulation of sensory perception of pain 3.19E-02 0.037242938 4.08 Brain-specific GO:0030809 negative regulation of nucleotide biosynthetic process 3.17E-02 0.037242938 4.08 Brain-specific GO:0021884 forebrain neuron development 3.61E-02 0.041545251 5.24 Brain-specific GO:0006140 regulation of nucleotide metabolic process 3.70E-02 0.042344444 2.14 Brain-specific GO:0017156 calcium ion regulated exocytosis 4.11E-02 0.046099459 3.31 Brain-specific GO:0035556 intracellular signal transduction 4.13E-02 0.046099459 1.36 Brain-specific GO:1904936 interneuron migration 4.14E-02 0.046099459 8.16 Brain-specific GO:0021877 forebrain neuron fate commitment 4.11E-02 0.046099459 8.16 Brain-specific GO:0021853 cerebral cortex GABAergic interneuron migration 4.09E-02 0.046099459 8.16 Brain-specific GO:0043266 regulation of potassium ion transport 4.44E-02 0.048651064 3.06 Brain-specific GO:0031644 regulation of neurological system process 4.41E-02 0.048580749 3.06 Brain-specific GO:0051648 vesicle localization 4.41E-02 0.048580749 2.45 Brain-specific GO:0043087 regulation of GTPase activity 4.75E-02 0.051238579 1.55 Brain-specific GO:0030818 negative regulation of cAMP biosynthetic process 4.89E-02 0.051238579 4.28 Brain-specific GO:0045980 negative regulation of nucleotide metabolic process 4.90E-02 0.051238579 3.22 Brain-specific GO:1900543 negative regulation of purine nucleotide metabolic process 4.88E-02 0.051238579 3.22 Brain-specific GO:0031281 positive regulation of cyclase activity 4.85E-02 0.051238579 3.22 Brain-specific GO:0042552 myelination 4.83E-02 0.051238579 3.22 Brain-specific GO:0051349 positive regulation of lyase activity 4.80E-02 0.051238579 3.22 Brain-specific GO:0008277 regulation of G-protein coupled receptor protein signaling pathway 4.89E-02 0.051238579 2.42 Brain-specific GO:0044087 regulation of cellular component biogenesis 4.87E-02 0.051238579 1.54 Brain-specific GO:0015711 organic anion transport 5.04E-02 0.051912 1.73 Brain-specific GO:0031111 negative regulation of microtubule polymerization or depolymerization 5.04E-02 0.051912 4.89 Brain-specific GO:0060079 excitatory postsynaptic potential 5.01E-02 0.051912 4.89 Brain-specific GO:0006835 dicarboxylic acid transport 5.14E-02 0.052678607 2.82 Brain-specific GO:0008366 axon ensheathment 5.78E-02 0.058654187 3.14 Brain-specific GO:0007272 ensheathment of neurons 5.76E-02 0.058654187 3.14 Brain-specific GO:0046942 carboxylic acid transport 6.06E-02 0.061194118 1.89 Brain-specific GO:0030517 negative regulation of axon extension 6.32E-02 0.0632 4.08 Brain-specific GO:0050795 regulation of behavior 6.31E-02 0.0632 3.34 Cerebellum-specific GO:0023052 signaling 6.84E-09 4.06E-07 2.58 Cerebellum-specific GO:0044700 single organism signaling 7.59E-09 4.06E-07 2.56 Cerebellum-specific GO:0007267 cell-cell signaling 5.42E-08 1.93E-06 2.54 Cerebellum-specific GO:0098916 anterograde trans-synaptic signaling 3.53E-06 4.87E-05 3.01 Cerebellum-specific GO:0007268 chemical synaptic transmission 2.82E-06 4.87E-05 3.01 Cerebellum-specific GO:0099536 synaptic signaling 2.72E-06 4.87E-05 3 Cerebellum-specific GO:0099537 trans-synaptic signaling 2.33E-06 4.87E-05 3 Cerebellum-specific GO:0007399 nervous system development 3.64E-06 4.87E-05 2.99 Cerebellum-specific GO:0007154 cell communication 4.81E-06 5.72E-05 2.12 Cerebellum-specific GO:0050804 modulation of synaptic transmission 4.47E-05 0.00047829 2.91 Cerebellum-specific GO:0048731 system development 1.10E-04 0.00107 2.07 Cerebellum-specific GO:0099531 presynaptic process involved in chemical synaptic transmission 1.60E-04 0.001222857 4.17 Cerebellum-specific GO:0099643 signal release from synapse 1.49E-04 0.001222857 4.63 Cerebellum-specific GO:0043269 regulation of ion transport 1.57E-04 0.001222857 2.22 Cerebellum-specific GO:0023061 signal release 2.89E-04 0.002061533 3.64 Cerebellum-specific GO:0016079 synaptic vesicle exocytosis 4.57E-04 0.002624316 6.15 Cerebellum-specific GO:0034765 regulation of ion transmembrane transport 4.33E-04 0.002624316 2.51 Cerebellum-specific