Supplemental Table 3: Process-specific performance of data integration. Each column in the table represents one of four data integration schemes (classifiers trained and evaluated for individual processes, process-specific classifiers trained for specific processes and reintegrated, a single process-independent classifier trained globally and evaluated for individual processes, or an unregularized global classifier), and each scheme is evaluated using the entire genome or a set of ~6,000 holdout genes. Each cell in the table represents the AUPRC over the precision (functional relationships) and recall (genes) in each of the 229 analyzed processes, sorted in order of decreasing number of genes. This performance evaluates predicted functional relationships using a gold standard derived from multiple curated functional catalogs (including the Gene Ontology, KEGG, and others); each process's performance is evaluated using the subset of this gold standard associated with the process (see Methods). While there is a clear correlation between process size and performance (due to the fact that more training data makes the machine learning task easier), certain processes are also predicted more accurately than others independent of size, such as defense response to virus or protein polymerization. The most specific classifiers overfit somewhat to the smallest terms, but this effect is mitigated in larger terms or by reintegration into the process-specific classifier. For medium and large processes, increased specificity provides increased performance, with individual process classifiers outperforming the process-specific classifier, which in turn outperforms the process-independent classifier. Finally, the unregularized classifier is outperformed in essentially every process.

Term	Size	All genes, individual processes	Holdout genes, individual processes	All genes, process-specific	Holdout genes, process-specific	Holdout genes, process-independent	All genes, process-independent	All genes, process-independent, unregularized
organismal physiological process	2382	0.402833594	0.39555938	0.426638112	0.41447114	0.441419807	0.446231334	0.341625183
cell surface receptor linked signal transduction	1636	0.348251956	0.342738892	0.46532733	0.326584701	0.471335526	0.366036834	0.219275968
phosphorus metabolism	857	0.353788921	0.337178762	0.268149911	0.204764516	0.262956623	0.213784841	0.107053983
ion transport	725	0.251432011	0.244409846	0.269577015	0.254090399	0.255838248	0.265278219	0.132101693
cell death	721	0.3489487	0.345823251	0.278384201	0.237289193	0.273877064	0.231950595	0.101184006
cell adhesion	663	0.272660721	0.27255052	0.249846464	0.206522452	0.262229548	0.219827806	0.09525396
lipid metabolism	648	0.217517493	0.184910125	0.105766593	0.077831859	0.099749396	0.080843365	0.052647347
establishment of protein localization	641	0.131770568	0.129931096	0.122986986	0.07784283	0.118342614	0.081959987	0.051090433
proteolysis	638	0.166293524	0.150639149	0.127482174	0.11270801	0.124764117	0.120673218	0.062519726
transcription from RNA polymerase II promoter	579	0.275759985	0.273674709	0.215125572	0.174931612	0.209125669	0.178612771	0.060645543
regulation of progression through cell cycle	496	0.251313281	0.258899832	0.233530757	0.165906864	0.23537375	0.170706473	0.124882611
organic acid metabolism	459	0.159734371	0.154372863	0.091187857	0.063635489	0.089937788	0.064080069	0.041773404
ubiquitin cycle	449	0.089890822	0.089553886	0.096031144	0.064276917	0.093669318	0.065975042	0.042714882
carbohydrate metabolism	448	0.120926975	0.095369476	0.065705333	0.046054643	0.064477458	0.04680206	0.028899974
cytoskeleton organization and biogenesis	421	0.323340459	0.297590274	0.230560366	0.120836176	0.211848016	0.134855409	0.086344934
vesicle mediated transport	417	0.214336325	0.181992669	0.178647372	0.118764386	0.167615804	0.1197201	0.043232933
