Enriched and Depleted GO terms for each geneset were generated with Ontologizer 2.0 using parent-child intersection and Benjamini-Hochberg multiple test correction All terms with a corrected p-value <= 0.01 are shown here. All olfactory genes were removed prior to analysis. The background geneset corresponded to all of the mouse or zebrafish genes in our orthologous gene family data. MOUSE ############################################################################################################################## Enriched for retained WGD duplicates ************************ GO_name GO_namespace ID Pop.total Pop.term Study.total Study.term Pop.family Study.family nparents is.trivial p p.adjusted p.min biological regulation biological_process GO:0065007 8222 2641 2708 1220 6236 2188 1 FALSE 7.39E-56 2.44E-52 0 cell communication biological_process GO:0007154 8222 1339 2708 712 5335 1887 1 FALSE 2.47E-54 4.07E-51 0 multicellular organismal process biological_process GO:0032501 8222 1403 2708 731 6236 2188 1 FALSE 1.98E-50 2.18E-47 0 molecular transducer activity molecular_function GO:0060089 8222 599 2708 352 7048 2420 1 FALSE 1.78E-37 1.47E-34 0 developmental process biological_process GO:0032502 8222 1487 2708 711 6236 2188 1 FALSE 2.16E-31 1.42E-28 0 transcription regulator activity molecular_function GO:0030528 8222 603 2708 335 7048 2420 1 FALSE 4.99E-29 2.75E-26 0 membrane cellular_component GO:0016020 8222 2737 2708 1144 6420 2196 1 FALSE 1.84E-28 8.65E-26 0 DNA binding molecular_function GO:0003677 8222 882 2708 393 1404 489 1 FALSE 1.51E-24 6.22E-22 0 protein complex cellular_component GO:0043234 8222 849 2708 283 1178 306 1 FALSE 7.86E-24 2.88E-21 3.78E-302 cytoskeleton cellular_component GO:0005856 8222 482 2708 181 881 227 1 FALSE 1.40E-19 4.61E-17 1.15E-262 phosphorus metabolic process biological_process GO:0006793 8222 463 2708 232 3617 1142 1 FALSE 3.99E-19 1.20E-16 0 plasma membrane cellular_component GO:0005886 8222 876 2708 473 2737 1144 1 FALSE 6.44E-19 1.77E-16 0 RNA metabolic process biological_process GO:0016070 8222 1220 2708 466 1499 502 2 FALSE 7.48E-18 1.90E-15 5.410343891875E-312 synapse cellular_component GO:0045202 8222 133 2708 92 6732 2321 1 FALSE 1.92E-16 4.52E-14 3.97E-283 ion transport biological_process GO:0006811 8222 332 2708 193 1251 490 1 FALSE 2.19E-16 4.81E-14 1.69321405523E-313 kinase activity molecular_function GO:0016301 8222 449 2708 228 548 237 1 FALSE 4.69E-16 9.68E-14 8.49E-112 "phosphotransferase activity, alcohol group as acceptor" molecular_function GO:0016773 8222 389 2708 208 548 237 1 FALSE 6.03E-15 1.17E-12 1.22E-142 sequence-specific DNA binding molecular_function GO:0043565 8222 292 2708 184 882 393 1 FALSE 6.81E-15 1.25E-12 2.17E-242 transporter activity molecular_function GO:0005215 8222 564 2708 277 7048 2420 1 FALSE 3.42E-14 5.94E-12 0 biological_process biological_process GO:0008150 8222 6236 2708 2188 8222 2708 1 FALSE 5.62E-14 9.27E-12 0 transcription biological_process GO:0006350 8222 1012 2708 476 1068 477 3 FALSE 6.08E-14 9.54E-12 7.75E-95 RNA biosynthetic process biological_process GO:0032774 8222 913 2708 452 974 455 2 FALSE 1.33E-13 1.99E-11 1.73E-98 anatomical structure development biological_process GO:0048856 8222 1053 2708 565 1487 711 1 FALSE 1.11E-12 1.59E-10 0 molecular_function molecular_function GO:0003674 8222 7048 2708 2420 8222 2708 1 FALSE 8.83E-12 1.21E-09 0 "transferase activity, transferring phosphorus-containing groups" molecular_function GO:0016772 8222 548 2708 237 992 340 1 FALSE 1.83E-11 2.42E-09 2.21E-295 passive transmembrane transporter activity molecular_function GO:0022803 8222 167 2708 122 410 220 1 FALSE 3.67E-11 4.65E-09 1.13E-119 cellular_component cellular_component GO:0005575 8222 6732 2708 2321 8222 2708 1 FALSE 8.31E-11 1.02E-08 0 protein binding molecular_function GO:0005515 8222 3123 2708 1227 5631 2008 1 FALSE 1.20E-10 1.41E-08 0 transferase activity molecular_function GO:0016740 8222 992 2708 340 2899 783 1 FALSE 2.11E-10 2.32E-08 0 post-translational protein modification biological_process GO:0043687 8222 518 2708 248 695 286 1 FALSE 2.07E-10 2.32E-08 1.56E-170 phosphoric ester hydrolase activity molecular_function GO:0042578 8222 179 2708 93 388 138 1 FALSE 3.36E-10 3.46E-08 1.25E-115 enzyme regulator activity molecular_function GO:0030234 8222 306 2708 157 7048 2420 1 FALSE 3.35E-10 3.46E-08 0 monocarboxylic acid metabolic process biological_process GO:0032787 8222 153 2708 61 303 76 1 FALSE 8.89E-10 8.88E-08 1.36E-90 biological adhesion biological_process GO:0022610 8222 232 2708 124 6236 2188 1 FALSE 4.23E-09 4.11E-07 0 primary metabolic process biological_process GO:0044238 8222 3499 2708 1132 3983 1229 1 FALSE 9.06E-09 8.54E-07 0 calcium ion binding molecular_function GO:0005509 8222 326 2708 170 1473 568 2 FALSE 1.12E-08 1.03E-06 0 cell proliferation biological_process GO:0008283 8222 310 2708 155 5335 1887 1 FALSE 3.72E-08 3.32E-06 0 cytoskeletal protein binding molecular_function GO:0008092 8222 168 2708 100 3123 1227 1 FALSE 4.09E-08 3.55E-06 2.00E-283 localization biological_process GO:0051179 8222 1444 2708 592 6236 2188 1 FALSE 5.86E-08 4.96E-06 0 transcription factor activity molecular_function GO:0003700 8222 395 2708 264 495 301 2 FALSE 6.08E-08 5.01E-06 1.50E-107 ion channel complex cellular_component GO:0034702 8222 39 2708 33 155 76 2 FALSE 1.60E-07 1.29E-05 1.45E-37 amino acid derivative metabolic process biological_process GO:0006575 8222 63 2708 24 184 32 1 FALSE 2.44E-07 1.92E-05 7.20E-51 behavior biological_process GO:0007610 8222 150 2708 80 799 281 1 FALSE 3.14E-07 2.41E-05 7.38E-167 locomotion biological_process GO:0040011 8222 156 2708 85 6236 2188 1 FALSE 4.10E-07 3.07E-05 5.2131737E-316 receptor complex cellular_component GO:0043235 8222 24 2708 20 849 283 1 FALSE 4.55E-07 3.34E-05 4.38E-47 biosynthetic process biological_process GO:0009058 8222 1806 2708 627 3983 1229 1 FALSE 9.40E-07 6.74E-05 0 receptor binding molecular_function GO:0005102 8222 208 2708 115 3123 1227 1 FALSE 9.92E-07 6.82E-05 0 macromolecule metabolic process biological_process GO:0043170 8222 2930 2708 965 3983 1229 1 FALSE 9.83E-07 6.82E-05 0 Golgi apparatus cellular_component GO:0005794 8222 355 2708 123 1706 420 2 FALSE 1.09E-06 7.33E-05 0 "ATPase activity, coupled to movement of substances" molecular_function GO:0043492 8222 65 2708 28 139 34 1 FALSE 1.36E-06 8.94E-05 2.84E-41 binding molecular_function GO:0005488 8222 5631 2708 2008 7048 2420 1 FALSE 1.44E-06 9.29E-05 0 dioxygenase activity molecular_function GO:0051213 8222 37 2708 19 417 77 1 FALSE 1.78E-06 1.12E-04 8.10E-54 "hydrolase activity, acting on ester bonds" molecular_function GO:0016788 8222 388 2708 138 1167 313 1 FALSE 1.81E-06 1.12E-04 2.036E-321 "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen" molecular_function GO:0016701 8222 38 2708 19 417 77 1 FALSE 3.05E-06 1.86E-04 8.10E-55 cytoskeleton organization and biogenesis biological_process GO:0007010 8222 214 2708 76 589 145 1 FALSE 3.70E-06 2.22E-04 6.90E-167 growth biological_process GO:0040007 8222 165 2708 86 6236 2188 1 FALSE 4.11E-06 2.42E-04 0 potassium ion binding molecular_function GO:0030955 8222 37 2708 32 76 46 1 FALSE 5.53E-06 3.20E-04 1.49E-22 metal ion transmembrane transporter activity molecular_function GO:0046873 8222 139 2708 99 341 194 1 FALSE 6.41E-06 3.64E-04 1.77E-99 biopolymer modification biological_process GO:0043412 8222 724 2708 289 2528 843 1 FALSE 6.54E-06 3.65E-04 0 transcription factor complex cellular_component GO:0005667 8222 134 2708 69 211 85 