GO:0042391 regulation of membrane potential 4.56E-04 0.002624316 2.49 Cerebellum-specific GO:0097479 synaptic vesicle localization 4.66E-04 0.002624316 4.73 Cerebellum-specific GO:0017156 calcium ion regulated exocytosis 7.91E-04 0.004030333 5.26 Cerebellum-specific GO:0060078 regulation of postsynaptic membrane potential 7.61E-04 0.004030333 5.75 Cerebellum-specific GO:0050807 regulation of synapse organization 9.07E-04 0.004411318 3.6 Cerebellum-specific GO:0034762 regulation of transmembrane transport 1.11E-03 0.005163913 2.38 Cerebellum-specific GO:0051960 regulation of nervous system development 1.40E-03 0.006241667 1.89 Cerebellum-specific GO:0098660 inorganic ion transmembrane transport 1.78E-03 0.0076184 2.02 Cerebellum-specific GO:0051648 vesicle localization 2.86E-03 0.011334074 3.44 Cerebellum-specific GO:0050789 regulation of biological process 2.86E-03 0.011334074 1.14 Cerebellum-specific GO:0065007 biological regulation 7.07E-03 0.022559167 1.12 Cerebellum-specific GO:0048489 synaptic vesicle transport 6.86E-03 0.022559167 4.23 Cerebellum-specific GO:0097480 establishment of synaptic vesicle localization 6.63E-03 0.022559167 4.23 Cerebellum-specific GO:0051962 positive regulation of nervous system development 6.73E-03 0.022559167 2.08 Cerebellum-specific GO:0045595 regulation of cell differentiation 7.09E-03 0.022559167 1.56 Cerebellum-specific GO:0099003 vesicle-mediated transport in synapse 6.89E-03 0.022559167 3.9 Cerebellum-specific GO:1903530 regulation of secretion by cell 7.48E-03 0.022559167 1.94 Cerebellum-specific GO:0046834 lipid phosphorylation 7.59E-03 0.022559167 3.28 Cerebellum-specific GO:0050794 regulation of cellular process 7.53E-03 0.022559167 1.14 Cerebellum-specific GO:0001505 regulation of neurotransmitter levels 7.84E-03 0.022672432 3.01 Cerebellum-specific GO:0006351 "transcription, DNA-templated" 9.15E-03 0.025252 1.43 Cerebellum-specific GO:0097659 nucleic acid-templated transcription 9.23E-03 0.025252 1.43 Cerebellum-specific GO:0034220 ion transmembrane transport 9.44E-03 0.025252 1.73 Cerebellum-specific GO:0050767 regulation of neurogenesis 9.71E-03 0.025340732 1.83 Cerebellum-specific GO:0045664 regulation of neuron differentiation 1.09E-02 0.027372093 1.91 Cerebellum-specific GO:0051650 establishment of vesicle localization 1.10E-02 0.027372093 3.29 Cerebellum-specific GO:0060284 regulation of cell development 1.31E-02 0.031856818 1.76 Cerebellum-specific GO:0098655 cation transmembrane transport 1.48E-02 0.035123913 1.9 Cerebellum-specific GO:0051965 positive regulation of synapse assembly 1.51E-02 0.035123913 4.05 Cerebellum-specific GO:0050974 detection of mechanical stimulus involved in sensory perception 1.59E-02 0.036197872 6.3 Cerebellum-specific GO:0051049 regulation of transport 1.95E-02 0.04346875 1.47 Cerebellum-specific GO:0007270 neuron-neuron synaptic transmission 2.52E-02 0.055028571 4.56 Cerebellum-specific GO:0032940 secretion by cell 2.68E-02 0.057352 1.98 Cerebellum-specific GO:0098662 inorganic cation transmembrane transport 2.80E-02 0.057739623 1.93 Cerebellum-specific GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 2.86E-02 0.057739623 2.59 Cerebellum-specific GO:0017158 regulation of calcium ion-dependent exocytosis 2.86E-02 0.057739623 4.05 Cerebellum-specific GO:0051963 regulation of synapse assembly 2.99E-02 0.059246296 3.47 Cerebellum-specific GO:0051046 regulation of secretion 3.08E-02 0.05992 1.79 Cerebellum-specific GO:0044708 single-organism behavior 3.37E-02 0.064391071 2.07 Cerebellum-specific GO:0007416 synapse assembly 3.63E-02 0.068142105 4.29 Cerebellum-specific GO:0006887 exocytosis 3.95E-02 0.071635593 2.27 Cerebellum-specific GO:0032774 RNA biosynthetic process 3.91E-02 0.071635593 1.36 Cerebellum-specific GO:0090129 positive regulation of synapse maturation 4.23E-02 0.073031746 10.81 Cerebellum-specific GO:0050877 neurological system process 4.27E-02 0.073031746 1.69 Cerebellum-specific GO:0046928 regulation of neurotransmitter secretion 4.25E-02 0.073031746 4.17 Cerebellum-specific GO:0030001 