regulation of cell proliferation	404	0.274787021	0.248720206	0.141072952	0.127223667	0.143747029	0.124364325	0.054004241
regulation of catalytic activity	403	0.254081433	0.229981994	0.142090364	0.11463607	0.138655194	0.117688902	0.054371831
nitrogen compound metabolism	401	0.152689148	0.138640493	0.07799608	0.061902405	0.076607877	0.064416641	0.038256606
regulation of signal transduction	392	0.19640903	0.17349343	0.113316879	0.069948404	0.110120137	0.072491059	0.037535687
cell morphogenesis	389	0.288406229	0.237295729	0.164376996	0.121811687	0.161020305	0.136492218	0.053037163
response to wounding	375	0.357808027	0.331924278	0.266451399	0.234444666	0.280464619	0.239610674	0.13185694
electron transport	367	0.1615177	0.159684259	0.158946059	0.089709574	0.155187134	0.087439701	0.074454861
small GTPase mediated signal transduction	355	0.216006204	0.200400615	0.125210848	0.095935086	0.114779561	0.092062315	0.023942922
protein kinase cascade	347	0.365685593	0.316531702	0.254435613	0.180895952	0.245015023	0.187459192	0.043809363
chromosome organization and biogenesis (sensu Eukaryota)	320	0.222060149	0.212562624	0.249344136	0.15626678	0.223568398	0.165070957	0.0462165
protein complex assembly	312	0.179214347	0.176787174	0.139773204	0.107715489	0.12255105	0.11146766	0.056238224
amino acid and derivative metabolism	295	0.121744785	0.122513967	0.069187177	0.048307802	0.067660545	0.049810959	0.033611814
DNA packaging	292	0.292957575	0.259368086	0.376757861	0.297672351	0.33733285	0.3140436	0.051601503
response to DNA damage stimulus	280	0.162887283	0.160942706	0.1787488	0.1433004	0.164803399	0.149137997	0.128258316
sexual reproduction	280	0.06406893	0.046021589	0.029714125	0.032960846	0.030820969	0.034056385	0.025941691
alcohol metabolism	277	0.095296574	0.074647911	0.050898642	0.03218226	0.050645377	0.034041607	0.022347816
mRNA metabolism	266	0.136169986	0.135341698	0.150320243	0.082169919	0.150737284	0.087724298	0.052866699
negative regulation of transcription	259	0.163035565	0.142924783	0.084540716	0.071038961	0.083402146	0.071435004	0.027755719
mitotic cell cycle	258	0.32748639	0.312854633	0.308120154	0.186375609	0.296946357	0.207799591	0.264579603
positive regulation of transcription	255	0.193812544	0.181923481	0.118916357	0.078059953	0.117775047	0.081260244	0.03018729
M phase	236	0.340282024	0.329320152	0.340589683	0.217203802	0.334449966	0.243275224	0.29010108
protein folding	220	0.085007001	0.083897362	0.099778976	0.069288143	0.097860812	0.076633215	0.04790717
generation of neurons	219	0.131589978	0.099682435	0.10536196	0.077022347	0.102379939	0.094180221	0.034518712
second messenger mediated signaling	216	0.165541263	0.141992355	0.155598358	0.151519671	0.15179292	0.127106462	0.06255103
cell division	212	0.266950873	0.264965521	0.328698176	0.27918504	0.317039919	0.285259767	0.1863651
nucleotide metabolism	208	0.127015432	0.093687347	0.118308015	0.083283673	0.112166777	0.094998728	0.03901854
skeletal development	206	0.168900654	0.144282692	0.181320862	0.168592918	0.197302222	0.167597115	0.053547566
cell migration	205	0.116809846	0.093225808	0.080009268	0.05976059	0.080942694	0.059986669	0.038456318
central nervous system development	197	0.117114411	0.094132957	0.052812191	0.063355947	0.052754403	0.062603996	0.033889717
RNA splicing	197	0.125771407	0.129717948	0.19569593	0.187898865	0.19247379	0.190290617	0.081206423
cofactor metabolism	192	0.094548459	0.082278721	0.079822819	0.050134287	0.078323467	0.054408703	0.048013402
DNA replication	178	0.234960555	0.233099016	0.271128248	0.199257258	0.255095466	0.208462453	0.218130532
ion homeostasis	173	0.098997615	0.089498982	0.095074189	0.082788775	0.097872053	0.083944318	0.047703662
regulation of protein biosynthesis	157	0.113266795	0.105561667	0.07405875	0.057606566	0.072914128	0.057850858	0.042581004