2 FALSE 7.53E-06 4.14E-04 1.30E-59 protein serine/threonine phosphatase complex cellular_component GO:0008287 8222 23 2708 18 835 277 2 FALSE 9.14E-06 4.94E-04 2.22E-45 vesicle cellular_component GO:0031982 8222 242 2708 101 4072 1185 1 FALSE 1.02E-05 5.43E-04 0 potassium ion transport biological_process GO:0006813 8222 73 2708 60 116 78 2 FALSE 1.07E-05 5.60E-04 7.96E-33 nucleus cellular_component GO:0005634 8222 2125 2708 664 3615 1034 1 FALSE 1.44E-05 7.43E-04 0 establishment or maintenance of chromatin architecture biological_process GO:0006325 8222 142 2708 43 186 44 1 FALSE 2.07E-05 0.001048551 9.34E-44 membrane organization biological_process GO:0016044 8222 142 2708 71 1005 346 1 FALSE 2.68E-05 0.001337505 4.65E-177 localization of cell biological_process GO:0051674 8222 190 2708 104 1444 592 1 FALSE 2.90E-05 0.001388276 2.10E-243 leading edge cellular_component GO:0031252 8222 49 2708 31 6420 2196 1 FALSE 2.90E-05 0.001388276 1.97E-124 actin filament-based process biological_process GO:0030029 8222 89 2708 46 214 76 1 FALSE 2.85E-05 0.001388276 1.44E-62 regulation of transcription from RNA polymerase II promoter biological_process GO:0006357 8222 286 2708 169 305 171 2 FALSE 3.00E-05 0.00141387 1.36E-30 "hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances" molecular_function GO:0016820 8222 65 2708 28 320 73 1 FALSE 3.13E-05 0.001453529 1.31E-69 phosphatidylinositol metabolic process biological_process GO:0046488 8222 10 2708 9 42 14 1 FALSE 3.88E-05 0.001776705 6.80E-10 positive regulation of gene expression biological_process GO:0010628 8222 247 2708 146 1044 501 1 FALSE 4.16E-05 0.001878592 2.97E-247 coated vesicle cellular_component GO:0030135 8222 71 2708 43 189 79 1 FALSE 4.65E-05 0.002075024 7.82E-54 lipid binding molecular_function GO:0008289 8222 150 2708 77 5631 2008 1 FALSE 4.91E-05 0.002158722 1.09E-299 protein complex assembly biological_process GO:0006461 8222 111 2708 41 221 56 1 FALSE 5.28E-05 0.002291568 5.55E-66 alkali metal ion binding molecular_function GO:0031420 8222 76 2708 46 1473 568 2 FALSE 5.72E-05 0.00245172 2.22E-129 "phosphotransferase activity, nitrogenous group as acceptor" molecular_function GO:0016775 8222 15 2708 14 548 237 1 FALSE 5.86E-05 0.002452224 1.31E-29 "ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism" molecular_function GO:0015662 8222 31 2708 22 52 25 1 FALSE 5.97E-05 0.002452224 5.21E-15 actin cytoskeleton cellular_component GO:0015629 8222 89 2708 50 482 181 1 FALSE 6.02E-05 0.002452224 1.56E-99 chemical homeostasis biological_process GO:0048878 8222 155 2708 79 284 115 1 FALSE 5.92E-05 0.002452224 2.23E-84 protein domain specific binding molecular_function GO:0019904 8222 73 2708 45 3123 1227 1 FALSE 7.78E-05 0.003131504 8.22E-150 calmodulin binding molecular_function GO:0005516 8222 39 2708 27 3123 1227 1 FALSE 1.36E-04 0.005388054 1.33E-90 chromatin cellular_component GO:0000785 8222 87 2708 26 168 32 1 FALSE 1.54E-04 0.006032504 4.84E-50 energy reserve metabolic process biological_process GO:0006112 8222 19 2708 11 42 12 1 FALSE 1.62E-04 0.006278237 2.24E-12 nucleoside transport biological_process GO:0015858 8222 5 2708 5 47 10 1 FALSE 1.64E-04 0.00629222 6.52E-07 carbonate dehydratase activity molecular_function GO:0004089 8222 15 2708 12 35 15 1 FALSE 1.66E-04 0.00629222 3.08E-10 phosphofructokinase activity molecular_function GO:0008443 8222 6 2708 6 15 6 2 FALSE 2.00E-04 0.007490237 2.00E-04 nucleoplasm cellular_component GO:0005654 8222 288 2708 104 379 119 2 FALSE 2.20E-04 0.008142754 3.92E-90 skeletal development biological_process GO:0001501 8222 89 2708 63 799 424 1 FALSE 2.41E-04 0.008822086 1.27E-120 Enriched for genes with bidirectional promoters ************************ GO_name GO_namespace ID Pop.total Pop.term Study.total Study.term Pop.family Study.family nparents is.trivial p p.adjusted p.min response to DNA damage stimulus biological_process GO:0006974 8222 171 1102 53 473 69 1 FALSE 9.25E-14 2.05E-10 1.03E-133 cellular response to stimulus biological_process GO:0051716 8222 193 1102 52 683 81 2 FALSE 5.66E-13 6.27E-10 7.40E-176 intracellular cellular_component GO:0005622 8222 5065 1102 772 6420 887 1 FALSE 1.36E-11 1.00E-08 0 organelle cellular_component GO:0043226 8222 4072 1102 635 6732 903 1 FALSE 2.71E-11 1.50E-08 0 macromolecular complex cellular_component GO:0032991 8222 1178 1102 228 6732 903 1 FALSE 1.66E-10 7.33E-08 0 RNA processing biological_process GO:0006396 8222 258 1102 71 1196 174 2 FALSE 3.03E-10 1.12E-07 5.13E-270 organelle organization biological_process GO:0006996 8222 589 1102 108 1005 135 1 FALSE 1.57E-08 4.97E-06 3.60E-295 cell cellular_component GO:0005623 8222 6420 1102 887 6732 903 1 FALSE 8.41E-07 2.33E-04 0 DNA metabolic process biological_process GO:0006259 8222 248 1102 68 1499 251 2 FALSE 2.11E-06 5.20E-04 3.34E-291 transition metal ion binding molecular_function GO:0046914 8222 1116 1102 167 1473 189 2 FALSE 3.21E-06 7.11E-04 0 ncRNA metabolic process biological_process GO:0034660 8222 146 1102 41 1220 181 1 FALSE 6.95E-06 0.001398971 2.45E-193 cellular localization biological_process GO:0051641 8222 428 1102 73 1024 121 2 FALSE 9.65E-06 0.001781569 2.26E-301 macromolecule localization biological_process GO:0033036 8222 481 1102 79 1444 162 1 FALSE 1.10E-05 0.001877905 0 ribonucleoprotein complex biogenesis and assembly biological_process GO:0022613 8222 109 1102 30 1005 135 1 FALSE 2.47E-05 0.003914765 3.66E-149 membrane-bounded organelle cellular_component GO:0043227 8222 3618 1102 592 4072 635 1 FALSE 4.01E-05 0.005545216 0 DNA packaging biological_process GO:0006323 8222 65 1102 21 1005 135 1 FALSE 3.80E-05 0.005545216 4.95E-104 response to stress biological_process GO:0006950 8222 473 1102 69 799 88 1 FALSE 4.87E-05 0.006348744 8.42E-234 metabolic process biological_process GO:0008152 8222 3983 1102 558 6236 797 1 FALSE 5.48E-05 0.006748787 0 Enriched for genes with PCNEs ************************ GO_name GO_namespace ID Pop.total Pop.term Study.total Study.term Pop.family Study.family nparents is.trivial p p.adjusted p.min transcription regulator activity molecular_function GO:0030528 8222 603 1231 270 7048 1128 1 FALSE 5.62E-70 1.45E-66 0 nucleic acid binding molecular_function GO:0003676 8222 1404 1231 412 5631 953 1 FALSE 1.05E-42 1.36E-39 0 multicellular organismal process biological_process GO:0032501 8222 1403 1231 376 6236 994 1 FALSE 2.01E-33 1.73E-30 0 nucleus cellular_component GO:0005634 8222 2125 1231 504 3615 639 1 FALSE 5.07E-32 3.27E-29 0 developmental process biological_process GO:0032502 8222 1487 1231 386 6236 994 1 FALSE 4.07E-31 2.10E-28 0 gene expression biological_process GO:0010467 8222 1528 1231 394 5335 876 1 FALSE 8.29E-30 3.57E-27 0 "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" biological_process GO:0006139 8222 1639 1231 413 3397 600 2 FALSE 2.96E-29 1.09E-26 0 biological regulation biological_process GO:0065007 8222 2641 1231 573 6236 994 1 FALSE 2.66E-26 8.60E-24 0 biosynthetic process biological_process GO:0009058 8222 1806 1231 411 3983 664 1 FALSE 4.85E-21 1.39E-18 0 DNA binding molecular_function GO:0003677 8222 882 1231 333 1404 412 1 FALSE 1.39E-20 3.59E-18 0 cell fate commitment biological_process GO:0045165 8222 84 1231 62 712 216 2 FALSE 1.72E-18 4.04E-16 1.34E-111 RNA metabolic process biological_process GO:0016070 8222 1220 1231 369 1499 392 2 FALSE 1.68E-16 3.61E-14 5.410343891875E-312 regulation of metabolic process biological_process GO:0019222 8222 1180 1231 373 1637 432 2 FALSE 5.66E-16 1.12E-13 0 protein-DNA complex