Supplemental Table S-5. Gene scores for signaling pathway components. Genes are flagged with an asterisk in the comments column if RNA-seq data (available for only 4 of the lines) contradicts the microarray data given here. Data for flagged genes are considered unreliable. pathway category Gene_FBgn ANNOTATION_SYMBOL NAME SYMBOL CME_L1 Sg4 ML-DmD11 ML-DmD20-c2 ML-DmD20-c5 Kc167 GM2 S2-DRSC S2R+ S1 1182-4H ML-DmD16-c3 ML-DmD32 ML-DmD17-c3 ML-DmD8 CME W1 cl.8+ ML-DmD9 ML-DmBG1-c1 ML-DmD21 ML-DmD4-c1 ML-DmBG3-c2 S3 CME W2 mbn2 ML-DmBG2-c2 comments insulin ligand FBgn0036046 CG8167 Insulin-related peptide Ilp2 80 29 12 25 109 78 85 100 0 121 32 49 53 72 54 105 22 56 74 44 0 38 42 78 50 insulin ligand FBgn0044046 CG13317 Insulin-like peptide 7 Ilp7 69 104 94 118 65 0 77 74 48 107 120 105 71 2 34 94 51 157 45 58 58 56 96 40 66 insulin ligand FBgn0044047 CG14049 Ilp6 Ilp6 118 226 44 111 75 184 392 157 125 260 282 139 93 155 66 276 53 89 65 148 100 279 183 705 13 insulin ligand FBgn0044048 CG33273 insulin-like peptide 5 Ilp5 0 28 37 0 73 100 386 97 32 17 0 1 29 129 0 21 0 0 0 0 34 57 0 0 34 insulin ligand FBgn0044049 CG6736 insulin-like peptide 4 Ilp4 36 69 71 57 57 178 78 59 202 50 0 49 75 106 101 42 77 26 75 29 24 56 27 62 51 insulin ligand FBgn0044050 CG14167 insulin-like peptide 3 Ilp3 67 29 38 73 7 0 25 52 30 91 17 24 92 51 40 85 73 7 44 38 95 42 62 27 30 insulin ligand FBgn0044051 CG14173 Ilp1 Ilp1 127 37 90 0 105 21 80 10 105 17 40 73 70 98 0 40 0 5 142 0 56 59 23 20 22 insulin receptor FBgn0013984 CG18402 Insulin-like receptor InR 455 701 665 455 207 1007 2090 927 722 1210 1044 351 1025 554 501 572 742 661 582 709 788 439 353 1464 1385 insulin intracellular FBgn0024248 CG5686 chico chico 651 861 602 550 627 357 882 626 418 1074 858 604 902 265 549 647 833 784 494 528 319 698 806 912 960 insulin intracellular FBgn0020622 CG2699 Pi3K21B Pi3K21B 1263 1080 807 899 1382 554 2028 629 664 1207 1040 1095 928 1296 779 1093 1094 1751 934 964 1653 1807 1410 1295 968 insulin intracellular FBgn0015279 CG4141 Pi3K92E Pi3K92E 487 441 509 510 493 555 1611 798 564 1039 1268 355 972 548 593 543 1288 509 523 486 498 599 727 1414 594 insulin intracellular FBgn0026379 CG5671 Pten Pten 396 518 498 252 418 330 662 291 419 696 622 470 530 514 480 447 639 453 673 534 310 491 509 591 842 insulin intracellular FBgn0020386 CG1210 Protein kinase 61C Pk61C 1016 633 810 3988 2991 1989 1735 3662 1763 3248 2825 1844 1059 460 995 1116 460 1514 490 839 1402 824 549 974 1117 insulin intracellular FBgn0026317 CG6147 Tsc1 Tsc1 814 939 944 1071 1015 924 1043 614 394 1243 1186 455 718 440 607 645 748 955 1007 587 733 940 984 669 344 insulin intracellular FBgn0005198 CG6975 gigas gig 1139 1367 795 866 1244 897 2386 927 296 1129 1123 530 601 418 879 894 1063 1031 729 923 1184 1609 891 756 569 insulin intracellular FBgn0015806 CG10539 RPS6-p70-protein kinase S6k 2849 1790 2655 1817 2617 2184 6407 3324 2343 3397 5360 2336 2031 1257 2474 1568 4691 4102 2302 2529 3641 2012 2630 5363 4806 insulin intracellular FBgn0010379 CG4006 Akt1 Akt1 1094 1000 432 573 797 1141 1763 1115 943 2108 1998 812 1629 1354 1034 926 1014 687 1115 1208 1073 1563 834 1355 1029 insulin intracellular FBgn0021796 CG5092 Target of rapamycin Tor 599 501 591 566 606 425 414 601 317 997 974 570 443 701 812 436 760 596 801 524 655 516 654 494 795 insulin intracellular FBgn0031006 CG8002 rapamycin-insensitive companion of Tor rictor 592 554 563 577 583 471 1371 834 332 726 746 472 1020 603 895 792 486 676 739 480 1424 462 612 852 982 insulin intracellular FBgn0029840 CG4320 raptor raptor 334 297 376 358 363 244 567 462 230 519 569 363 138 488 451 396 492 419 398 398 589 409 341 249 408 insulin intracellular FBgn0041191 CG1081 Rheb Rheb 2369 2699 2689 2992 3507 1482 3849 2352 2731 2468 2427 1632 3018 1768 1934 2387 2370 2029 2812 1883 2668 2485 2163 2707 1232 insulin intracellular FBgn0033935 CG10105 SAPK-interacting protein 1 Sin1 169 191 