ectoderm development	149	0.230734249	0.201469494	0.190769869	0.1788984	0.169524468	0.168026792	0.060500974
muscle development	146	0.15363555	0.083526569	0.082195954	0.065154703	0.084220837	0.065557624	0.030858703
glycoprotein metabolism	145	0.142155039	0.07986914	0.046422039	0.02466178	0.04344086	0.025447907	0.010710957
vasculature development	143	0.223778132	0.128076481	0.064165244	0.071596145	0.070472069	0.074304711	0.033900732
chemotaxis	137	0.174720772	0.155792961	0.117786921	0.091051084	0.119759055	0.092390484	0.062338303
translation	136	0.110289696	0.101564793	0.121630351	0.111864347	0.119123915	0.127982997	0.110007699
nucleocytoplasmic transport	129	0.08167124	0.070414995	0.106224149	0.090223626	0.100077561	0.084040908	0.021780009
nuclear transport	118	0.062009893	0.047726134	0.049714926	0.043269046	0.050769784	0.046530421	0.015513339
regulation of cell differentiation	117	0.122052024	0.058050787	0.036927949	0.029005338	0.036106625	0.030592192	0.012961574
cytoskeleton dependent intracellular transport	110	0.187824699	0.15040946	0.103264733	0.05468087	0.093768357	0.052618554	0.037596046
aromatic compound metabolism	108	0.139422185	0.063404429	0.047058071	0.026551907	0.042481113	0.024898087	0.012096919
reproductive physiological process	102	0.180684907	0.146610065	0.178765754	0.18583131	0.162280182	0.167621163	0.042013852
tRNA metabolism	101	0.074551654	0.067520228	0.060291177	0.056660436	0.058459446	0.057739047	0.048864783
DNA recombination	94	0.069714631	0.051179222	0.048242368	0.035172638	0.045652148	0.036651515	0.019059527
response to bacterium	94	0.080483027	0.043069701	0.033749772	0.030084767	0.034376524	0.03130371	0.033078558
regulation of transport	93	0.159764352	0.041781918	0.024189963	0.023828622	0.023349929	0.023996086	0.014847691
peptidyl amino acid modification	92	0.181400338	0.076987878	0.049457843	0.028070332	0.04618005	0.02770364	0.015702508
coagulation	90	0.157620779	0.123635751	0.120419112	0.085936103	0.133609253	0.088932607	0.053411473
oxygen and reactive oxygen species metabolism	87	0.056986234	0.018028115	0.016099439	0.015167854	0.016387389	0.015372021	0.01412962
heart development	86	0.143240697	0.094548566	0.102527908	0.070909562	0.096709441	0.070675483	0.015932452
positive regulation of protein metabolism	85	0.285182497	0.113169277	0.060077994	0.050146	0.058450871	0.053433703	0.035166607
biomineral formation	84	0.097238016	0.063054209	0.075549429	0.071240822	0.08069636	0.071959256	0.028509869
lipid transport	82	0.346932244	0.236065225	0.197808355	0.118901537	0.175018936	0.159488988	0.016406996
negative regulation of protein metabolism	81	0.305210011	0.105591698	0.051655872	0.030281343	0.04258734	0.030514826	0.010696001
one carbon compound metabolism	80	0.115665356	0.048068426	0.067963893	0.051917648	0.051124411	0.046024386	0.005046886
hydrogen transport	80	0.117478388	0.103205858	0.095391989	0.042390433	0.101444288	0.046093688	0.055252352
cell fate commitment	79	0.114164845	0.0603916	0.060619174	0.066142354	0.063117425	0.058042455	0.016220396
response to radiation	79	0.106901157	0.044691613	0.046274272	0.043114119	0.046675888	0.041518578	0.02792859
interphase	77	0.264622489	0.235975275	0.285260321	0.296731696	0.287218335	0.296202105	0.141171083
cytokine metabolism	73	0.09187433	0.057713379	0.036094536	0.031418141	0.035639649	0.02954735	0.024472246
hormone metabolism	73	0.078885285	0.05173725	0.045631113	0.027843459	0.046473764	0.025801795	0.013819345
protein processing	72	0.196967653	0.069701334	0.083529592	0.052567385	0.080341839	0.049388539	0.008287996
cellular defense response	71	0.14980949	0.101691516	0.064229941	0.048286329	0.061428193	0.046441169	0.039654402
heterocycle metabolism	66	0.042542886	0.017736849	0.019371063	0.01147649	0.020203295	0.011938724	0.007545842