cellular_component GO:0032993 8222 44 1231 30 1178 214 1 FALSE 1.11E-13 2.04E-11 4.44E-81 cell proliferation biological_process GO:0008283 8222 310 1231 99 5335 876 1 FALSE 2.48E-12 4.27E-10 0 macromolecule metabolic process biological_process GO:0043170 8222 2930 1231 557 3983 664 1 FALSE 4.15E-12 6.69E-10 0 molecular_function molecular_function GO:0003674 8222 7048 1231 1128 8222 1231 1 FALSE 7.16E-12 1.09E-09 0 localization of cell biological_process GO:0051674 8222 190 1231 64 1444 229 1 FALSE 3.35E-11 4.80E-09 2.10E-243 sequence-specific DNA binding molecular_function GO:0043565 8222 292 1231 155 882 333 1 FALSE 4.26E-11 5.80E-09 2.17E-242 cellular biopolymer metabolic process biological_process GO:0034960 8222 1723 1231 412 2511 517 2 FALSE 2.57E-10 3.31E-08 0 DNA packaging biological_process GO:0006323 8222 65 1231 33 1005 186 1 FALSE 9.17E-10 1.13E-07 4.95E-104 intermediate filament cytoskeleton cellular_component GO:0045111 8222 77 1231 34 482 85 1 FALSE 1.48E-09 1.73E-07 2.27E-91 organelle cellular_component GO:0043226 8222 4072 1231 723 6732 1056 1 FALSE 3.18E-09 3.57E-07 0 biopolymer metabolic process biological_process GO:0043283 8222 2528 1231 519 2930 557 1 FALSE 1.44E-08 1.55E-06 0 transcription factor complex cellular_component GO:0005667 8222 134 1231 62 211 70 2 FALSE 2.54E-08 2.62E-06 1.30E-59 positive regulation of biological process biological_process GO:0048518 8222 603 1231 183 2509 555 2 FALSE 3.37E-08 3.34E-06 0 pattern specification process biological_process GO:0007389 8222 156 1231 75 1190 346 2 FALSE 5.34E-08 5.11E-06 5.08E-200 chromatin cellular_component GO:0000785 8222 87 1231 40 168 48 1 FALSE 1.20E-07 1.11E-05 4.84E-50 endocrine system development biological_process GO:0035270 8222 46 1231 31 962 297 1 FALSE 1.87E-07 1.67E-05 9.76E-80 nucleosome organization biological_process GO:0034728 8222 46 1231 29 142 47 1 FALSE 2.72E-07 2.34E-05 2.02E-38 embryonic development biological_process GO:0009790 8222 346 1231 136 1190 346 2 FALSE 6.69E-07 5.57E-05 1.1133042579204E-310 gland development biological_process GO:0048732 8222 61 1231 38 799 263 1 FALSE 9.27E-07 7.48E-05 4.69E-93 protein-DNA complex assembly biological_process GO:0065004 8222 71 1231 30 179 42 1 FALSE 2.01E-06 1.57E-04 1.01E-51 biopolymer biosynthetic process biological_process GO:0043284 8222 1361 1231 372 1442 377 2 FALSE 2.31E-06 1.75E-04 7.61E-135 anatomical structure development biological_process GO:0048856 8222 1053 1231 308 1487 386 1 FALSE 2.71E-06 2.00E-04 0 zinc ion binding molecular_function GO:0008270 8222 859 1231 165 1116 185 1 FALSE 3.41E-06 2.45E-04 1.02E-260 transcription biological_process GO:0006350 8222 1012 1231 343 1068 347 3 FALSE 4.13E-06 2.88E-04 7.75E-95 locomotion biological_process GO:0040011 8222 156 1231 47 6236 994 1 FALSE 5.08E-06 3.36E-04 5.2131737E-316 biological_process biological_process GO:0008150 8222 6236 1231 994 8222 1231 1 FALSE 5.21E-06 3.36E-04 0 transcription factor binding molecular_function GO:0008134 8222 142 1231 46 3123 539 1 FALSE 4.97E-06 3.36E-04 4.12E-250 binding molecular_function GO:0005488 8222 5631 1231 953 7048 1128 1 FALSE 1.03E-05 6.48E-04 0 intracellular cellular_component GO:0005622 8222 5065 1231 854 6420 1019 1 FALSE 1.07E-05 6.55E-04 0 RNA biosynthetic process biological_process GO:0032774 8222 913 1231 334 974 341 2 FALSE 1.74E-05 0.001047413 1.73E-98 anatomical structure morphogenesis biological_process GO:0009653 8222 627 1231 213 1053 308 2 FALSE 2.50E-05 0.001468031 9.99E-308 regulation of cell differentiation biological_process GO:0045595 8222 135 1231 64 244 88 3 FALSE 2.88E-05 0.001652392 2.76E-72 skeletal development biological_process GO:0001501 8222 89 1231 47 799 263 1 FALSE 3.09E-05 0.001734356 1.27E-120 plasma membrane cellular_component GO:0005886 8222 876 1231 136 2737 325 1 FALSE 4.48E-05 0.002410373 0 chromosome organization and biogenesis biological_process GO:0051276 8222 186 1231 51 589 105 1 FALSE 4.42E-05 0.002410373 8.34E-159 cellular_component cellular_component GO:0005575 8222 6732 1231 1056 8222 1231 1 FALSE 4.63E-05 0.002439671 0 stem cell division biological_process GO:0017145 8222 4 1231 4 122 12 1 FALSE 5.64E-05 0.00291137 1.14E-07 cell-cell signaling biological_process GO:0007267 8222 214 1231 57 1339 227 1 FALSE 6.09E-05 0.003083384 1.05E-254 passive transmembrane transporter activity molecular_function GO:0022803 8222 167 1231 41 410 65 1 FALSE 6.44E-05 0.003138916 1.13E-119 primary metabolic process biological_process GO:0044238 8222 3499 1231 612 3983 664 1 FALSE 6.32E-05 0.003138916 0 transcription from RNA polymerase II promoter biological_process GO:0006366 8222 311 1231 141 909 334 1 FALSE 7.71E-05 0.003687572 8.63E-253 chromatin assembly or disassembly biological_process GO:0006333 8222 70 1231 34 142 47 1 FALSE 9.76E-05 0.004584695 2.72E-42 chromatin binding molecular_function GO:0003682 8222 70 1231 25 5631 953 1 FALSE 1.08E-04 0.00499139 5.30E-163 cell differentiation biological_process GO:0030154 8222 712 1231 216 763 220 1 FALSE 1.66E-04 0.007528417 8.40E-81 Enriched for segmental duplicates ************************ GO_name GO_namespace ID Pop.total Pop.term Study.total Study.term Pop.family Study.family nparents is.trivial p p.adjusted p.min intermediate filament cytoskeleton cellular_component GO:0045111 8222 77 583 61 482 68 1 FALSE 5.86E-54 8.00E-51 2.27E-91 protein-DNA complex cellular_component GO:0032993 8222 44 583 21 1178 40 1 FALSE 3.59E-22 2.45E-19 4.44E-81 structural molecule activity molecular_function GO:0005198 8222 284 583 69 7048 535 1 FALSE 3.77E-19 1.72E-16 0 carboxylesterase activity molecular_function GO:0004091 8222 61 583 28 388 39 1 FALSE 3.08E-17 1.05E-14 8.93E-73 non-membrane-bounded organelle cellular_component GO:0043228 8222 881 583 93 4072 197 1 FALSE 2.48E-16 5.66E-14 0 lipid metabolic process biological_process GO:0006629 8222 389 583 56 3499 161 1 FALSE 2.19E-16 5.66E-14 0 oxidation reduction biological_process GO:0055114 8222 332 583 59 3983 238 1 FALSE 1.49E-15 2.91E-13 0 tetrapyrrole binding molecular_function GO:0046906 8222 64 583 24 5631 331 1 FALSE 3.73E-14 6.37E-12 1.67E-151 extracellular region cellular_component GO:0005576 8222 445 583 71 6732 430 1 FALSE 1.30E-13 1.97E-11 0 nucleosome organization biological_process GO:0034728 8222 46 583 21 142 21 1 FALSE 1.07E-12 1.46E-10 2.02E-38 DNA packaging biological_process GO:0006323 8222 65 583 21 1005 57 1 FALSE 1.49E-12 1.85E-10 4.95E-104 iron ion binding molecular_function GO:0005506 8222 156 583 27 1116 51 1 FALSE 1.30E-11 1.48E-09 2.39E-195 organelle part cellular_component GO:0044422 8222 1920 583 138 4072 197 2 FALSE 2.31E-11 2.43E-09 0 enzyme inhibitor activity molecular_function GO:0004857 8222 65 583 22 306 29 1 FALSE 3.15E-11 3.07E-09 3.38E-68 defense response biological_process GO:0006952 8222 109 583 28 473 43 1 FALSE 5.71E-10 5.20E-08 2.97E-110 CoA hydrolase activity molecular_function GO:0016289 8222 15 583 11 62 11 1 FALSE 2.69E-09 2.29E-07 1.07E-14 multi-organism process biological_process GO:0051704 8222 103 583 25 6236 432 1 FALSE 1.87E-08 1.50E-06 3.08E-227 "transferase activity, transferring sulfur-containing groups" molecular_function GO:0016782 8222 27 583 11 992 57 1 FALSE 5.47E-08 4.15E-06 1.93E-53 chromatin assembly or disassembly biological_process GO:0006333 8222 70 583 21 142 21 1 FALSE 5.91E-08 4.25E-06 2.72E-42 electron carrier activity molecular_function GO:0009055 8222 108 583 26 7048 535 1 FALSE 7.95E-08 5.43E-06 7.74E-242 organic acid metabolic process biological_process GO:0006082 8222 303 583 