106 166 159 117 199 305 92 168 105 127 69 117 102 136 154 135 153 119 168 172 123 210 124 insulin intracellular FBgn0022073 CG8846 Thor Thor 2284 3174 1050 519 755 162 1748 2104 763 565 734 545 2040 112 497 799 1856 378 2100 1475 454 564 1406 4495 2627 insulin intracellular FBgn0004922 CG10944 Ribosomal protein S6 RpS6 10146 8325 12091 13886 11420 13943 8125 13950 11301 6030 7599 10832 8960 11141 15957 8219 8161 9187 12600 8208 11982 6228 7265 5548 5037 insulin intracellular FBgn0015218 CG4035 Eukaryotic initiation factor 4E eIF-4E 4418 4942 4334 4574 4016 3046 3068 4163 2398 5011 4580 3793 3750 4050 7290 4685 6572 3187 5340 4254 5179 4571 3879 4177 3087 insulin intracellular FBgn0038167 CG9374 lkb1 lkb1 711 617 861 635 746 405 392 824 294 551 563 430 519 622 372 629 429 536 472 374 567 827 367 211 378 insulin intracellular FBgn0023169 CG3051 SNF1A/AMP-activated protein kinase SNF1A 984 1292 750 1055 886 418 741 503 1081 758 1133 355 974 1300 1465 752 521 432 1274 986 850 937 1290 751 561 insulin intracellular FBgn0025803 CG17299 SNF4/AMP-activated protein kinase gamma subunit SNF4Agamma 1646 1145 934 1347 1117 912 3505 2693 862 1818 1327 966 1137 1106 2167 1589 1541 1456 1341 2044 1715 507 1368 1798 1515 insulin intracellular FBgn0086779 CG11628 steppke step 1332 956 1116 1110 1709 724 941 1900 2123 2372 1790 1244 1545 921 1699 2125 1990 1335 1619 1745 722 1434 2055 3363 2517 insulin intracellular FBgn0003371 CG2621 shaggy sgg 1869 1615 2296 1235 1459 1287 1750 1044 1012 2124 2158 1862 1745 2329 1976 2094 3041 1965 1630 1603 3161 1764 2051 1348 2309 insulin intracellular FBgn0033504 CG18408 CAP CAP 1041 1180 381 653 385 287 1365 856 1238 349 434 573 590 6703 541 445 529 425 983 691 438 552 668 1414 584 insulin intracellular FBgn0024754 CG8200 flotillin Flo 1350 1726 1067 2785 2514 1388 1674 1715 1031 1559 2424 1037 1885 1536 1523 1503 1493 1072 2629 1339 738 1254 1731 819 1199 insulin intracellular FBgn0037647 CG11968 RagA RagA 402 656 802 808 1170 276 596 614 365 373 765 712 736 745 545 607 324 784 784 947 516 524 1239 743 650 insulin intracellular FBgn0033272 CG8707 RagC RagC 862 913 776 888 937 579 1333 908 557 880 850 582 706 974 771 891 649 875 1140 899 673 667 996 581 1513 insulin target gene FBgn0038197 CG3143 "forkhead box, sub-group O" foxo 1830 1582 1406 1469 1670 1132 1325 5413 394 1327 1379 1461 3854 1432 2258 1619 1294 1689 1659 1565 2519 2592 902 695 1752 insulin target gene FBgn0015542 CG7951 similar sima 1564 1333 1260 1252 1020 1482 2409 1601 1513 1463 2139 1403 1164 1188 4100 1876 3021 1983 1236 2701 2730 1317 1860 2946 1812 insulin target gene FBgn0000472 CG10798 diminutive dm 2598 1659 1729 1062 1857 3253 1513 1007 1912 1474 4329 2032 1433 1049 4668 2701 2111 3005 2049 2649 4529 1295 2297 1438 1842 EGFR and PVR ligand FBgn0005672 CG10334 spitz spi 3603 4036 1776 2981 2878 4766 3362 5401 4295 2004 7164 2077 5759 1411 3483 3291 3062 1533 3178 2472 5062 3849 2444 4389 2536 EGFR and PVR ligand FBgn0001137 CG17610 gurken grk 309 836 59 166 135 300 143 1007 342 323 143 76 111 139 85 165 106 232 66 76 92 715 301 697 227 EGFR and PVR ligand FBgn0003984 CG10491 vein vn 212 138 143 201 76 220 235 526 81 65 407 194 167 177 92 343 377 91 188 129 143 134 159 213 65 EGFR and PVR ligand FBgn0052179 CG32179 Keren Krn 668 624 648 577 218 537 1584 421 300 471 849 346 546 252 741 617 318 463 446 599 814 906 634 856 444 EGFR and PVR ligand FBgn0004569 CG4531 argos argos 1432 478 1003 467 107 512 31 138 123 237 4089 249 4891 428 497 345 2493 843 668 100 773 68 525 133 76 EGFR and PVR ligand FBgn0085407 CG34378 PDGF- and VEGF-related factor 3 Pvf3 2202 1117 207 531 495 303 173 60 142 1327 463 945 148 126 543 194 174 129 686 1346 266 603 264 947 149 EGFR and PVR ligand FBgn0030964 CG7103 PDGF- and VEGF-related factor 1 Pvf1 150 92 321 233 181 173 1027 54 199 101 424 554 652 297 2157 122 199 610 823 391 469 173 143 250 489 EGFR and PVR ligand FBgn0031888 CG13780 