Combinatorial binding of transcription factors in the pluripotency control regions of the genome Table S6 Transfac/JASPAR Centroids "Note: In Figure 4, singleton predictions and non-Vertebrate JASPAR PWMS were removed." OCT4 OCT1 MATRIX # Oligos Averaged 1.135 0.436090909 M00136-V$OCT1_02 "counts:12,11" 0.94285 0.332128205 M00138-V$OCT1_04 "counts:40,39" 0.93375 0.32775 M00133-V$TST1_01 "counts:4,4" 0.873666667 0.321333333 M00473-V$FOXO1_01 "counts:6,6" 0.863266667 0.328137931 M00464-V$POU3F2_02 "counts:60,58" 0.821 0.21075 M00109-V$CEBPB_01 "counts:4,4" 0.806391304 0.38793617 M00135-V$OCT1_01 "counts:46,47" 0.753263889 0.296913043 M00248-V$OCT1_07 "counts:72,69" 0.727166667 0.251 M00105-V$CDPCR3_01 "counts:6,6" 0.6645 0.15 M00035-V$VMAF_01 "counts:2,2" 0.605378378 0.132837838 M00463-V$POU3F2_01 "counts:37,37" 0.5735 0.23625 MA0043-HLF "counts:4,4" 0.565375 0.1828125 M00465-V$POU6F1_01 "counts:16,16" 0.548135135 0.223972973 M00210-V$OCT_C "counts:74,74" 0.523622222 0.123931034 MA0015-CF2-II "counts:90,87" 0.499790698 0.125904762 MA0047-HNF-3beta "counts:43,42" 0.4987 0.1439 M00251-V$XBP1_01 "counts:10,10" 0.481909091 0.078714286 M00451-V$NKX3A_01 "counts:22,21" 0.481515625 0.125092308 M00293-V$FREAC7_01 "counts:64,65" 0.44225 0.17596 M00195-V$OCT1_Q6 "counts:24,25" 0.435 -0.029 M00223-V$STAT_01 "counts:1,2" 0.4334 0.2081 MA0069-Pax6 "counts:10,10" 0.405883721 0.156627907 M00129-V$HFH1_01 "counts:43,43" 0.402033333 0.064862069 MA0025-E4BP4 "counts:30,29" 0.396714286 0.189153846 M00416-V$CART1_01 "counts:14,13" 0.388214286 0.204392857 M00437-V$CHX10_01 "counts:28,28" 0.3361 -0.034727273 M00291-V$FREAC3_01 "counts:10,11" 0.333 0.193 MA0001-AGL3 "counts:4,4" 0.326315068 0.069722222 M00131-V$HNF3B_01 "counts:73,72" 0.279333333 0.108928571 M00477-V$FOXO3_01 "counts:27,28" 0.2774 0.080443299 M00267-V$XFD1_01 "counts:95,97" 0.27625641 0.098526316 MA0040-HFH-1 "counts:39,38" 0.2545 -0.01925 M00095-V$CDP_01 "counts:4,4" 0.252384615 0.122346154 M00474-V$FOXO1_02 "counts:26,26" 0.247565217 0.108 M00161-V$OCT1_05 "counts:46,46" 0.178818182 0.118054545 M00294-V$HFH8_01 "counts:55,55" 0.178538462 0.190769231 M00099-V$S8_01 "counts:13,13" 0.178472222 -0.041027778 M00045-V$E4BP4_01 "counts:36,36" 0.176857143 0.144142857 M00070-V$TAL1BETAITF2_01 "counts:7,7" 0.172363636 -0.153181818 M00162-V$OCT1_06 "counts:11,11" 0.169238095 -0.01935 M00103-V$CLOX_01 "counts:21,20" 0.166633333 0.093365079 M00510-V$LHX3_01 "counts:60,63" 0.164083333 0.004461538 M00124-V$PBX1_02 "counts:12,13" 0.140054348 0.087912088 M00289-V$HFH3_01 "counts:92,91" 0.139411765 -0.138411765 M00206-V$HNF1_C "counts:17,17" 0.1065 0.185833333 M00249-V$CHOP_01 "counts:6,6" 0.094375 0.191428571 MA0019-Chop-cEBP "counts:8,7" 0.093740741 0.047555556 MA0008-Athb-1 "counts:27,27" 0.091283582 0.073830882 M00422-V$FOXJ2_01 "counts:134,136" 0.085695238 0.126942857 M00130-V$FOXD3_01 "counts:105,105" 0.084888889 0.066333333 M00209-V$NFY_C "counts:18,18" 0.07375 0.0055 M00302-V$NFAT_Q6 "counts:4,4" 0.0668 0.0504 M00260-V$HLF_01 "counts:10,10" 0.0668 0.0504 M00228-V$VBP_01 "counts:10,10" 0.0656 0.0116 M00264-V$STAF_02 "counts:10,10" 0.0615 0.0285 M00211-V$PADS_C "counts:2,2" 0.06125 0.0625 M00117-V$CEBPB_02 "counts:4,4" 0.057045455 -0.068391304 M00132-V$HNF1_01 "counts:22,23" 0.054071429 -0.004410714 M00268-V$XFD2_01 "counts:56,56" 0.053545455 0.095753521 MA0042-HFH-3 "counts:143,142" 0.053 0.09525 M00454-V$MRF2_01 "counts:4,4" 0.0388 0.0886 M00538-V$HTF_01 "counts:5,5" 0.035985612 0.116057554 MA0041-HFH-2 "counts:139,139" 0.035615385 0.031916667 MA0017-COUP-TF "counts:13,12" 0.035615385 0.031916667 M00158-V$COUP_01 "counts:13,12" 0.032 -0.163733333 MA0070-Pbx "counts:14,15" 0.031045455 -0.026545455 M00037-V$NFE2_01 "counts:22,22" 0.029333333 -0.032 M00189-V$AP2_Q6 "counts:3,3" 0.0151875 0.168875 M00420-V$MEIS1AHOXA9_01 "counts:16,16" 0.012666667 -0.0921 MA0046-HNF-1 "counts:30,30" 0.012473684 -0.069473684 M00145-V$BRN2_01 "counts:19,19" 0.008 0.102666667 MA0007-Androgen "counts:6,6" 0.001113636 0.057295455 MA0010-Broad-complex_1 "counts:44,44" -0.012428571 0.000142857 M00284-V$TCF11MAFG_01 "counts:7,7" -0.015333333 0.050875 M00269-V$XFD3_01 "counts:24,24" -0.0185 0.10625 M00186-V$SRF_Q6 "counts:4,4" -0.020972222 -0.001555556 M00421-V$MEIS1BHOXA9_02 "counts:36,36" -0.029 0.1455 M00242-V$PPARA_01 "counts:2,2" -0.032 0.232 M00017-V$ATF_01 "counts:2,2" -0.036 0.03 M00241-V$NKX25_02 "counts:3,3" -0.037894737 0.077473684 M00459-V$STAT5B_01 "counts:19,19" -0.045 -0.125875 M00478-V$CDC5_01 "counts:7,8" -0.046404255 0.020744681 M00424-V$NKX61_01 "counts:47,47" -0.04905 0.12255 M00290-V$FREAC2_01 "counts:20,20" -0.0519375 0.069625 MA0029-Evi-1 "counts:16,16" -0.055677966 0.004517241 MA0055-Myf "counts:59,58" -0.061473684 0.026736842 M00292-V$FREAC4_01 "counts:19,19" -0.062115108 0.09265035 MA0045-HMG-IY "counts:139,143" -0.06825 0.06025 MA0013-Broad-complex_4 "counts:4,4" -0.082954545 0.017681818 MA0051-Irf-2 "counts:22,22" -0.087846154 0.132692308 M00453-V$IRF7_01 "counts:13,13" -0.088 -0.0405 MA0066-PPARgamma "counts:2,2" -0.0913 -0.0943 MA0088-Staf "counts:10,10" -0.092777778 0.0922 M00410-V$SOX9_B1 "counts:9,10" -0.095238095 0.0355 MA0050-Irf-1 "counts:21,22" -0.095761905 -0.105818182 M00212-V$POLY_C "counts:21,22" -0.1014 0.0902 M00201-V$CEBP_C "counts:5,5" -0.108 0.0476 M00244-V$NGFIC_01 "counts:10,10" -0.108707317 -0.043860465 MA0082-SQUA "counts:41,43" -0.109032258 0.047796875 M00081-V$EVI1_04 "counts:62,64" -0.110361111 -0.015028571 M00423-V$FOXJ2_02 "counts:36,35" -0.111227848 0.1019125 MA0049-Hunchback "counts:79,80" -0.112571429 0.178285714 M00456-V$FAC1_01 "counts:7,7" -0.1126875 -0.0895 M00052-V$NFKAPPAB65_01 "counts:16,16" -0.115785714 -0.043714286 MA0110-ATHB5 "counts:14,14" -0.124111111 0.233222222 M00088-V$IK3_01 "counts:9,9" -0.1326 0.1938 MA0060-NF-Y "counts:10,10" -0.1379 -0.062272727 