35 3617 164 1 FALSE 1.03E-07 6.68E-06 0 hormone metabolic process biological_process GO:0042445 8222 53 583 15 3983 238 1 FALSE 2.31E-07 1.44E-05 9.35E-122 chromatin cellular_component GO:0000785 8222 87 583 21 168 21 1 FALSE 2.65E-07 1.57E-05 4.84E-50 oxidoreductase activity molecular_function GO:0016491 8222 417 583 65 2899 256 1 FALSE 7.47E-07 4.25E-05 0 intermediate filament-based process biological_process GO:0045103 8222 18 583 8 214 14 1 FALSE 1.05E-06 5.75E-05 1.51E-26 molecular_function molecular_function GO:0003674 8222 7048 583 535 8222 583 1 FALSE 2.83E-06 1.49E-04 0 protein-DNA complex assembly biological_process GO:0065004 8222 71 583 21 179 26 1 FALSE 4.95E-06 2.50E-04 1.01E-51 cytokine and chemokine mediated signaling pathway biological_process GO:0019221 8222 24 583 9 491 33 1 FALSE 5.93E-06 2.89E-04 2.85E-41 2'-5'-oligoadenylate synthetase activity molecular_function GO:0001730 8222 4 583 4 86 6 1 FALSE 7.06E-06 3.33E-04 4.71E-07 anchored to membrane cellular_component GO:0031225 8222 41 583 13 1895 152 1 FALSE 8.41E-06 3.83E-04 2.15E-85 protein metabolic process biological_process GO:0019538 8222 1518 583 63 2913 84 2 FALSE 1.09E-05 4.80E-04 0 lipid biosynthetic process biological_process GO:0008610 8222 168 583 17 1806 59 1 FALSE 1.14E-05 4.86E-04 5.71E-242 response to stimulus biological_process GO:0050896 8222 799 583 84 6236 432 1 FALSE 3.39E-05 0.001403099 0 nonprotein amino acid metabolic process biological_process GO:0019794 8222 5 583 4 137 9 1 FALSE 4.35E-05 0.001748089 2.68E-09 cellular component assembly biological_process GO:0022607 8222 255 583 28 1005 57 1 FALSE 5.86E-05 0.002288498 2.12E-246 cell surface receptor linked signal transduction biological_process GO:0007166 8222 491 583 33 1169 47 1 FALSE 6.29E-05 0.002386471 0 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen" molecular_function GO:0016712 8222 13 583 10 40 13 2 FALSE 7.18E-05 0.002651682 8.31E-11 steroid dehydrogenase activity molecular_function GO:0016229 8222 15 583 9 417 65 1 FALSE 7.52E-05 0.002702836 8.42E-28 monooxygenase activity molecular_function GO:0004497 8222 49 583 18 417 65 1 FALSE 8.34E-05 0.002919651 4.71E-65 cytoskeleton cellular_component GO:0005856 8222 482 583 68 881 93 1 FALSE 9.48E-05 0.003220244 1.15E-262 peptidyl-amino acid modification biological_process GO:0018193 8222 56 583 8 695 21 1 FALSE 9.67E-05 0.003220244 4.89E-84 calcium-independent cell-cell adhesion biological_process GO:0016338 8222 15 583 7 99 11 1 FALSE 1.04E-04 0.003366463 4.64E-18 glutathione transferase activity molecular_function GO:0004364 8222 8 583 6 26 6 1 FALSE 1.22E-04 0.003863477 6.40E-07 macromolecular complex subunit organization biological_process GO:0043933 8222 238 583 26 1005 57 2 FALSE 1.48E-04 0.00460619 4.12E-238 Enriched for genes with ancient synteny ************************ GO_name GO_namespace ID Pop.total Pop.term Study.total Study.term Pop.family Study.family nparents is.trivial p p.adjusted p.min transcription regulator activity molecular_function GO:0030528 8222 603 1581 178 7048 1343 1 FALSE 5.37E-11 1.58E-07 0 protein-DNA complex cellular_component GO:0032993 8222 44 1581 28 1178 262 1 FALSE 2.02E-09 2.97E-06 4.44E-81 nucleic acid binding molecular_function GO:0003676 8222 1404 1581 350 5631 1111 1 FALSE 1.82E-08 1.79E-05 0 DNA packaging biological_process GO:0006323 8222 65 1581 35 1005 241 1 FALSE 7.16E-08 5.28E-05 4.95E-104 organelle cellular_component GO:0043226 8222 4072 1581 867 6732 1307 1 FALSE 7.15E-07 4.22E-04 0 gene expression biological_process GO:0010467 8222 1528 1581 361 5335 1065 1 FALSE 1.63E-05 0.008005822 0 Depleted for retained WGD duplicates ************************ GO_name GO_namespace ID Pop.total Pop.term Study.total Study.term Pop.family Study.family nparents is.trivial p p.adjusted p.min RNA processing biological_process GO:0006396 8222 258 5517 241 1196 732 2 FALSE 2.12E-39 9.43E-36 5.13E-270 ncRNA metabolic process biological_process GO:0034660 8222 146 5517 145 1220 755 1 FALSE 1.06E-31 2.36E-28 2.45E-193 organelle cellular_component GO:0043226 8222 4072 5517 2889 6732 4414 1 FALSE 1.58E-30 2.34E-27 0 intracellular cellular_component GO:0005622 8222 5065 5517 3509 6420 4227 1 FALSE 1.52E-28 1.69E-25 0 catalytic activity molecular_function GO:0003824 8222 2899 5517 2118 7048 4631 1 FALSE 4.33E-28 3.85E-25 0 metabolic process biological_process GO:0008152 8222 3983 5517 2757 6236 4051 1 FALSE 7.34E-21 5.44E-18 0 ribonucleoprotein complex cellular_component GO:0030529 8222 299 5517 281 1095 847 2 FALSE 1.13E-18 7.20E-16 5.78E-278 DNA metabolic process biological_process GO:0006259 8222 248 5517 219 1499 998 2 FALSE 1.48E-17 8.21E-15 3.34E-291 macromolecule localization biological_process GO:0033036 8222 481 5517 355 1444 853 1 FALSE 2.37E-16 1.17E-13 0 ribonucleoprotein complex biogenesis and assembly biological_process GO:0022613 8222 109 5517 105 1005 659 1 FALSE 3.18E-16 1.41E-13 3.66E-149 cellular response to stimulus biological_process GO:0051716 8222 193 5517 166 683 433 2 FALSE 6.52E-16 2.63E-13 7.40E-176 mitochondrion cellular_component GO:0005739 8222 631 5517 543 1706 1287 2 FALSE 7.27E-16 2.69E-13 0 organelle organization biological_process GO:0006996 8222 589 5517 444 1005 659 1 FALSE 6.46E-15 2.21E-12 3.60E-295 nucleotidyltransferase activity molecular_function GO:0016779 8222 86 5517 79 548 311 1 FALSE 1.23E-14 3.80E-12 8.12E-103 mRNA metabolic process biological_process GO:0016071 8222 157 5517 138 1220 755 1 FALSE 1.28E-14 3.80E-12 1.17E-202 death biological_process GO:0016265 8222 389 5517 265 1487 776 1 FALSE 1.11E-13 3.08E-11 0 cytoplasmic part cellular_component GO:0044444 8222 2037 5517 1522 3243 2277 2 FALSE 3.01E-13 7.86E-11 0 RNA binding molecular_function GO:0003723 8222 336 5517 272 1404 916 1 FALSE 5.76E-13 1.42E-10 0 transition metal ion binding molecular_function GO:0046914 8222 1116 5517 742 1473 905 2 FALSE 2.46E-12 5.75E-10 0 macromolecular complex cellular_component GO:0032991 8222 1178 5517 873 6732 4414 1 FALSE 2.92E-12 6.49E-10 0 response to DNA damage stimulus biological_process GO:0006974 8222 171 5517 152 473 334 1 FALSE 5.94E-12 1.26E-09 1.03E-133 envelope cellular_component GO:0031975 8222 356 5517 289 6732 4414 1 FALSE 1.91E-11 3.87E-09 0 nuclease activity molecular_function GO:0004518 8222 84 5517 77 388 250 1 FALSE 2.08E-10 4.02E-08 1.88E-87 "transferase activity, transferring one-carbon groups" molecular_function GO:0016741 8222 107 5517 97 992 653 1 FALSE 4.02E-10 7.45E-08 1.09E-146 structural constituent of ribosome molecular_function GO:0003735 8222 115 5517 111 284 228 1 FALSE 9.79E-10 1.74E-07 1.17E-82 cell redox homeostasis biological_process GO:0045454 8222 42 5517 41 110 72 2 FALSE 1.89E-09 3.23E-07 2.19E-31 oxidation reduction biological_process GO:0055114 8222 332 5517 273 3983 2757 1 FALSE 1.48E-08 2.43E-06 0 structural molecule activity molecular_function GO:0005198 8222 284 5517 228 7048 4631 1 FALSE 2.61E-08 4.14E-06 0 regulation of developmental process biological_process GO:0050793 8222 418 5517 244 1041 501 2 FALSE 4.02E-08 6.17E-06 1.12E-303 "DNA-directed RNA polymerase II, holoenzyme" cellular_component GO:0016591 8222 43 5517 40 211 126 2 FALSE 8.75E-08 1.30E-05 6.83E-46 electron carrier activity molecular_function GO:0009055 8222 108 5517 95 7048 4631 1 FALSE 9.78E-08 1.40E-05 7.74E-242 cellular localization biological_process GO:0051641 8222 428 5517 302 1024 627 2 FALSE 1.21E-07 1.68E-05 2.26E-301 intermediate filament cytoskeleton cellular_component GO:0045111 8222 77 5517 67 482 301 1 FALSE 