PDGF- and VEGF-related factor 2 Pvf2 6771 2936 997 1601 3199 4424 5370 970 208 2268 1513 1010 1469 131 774 6152 1281 1800 1401 1048 1618 2822 5534 3471 940 EGFR and PVR receptor FBgn0003731 CG10079 Epidermal growth factor receptor Egfr 199 245 406 494 290 31 283 290 190 353 176 41 215 912 253 769 125 406 294 234 478 146 110 149 236 EGFR and PVR receptor FBgn0032006 CG8222 PDGF- and VEGF-receptor related Pvr 8417 8198 6979 6426 4993 4967 4029 7584 4265 7302 8341 10627 11810 6842 8714 8337 6319 9952 7975 9965 5800 10995 7031 7858 6526 EGFR and PVR intracellular FBgn0010583 CG3727 dreadlocks dock 480 405 479 653 481 850 537 829 350 393 546 454 665 1198 649 306 647 582 842 480 870 483 316 898 409 EGFR and PVR intracellular FBgn0001965 CG7793 Son of sevenless Sos 908 1245 846 907 1321 546 1250 1215 352 1256 1301 1116 1090 1460 925 817 1409 819 1348 724 1051 1091 886 1064 934 EGFR and PVR intracellular FBgn0004638 CG6033 downstream of receptor kinase drk 2377 2433 1668 1794 2240 3508 3427 1794 2856 2314 3080 1628 1988 2960 2271 2792 2288 2703 3242 2700 1934 4863 1878 3319 3442 EGFR and PVR intracellular FBgn0015296 CG3715 SHC-adaptor protein Shc 1009 710 512 912 1082 472 1231 994 805 865 1430 625 785 842 878 739 909 663 993 839 891 574 774 1349 601 EGFR and PVR intracellular FBgn0016794 CG1044 daughter of sevenless dos 983 1026 766 1373 1024 690 1634 2638 1248 2176 1655 908 1221 998 763 1118 1027 798 993 1178 2448 854 731 1806 1168 EGFR and PVR intracellular FBgn0003079 CG2845 pole hole phl 454 877 1159 1070 888 291 1050 1002 621 1115 1133 470 844 639 1188 640 858 317 680 748 1696 788 621 1296 574 EGFR and PVR intracellular FBgn0003205 CG9375 Ras oncogene at 85D Ras85D 1918 1708 884 1410 1316 1329 1930 2371 1419 1519 1638 1214 1157 1402 1474 991 1138 989 1584 1606 2362 1499 1201 1833 932 EGFR and PVR intracellular FBgn0010269 CG15793 Downstream of raf1 Dsor1 621 536 549 810 599 399 914 450 421 665 666 418 521 609 566 362 954 638 783 443 547 541 451 399 560 EGFR and PVR intracellular FBgn0003256 CG12559 rolled rl 1632 1583 2922 1805 2379 1715 1943 1409 1983 2541 1668 1759 2408 1364 2351 2284 1459 1812 2511 2286 1594 1526 1230 1836 3623 EGFR and PVR intracellular FBgn0004390 CG6721 GTPase-activating protein 1 Gap1 1395 1088 827 651 574 699 638 882 852 1223 217 712 668 843 3574 1468 1913 1058 1238 1831 9967 675 1387 810 719 EGFR and PVR intracellular FBgn0000382 CG3954 corkscrew csw 1106 966 1122 1122 1102 957 1246 1011 1466 766 1944 1118 1857 2735 1772 994 1470 783 1721 1764 3051 941 936 1149 1107 EGFR and PVR intracellular FBgn0015402 CG2899 kinase suppressor of ras ksr 350 405 402 425 526 181 588 387 233 378 417 262 544 350 367 386 431 608 384 345 493 386 368 400 358 EGFR and PVR intracellular FBgn0021818 CG6556 connector enhancer of ksr cnk 755 759 1104 1003 820 588 1095 1047 430 1156 1451 604 1067 1081 1412 761 960 1366 1135 842 1602 997 836 758 1578 EGFR and PVR intracellular FBgn0014388 CG1921 sprouty sty 5488 5012 1323 1224 2065 5321 4051 4351 4022 3032 3793 4655 4972 1981 4599 4037 5812 3509 5222 2705 4406 8274 3386 8259 3878 EGFR and PVR intracellular FBgn0016641 CG9856 Protein tyrosine phosphatase-ERK/Enhancer of Ras1 PTP-ER 396 406 382 404 468 286 705 395 253 546 423 277 294 255 369 357 416 438 305 363 464 563 539 410 437 EGFR and PVR intracellular FBgn0042693 CG7913 PP2A-B' PP2A-B' 1226 1108 1240 1347 1164 384 1460 1404 1372 1601 1424 916 1453 1397 1144 1095 1394 1340 1019 1513 1018 1532 1381 1559 1575 EGFR and PVR intracellular FBgn0036844 CG14080 Mitogen-activated protein kinase phosphatase 3 Mkp3 2568 2064 2836 934 2032 4301 3908 2231 2435 3503 3227 2067 3024 2055 5889 2638 3701 2342 3936 4388 5751 3107 1262 2234 2285 EGFR and PVR intracellular FBgn0083992 CG34099 MAP kinase-specific phosphatase Mkp 424 542 307 1131 1403 353 435 624 859 467 809 583 317 259 802 472 192 838 607 451 877 430 454 276 242 EGFR and PVR intracellular FBgn0029157 CG6238 slingshot