sulfur metabolism	66	0.112540799	0.034227459	0.025441027	0.009756471	0.019639166	0.009308933	0.003639975
organic acid transport	64	0.114844357	0.0338038	0.039055966	0.022478634	0.03916662	0.019505562	0.011423749
stress activated protein kinase signaling pathway	64	0.427340116	0.256649226	0.276216187	0.201180967	0.255132223	0.192039648	0.01496462
nucleobase, nucleoside, nucleotide and nucleic acid transport	64	0.069796888	0.059728374	0.070981255	0.049268007	0.06628792	0.053618413	0.02103428
vitamin metabolism	62	0.146223638	0.014322753	0.007185677	0.005748445	0.008267052	0.005342236	0.00325152
morphogenesis of an epithelium	61	0.11943033	0.04004014	0.030870333	0.034974749	0.032583879	0.035751698	0.018189081
embryonic development (sensu Vertebrata)	61	0.250112599	0.047536793	0.050713381	0.039946785	0.043895161	0.043110307	0.00669251
lipoprotein metabolism	60	0.13806483	0.062429226	0.04316191	0.045390179	0.04735238	0.03547997	0.005122943
amine transport	60	0.414980401	0.190952373	0.152716999	0.172492934	0.13428541	0.163693616	0.008062885
rRNA metabolism	59	0.070626758	0.04251346	0.058731898	0.02031019	0.048683313	0.029838823	0.012600841
chromosome segregation	59	0.151379612	0.11503827	0.094640298	0.046749082	0.0935144	0.049246286	0.101501853
meiotic cell cycle	58	0.08134642	0.042036645	0.033334679	0.018658189	0.033909786	0.019319884	0.013980922
transcription initiation	57	0.205402816	0.247605413	0.123807863	0.13242466	0.108912603	0.123256986	0.012626301
sensory organ development	56	0.037729406	0.019329848	0.023366972	0.019526858	0.018855481	0.020372692	0.01465006
ribosome biogenesis	55	0.083603246	0.039544866	0.060237294	0.020567881	0.049744575	0.030936882	0.012585376
establishment of RNA localization	55	0.071954692	0.055374893	0.063925473	0.06100808	0.055457694	0.057325965	0.029616831
intracellular receptor mediated signaling pathway	53	0.197175403	0.127345601	0.109774242	0.080824688	0.109085539	0.083829249	0.006958714
regulation of cell motility	51	0.29224299	0.097300143	0.054462985	0.031999434	0.054344979	0.031525823	0.005079196
anterior posterior pattern formation	51	0.078225009	0.031047519	0.019627289	0.014419796	0.018629539	0.017833796	0.002677771
protein polymerization	51	0.464603917	0.465136264	0.37698653	0.42793379	0.402530949	0.419048963	0.074241796
mesoderm development	51	0.159113457	0.044378829	0.039733408	0.026439254	0.037994723	0.024284912	0.008566003
viral life cycle	50	0.185166429	0.012801453	0.011733427	0.007202962	0.011803593	0.009334941	0.007085651
neurotransmitter transport	48	0.040114943	0.010511743	0.021633402	0.016034564	0.020901013	0.013543799	0.005551758
detection of external stimulus	48	0.059206101	0.03377546	0.033784681	0.027547027	0.034066719	0.026975403	0.01940363
cell redox homeostasis	47	0.08908286	0.017442974	0.045062576	0.048022203	0.042588578	0.045097898	0.021297338
mitochondrial transport	47	0.122169566	0.131809699	0.192801736	0.163439469	0.16324882	0.167676141	0.005305339
development of primary sexual characteristics	47	0.128595031	0.033719772	0.010960979	0.010653027	0.011400022	0.011131651	0.005400947
RNA catabolism	46	0.04511649	0.023047974	0.031866301	0.013989799	0.031598639	0.014428655	0.004730755
response to unfolded protein	45	0.094035757	0.053599361	0.050968191	0.033780607	0.044879375	0.031982382	0.00427073
regulation of DNA metabolism	43	0.077942034	0.046023066	0.044565186	0.037417754	0.041488337	0.043432038	0.024798556
regulation of gene expression, epigenetic	42	0.137448155	0.016343573	0.012745239	0.009888334	0.011544613	0.010165475	0.004976305
energy reserve metabolism	42	0.311981054	0.050991631	0.028449709	0.023642181	0.028572388	0.024997916	0.01004918
regulation of secretion	41	0.133332573	0.017114505	0.008771508	0.008638931	0.008663226	0.008658248	0.006743907
detection of abiotic stimulus	41	0.127641689	0.034516995	0.100860621	0.070505151	0.089705013	0.062106009	0.012934685