2.53E-07 3.41E-05 2.27E-91 calcium-independent cell-cell adhesion biological_process GO:0016338 8222 15 5517 15 99 43 1 FALSE 7.04E-07 9.06E-05 4.64E-18 cilium cellular_component GO:0005929 8222 55 5517 46 238 132 1 FALSE 7.14E-07 9.06E-05 2.17E-55 translation biological_process GO:0006412 8222 257 5517 231 342 287 4 FALSE 9.16E-07 1.13E-04 1.04E-82 cofactor binding molecular_function GO:0048037 8222 137 5517 113 5631 3625 1 FALSE 1.91E-06 2.29E-04 3.93E-279 inorganic cation transmembrane transporter activity molecular_function GO:0022890 8222 83 5517 55 254 115 1 FALSE 2.50E-06 2.92E-04 3.73E-69 cellular amino acid and derivative metabolic process biological_process GO:0006519 8222 184 5517 152 3397 2303 2 FALSE 2.61E-06 2.97E-04 6.5867571202793E-310 microtubule cytoskeleton cellular_component GO:0015630 8222 205 5517 152 482 301 1 FALSE 3.22E-06 3.57E-04 4.82E-142 protein modification by small protein conjugation biological_process GO:0032446 8222 42 5517 38 695 409 1 FALSE 3.86E-06 4.18E-04 2.15E-68 organelle part cellular_component GO:0044422 8222 1920 5517 1427 4072 2889 2 FALSE 4.20E-06 4.45E-04 0 GPI anchor metabolic process biological_process GO:0006505 8222 20 5517 20 42 28 1 FALSE 6.05E-06 6.25E-04 1.95E-12 microtubule-based process biological_process GO:0007017 8222 100 5517 80 214 138 1 FALSE 6.52E-06 6.59E-04 1.10E-63 cell cycle biological_process GO:0007049 8222 350 5517 263 5335 3450 1 FALSE 9.06E-06 8.78E-04 0 oxidoreductase activity molecular_function GO:0016491 8222 417 5517 340 2899 2118 1 FALSE 9.09E-06 8.78E-04 0 membrane-enclosed lumen cellular_component GO:0031974 8222 536 5517 396 6732 4414 1 FALSE 1.04E-05 9.80E-04 0 isomerase activity molecular_function GO:0016853 8222 84 5517 77 2899 2118 1 FALSE 1.55E-05 0.001439279 1.66E-164 nucleic acid transport biological_process GO:0050657 8222 41 5517 37 47 37 1 FALSE 1.96E-05 0.001773346 9.31E-08 "nucleobase, nucleoside, nucleotide kinase activity" molecular_function GO:0019205 8222 19 5517 18 449 221 1 FALSE 2.10E-05 0.001864026 7.25E-34 metal cluster binding molecular_function GO:0051540 8222 30 5517 29 5631 3625 1 FALSE 3.10E-05 0.002651772 8.70E-81 microtubule organizing center cellular_component GO:0005815 8222 79 5517 67 109 80 3 FALSE 3.07E-05 0.002651772 1.64E-27 response to stress biological_process GO:0006950 8222 473 5517 334 799 519 1 FALSE 3.90E-05 0.003270438 8.42E-234 carbohydrate transmembrane transporter activity molecular_function GO:0015144 8222 19 5517 17 379 170 1 FALSE 4.68E-05 0.003848662 1.95E-32 helicase activity molecular_function GO:0004386 8222 90 5517 81 2899 2118 1 FALSE 5.42E-05 0.004380792 1.50E-173 establishment of localization biological_process GO:0051234 8222 1263 5517 770 1444 853 2 FALSE 8.66E-05 0.006867378 6.26E-236 ncRNA processing biological_process GO:0034470 8222 105 5517 105 258 241 1 FALSE 9.45E-05 0.007366772 3.81E-75 ligase activity molecular_function GO:0016874 8222 223 5517 186 2899 2118 1 FALSE 1.09E-04 0.00833634 0 intracellular part cellular_component GO:0044424 8222 4837 5517 3377 5065 3509 2 FALSE 1.31E-04 0.009748992 0 nitrogen compound metabolic process biological_process GO:0006807 8222 217 5517 174 3983 2757 1 FALSE 1.32E-04 0.009748992 0 Depleted for genes with bidirectional promoters ************************ GO_name GO_namespace ID Pop.total Pop.term Study.total Study.term Pop.family Study.family nparents is.trivial p p.adjusted p.min multicellular organismal process biological_process GO:0032501 8222 1403 7125 1312 6236 5443 1 FALSE 1.72E-17 8.48E-14 0 cell communication biological_process GO:0007154 8222 1339 7125 1242 5335 4628 1 FALSE 1.94E-15 4.80E-12 0 biological regulation biological_process GO:0065007 8222 2641 7125 2391 6236 5443 1 FALSE 1.44E-11 1.77E-08 0 extracellular region cellular_component GO:0005576 8222 445 7125 427 6732 5834 1 FALSE 1.11E-11 1.77E-08 0 developmental process biological_process GO:0032502 8222 1487 7125 1367 6236 5443 1 FALSE 8.76E-11 8.65E-08 0 plasma membrane cellular_component GO:0005886 8222 876 7125 821 2737 2431 1 FALSE 4.08E-09 3.35E-06 0 molecular transducer activity molecular_function GO:0060089 8222 599 7125 564 7048 6159 1 FALSE 9.87E-09 6.96E-06 0 membrane cellular_component GO:0016020 8222 2737 7125 2431 6420 5538 1 FALSE 1.38E-07 8.51E-05 0 cytoskeleton cellular_component GO:0005856 8222 482 7125 432 881 741 1 FALSE 6.73E-07 3.69E-04 1.15E-262 sequence-specific DNA binding molecular_function GO:0043565 8222 292 7125 276 882 770 1 FALSE 1.39E-06 6.85E-04 2.17E-242 molecular_function molecular_function GO:0003674 8222 7048 7125 6159 8222 7125 1 FALSE 2.48E-06 0.001113918 0 biological adhesion biological_process GO:0022610 8222 232 7125 222 6236 5443 1 FALSE 9.28E-06 0.003815066 0 Depleted for genes with PCNEs ************************ GO_name GO_namespace ID Pop.total Pop.term Study.total Study.term Pop.family Study.family nparents is.trivial p p.adjusted p.min cytoplasm cellular_component GO:0005737 8222 3243 6994 2855 4837 4029 1 FALSE 8.56E-35 4.14E-31 0 protein metabolic process biological_process GO:0019538 8222 1518 6994 1346 2913 2361 2 FALSE 2.31E-28 5.59E-25 0 catalytic activity molecular_function GO:0003824 8222 2899 6994 2554 7048 5923 1 FALSE 1.97E-15 3.18E-12 0 membrane cellular_component GO:0016020 8222 2737 6994 2414 6420 5404 1 FALSE 8.18E-15 9.89E-12 0 RNA processing biological_process GO:0006396 8222 258 6994 226 1196 830 2 FALSE 2.47E-14 2.39E-11 5.13E-270 ncRNA metabolic process biological_process GO:0034660 8222 146 6994 136 1220 851 1 FALSE 2.91E-13 2.35E-10 2.45E-193 establishment of localization biological_process GO:0051234 8222 1263 6994 1100 1444 1217 2 FALSE 1.63E-12 1.12E-09 6.26E-236 RNA binding molecular_function GO:0003723 8222 336 6994 283 1404 992 1 FALSE 5.28E-11 3.19E-08 0 DNA metabolic process biological_process GO:0006259 8222 248 6994 217 1499 1107 2 FALSE 1.09E-08 5.83E-06 3.34E-291 chromatin modification biological_process GO:0016568 8222 94 6994 78 142 95 1 FALSE 2.16E-08 1.04E-05 5.01E-39 condensed chromosome cellular_component GO:0000793 8222 55 6994 54 200 147 1 FALSE 4.58E-08 2.01E-05 1.30E-50 oxidation reduction biological_process GO:0055114 8222 332 6994 308 3983 3320 1 FALSE 1.23E-07 4.96E-05 0 G-protein coupled receptor protein signaling pathway biological_process GO:0007186 8222 191 6994 175 491 397 1 FALSE 4.12E-07 1.53E-04 8.43E-142 biopolymer modification biological_process GO:0043412 8222 724 6994 620 2528 2010 1 FALSE 4.72E-07 1.63E-04 0 structural constituent of ribosome molecular_function GO:0003735 8222 115 6994 108 284 229 1 FALSE 8.82E-07 2.84E-04 1.17E-82 "chromosome, centromeric region" cellular_component GO:0000775 8222 43 6994 42 168 120 1 FALSE 9.43E-07 2.85E-04 4.50E-41 cytoplasmic part cellular_component GO:0044444 8222 2037 6994 1836 3243 2855 2 FALSE 1.53E-06 4.34E-04 0 purine nucleotide binding molecular_function GO:0017076 8222 1027 6994 903 1195 1026 1 FALSE 2.01E-06 5.40E-04 5.74E-210 lipid metabolic process biological_process GO:0006629 8222 389 6994 352 3499 2888 1 FALSE 2.29E-06 5.84E-04 0 ribonucleoprotein complex cellular_component GO:0030529 8222 299 6994 270 1095 897 2 FALSE 2.85E-06 6.89E-04 5.78E-278 lipid biosynthetic process biological_process GO:0008610 8222 168 6994 151 1806 1396 1 FALSE 8.77E-06 0.002018785 5.71E-242 reproductive structure development biological_process GO:0048608 8222 35 6994 32 52 37 2 FALSE 9.36E-06 0.002055965 4.56E-14 electron carrier activity molecular_function GO:0009055 8222 108 6994 105 7048 5923 1 FALSE 1.02E-05 0.002141264 7.74E-242 