ssh 606 856 328 491 704 393 637 561 710 565 836 366 507 529 521 474 547 504 368 534 568 691 676 514 432 EGFR and PVR intracellular FBgn0004635 CG1004 rhomboid rho 1217 1476 230 450 348 357 4870 963 238 89 803 95 507 480 436 862 516 136 395 177 1998 1354 838 683 1701 EGFR and PVR intracellular FBgn0011285 CG17596 RPS6-protein kinase-II S6kII 197 214 234 300 261 195 482 267 133 168 270 217 326 115 261 184 258 214 290 179 281 214 178 188 202 EGFR and PVR intracellular FBgn0015296 CG3715 SHC-adaptor protein Shc 1009 710 512 912 1082 472 1231 994 805 865 1430 625 785 842 878 739 909 663 993 839 891 574 774 1349 601 EGFR and PVR intracellular FBgn0015399 CG12283 kekkon-1 kek1 1449 647 2692 1714 2228 719 3111 1015 719 1370 3315 1483 3613 1611 3161 1690 4341 1016 2867 1880 4431 620 2976 1032 903 EGFR and PVR intracellular FBgn0026252 CG7935 moleskin msk 5266 4712 3139 3323 4239 2991 3810 5455 3636 3345 4244 2630 1977 2092 4260 3000 2542 3677 2884 3314 2537 6645 3310 3498 3360 EGFR and PVR intracellular FBgn0003501 CG7524 Src oncogene at 64B Src64B 679 575 460 558 811 306 159 259 495 605 833 703 602 1220 862 650 1347 367 376 747 1577 1133 368 1211 960 EGFR and PVR intracellular FBgn0003310 CG4385 Star S 356 360 274 412 337 643 591 597 332 422 517 337 4646 659 368 253 415 388 444 227 425 385 242 514 240 EGFR and PVR intracellular FBgn0020224 CG7037 Cbl Cbl 1540 1886 1220 750 1448 995 1800 1117 835 1485 1027 750 1070 1376 1803 872 1645 1435 1546 1470 1710 2000 1519 2631 1656 EGFR and PVR intracellular FBgn0004603 CG7873 Src oncogene at 42A Src42A 1918 1620 1273 1883 2062 1666 1788 1468 1276 1923 2290 1496 1920 1854 2787 1921 2160 1700 1664 2457 2390 2315 1790 1679 2563 EGFR and PVR target gene FBgn0003118 CG17077 pointed pnt 3745 2516 2082 2225 2748 4969 3674 4996 10538 2725 4317 3452 4470 2307 5550 4027 7451 2645 3472 2429 2671 3748 2961 7896 2043 EGFR and PVR target gene FBgn0000097 CG3166 anterior open aop 1141 1208 912 798 962 630 1202 874 1647 730 2180 1397 1673 864 1909 971 2176 1182 1135 1427 1242 1494 1214 1932 724 JAK/STAT ligand FBgn0004956 CG5993 outstretched os 120 123 139 80 167 49 119 69 30 288 138 76 71 56 81 125 10 0 97 51 107 93 93 107 107 JAK/STAT ligand FBgn0030904 CG5988 unpaired 2 upd2 64 85 111 238 61 90 291 104 169 88 178 116 44 123 94 201 200 57 66 102 132 48 195 89 226 JAK/STAT ligand FBgn0053542 CG33542 unpaired 3 upd3 271 176 134 214 98 292 997 229 123 238 209 156 86 40 147 374 257 192 109 115 102 133 181 283 738 JAK/STAT receptor FBgn0043903 CG14226 domeless dome 440 451 427 271 301 201 544 569 300 543 804 218 504 500 558 511 665 489 541 371 619 550 285 769 1074 JAK/STAT intracellular FBgn0004864 CG1594 hopscotch hop 702 658 449 376 577 334 949 765 294 680 669 552 724 521 713 418 1204 614 437 538 550 606 494 968 834 JAK/STAT intracellular FBgn0041184 CG15154 Suppressor of cytokine signaling at 36E Socs36E 812 777 900 979 981 416 6023 853 474 3088 2083 636 1610 719 1303 1684 2102 1154 1403 1375 1126 363 1399 1980 3720 JAK/STAT intracellular FBgn0003138 CG9181 Protein tyrosine phosphatase 61F Ptp61F 803 733 785 1475 1410 1053 2244 1431 1081 1150 1487 1554 1085 1516 1451 728 2247 1273 841 905 3074 1130 898 1473 559 JAK/STAT target gene FBgn0003612 CG8068 Suppressor of variegation 2-10 Su(var)2-10 1635 1663 1458 1541 1575 1755 1978 1763 1839 1944 1599 1178 1622 1218 1874 1398 2178 2391 1673 1897 1645 2332 1704 1901 2261 JAK/STAT target gene FBgn0011236 CG5575 ken and barbie ken 532 527 611 463 756 301 738 1427 391 959 649 609 639 689 580 490 758 354 340 499 827 549 592 833 533 JAK/STAT target gene FBgn0016917 CG4257 Signal-transducer and activator of transcription protein at 92E Stat92E 2676 1701 3708 2123 3298 1533 2588 2674 1563 3195 3227 2634 2981 3157 1044 2045 2542 2641 1898 1724 1067 1748 2789 3180 1732 TGFbeta ligand FBgn0000490 CG9885 decapentaplegic dpp 182 172 138 179 110 36 165 201 102 66 108 159 121 139 52 127 88 90 117 154 95 125 116 