M00026-V$RSRFC4_01 "counts:10,11" -0.143911765 -0.005647059 M00485-V$NKX22_01 "counts:34,34" -0.146333333 0.062 M00011-V$EVI1_06 "counts:9,9" -0.1475 0.173166667 M00412-V$AREB6_01 "counts:6,6" -0.150083333 0.05875 M00062-V$IRF1_01 "counts:24,24" -0.15075 0.078 M00065-V$TAL1BETAE47_01 "counts:8,8" -0.15475 0.1865 M00185-V$NFY_Q6 "counts:4,4" -0.156 0.085 M00483-V$ATF6_01 "counts:2,2" -0.1575 -0.2465 M00262-V$STAF_01 "counts:2,2" -0.1664 0.0012 M00457-V$STAT5A_01 "counts:10,10" -0.166535714 -0.06725 MA0090-TEF-1 "counts:28,28" -0.167606061 0.0089 MA0052-MEF2 "counts:33,30" -0.170333333 0.0654 MA0091-Tal1beta-E47S "counts:9,10" -0.172857143 0.086857143 M00287-V$NFY_01 "counts:7,7" -0.174875 0.02225 MA0083-SRF "counts:8,8" -0.176 0.279 M00214-V$SEF1_C "counts:2,2" -0.1794 0.020333333 M00079-V$EVI1_02 "counts:15,15" -0.181764706 0.071176471 MA0031-FREAC-4 "counts:17,17" -0.184066667 -0.1484375 M00001-V$MYOD_01 "counts:15,16" -0.19 0.075 M00528-V$PPARG_03 "counts:9,9" -0.1915 -0.342 M00173-V$AP1_Q2 "counts:2,2" -0.192666667 -0.145833333 M00066-V$TAL1ALPHAE47_01 "counts:9,6" -0.1955 -0.001607143 M00216-V$TATA_C "counts:28,28" -0.195642857 -0.055461538 M00215-V$SRF_C "counts:14,13" -0.197 -0.312 MA0101-c-REL "counts:2,1" -0.197 -0.312 M00053-V$CREL_01 "counts:2,1" -0.199636364 -0.036545455 M00086-V$IK1_01 "counts:11,11" -0.204173913 0.008173913 M00418-V$TGIF_01 "counts:23,23" -0.2075 0.018470588 M00526-V$GCNF_01 "counts:18,17" -0.210333333 -0.163217391 MA0107-p65 "counts:24,23" -0.217473684 0.024263158 M00476-V$FOXO4_02 "counts:19,19" -0.2185 -0.0992 MA0105-p50 "counts:16,15" -0.221904762 -0.06047619 MA0072-RORalfa-2 "counts:21,21" -0.221904762 -0.06047619 M00157-V$RORA2_01 "counts:21,21" -0.2265 0.2215 M00007-V$ELK1_01 "counts:2,2" -0.23 0.098666667 M00233-V$MEF2_04 "counts:2,3" -0.232466667 -0.010125 M00411-V$HNF4_01_B "counts:15,16" -0.234375 0.079625 MA0009-Brachyury "counts:8,8" -0.2345 0.0535 M00080-V$EVI1_03 "counts:2,2" -0.237833333 -0.117416667 M00057-V$COMP1_01 "counts:12,12" -0.238 -0.335 M00041-V$CREBP1CJUN_01 "counts:2,1" -0.238 -0.335 M00039-V$CREB_01 "counts:2,1" -0.238 -0.333 M00024-V$E2F_01 "counts:2,1" -0.2400625 -0.0853125 MA0030-FREAC-2 "counts:16,16" -0.245111111 0.110888889 M00495-V$BACH1_01 "counts:9,9" -0.245307692 -0.022 M00258-V$ISRE_01 "counts:13,13" -0.246642857 -0.107916667 M00051-V$NFKAPPAB50_01 "counts:14,12" -0.2475 -0.057954545 M00532-V$RP58_01 "counts:24,22" -0.25 -0.02475 MA0085-SU_h "counts:8,8" -0.251142857 -0.073571429 M00346-V$GATA1_05 "counts:7,7" -0.25375 0.19175 M00347-V$GATA1_06 "counts:4,4" -0.254636364 -0.0678 M00208-V$NFKB_C "counts:11,10" -0.259 -0.248 M00350-V$GATA3_02 "counts:2,1" -0.259 -0.248 M00349-V$GATA2_03 "counts:2,1" -0.259 -0.248 M00348-V$GATA2_02 "counts:2,1" -0.259311828 -0.0315 MA0073-RREB-1 "counts:93,92" -0.261 0.2305 M00108-V$NRF2_01 "counts:2,2" -0.261833333 -0.091 M00176-V$AP4_Q6 "counts:6,6" -0.263285714 0.0145 