regulation of anatomical structure morphogenesis biological_process GO:0022603 8222 37 6994 34 189 119 2 FALSE 1.45E-05 0.002799043 3.54E-40 catabolic process biological_process GO:0009056 8222 588 6994 524 3983 3320 1 FALSE 1.50E-05 0.002799043 0 endomembrane system cellular_component GO:0012505 8222 557 6994 502 6420 5404 1 FALSE 1.51E-05 0.002799043 0 organic acid metabolic process biological_process GO:0006082 8222 303 6994 276 3617 3000 1 FALSE 1.85E-05 0.00331757 0 regulation of multicellular organismal process biological_process GO:0051239 8222 131 6994 109 966 662 2 FALSE 3.73E-05 0.006442317 8.11E-166 generation of precursor metabolites and energy biological_process GO:0006091 8222 138 6994 130 3617 3000 1 FALSE 5.71E-05 0.009520533 8.66E-254 Depleted for segmental duplicates ************************ GO_name GO_namespace ID Pop.total Pop.term Study.total Study.term Pop.family Study.family nparents is.trivial p p.adjusted p.min macromolecule metabolic process biological_process GO:0043170 8222 2930 7640 2846 3983 3746 1 FALSE 4.74E-37 2.37E-33 0 cellular process biological_process GO:0009987 8222 5335 7640 5063 6236 5805 1 FALSE 1.11E-33 2.78E-30 0 binding molecular_function GO:0005488 8222 5631 7640 5300 7048 6514 1 FALSE 1.49E-23 2.49E-20 0 gene expression biological_process GO:0010467 8222 1528 7640 1509 5335 5063 1 FALSE 7.32E-20 9.16E-17 0 biological regulation biological_process GO:0065007 8222 2641 7640 2545 6236 5805 1 FALSE 1.11E-19 1.11E-16 0 membrane-bounded organelle cellular_component GO:0043227 8222 3618 7640 3489 4072 3876 1 FALSE 8.59E-19 7.17E-16 0 primary metabolic process biological_process GO:0044238 8222 3499 7640 3339 3983 3746 1 FALSE 1.02E-17 7.31E-15 0 "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" biological_process GO:0006139 8222 1639 7640 1615 3397 3252 2 FALSE 3.41E-16 2.14E-13 0 structural constituent of ribosome molecular_function GO:0003735 8222 115 7640 113 284 215 1 FALSE 6.09E-16 3.39E-13 1.17E-82 microtubule cytoskeleton cellular_component GO:0015630 8222 205 7640 202 482 414 1 FALSE 3.72E-14 1.86E-11 4.82E-142 transcription regulator activity molecular_function GO:0030528 8222 603 7640 594 7048 6514 1 FALSE 3.00E-12 1.37E-09 0 chromatin modification biological_process GO:0016568 8222 94 7640 94 142 121 1 FALSE 3.42E-12 1.43E-09 5.01E-39 nuclear part cellular_component GO:0044428 8222 607 7640 601 754 726 2 FALSE 8.03E-12 3.09E-09 7.75E-161 biosynthetic process biological_process GO:0009058 8222 1806 7640 1747 3983 3746 1 FALSE 1.73E-11 6.19E-09 0 cell cellular_component GO:0005623 8222 6420 7640 6044 6732 6303 1 FALSE 1.94E-11 6.46E-09 0 biopolymer metabolic process biological_process GO:0043283 8222 2528 7640 2480 2930 2846 1 FALSE 2.76E-11 8.63E-09 0 zinc ion binding molecular_function GO:0008270 8222 859 7640 841 1116 1065 1 FALSE 8.18E-11 2.41E-08 1.02E-260 organelle cellular_component GO:0043226 8222 4072 7640 3876 6732 6303 1 FALSE 1.08E-10 3.00E-08 0 response to DNA damage stimulus biological_process GO:0006974 8222 171 7640 171 473 430 1 FALSE 1.29E-09 3.41E-07 1.03E-133 intracellular cellular_component GO:0005622 8222 5065 7640 4813 6420 6044 1 FALSE 2.24E-08 5.60E-06 0 developmental process biological_process GO:0032502 8222 1487 7640 1426 6236 5805 1 FALSE 1.82E-07 4.35E-05 0 cellular_component cellular_component GO:0005575 8222 6732 7640 6303 8222 7640 1 FALSE 2.50E-07 5.68E-05 0 macromolecular complex cellular_component GO:0032991 8222 1178 7640 1139 6732 6303 1 FALSE 2.72E-07 5.91E-05 0 membrane-enclosed lumen cellular_component GO:0031974 8222 536 7640 525 6732 6303 1 FALSE 1.12E-06 2.33E-04 0 nucleus cellular_component GO:0005634 8222 2125 7640 2075 3615 3486 1 FALSE 2.43E-06 4.87E-04 0 intracellular signaling cascade biological_process GO:0007242 8222 607 7640 598 1169 1122 1 FALSE 2.54E-06 4.90E-04 0 macromolecule localization biological_process GO:0033036 8222 481 7640 472 1444 1365 1 FALSE 4.07E-06 7.55E-04 0 extracellular region part cellular_component GO:0044421 8222 193 7640 179 445 374 2 FALSE 5.30E-06 9.48E-04 1.46E-131 ligase activity molecular_function GO:0016874 8222 223 7640 219 2899 2644 1 FALSE 7.30E-06 0.00126078 0 protein complex cellular_component GO:0043234 8222 849 7640 834 1178 1139 1 FALSE 8.41E-06 0.001404564 3.78E-302 metal ion binding molecular_function GO:0046872 8222 1664 7640 1569 1709 1602 1 FALSE 9.87E-06 0.001595038 7.21E-90 transferase activity molecular_function GO:0016740 8222 992 7640 935 2899 2644 1 FALSE 1.13E-05 0.001765624 0 protein binding molecular_function GO:0005515 8222 3123 7640 2977 5631 5300 1 FALSE 1.27E-05 0.001925217 0 GTPase regulator activity molecular_function GO:0030695 8222 179 7640 173 306 277 1 FALSE 1.58E-05 0.002334356 1.41E-89 cellular response to stimulus biological_process GO:0051716 8222 193 7640 191 683 637 2 FALSE 2.65E-05 0.003786023 7.40E-176 immune effector process biological_process GO:0002252 8222 39 7640 38 109 83 2 FALSE 2.90E-05 0.004031166 1.69E-30 membrane lipid metabolic process biological_process GO:0006643 8222 118 7640 113 341 292 1 FALSE 3.17E-05 0.004291075 6.73E-95 amine biosynthetic process biological_process GO:0009309 8222 40 7640 40 45 41 2 FALSE 3.36E-05 0.004422614 8.18E-07 multicellular organismal process biological_process GO:0032501 8222 1403 7640 1338 6236 5805 1 FALSE 4.57E-05 0.005871905 0 metabolic process biological_process GO:0008152 8222 3983 7640 3746 6236 5805 1 FALSE 5.26E-05 0.00658265 0 transition metal ion binding molecular_function GO:0046914 8222 1116 7640 1065 1473 1384 2 FALSE 5.84E-05 0.007134917 0 neurofilament cytoskeleton organization and biogenesis biological_process GO:0060052 8222 8 7640 8 16 8 1 FALSE 7.77E-05 0.009264809 7.77E-05 Depleted for genes with ancient syteny ************************ GO_name GO_namespace ID Pop.total Pop.term Study.total Study.term Pop.family Study.family nparents is.trivial p p.adjusted p.min excitatory extracellular ligand-gated ion channel activity molecular_function GO:0005231 8222 26 6647 26 36 28 1 FALSE 1.49E-06 0.007087495 3.93E-09 ZEBRAFISH ############################################################################################################################## Enriched for retained WGD duplicates ************************ GO_name GO_namespace ID Pop.total Pop.term Study.total Study.term Pop.family Study.family nparents is.trivial p p.adjusted p.min biological regulation biological_process GO:0065007 4809 1126 1533 538 3296 1083 1 FALSE 9.59E-39 1.20E-35 0 transcription regulator activity molecular_function GO:0030528 4809 392 1533 226 4117 1355 1 FALSE 2.72E-26 1.70E-23 0 molecular transducer activity molecular_function GO:0060089 4809 323 1533 185 4117 1355 1 FALSE 5.71E-21 2.38E-18 0 cell communication biological_process GO:0007154 4809 523 1533 256 2566 843 1 FALSE 6.23E-18 1.95E-15 0 multicellular organismal process biological_process GO:0032501 4809 481 1533 234 3296 1083 1 FALSE 4.99E-15 1.25E-12 0 cytoskeleton cellular_component GO:0005856 4809 140 1533 54 314 63 1 FALSE 6.68E-14 1.39E-11 4.19E-93 "transferase activity, transferring phosphorus-containing groups" molecular_function GO:0016772 4809 311 1533 141 583 191 1 FALSE 1.98E-12 3.53E-10 3.52E-174 DNA binding molecular_function GO:0003677 4809 527 1533 242 883 328 1 FALSE 2.28E-11 3.56E-09 9.77E-258 protein complex cellular_component GO:0043234 4809 301 1533 93 475 104 1 FALSE 2.67E-11 3.70E-09 7.86E-135 post-translational protein modification biological_process GO:0043687 4809 244 1533 119 328 130 1 FALSE 1.45E-09 1.81E-07 