Target isoform 2hours 4hours 6hours 8hours 12hours 24hours 36hours 48hours 60hours 72hours RA Gavage(compared to wt) 7.5dpc(compared to 10dpc) 9.5dpc (compared to 10dpc) 10.5dpc(compared to 10dpc) Mean 95% value ci low 95% value ci high mean 95% value ci low 95% value ci high mean 95% value ci low 95% value ci high mean 95% value ci low 95% value ci high mean 95% value ci low 95% value ci high mean 95% value ci low 95% value ci high mean 95% value ci low 95% value ci high mean 95% value ci low 95% value ci high mean 95% value ci low 95% value ci high mean 95% value ci low 95% value ci high mean 95% value ci low 95% value ci high mean 95% value ci low 95% value ci high mean 95% value ci low 95% value ci high mean 95% value ci low 95% value ci high Halr1 1 1.588 0.651 3.872 1.973 0.401 9.715 1.542 0.243 9.792 5.201 3.721 7.269 4.71 2.306 9.619 4.37 0.056 340.442 3.932 3.245 4.764 1.652 0.031 87.822 1.297 0.538 3.129 1.566 0.165 14.881 2.108 1.64 2.709 0.914 0.617 1.356 0.704 0.527 0.942 1.221 0.823 1.811 Halr1 2 1.397 0.433 4.502 1.397 0.327 5.963 1.035 0.163 6.557 0.807 0.398 1.635 0.656 0.25 1.721 1.199 0.136 10.557 0.829 0.339 2.026 0.415 0.325 0.53 0.319 0.141 0.721 0.347 0.271 0.444 2.55 1.76 3.693 0.827 0.456 1.499 0.514 0.313 0.843 0.983 0.578 1.669 Halr1 3 2.047 0.716 5.85 2.773 1.508 5.098 2.213 0.519 9.436 2.942 2.625 3.298 2.798 2.195 3.567 3.635 1.423 9.287 2.84 0.409 19.721 1.73 1.702 1.758 1.204 0.254 5.704 1.3 1.112 1.519 2.892 2.115 3.955 1.813 0.078 41.885 0.577 0.455 0.731 1.067 0.674 1.691 Halr1 4 2.6 1.31 5.16 2.868 0.6 13.713 2.864 0.758 10.824 5.827 3.456 9.824 6.436 2.644 15.664 8.706 2.05 36.968 5.435 0.493 59.879 2.132 2.118 2.145 2.058 0.377 11.226 2.222 0.146 33.769 1.927 0.647 5.74 0.586 0.467 0.737 0.366 0.223 0.602 1.028 0.598 1.766 Halr1 5 1.831 0.579 5.794 1.399 0.043 45.775 1.929 0.13 28.541 4.102 3.856 4.364 5.659 1.892 16.922 3.802 0.717 20.149 1.832 0.247 13.591 0.92 0.193 4.374 0.707 0.601 0.83 0.873 0.104 7.302 2.28 0.635 8.189 0.59 0.443 0.786 0.508 0.217 1.186 1.139 0.666 1.946 Halr1os1 1 1.946 0.359 10.54 1.626 0.044 60.456 1.498 0.157 14.297 6.143 3.412 11.059 6.637 2.996 14.704 5.459 0.07 427.053 3.092 1.973 4.846 1.274 0.546 2.969 1.341 0.583 3.085 1.465 0.071 30.053 1.884 0.6 5.917 0.642 0.377 1.091 0.554 0.515 0.595 1.127 0.629 2.018 Halr1os1 2 1.762 0.797 3.897 1.915 1.086 3.376 1.428 1.077 1.893 1.685 1.443 1.968 1.416 1.308 1.533 1.584 0.708 3.542 1.153 0.775 1.716 0.701 0.592 0.831 0.577 0.407 0.819 0.591 0.326 1.072 2.254 1.707 2.975 1.621 0.112 23.441 0.723 0.525 0.996 1.078 0.785 1.48 HotAirm1 0.574 0.156 2.117 0.676 0.131 3.488 0.65 0.002 279.92 1.368 0.753 2.487 1.645 1.06 2.553 2.112 0.13 34.38 2.429 1.492 3.955 1.957 0.888 4.31 1.705 1.558 1.867 2.318 0.052 102.767 2.966 2.042 4.308 10.062 3.463 29.231 1.272 0.884 1.83 1.215 0.817 1.807 HotAirm2 0.477 0.054 4.232 0.461 0.373 0.57 0.552 0.115 2.662 0.611 0.328 1.137 0.994 0.415 2.377 1.094 0.293 4.082 1.86 0.987 3.506 1.255 0.656 2.399 0.952 0.425 2.133 0.296 0 298.269 2.907 1.724 4.904 10.753 4.135 27.964 1.095 0.718 1.669 1.093 0.728 1.641 Hobbit 1 1 0.357 2.802 1.298 0.294 5.729 1.017 0.196 5.271 2.881 1.752 4.739 3.198 1.728 5.92 8.231 1.298 52.191 18.586 1.459 236.789 8.22 0.083 812.447 1.74 0 0 1.47 0.824 2.624 3.913 1.347 11.364 0.381 0.108 1.337 0.404 0.346 0.472 1.629 1.357 1.954 Mean = Mean fold change Hobbit levels are compared against 2 hours of RA teratment for ES Cell