Supplemental Table S11								
								
# Lowly expressed brain-specific paralogs of old and ancient duplication ages in human								
# P-value - uncorrected P value								
# P-value adjusted - P value corrected for 104 tests (Benjamini-Hochberg method)								
								
								
								
GO Term	Description	P-value	P-value adjusted	Enrichment				
GO:0007268	synaptic transmission	8.42E-34	8.76E-32	4.56				
GO:0007267	cell-cell signaling	1.53E-30	7.96E-29	3.45				
GO:0044700	single organism signaling	9.66E-30	2.51E-28	3.38				
GO:0023052	signaling	9.66E-30	2.51E-28	3.38				
GO:0007154	cell communication	1.02E-26	2.12E-25	2.95				
GO:0007186	G-protein coupled receptor signaling pathway	5.55E-25	9.62E-24	3.63				
GO:0050877	neurological system process	8.72E-19	1.30E-17	2.96				
GO:0003008	system process	6.89E-14	8.96E-13	2.26				
GO:0007610	behavior	3.08E-13	3.56E-12	3.16				
GO:0007166	cell surface receptor signaling pathway	1.38E-12	1.44E-11	1.76				
GO:0007600	sensory perception	3.20E-12	3.03E-11	2.9				
GO:0007214	gamma-aminobutyric acid signaling pathway	9.21E-12	7.98E-11	10.15				
GO:0044708	single-organism behavior	3.05E-10	2.44E-09	3.06				
GO:0006811	ion transport	9.05E-10	6.72E-09	2.01				
GO:0050953	sensory perception of light stimulus	4.23E-09	2.93E-08	3.38				
GO:0007218	neuropeptide signaling pathway	3.28E-08	2.13E-07	5.53				
GO:0007601	visual perception	4.06E-08	2.48E-07	3.24				
GO:0044763	single-organism cellular process	1.20E-07	6.93E-07	1.2				
GO:0007187	"G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"	3.25E-07	1.69E-06	3.53				
GO:0007611	learning or memory	3.25E-07	1.69E-06	3.53				
GO:0006813	potassium ion transport	3.47E-07	1.72E-06	4.21				
GO:0031644	regulation of neurological system process	4.50E-07	2.13E-06	3.06				
GO:0007165	signal transduction	5.15E-07	2.33E-06	1.36				
GO:0050890	cognition	6.96E-07	3.02E-06	3.27				
GO:0044707	single-multicellular organism process	1.39E-06	5.78E-06	1.41				
GO:0030001	metal ion transport	2.15E-06	8.60E-06	2.21				
GO:0006812	cation transport	2.62E-06	1.01E-05	2.05				
GO:0032501	multicellular organismal process	2.80E-06	1.04E-05	1.39				
GO:0051960	regulation of nervous system development	3.10E-06	1.07E-05	2.17				
GO:0045664	regulation of neuron differentiation	3.11E-06	1.07E-05	2.4				
GO:0048666	neuron development	3.18E-06	1.07E-05	3.64				
GO:0007626	locomotory behavior	3.30E-06	1.07E-05	3.33				
GO:0050804	regulation of synaptic transmission	3.69E-06	1.16E-05	3.08				
GO:0048731	system development	3.81E-06	1.17E-05	1.92				
GO:0044699	single-organism process	4.26E-06	1.27E-05	1.15				
GO:0044057	regulation of system process	4.95E-06	1.43E-05	2.19				
GO:0021953	central nervous system neuron differentiation	5.28E-06	1.46E-05	4.82				
GO:0030182	neuron differentiation	5.35E-06	1.46E-05	2.83				
GO:0007612	learning	5.49E-06	1.46E-05	4.44				
GO:0050767	regulation of neurogenesis	6.96E-06	1.81E-05	2.21				
GO:0051969	regulation of transmission of nerve impulse	7.46E-06	1.89E-05	2.86				
GO:0060284	regulation of cell development	1.08E-05	2.67E-05	2.04				
GO:0021515	cell differentiation in spinal cord	1.61E-05	3.89E-05	6.91				
GO:0007631	feeding behavior	1.75E-05	4.14E-05	4.34				
GO:0030534	adult behavior	1.99E-05	4.60E-05	3.53				
GO:0042391	regulation of membrane potential	2.14E-05	4.84E-05	2.85				
GO:0007399	nervous system development	2.84E-05	6.28E-05	2.35				
GO:0015672	monovalent inorganic cation transport	3.46E-05	7.50E-05	2.48				
GO:0051952	regulation of amine transport	3.84E-05	8.15E-05	4.39				
GO:0007204	elevation of cytosolic calcium ion concentration	4.38E-05	9.11E-05	2.8				
GO:0006873	cellular ion homeostasis	4.67E-05	9.52E-05	1.9				
GO:0051963	regulation of synapse assembly	5.03E-05	9.87E-05	5.26				