99 621 TGFbeta ligand FBgn0024234 CG5562 glass bottom boat gbb 938 1082 679 1758 1155 377 561 1131 658 2775 2228 975 1131 1579 983 1087 800 996 1876 803 967 700 761 837 760 TGFbeta receptor FBgn0003169 CG7904 punt put 1372 1170 1348 942 1451 991 672 2040 785 1338 2134 988 1870 1289 1709 2115 1634 1482 1569 1285 1796 1723 868 1492 602 TGFbeta receptor FBgn0011300 CG8224 baboon babo 845 1305 613 623 769 734 1267 520 766 1765 1236 754 1065 620 1169 1243 1547 848 715 954 1363 2314 828 1089 1845 TGFbeta receptor FBgn0003716 CG14026 thickveins tkv 477 213 403 480 337 458 480 650 247 640 648 607 643 1201 3754 698 668 405 620 1300 1009 657 409 538 273 TGFbeta receptor FBgn0003317 CG1891 saxophone sax 1274 1019 571 505 547 620 1064 1344 1690 1033 1091 651 1318 921 1027 855 913 1248 800 788 1320 792 695 772 1151 TGFbeta target gene FBgn0011648 CG12399 Mothers against dpp Mad 516 662 691 471 655 330 211 824 261 832 783 433 835 2005 571 686 766 483 1500 860 1223 820 512 731 544 TGFbeta target gene FBgn0020493 CG5201 Daughters against dpp Dad 231 280 408 676 440 458 286 541 255 540 277 330 253 301 269 218 272 121 177 293 169 290 191 320 657 TGFbeta target gene FBgn0011655 CG1775 Medea Med 777 1170 795 679 1175 687 1370 1515 805 978 967 583 1004 1306 1213 926 1184 807 1215 740 1543 946 540 885 726 TGFbeta target gene FBgn0003396 CG7734 schnurri shn 850 797 682 768 728 563 1625 922 794 886 861 662 886 512 983 453 1206 851 370 737 780 1329 608 1625 473 hedgehog ligand FBgn0004644 CG4637 hedgehog hh 85 75 52 24 23 21 64 9 135 41 50 47 36 73 34 9 75 38 29 155 37 66 62 71 25 hedgehog receptor FBgn0011577 CG4974 division abnormally delayed dally 390 453 2163 485 1703 739 328 832 264 1596 2420 578 1411 1570 2401 336 2353 575 1515 379 1406 353 556 267 149 hedgehog receptor FBgn0041604 CG32146 dally-like dlp 319 636 131 206 108 1646 147 193 244 282 237 245 143 491 1849 276 679 132 141 133 1530 1434 267 127 92 hedgehog intracellular FBgn0003892 CG2411 patched ptc 494 270 288 225 113 257 61 651 1105 106 792 496 225 420 443 2715 1008 86 393 565 1537 647 230 572 254 hedgehog intracellular FBgn0003444 CG11561 smoothened smo 280 279 302 432 535 249 195 370 215 301 400 396 499 544 536 471 443 709 379 483 460 420 322 453 382 hedgehog intracellular FBgn0000352 CG1708 costa cos 603 582 487 418 561 499 532 428 492 400 553 434 592 356 572 437 386 468 429 440 598 588 513 483 687 hedgehog intracellular FBgn0001079 CG6551 fused fu 312 322 176 262 215 177 449 293 526 254 300 264 296 224 320 210 344 347 304 184 371 269 243 282 283 hedgehog intracellular FBgn0005355 CG6054 Suppressor of fused Su(fu) 369 368 367 468 471 251 462 505 281 480 431 304 335 445 323 309 284 358 401 364 336 470 389 227 227 hedgehog target gene FBgn0004859 CG2125 cubitus interruptus ci 718 442 1018 1083 956 219 226 50 19 17 1953 2765 1852 1136 5673 2205 2033 1367 2299 1887 2618 328 2259 42 1051 Wnt ligand FBgn0004009 CG4889 wingless wg 122 98 156 94 97 120 72 82 64 88 110 134 92 66 94 148 125 47 166 82 85 47 121 96 145 Wnt ligand FBgn0004360 CG1916 Wnt oncogene analog 2 Wnt2 283 133 274 280 170 142 221 305 63 136 174 139 156 33 189 124 313 167 246 53 162 123 147 216 108 * Wnt ligand FBgn0010453 CG4698 Wnt oncogene analog 4 Wnt4 28 48 57 10 3 75 15 23 12 24 26 72 48 25 17 58 16 49 51 31 56 43 56 70 1100 Wnt ligand FBgn0010194 CG6407 Wnt oncogene analog 5 Wnt5 258 306 180 227 246 232 268 292 143 303 358 213 296 166 306 159 323 216 361 185 362 565 247 18 217 * Wnt ligand FBgn0031902 CG4969 Wnt6 Wnt6 113 25 203 100 216 100 112 210 243 136 0 145 46 101 146 306 154 48 243 138 60 130 137 60 74 Wnt ligand FBgn0031903 CG4971 Wnt10 Wnt10 103 234 296 41 136 120 36 54 624 68 98 119 45 233 51 268 80 50 261 79 137 39 47 77 46 Wnt receptor FBgn0001085 CG17697 frizzled fz 598 769 204 302 57 120 80 66 121 86 307 506 240 618 1428 387 758 111 95 1019 981 1022 79 41 85 Wnt receptor FBgn0016797 CG9739 frizzled 2 fz2 522 728 404 455 226 404 543 