carbohydrate transport	41	0.153489323	0.012448668	0.020872316	0.009228998	0.019522228	0.008623535	0.005831131
appendage development	40	0.115776359	0.021982097	0.041888568	0.022018287	0.044375382	0.02017788	0.008525918
cellular respiration	40	0.07669824	0.072306826	0.055228638	0.051925013	0.059392365	0.053760526	0.041376638
gastrulation	39	0.206953172	0.044155287	0.035529764	0.02998426	0.034215798	0.027835926	0.00589549
regulated secretory pathway	39	0.066183209	0.028697004	0.022186514	0.017990023	0.019600526	0.018412121	0.016011278
secondary metabolism	39	0.166480347	0.013205627	0.045960571	0.020640008	0.039807693	0.019444968	0.004631499
muscle cell differentiation	38	0.088429182	0.005731671	0.005432578	0.006980117	0.009766644	0.005731441	0.001574813
negative regulation of cell organization and biogenesis	37	0.200739654	0.041876388	0.031032446	0.01472753	0.028462589	0.011963577	0.008469585
negative regulation of biosynthesis	36	0.070410775	0.000694697	0.000705384	0.002179141	0.000638412	0.00196102	0.001048853
protein depolymerization	35	0.717453204	0.107842057	0.10108009	0.060018744	0.073059756	0.082272758	0.005369679
morphogenesis of a branching structure	35	0.058871	0.020032673	0.008345852	0.006932565	0.010378551	0.007455201	0.003523336
protein amino acid ADP ribosylation	34	0.502931361	0.012867152	0.037848764	0.006906477	0.030203761	0.007797355	0.001869905
learning and or memory	34	0.03121324	0.003893956	0.01533209	0.008311577	0.013655207	0.008787337	0.003179702
respiratory tube development	34	0.259031072	0.023378577	0.081740619	0.033657108	0.067398363	0.034078432	0.00767059
membrane fusion	33	0.091639102	0.019316186	0.011127367	0.007271965	0.01027649	0.008386092	0.003396293
response to xenobiotic stimulus	33	0.069135445	0.03044493	0.021614861	0.014838133	0.016692637	0.014533166	0.008163482
urogenital system development	33	0.491946956	0.099143228	0.102736783	0.096354262	0.103306774	0.101788157	0.005539905
feeding behavior	32	0.067841684	0.040786279	0.034779547	0.034101943	0.03666127	0.033999168	0.018789564
keratinocyte differentiation	31	0.210255486	0.068874166	0.013483352	0.031584873	0.013827358	0.031086092	0.019686107
response to hormone stimulus	31	0.517601552	0.149824392	0.194239975	0.205856859	0.194363294	0.188725081	0.028626696
male sex differentiation	29	0.42905201	0.015330063	0.001482535	0.002777216	0.001350945	0.003053556	0.002587562
gland development	29	0.045587489	0.000837838	0.005811217	0.001207295	0.00813899	0.001170559	0.001061915
nucleoside metabolism	29	0.045443332	0.016047293	0.016704358	0.012443819	0.016432937	0.013433767	0.010543889
response to temperature stimulus	29	0.118321104	0.008861366	0.006936687	0.009568753	0.006953228	0.009264583	0.007040104
odontogenesis	28	0.332214107	0.0553522	0.074711647	0.060493141	0.074432738	0.066659205	0.004922936
peptide transport	28	0.503238772	0.028662543	0.041296211	0.023442641	0.030798991	0.02619337	0.011059091
interspecies interaction between organisms	28	0.121134108	0.001973647	0.00633832	0.005881938	0.005833286	0.005886272	0.005772721
embryonic pattern specification	28	0.046022086	0.011681995	0.011593438	0.006583039	0.007978141	0.007285383	0.004504423
transcription from RNA polymerase III promoter	27	0.081144977	0.033332344	0.032912579	0.041125714	0.032310088	0.03906565	0.00218792
mitochondrion organization and biogenesis	27	0.13968023	0.037226098	0.033321444	0.019370225	0.030228675	0.018282769	0.011212675
mesenchymal cell differentiation	26	0.108400039	0.007141661	0.01440722	0.016352128	0.016488912	0.016424125	0.004708919
female sex differentiation	26	0.130594346	0.01451721	0.007281441	0.008878726	0.007876811	0.00920345	0.004335596
synapse organization and biogenesis	25	0.083578179	0.038129194	0.024258125	0.018210036	0.02198685	0.018164243	0.010001887