metal ion transport 4.30E-02 0.073031746 1.77 Cerebellum-specific GO:0051588 regulation of neurotransmitter transport 4.52E-02 0.075558462 3.77 Cerebellum-specific GO:0010720 positive regulation of cell development 4.59E-02 0.075558462 1.92 Cerebellum-specific GO:0051899 membrane depolarization 5.03E-02 0.080329851 4.05 Cerebellum-specific GO:0051094 positive regulation of developmental process 4.98E-02 0.080329851 1.54 Cerebellum-specific GO:0050808 synapse organization 5.68E-02 0.087892857 2.87 Cerebellum-specific GO:0046854 phosphatidylinositol phosphorylation 5.67E-02 0.087892857 3.01 Cerebellum-specific GO:2000026 regulation of multicellular organismal development 5.75E-02 0.087892857 1.43 Cerebellum-specific GO:0021549 cerebellum development 6.19E-02 0.091990278 4.93 Cerebellum-specific GO:0035725 sodium ion transmembrane transport 6.19E-02 0.091990278 3.14 Cerebellum-specific GO:0045666 positive regulation of neuron differentiation 6.39E-02 0.093661644 2.09 Cerebellum-specific GO:0006811 ion transport 6.84E-02 0.09864878 1.47 Cerebellum-specific GO:0050890 cognition 7.10E-02 0.09864878 2.24 Cerebellum-specific GO:0051932 "synaptic transmission, GABAergic" 7.41E-02 0.09864878 9.26 Cerebellum-specific GO:0090128 regulation of synapse maturation 7.31E-02 0.09864878 9.26 Cerebellum-specific GO:0060012 "synaptic transmission, glycinergic" 7.22E-02 0.09864878 9.26 Cerebellum-specific GO:0055085 transmembrane transport 7.36E-02 0.09864878 1.51 Cerebellum-specific GO:0050806 positive regulation of synaptic transmission 7.56E-02 0.09864878 3.04 Cerebellum-specific GO:0032412 regulation of ion transmembrane transporter activity 7.50E-02 0.09864878 2.64 Cerebellum-specific GO:0046488 phosphatidylinositol metabolic process 7.43E-02 0.09864878 2.39 Cerebellum-specific GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 7.87E-02 0.098944944 2.73 Cerebellum-specific GO:0098815 modulation of excitatory postsynaptic potential 8.17E-02 0.098944944 5.4 Cerebellum-specific GO:0060999 positive regulation of dendritic spine development 8.07E-02 0.098944944 5.4 Cerebellum-specific GO:0031346 positive regulation of cell projection organization 7.99E-02 0.098944944 2.04 Cerebellum-specific GO:0050769 positive regulation of neurogenesis 7.99E-02 0.098944944 1.92 Cerebellum-specific GO:0006812 cation transport 8.23E-02 0.098944944 1.6 Cerebellum-specific GO:0061337 cardiac conduction 8.22E-02 0.098944944 4.05 Cerebellum-specific GO:0048167 regulation of synaptic plasticity 8.54E-02 0.100415385 2.59 Cerebellum-specific GO:0050982 detection of mechanical stimulus 8.50E-02 0.100415385 4.54 Cerebellum-specific GO:0007165 signal transduction 8.73E-02 0.101247312 1.22 Cerebellum-specific GO:0007610 behavior 8.80E-02 0.101247312 1.8 Cerebellum-specific GO:0032502 developmental process 9.13E-02 0.103926596 1.21 Cerebellum-specific GO:0001508 action potential 9.86E-02 0.107540404 3.56 Cerebellum-specific GO:0061001 regulation of dendritic spine morphogenesis 9.90E-02 0.107540404 5.12 Cerebellum-specific GO:0022898 regulation of transmembrane transporter activity 9.95E-02 0.107540404 2.53 Cerebellum-specific GO:0030182 neuron differentiation 9.86E-02 0.107540404 2.19 Cerebellum-specific GO:0045956 positive regulation of calcium ion-dependent exocytosis 9.83E-02 0.107540404 6.23 Cerebellum-specific GO:0006836 neurotransmitter transport 1.07E-01 0.11449 2.86 Cerebellum-specific GO:0032879 regulation of localization 1.12E-01 0.118653465 1.31 Cerebellum-specific GO:0048170 positive regulation of long-term neuronal synaptic plasticity 1.14E-01 0.119466019 12.16 Cerebellum-specific GO:0046903 secretion 1.15E-01 0.119466019 1.73 Cerebellum-specific GO:0009581 detection of external stimulus 1.18E-01 0.120247619 2.82 Cerebellum-specific GO:0051239 regulation of multicellular organismal process 1.17E-01 0.120247619 1.3 Cerebellum-specific GO:0086010 membrane depolarization during action potential 1.22E-01 0.122 4.86 Cerebellum-specific GO:1903506 regulation of nucleic acid-templated transcription 1.21E-01 0.122 1.25