114 367 231 446 2154 380 275 3726 352 228 360 451 614 2466 286 131 340 481 Wnt receptor FBgn0027342 CG4626 frizzled 4 fz4 433 502 260 162 297 314 893 521 515 462 433 279 409 700 515 455 503 394 333 184 216 196 319 448 246 Wnt receptor FBgn0027343 CG16785 frizzled 3 fz3 40 134 150 30 41 2 31 31 0 54 133 20 119 65 57 816 45 122 66 16 141 29 80 12 23 Wnt receptor FBgn0041604 CG32146 dally-like dlp 319 636 131 206 108 1646 147 193 244 282 237 245 143 491 1849 276 679 132 141 133 1530 1434 267 127 92 Wnt receptor FBgn0011577 CG4974 division abnormally delayed dally 390 453 2163 485 1703 739 328 832 264 1596 2420 578 1411 1570 2401 336 2353 575 1515 379 1406 353 556 267 149 Wnt intracellular FBgn0026598 CG6193 Adenomatous polyposis coli tumor suppressor homolog 2 Apc2 364 406 362 256 462 342 257 339 298 453 553 426 322 316 429 447 470 340 317 294 440 512 540 438 256 Wnt intracellular FBgn0015589 CG1451 APC-like Apc 764 572 483 635 939 308 1917 1067 441 780 909 772 282 543 812 788 657 431 379 613 577 1004 573 2016 542 Wnt intracellular FBgn0000119 CG5912 arrow arr 294 314 169 399 232 673 252 385 544 287 333 505 220 486 358 259 209 224 301 310 477 433 188 404 3054 Wnt intracellular FBgn0026597 CG7926 Axin Axn 650 798 404 567 691 439 574 1014 711 791 714 693 674 1017 722 603 628 813 764 555 696 653 540 765 892 Wnt intracellular FBgn0004132 CG30498 boca boca 1019 1067 454 1214 526 728 568 731 979 748 883 693 646 450 896 492 545 797 1255 590 655 1582 442 584 642 Wnt intracellular FBgn0015024 CG2028 Casein kinase Ialpha CkIalpha 2655 2783 2087 1626 933 2725 2155 1566 2823 2259 1545 2320 2748 890 2133 1626 2971 2452 2676 3604 2187 3006 2609 3225 2626 Wnt intracellular FBgn0000499 CG18361 dishevelled dsh 927 956 681 925 1033 873 701 1052 519 993 1258 759 745 1196 831 568 1250 494 1106 799 1285 889 720 1225 819 Wnt intracellular FBgn0044028 CG13076 Notum Notum 93 107 63 182 83 21 111 504 288 696 272 332 33 1066 16 153 120 198 1216 89 13 122 96 400 195 Wnt intracellular FBgn0002945 CG11614 naked cuticle nkd 243 189 250 332 233 142 150 209 121 204 128 290 159 278 348 737 872 103 247 149 1344 169 235 128 167 * Wnt intracellular FBgn0003371 CG2621 shaggy sgg 1869 1615 2296 1235 1459 1287 1750 1044 1012 2124 2158 1862 1745 2329 1976 2094 3041 1965 1630 1603 3161 1764 2051 1348 2309 Wnt target gene FBgn0000117 CG11579 armadillo arm 4845 5182 4965 5314 4184 2772 3893 5321 4443 4641 5522 4288 4331 4466 6393 3584 6019 2193 7156 2451 11656 5057 4575 3383 2888 Wnt target gene FBgn0085432 CG34403 pangolin pan 1035 1068 1622 1161 1838 1614 1123 1489 1387 2631 3333 3074 2307 2019 4851 10982 3057 1295 1410 2287 2489 2445 1950 3052 2904 Wnt target gene FBgn0039907 CG2041 legless lgs 614 602 473 426 782 405 689 541 522 960 1098 830 601 629 913 585 713 644 489 808 901 1180 837 1174 1099 Wnt target gene FBgn0015624 CG15319 nejire nej 1248 956 1426 1721 1706 1061 2258 1795 1852 2526 1907 1911 1449 2201 2341 1629 3717 2093 1982 1152 2469 1347 1198 1803 1672 Wnt target gene FBgn0043900 CG11518 pygopus pygo 351 411 395 255 354 375 328 374 303 365 392 230 332 459 351 296 363 219 431 321 624 413 180 322 340 Hippo ligand FBgn0000497 CG17941 dachsous ds 82 58 123 97 97 91 78 55 107 57 36 87 84 82 169 124 62 137 99 89 65 43 45 39 69 Hippo receptor FBgn0001075 CG3352 fat ft 130 98 818 122 69 262 112 140 183 66 131 57 84 115 50 120 233 128 51 76 94 74 129 133 37 Hippo intracellular FBgn0086896 CG10595 dachs d 188 154 218 194 99 123 112 129 298 120 147 192 130 433 267 210 237 98 91 176 179 146 111 151 88 Hippo intracellular FBgn0000658 CG10917 four-jointed fj 13 15 13 5 9 19 13 10 13 7 4 0 0 0 16 8 0 0 32 17 40 11 29 4 12 Hippo intracellular FBgn0004583 CG4114 expanded ex 753 769 1119 1200 1351 325 913 1034 669 935 2042 609 699 1107 397 435 708 763 612 321 403 937 551 1875 808 Hippo intracellular FBgn0086384 CG14228 Merlin Mer 766 928 881 999 1077 1584 1942 1048 554 994 1272 440 1104 688 1223 1106 1582 1032 