M00238-V$BARBIE_01 "counts:14,14" -0.265142857 -0.108631579 MA0061-NF-kappaB "counts:21,19" -0.269166667 -0.162111111 M00205-V$GRE_C "counts:18,18" -0.274875 -0.13 M00250-V$GFI1_01 "counts:8,8" -0.277857143 -0.155 M00280-V$RFX1_01 "counts:7,7" -0.279 0.021 M00236-V$ARNT_01 "counts:3,4" -0.27925 0.147 M00490-V$BACH2_01 "counts:4,4" -0.279666667 -0.097 M00139-V$AHR_01 "counts:6,6" -0.27975 0.176 M00254-V$CAAT_01 "counts:4,4" -0.282 -0.043428571 M00261-V$OLF1_01 "counts:7,7" -0.282803419 -0.056698276 M00257-V$RREB1_01 "counts:117,116" -0.28375 -0.18475 M00063-V$IRF2_01 "counts:4,4" -0.285923077 -0.09825 M00194-V$NFKB_Q6 "counts:13,12" -0.2872 -0.058636364 M00231-V$MEF2_02 "counts:10,11" -0.289153846 -0.004466667 M00232-V$MEF2_03 "counts:13,15" -0.2915 -0.176 M00517-V$AP1_01 "counts:4,4" -0.293242424 0.027030303 M00491-V$MAZR_01 "counts:33,33" -0.295939394 -0.18215625 M00155-V$ARP1_01 "counts:33,32" -0.2967 -0.119222222 MA0023-Dorsal_2 "counts:10,9" -0.2968 -0.103 M00082-V$EVI1_05 "counts:5,5" -0.2995 -0.3075 M00069-V$YY1_02 "counts:2,2" -0.304 -0.3375 M00004-V$CMYB_01 "counts:2,2" -0.306846154 -0.117583333 M00054-V$NFKAPPAB_01 "counts:13,12" -0.3075 -0.21 M00480-V$LUN1_01 "counts:2,2" -0.309333333 -0.017333333 M00071-V$E47_02 "counts:6,6" -0.30952381 0.05447619 M00255-V$GC_01 "counts:21,21" -0.317035714 0.004962963 M00196-V$SP1_Q6 "counts:56,54" -0.319571429 -0.261142857 M00102-V$CDP_02 "counts:7,7" -0.3254 -0.0806 M00068-V$HEN1_01 "counts:5,5" -0.3278 0.037666667 M00222-V$HAND1E47_01 "counts:5,6" -0.3286 0.0305 M00281-V$RFX1_02 "counts:5,4" -0.329733333 0.040933333 M00006-V$MEF2_01 "counts:15,15" -0.331090909 -0.076 MA0016-CFI-USP "counts:11,11" -0.3316 -0.114666667 M00134-V$HNF4_01 "counts:5,6" -0.335666667 -0.029333333 M00143-V$PAX5_01 "counts:3,3" -0.34 -0.2085 MA0076-SAP-1 "counts:2,2" -0.3412 -0.10825 M00179-V$CREBP1_Q2 "counts:5,4" -0.347 -0.24325 M00246-V$EGR2_01 "counts:4,4" -0.347 -0.24325 M00245-V$EGR3_01 "counts:4,4" -0.347 -0.24325 M00243-V$EGR1_01 "counts:4,4" -0.3505 -0.0365 M00058-V$HEN1_02 "counts:4,4" -0.351 0.1365 M00085-V$ZID_01 "counts:2,2" -0.35625 0.07525 M00193-V$NF1_Q6 "counts:4,4" -0.3565 -0.0355 MA0048-Hen-1 "counts:6,6" -0.362833333 -0.079470588 M00156-V$RORA1_01 "counts:18,17" -0.363266667 -0.197 MA0022-Dorsal_1 "counts:15,15" -0.363714286 0.050333333 MA0068-Pax-4 "counts:7,6" -0.382714286 -0.150642857 M00220-V$SREBP1_01 "counts:14,14" -0.386583333 -0.252416667 MA0074-RXR-VDR "counts:12,12" -0.391375 0.005125 M00084-V$MZF1_02 "counts:8,8" -0.392 -0.199 M00235-V$AHRARNT_01 "counts:6,6" -0.3925 0.025 M00414-V$AREB6_03 "counts:2,2" -0.392583333 -0.114818182 MA0071-RORalfa-1 "counts:12,11" -0.3935 -0.337 M00115-V$TAXCREB_02 "counts:2,2" -0.412571429 -0.214357143 M00141-V$LYF1_01 "counts:14,14" -0.42625 -0.0665 M00413-V$AREB6_02 "counts:4,4" -0.462333333 0.035666667 M00002-V$E47_01 "counts:3,3" -0.554833333 -0.144166667 M00460-V$STAT5A_02 "counts:6,6"