GO:0007270	neuron-neuron synaptic transmission	5.03E-05	9.87E-05	5.26				
GO:0050807	regulation of synapse organization	5.52E-05	1.01E-04	4.23				
GO:0002209	behavioral defense response	5.53E-05	1.01E-04	7.1				
GO:0001662	behavioral fear response	5.53E-05	1.01E-04	7.1				
GO:0021527	spinal cord association neuron differentiation	5.53E-05	1.01E-04	7.1				
GO:0048856	anatomical structure development	6.10E-05	1.09E-04	1.38				
GO:0010769	regulation of cell morphogenesis involved in differentiation	6.33E-05	1.12E-04	2.73				
GO:0055082	cellular chemical homeostasis	6.53E-05	1.13E-04	1.84				
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	6.69E-05	1.14E-04	3.83				
GO:0033555	multicellular organismal response to stress	8.45E-05	1.42E-04	4.44				
GO:0055074	calcium ion homeostasis	8.75E-05	1.44E-04	2.29				
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	9.28E-05	1.51E-04	3.28				
GO:0050433	regulation of catecholamine secretion	1.04E-04	1.66E-04	5.53				
GO:0051480	cytosolic calcium ion homeostasis	1.07E-04	1.69E-04	2.63				
GO:0007411	axon guidance	1.12E-04	1.73E-04	2.02				
GO:0042596	fear response	1.13E-04	1.73E-04	6.46				
GO:0051716	cellular response to stimulus	1.26E-04	1.90E-04	1.24				
GO:0032502	developmental process	1.47E-04	2.18E-04	1.26				
GO:0050801	ion homeostasis	1.52E-04	2.23E-04	1.76				
GO:0006836	neurotransmitter transport	1.58E-04	2.28E-04	3.52				
GO:0008306	associative learning	1.86E-04	2.64E-04	4.51				
GO:0072507	divalent inorganic cation homeostasis	1.88E-04	2.64E-04	2.19				
GO:0006874	cellular calcium ion homeostasis	2.04E-04	2.83E-04	2.27				
GO:0010975	regulation of neuron projection development	2.11E-04	2.89E-04	2.37				
GO:0045165	cell fate commitment	2.29E-04	3.09E-04	3.02				
GO:0051899	membrane depolarization	2.64E-04	3.52E-04	3.59				
GO:0050808	synapse organization	3.15E-04	4.15E-04	3.09				
GO:0051046	regulation of secretion	3.32E-04	4.32E-04	1.9				
GO:0051970	negative regulation of transmission of nerve impulse	3.62E-04	4.62E-04	5.47				
GO:0006816	calcium ion transport	3.64E-04	4.62E-04	2.65				
GO:0023061	signal release	3.91E-04	4.90E-04	3.02				
GO:0051968	"positive regulation of synaptic transmission, glutamatergic"	3.99E-04	4.94E-04	6.58				
GO:0055085	transmembrane transport	4.25E-04	5.15E-04	1.66				
GO:0031344	regulation of cell projection organization	4.31E-04	5.15E-04	2.11				
GO:0072503	cellular divalent inorganic cation homeostasis	4.31E-04	5.15E-04	2.15				
GO:0072511	divalent inorganic cation transport	4.90E-04	5.79E-04	2.49				
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway	6.00E-04	6.78E-04	11.84				
GO:0010578	regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway	6.00E-04	6.78E-04	11.84				
GO:0051932	"synaptic transmission, GABAergic"	6.00E-04	6.78E-04	11.84				
GO:0035106	operant conditioning	6.00E-04	6.78E-04	11.84				
GO:0051971	positive regulation of transmission of nerve impulse	7.31E-04	8.00E-04	3.79				
GO:0006939	smooth muscle contraction	7.31E-04	8.00E-04	3.79				
GO:0050806	positive regulation of synaptic transmission	7.31E-04	8.00E-04	3.79				
GO:0050805	negative regulation of synaptic transmission	7.43E-04	8.05E-04	5.92				
GO:0009798	axis specification	8.23E-04	8.82E-04	2.96				
GO:0034220	ion transmembrane transport	8.56E-04	9.07E-04	2.05				
GO:0051588	regulation of neurotransmitter transport	8.63E-04	9.07E-04	4.14				
GO:0051966	"regulation of synaptic transmission, glutamatergic"	9.12E-04	9.39E-04	4.74				
GO:0031645	negative regulation of neurological system process	9.12E-04	9.39E-04	4.74				
GO:0006810	transport	9.28E-04	9.46E-04	1.28				
GO:0008344	adult locomotory behavior	9.81E-04	9.91E-04	3.33				
GO:0051234	establishment of localization	9.99E-04	9.99E-04	1.27