731 1005 1451 1045 1097 882 1757 Hippo intracellular FBgn0034453 hippo hpo 681 735 462 632 973 383 596 524 443 747 526 403 459 576 680 630 543 586 836 739 831 723 620 834 530 Hippo intracellular FBgn0053193 CG33193 salvador sav 448 430 527 582 567 970 787 357 277 551 520 287 806 525 609 453 708 547 810 556 1019 421 461 274 443 Hippo intracellular FBgn0011739 CG12072 warts wts 923 565 442 265 489 1197 582 916 1007 1472 1553 530 643 1470 639 712 1172 709 507 660 916 821 449 1735 840 Hippo intracellular FBgn0038965 CG13852 mob as tumor suppressor mats 589 558 563 550 712 429 1041 439 793 837 610 370 518 807 836 632 839 488 646 701 790 562 578 576 480 Hippo intracellular FBgn0002413 CG2048 discs overgrown dco 1486 1571 1121 1611 1474 2265 1600 2851 1896 2760 2590 1439 1988 1688 3047 1980 2950 1715 2402 2152 2794 2618 1293 2240 1441 Hippo intracellular FBgn0053967 CG33967 kibra CG33967 725 735 966 445 1328 364 1214 1415 1656 1079 471 732 588 736 780 411 1150 805 337 827 881 1592 431 1434 690 Hippo target gene FBgn0003345 CG8544 scalloped sd 2540 1478 1971 1510 2673 10710 3417 1994 1595 4744 2082 2525 3558 2462 2161 1951 3367 2017 2740 2390 1527 1564 2636 2655 2786 Hippo target gene FBgn0034970 CG4005 yorkie yki 6382 7437 5301 6221 6730 6641 6046 6727 9587 6270 5034 5965 5290 8306 8193 6185 6061 5730 5200 4773 8353 4123 5874 5124 4877 Hippo target gene FBgn0003866 CG1374 teashirt tsh 309 516 40 152 212 189 46 985 977 706 215 467 223 1003 192 68 150 91 410 288 138 641 235 268 514 Notch ligand FBgn0000463 CG3619 Delta Dl 85 109 135 176 92 166 101 125 222 234 271 81 892 96 773 223 620 41 258 159 282 190 202 86 56 Notch ligand FBgn0004197 CG6127 Serrate Ser 167 92 673 488 578 156 748 659 539 254 627 1073 599 156 115 367 128 100 2728 160 233 431 233 357 116 Notch receptor FBgn0004647 CG3936 Notch N 1229 1667 733 629 239 322 1117 3233 562 1466 781 314 882 822 1376 1847 1917 547 916 1937 3018 481 1060 85 679 Notch intracellular FBgn0031458 CG2855 anterior pharynx defective 1 aph-1 866 645 550 334 544 311 1092 1071 808 913 999 383 923 382 661 445 959 578 885 695 834 692 626 968 565 Notch intracellular FBgn0000524 CG3929 deltex dx 420 433 426 441 441 445 643 497 301 414 471 604 683 749 929 365 732 501 953 464 788 601 379 251 448 Notch intracellular FBgn0002973 CG3779 numb numb 323 342 300 238 232 14 204 263 255 307 230 417 437 788 1079 138 632 562 846 731 571 548 249 143 235 Notch intracellular FBgn0000221 CG4934 brainiac brn 53 40 53 62 48 34 82 173 445 71 139 51 3 48 53 73 42 49 50 49 108 64 28 92 74 Notch intracellular FBgn0011591 CG10580 fringe fng 126 59 409 112 193 141 46 128 245 98 191 1197 713 1212 101 240 635 1145 1159 50 138 166 146 36 159 Notch intracellular FBgn0000180 CG4722 big brain bib 227 91 34 85 73 25 146 84 80 824 96 185 1553 211 1057 124 908 169 472 549 539 26 67 26 55 Notch intracellular FBgn0259984 CG7147 kuzbanian kuz 1640 1256 1463 1032 2149 1745 2168 1292 1669 2969 3205 3906 3594 3997 3350 2053 5538 2707 5011 4697 3078 1685 2407 2681 2476 Notch intracellular FBgn0039234 CG7012 nicastrin nct 1232 1376 1380 1436 1718 1364 2029 1872 2236 1966 1983 1876 1263 1154 2075 1060 1830 1423 1182 1505 1307 1088 1616 1769 1637 Notch target gene FBgn0003557 CG4244 Suppressor of deltex Su(dx) 1479 2163 1349 2245 1901 938 1746 1590 1589 2605 1003 766 1154 570 1133 1107 931 997 1161 1336 1149 1031 1447 1445 3108 Notch target gene FBgn0004837 CG3497 Suppressor of Hairless Su(H) 189 186 278 216 166 227 252 338 161 467 239 264 210 148 233 233 224 216 335 127 248 336 225 193 503 Notch target gene FBgn0002643 CG8118 mastermind mam 1348 1144 780 1287 974 656 1609 3426 646 900 916 713 1059 899 1424 1286 983 505 907 1100 8714 2042 1172 1097 2592 TNFalpha ligand FBgn0033483 CG12919 eiger egr 3409 4175 1239 2050 2527 390 617 4679 3572 382 3694 2073 3055 1207 2484 2175 1233 235 819 5679 885 5625 1705 3802 230 TNFalpha receptor FBgn0030941 CG6531 wengen wgn 768 327 921 1180 2436 