1.79E-80 developmental process biological_process GO:0032502 4809 517 1533 229 3296 1083 1 FALSE 2.18E-09 2.48E-07 0 RNA metabolic process biological_process GO:0016070 4809 580 1533 248 736 276 2 FALSE 2.98E-09 3.10E-07 2.18E-164 ion transport biological_process GO:0006811 4809 171 1533 89 541 185 1 FALSE 3.59E-09 3.45E-07 7.09E-146 cytoskeleton organization and biogenesis biological_process GO:0007010 4809 68 1533 32 158 41 1 FALSE 1.45E-07 1.30E-05 1.99E-46 passive transmembrane transporter activity molecular_function GO:0022803 4809 87 1533 61 206 102 1 FALSE 3.40E-07 2.84E-05 2.10E-60 membrane cellular_component GO:0016020 4809 1068 1533 420 2693 908 1 FALSE 4.03E-07 3.15E-05 0 phosphorus metabolic process biological_process GO:0006793 4809 228 1533 106 1754 559 1 FALSE 5.24E-07 3.85E-05 1.71E-293 transferase activity molecular_function GO:0016740 4809 583 1533 191 1699 434 1 FALSE 7.21E-07 5.01E-05 0 kinase activity molecular_function GO:0016301 4809 256 1533 132 311 141 1 FALSE 8.01E-07 5.27E-05 1.62E-62 macromolecule metabolic process biological_process GO:0043170 4809 1478 1533 489 2111 633 1 FALSE 9.26E-07 5.79E-05 0 primary metabolic process biological_process GO:0044238 4809 1736 1533 557 2111 633 1 FALSE 2.17E-06 1.29E-04 0 cellular_component cellular_component GO:0005575 4809 2804 1533 967 4809 1533 1 FALSE 2.38E-06 1.35E-04 0 metal ion transport biological_process GO:0030001 4809 90 1533 56 119 60 1 FALSE 3.82E-06 2.08E-04 2.36E-28 RNA biosynthetic process biological_process GO:0032774 4809 456 1533 240 481 242 2 FALSE 5.32E-06 2.77E-04 2.59E-42 binding molecular_function GO:0005488 4809 2829 1533 991 4117 1355 1 FALSE 9.35E-06 4.68E-04 0 transcription biological_process GO:0006350 4809 523 1533 257 545 258 3 FALSE 1.12E-05 5.39E-04 1.09E-39 sequence-specific DNA binding molecular_function GO:0043565 4809 244 1533 136 527 242 1 FALSE 1.90E-05 8.78E-04 2.77E-157 extracellular region cellular_component GO:0005576 4809 122 1533 64 2804 967 1 FALSE 2.34E-05 0.001043501 3.36E-217 metal ion transmembrane transporter activity molecular_function GO:0046873 4809 60 1533 44 182 94 1 FALSE 3.16E-05 0.001363121 1.24E-49 biosynthetic process biological_process GO:0009058 4809 869 1533 302 2111 633 1 FALSE 4.11E-05 0.001713863 0 growth biological_process GO:0040007 4809 37 1533 24 3296 1083 1 FALSE 6.07E-05 0.002449143 1.15E-87 molecular_function molecular_function GO:0003674 4809 4117 1533 1355 4809 1533 1 FALSE 8.27E-05 0.003229336 0 protein binding molecular_function GO:0005515 4809 761 1533 309 2829 991 1 FALSE 1.06E-04 0.004033662 0 "phosphotransferase activity, alcohol group as acceptor" molecular_function GO:0016773 4809 204 1533 108 311 141 1 FALSE 1.41E-04 0.005178494 2.41E-86 transporter activity molecular_function GO:0005215 4809 317 1533 134 4117 1355 1 FALSE 1.79E-04 0.006401448 0 inorganic anion transport biological_process GO:0015698 4809 19 1533 13 30 13 1 FALSE 2.27E-04 0.007866437 1.83E-08 transmembrane transporter activity molecular_function GO:0022857 4809 206 1533 102 317 134 1 FALSE 2.57E-04 0.008674545 1.51E-88 alkali metal ion binding molecular_function GO:0031420 4809 18 1533 14 759 271 2 FALSE 2.85E-04 0.009360843 1.12E-36 Enriched for genes with bidirectional promoters ************************ none Enriched for genes with PCNEs ************************ GO_name GO_namespace ID Pop.total Pop.term Study.total Study.term Pop.family Study.family nparents is.trivial p p.adjusted p.min transcription regulator activity molecular_function GO:0030528 4809 392 900 207 4117 818 1 FALSE 1.01E-53 1.12E-50 0 nucleic acid binding molecular_function GO:0003676 4809 883 900 324 2829 616 1 FALSE 1.94E-36 1.07E-33 0 gene expression biological_process GO:0010467 4809 770 900 273 2566 546 1 FALSE 6.20E-29 2.29E-26 0 multicellular organismal process biological_process GO:0032501 4809 481 900 187 3296 662 1 FALSE 1.97E-25 5.46E-23 0 developmental process biological_process GO:0032502 4809 517 900 194 3296 662 1 FALSE 3.50E-24 7.76E-22 0 biological regulation biological_process GO:0065007 4809 1126 900 331 3296 662 1 FALSE 3.07E-21 5.67E-19 0 "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" biological_process GO:0006139 4809 820 900 279 1660 408 2 FALSE 4.39E-19 6.95E-17 0 biosynthetic process biological_process GO:0009058 4809 869 900 277 2111 471 1 FALSE 1.41E-18 1.95E-16 0 nucleus cellular_component GO:0005634 4809 818 900 293 1107 329 1 FALSE 2.68E-15 3.30E-13 3.34E-275 organelle cellular_component GO:0043226 4809 1340 900 363 2804 603 1 FALSE 3.70E-12 4.10E-10 0 biopolymer metabolic process biological_process GO:0043283 4809 1255 900 359 1478 380 1 FALSE 5.04E-11 5.08E-09 1.69E-271 DNA binding molecular_function GO:0003677 4809 527 900 236 883 324 1 FALSE 6.30E-10 5.82E-08 9.77E-258 RNA metabolic process biological_process GO:0016070 4809 580 900 243 736 269 2 FALSE 1.15E-09 9.81E-08 2.18E-164 cellular_component cellular_component GO:0005575 4809 2804 900 603 4809 900 1 FALSE 1.98E-09 1.57E-07 0 macromolecule metabolic process biological_process GO:0043170 4809 1478 900 380 2111 471 1 FALSE 2.52E-09 1.86E-07 0 sequence-specific DNA binding molecular_function GO:0043565 4809 244 900 142 527 236 1 FALSE 6.52E-09 4.52E-07 2.77E-157 regulation of metabolic process biological_process GO:0019222 4809 563 900 252 669 271 2 FALSE 6.69E-08 4.36E-06 2.42E-126 molecular_function molecular_function GO:0003674 4809 4117 900 818 4809 900 1 FALSE 1.12E-07 6.89E-06 0 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" molecular_function GO:0016705 4809 34 900 16 266 35 1 FALSE 1.19E-07 6.94E-06 9.58E-44 intracellular cellular_component GO:0005622 4809 1889 900 455 2693 580 1 FALSE 3.00E-07 1.66E-05 0 membrane-bounded organelle cellular_component GO:0043227 4809 1107 900 329 1340 363 1 FALSE 5.62E-07 2.96E-05 4.86E-268 nervous system development biological_process GO:0007399 4809 139 900 75 334 129 1 FALSE 1.03E-06 5.19E-05 7.22E-98 binding molecular_function GO:0005488 4809 2829 900 616 4117 818 1 FALSE 2.43E-06 1.17E-04 0 cellular biopolymer metabolic process biological_process GO:0034960 4809 871 900 284 1244 359 2 FALSE 3.73E-06 1.72E-04 0 metabolic process biological_process GO:0008152 4809 2111 900 471 3296 662 1 FALSE 1.00E-05 4.44E-04 0 RNA biosynthetic process biological_process GO:0032774 4809 456 900 223 481 225 2 FALSE 2.43E-05 0.00103697 2.59E-42 primary metabolic process biological_process GO:0044238 4809 1736 900 416 2111 471 1 FALSE 3.28E-05 0.001347603 0 transcription biological_process GO:0006350 4809 523 900 241 545 242 3 FALSE 3.44E-05 0.001361852 1.09E-39 biological_process biological_process GO:0008150 4809 3296 900 662 4809 900 1 FALSE 1.62E-04 0.006179636 0 monooxygenase activity molecular_function GO:0004497 4809 43 900 14 266 35 1 FALSE 2.14E-04 0.007921073 1.18E-50 Enriched for segmental duplicates ************************ GO_name GO_namespace ID Pop.total Pop.term Study.total Study.term Pop.family Study.family nparents is.trivial p p.adjusted p.min carbohydrate binding molecular_function GO:0030246 4809 53 482 34 2829 264 1 FALSE 3.07E-23 2.47E-20 8.08E-114 monooxygenase activity molecular_function GO:0004497 4809 43 482 19 266 39 1 FALSE 1.47E-07 5.91E-05 1.18E-50 tetrapyrrole binding molecular_function GO:0046906 4809 46 482 17 2829 264 1 FALSE 2.71E-07 7.27E-05 1.33E-101 "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen" molecular_function GO:0016705 4809 34 482 15 266 39 1 FALSE 6.12E-06 0.001229998 9.58E-44 intermediate filament cytoskeleton cellular_component GO:0045111 4809 31 482 14 140 23 1 FALSE 9.56E-06 0.001502352 8.82E-32 electron carrier activity molecular_function GO:0009055 4809 79 482 22 4117 432 1 FALSE 1.12E-05 0.001502352 5.33E-169 non-membrane-bounded organelle cellular_component GO:0043228 4809 314 482 46 1340 115 1 FALSE 2.46E-05 0.002826011 5.5254977E-316 sugar binding molecular_function GO:0005529 4809 40 482 32 53 34 1 FALSE 5.25E-05 0.004686676 1.19E-12 apicolateral plasma membrane cellular_component GO:0016327 4809 31 482 11 119 15 1 FALSE 5.16E-05 0.004686676 2.74E-29 structural molecule activity molecular_function GO:0005198 4809 199 482 39 4117 432 1 FALSE 6.26E-05 0.005030075 0 "transferase activity, transferring alkyl or aryl (other than methyl) groups" molecular_function GO:0016765 4809 12 482 7 583 65 1 FALSE 7.94E-05 0.005801034 3.48E-25 iron ion binding molecular_function GO:0005506 4809 85 482 18 599 54 1 FALSE 1.39E-04 0.009288543 1.22E-105 Enriched for genes with ancient synteny ************************ GO_name GO_namespace ID Pop.total Pop.term Study.total Study.term Pop.family Study.family nparents is.trivial p p.adjusted p.min transcription regulator activity molecular_function GO:0030528 4809 392 528 78 4117 452 1 FALSE 3.13E-08 2.95E-05 0 organelle cellular_component GO:0043226 4809 1340 528 204 2804 337 1 FALSE 3.85E-07 1.81E-04 0 gene expression biological_process GO:0010467 4809 770 528 131 2566 313 1 FALSE 1.31E-06 4.11E-04 0 biosynthetic process biological_process GO:0009058 4809 869 528 141 2111 259 1 FALSE 2.93E-06 6.89E-04 0 Depleted for retained WGD duplicates ************************ GO_name GO_namespace ID Pop.total Pop.term Study.total Study.term Pop.family Study.family nparents is.trivial p p.adjusted p.min catalytic activity molecular_function GO:0003824 4809 1699 3277 1266 4117 2763 1 FALSE 8.69E-18 1.62E-14 0 RNA processing biological_process GO:0006396 4809 92 3277 85 567 320 2 FALSE 2.25E-16 2.10E-13 1.44E-108 ncRNA metabolic process biological_process GO:0034660 4809 51 3277 50 580 332 1 FALSE 3.38E-12 2.10E-09 1.74E-74 macromolecular complex cellular_component GO:0032991 4809 475 3277 371 2804 1838 1 FALSE 5.46E-11 2.55E-08 0 cytoplasm cellular_component GO:0005737 4809 773 3277 602 1611 1134 1 FALSE 1.46E-10 5.46E-08 0 DNA metabolic process biological_process GO:0006259 4809 97 3277 85 736 460 2 FALSE 4.54E-09 1.41E-06 5.92E-124 structural molecule activity molecular_function GO:0005198 4809 199 3277 168 4117 2763 1 FALSE 1.28E-08 3.42E-06 0 structural constituent of ribosome molecular_function GO:0003735 4809 92 3277 91 199 168 1 FALSE 1.59E-08 3.69E-06 3.87E-59 intracellular cellular_component GO:0005622 4809 1889 3277 1315 2693 1786 1 FALSE 2.47E-08 5.12E-06 0 non-membrane-bounded organelle cellular_component GO:0043228 4809 314 3277 251 1340 921 1 FALSE 3.50E-07 6.52E-05 5.5254977E-316 carbohydrate binding molecular_function GO:0030246 4809 53 3277 50 2829 1838 1 FALSE 4.03E-07 6.82E-05 8.08E-114 apicolateral plasma membrane cellular_component GO:0016327 4809 31 3277 28 119 64 1 FALSE 8.62E-07 1.34E-04 2.74E-29 macromolecule localization biological_process GO:0033036 4809 157 3277 126 594 385 1 FALSE 9.37E-07 1.34E-04 2.81E-148 ribonucleoprotein complex cellular_component GO:0030529 4809 156 3277 146 409 338 2 FALSE 1.27E-06 1.69E-04 2.06E-117 metabolic process biological_process GO:0008152 4809 2111 3277 1479 3296 2214 1 FALSE 1.62E-06 2.01E-04 0 oxidation reduction biological_process GO:0055114 4809 128 3277 111 2111 1479 1 FALSE 4.77E-06 5.55E-04 5.74E-209 cell-cell junction cellular_component GO:0005911 4809 33 3277 28 59 35 1 FALSE 7.67E-06 8.41E-04 2.53E-17 protein metabolic process biological_process GO:0019538 4809 745 3277 538 1473 986 2 FALSE 8.36E-06 8.66E-04 0 death biological_process GO:0016265 4809 55 3277 45 517 288 1 FALSE 1.74E-05 0.001705306 1.43E-75 cell cellular_component GO:0005623 4809 2693 3277 1786 2804 1838 1 FALSE 2.84E-05 0.002548782 3.17E-202 electron carrier activity molecular_function GO:0009055 4809 79 3277 69 4117 2763 1 FALSE 2.87E-05 0.002548782 5.33E-169 cellular response to stimulus biological_process GO:0051716 4809 54 3277 49 128 93 2 FALSE 5.33E-05 0.004313735 1.98E-37 nucleotidyltransferase activity molecular_function GO:0016779 4809 47 3277 38 311 170 1 FALSE 5.20E-05 0.004313735 6.98E-57 organic acid metabolic process biological_process GO:0006082 4809 98 3277 83 1754 1196 1 FALSE 1.09E-04 0.008457921 1.81E-163 mRNA metabolic process biological_process GO:0016071 4809 43 3277 36 580 332 1 FALSE 1.30E-04 0.009280734 4.44E-66 RNA binding molecular_function GO:0003723 4809 118 3277 92 883 555 1 FALSE 1.28E-04 0.009280734 4.02E-150 Depleted for genes with bidirectional promoters ************************ GO_name GO_namespace ID Pop.total Pop.term Study.total Study.term Pop.family Study.family nparents is.trivial p p.adjusted p.min biological regulation biological_process GO:0065007 4809 1126 4590 1099 3296 3144 1 FALSE 3.56E-06 0.007341719 0 Depleted for genes with PCNEs ************************ GO_name GO_namespace ID Pop.total Pop.term Study.total Study.term Pop.family Study.family nparents is.trivial p p.adjusted p.min cytoplasm cellular_component GO:0005737 4809 773 3913 669 1611 1214 1 FALSE 2.13E-24 4.21E-21 0 protein metabolic process biological_process GO:0019538 4809 745 3913 637 1473 1094 2 FALSE 5.29E-24 5.21E-21 0 catalytic activity molecular_function GO:0003824 4809 1699 3913 1441 4117 3303 1 FALSE 2.43E-10 1.60E-07 0 membrane cellular_component GO:0016020 4809 1068 3913 903 2693 2116 1 FALSE 3.33E-10 1.64E-07 0 DNA metabolic process biological_process GO:0006259 4809 97 3913 87 736 468 2 FALSE 5.99E-10 2.36E-07 5.92E-124 ncRNA metabolic process biological_process GO:0034660 4809 51 3913 47 580 338 1 FALSE 2.62E-08 8.60E-06 1.74E-74 organelle part cellular_component GO:0044422 4809 426 3913 347 1340 978 2 FALSE 7.83E-07 2.21E-04 0 purine nucleotide binding molecular_function GO:0017076 4809 563 3913 492 696 584 1 FALSE 1.24E-06 2.82E-04 9.28E-147 non-membrane-bounded organelle cellular_component GO:0043228 4809 314 3913 261 1340 978 1 FALSE 1.29E-06 2.82E-04 5.5254977E-316 RNA processing biological_process GO:0006396 4809 92 3913 72 567 325 2 FALSE 4.22E-06 8.33E-04 1.44E-108 G-protein coupled receptor protein signaling pathway biological_process GO:0007186 4809 86 3913 82 184 151 1 FALSE 4.98E-06 8.93E-04 1.02E-54 biopolymer modification biological_process GO:0043412 4809 347 3913 278 1255 897 1 FALSE 1.27E-05 0.002082197 1.7277E-320 nucleotide binding molecular_function GO:0000166 4809 696 3913 584 2829 2216 1 FALSE 1.65E-05 0.002495715 0 death biological_process GO:0016265 4809 55 3913 48 517 324 1 FALSE 2.10E-05 0.002960194 1.43E-75 regulation of developmental process biological_process GO:0050793 4809 61 3913 46 313 162 2 FALSE 2.54E-05 0.003331787 1.58E-66 cell communication biological_process GO:0007154 4809 523 3913 445 2566 2023 1 FALSE 3.54E-05 0.00435997 0 translation regulator activity molecular_function GO:0045182 4809 43 3913 43 4117 3303 1 FALSE 7.29E-05 0.008446387 2.82E-103 Depleted for segmental duplicates ************************ GO_name GO_namespace ID Pop.total Pop.term Study.total Study.term Pop.family Study.family nparents is.trivial p p.adjusted p.min cellular process biological_process GO:0009987 4809 2566 4330 2360 3296 2986 1 FALSE 7.92E-07 0.001623584 0 primary metabolic process biological_process GO:0044238 4809 1736 4330 1590 2111 1904 1 FALSE 8.74E-06 0.008952152 0 Depleted for genes with ancient synteny ************************ none