803 60 685 455 114 2046 907 1300 1356 830 1055 1623 669 1438 614 1510 234 669 368 58 TNFalpha intracellular FBgn0000229 CG5680 basket bsk 1282 1417 1406 1050 1277 1362 1426 1034 1115 2223 1855 1020 1243 1182 1461 1174 1176 1358 1634 1177 1106 1521 1080 1267 1900 TNFalpha intracellular FBgn0010303 CG4353 hemipterous hep 1793 1051 2267 1404 1777 363 2765 2328 718 1832 2834 853 2543 1035 1780 1555 2918 1293 1036 1406 2036 1629 1514 1762 1076 TNFalpha intracellular FBgn0010909 CG16973 misshapen msn 4922 3351 2778 5576 6520 2345 4959 4458 2627 4578 4495 7332 4545 4903 3959 2901 5271 3581 4616 3554 6133 2818 2777 3814 3568 TNFalpha intracellular FBgn0243512 CG7850 puckered puc 1239 1006 1187 980 911 1398 3729 2732 1638 1509 1294 1210 1790 2061 1581 1420 1796 1223 1982 1502 1290 936 2195 2032 1674 TNFalpha intracellular FBgn0030018 CG2272 slipper slpr 448 476 531 557 467 589 2483 592 454 1068 852 319 751 902 737 714 1161 723 470 628 894 522 584 534 588 TNFalpha intracellular FBgn0026323 CG18492 TGF-beta activated kinase 1 Tak1 636 657 551 512 582 658 997 1041 459 1043 795 541 666 506 577 467 752 651 768 470 704 678 451 864 387 TNFalpha intracellular FBgn0024329 CG7717 Mekk1 Mekk1 703 642 652 916 1120 455 1425 1256 673 792 964 777 922 325 620 910 798 308 792 744 964 571 618 946 1198 TNFalpha intracellular FBgn0004603 CG7873 Src oncogene at 42A Src42A 1918 1620 1273 1883 2062 1666 1788 1468 1276 1923 2290 1496 1920 1854 2787 1921 2160 1700 1664 2457 2390 2315 1790 1679 2563 TNFalpha intracellular FBgn0003501 CG7524 Src oncogene at 64B Src64B 679 575 460 558 811 306 159 259 495 605 833 703 602 1220 862 650 1347 367 376 747 1577 1133 368 1211 960 TNFalpha intracellular FBgn0003502 CG8049 Btk family kinase at 29A Btk29A 837 548 1432 1408 1219 683 2413 921 521 1215 1273 843 695 3107 1657 1219 1308 4112 2236 1862 1395 582 1204 758 1314 TNFalpha intracellular FBgn0015295 CG18247 "Src homology 2, ankyrin repeat, tyrosine kinase" shark 572 846 378 463 828 304 434 821 381 531 517 357 466 349 501 536 331 325 399 387 726 510 613 484 341 TNFalpha intracellular FBgn0044323 CG7392 Connector of kinase to AP-1 Cka 840 949 723 741 742 495 968 975 725 1250 1254 874 726 1417 1154 878 999 1058 1145 881 954 846 460 854 692 TNFalpha intracellular FBgn0259212 CG42312 canoe cno 592 673 1105 991 1715 624 1814 1090 801 1157 1341 1105 966 1739 788 753 1658 1074 792 957 813 936 798 1655 877 TNFalpha intracellular FBgn0014380 CG9366 rho-like RhoL 2570 2675 654 839 948 1314 2120 1663 848 914 1821 1359 1158 775 1319 1900 705 820 1201 2068 510 4547 836 1369 1046 TNFalpha intracellular FBgn0010333 CG2248 Rac1 Rac1 3043 3024 1471 3096 3879 3449 2430 2226 1970 2281 2567 1699 2201 2923 1913 1710 2263 1216 2514 2107 3515 2709 1873 1868 1080 TNFalpha intracellular FBgn0014011 CG8556 Rac2 Rac2 932 626 574 728 905 435 1526 622 556 826 1384 577 1076 1203 826 552 983 1217 1239 1291 839 547 845 866 362 TNFalpha intracellular FBgn0086356 CG13345 tumbleweed tum 1175 1445 781 1739 1625 1017 479 1365 1246 992 1141 1012 924 1188 1136 893 934 1060 1164 884 1281 1452 885 639 1071 TNFalpha intracellular FBgn0045843 CG2595 RacGAP84C RacGAP84C 223 110 145 74 88 148 37 64 124 137 101 89 76 135 81 169 62 153 89 75 162 78 65 69 69 TNFalpha intracellular FBgn0010341 CG12530 Cdc42 Cdc42 6279 5740 3775 5165 4837 4756 8081 6117 4775 5464 6419 2502 6953 5434 6038 5898 7066 4366 6239 6274 5671 5751 4239 3911 5934 TNFalpha target gene FBgn0001291 CG2275 Jun-related antigen Jra 1074 1254 776 703 926 608 1028 780 1102 1065 1053 537 1111 730 806 745 770 1046 1163 858 885 1150 922 1039 1195 TNFalpha target gene FBgn0001297 CG33956 kayak kay 2532 1867 2073 1697 2242 3182 3071 6222 5255 3438 3810 2056 3276 2579 3422 3476 4657 3123 3542 2625 3306 1489 2654 5663 2476 TNFalpha target gene FBgn0000097 CG3166 anterior open aop 1141 1208 912 798 962 630 1202 874 1647 730 2180 1397 1673 864 1909 971 2176 1182 1135 1427 1242 1494 1214 1932 724