dorsal ventral pattern formation	25	0.002790431	0.000368841	5.77E-05	0.000478466	4.51E-05	0.000462195	0.000444218
vacuole organization and biogenesis	25	0.569950995	0.02546354	0.048957521	0.021945124	0.049142888	0.020787267	0.00777893
hormone secretion	24	0.112341064	0.011948965	0.004923268	0.004533152	0.004666629	0.004502039	0.004357575
gliogenesis	23	0.118795061	0.021014106	0.011305279	0.011465218	0.011334967	0.010923221	0.006087954
peripheral nervous system development	23	0.105857453	0.016467195	0.014853349	0.012400201	0.014097669	0.012492383	0.015778395
glycerol ether metabolism	23	0.512106165	0.008112142	0.025818325	0.014515205	0.022490922	0.014612596	0.005085351
peptide metabolism	23	0.157525297	0.011969937	0.034543612	0.018620229	0.021774163	0.019295658	0.001307989
biopolymer biosynthesis	23	0.09811418	0.009137162	0.008694473	0.007993673	0.00899294	0.008535488	0.003556603
regulation of binding	23	0.635695111	0.140531596	0.16480823	0.17093719	0.162880216	0.17229689	0.052354654
maintenance of protein localization	22	0.035640456	0.006604191	0.004149527	0.000752283	0.000249294	0.000732933	0.001547157
cell recognition	22	0.099295039	0.010781479	0.011715799	0.005566051	0.008877762	0.005989384	0.003381676
segmentation	22	0.088373695	0.004743116	0.01163744	0.004434055	0.011330972	0.006148994	0.000395878
protein amino acid alkylation	21	0.068328131	0.004870537	0.002834345	0.002057992	0.002292466	0.002132935	0.003559842
response to hypoxia	21	0.498712567	0.056609985	0.030982917	0.025522215	0.029028903	0.025094378	0.012575719
protein amino acid acetylation	21	0.283842967	0.068691688	0.09130396	0.099487204	0.088727525	0.100081628	0.038116757
chromosome condensation	21	0.073487387	0.052195468	0.026620672	0.007652912	0.025088037	0.009676499	0.021872934
DNA catabolism	20	0.132304804	0.008255301	0.013249598	0.005821603	0.011082488	0.005860828	0.005407829
circadian rhythm	20	0.447783169	0.199110291	0.138510885	0.148027999	0.139495138	0.106259442	0.002327567
epithelial cell proliferation	20	0.622488148	0.005573351	0.032347631	0.03293996	0.03105734	0.032440645	0.003093192
autophagy	20	0.619063114	0.001021605	0.017277344	0.010488534	0.017717808	0.01055214	0.000532059
activation of NF kappaB transcription factor	19	0.213744899	0.014324767	0.011807794	0.010624824	0.011540512	0.011300571	0.000881146
gene silencing	19	0.21735945	0.001742524	0.011018289	0.014113612	0.010652079	0.013999804	0.001139875
vacuolar transport	19	0.006506301	1.00E-10	0.003170121	0.000283235	0.001168226	0.000397781	0.000131556
ER nuclear signaling pathway	18	0.082545159	0.007724688	0.008966513	0.005998992	0.007434896	0.005302259	0.000760289
regulation of RNA metabolism	18	0.043105209	0.006544049	0.005476761	0.001806652	0.005506559	0.001867392	0.001909218
peroxisome organization and biogenesis	18	0.029982949	0.006638324	0.004929044	0.004792637	0.004646341	0.004770329	0.00152568
DNA modification	18	0.091893879	0.010553079	0.007472249	0.008330994	0.006703013	0.008227232	0.007507447
regulation of body size	18	0.077816941	0.01347062	0.009186647	0.007313272	0.008664219	0.00717747	0.003651367
sex determination	18	0.639060939	0.000217865	0.00255159	0.00169828	0.001829786	0.001549301	0.002132081
embryonic organ development	18	0.047847308	0.000430272	0.001739843	0.000179398	0.000389384	0.000167535	0.000240558
endocrine system development	18	0.123037233	0.011676805	0.006925761	0.003573436	0.006568965	0.003473349	0.003498288
aging	17	0.093963728	0.006665068	0.006106451	0.000260675	0.005321451	0.000494632	0.000833259
intercellular junction assembly and maintenance	17	0.100653384	0.015072167	0.01714936	0.012676596	0.016578034	0.012248535	0.004295508
response to nutrient	17	0.286192261	0.011020741	0.016509847	0.015994616	0.016319342	0.01421935	0.003455104
microtubule organizing center organization and biogenesis	17	0.156372387	0.008596427	0.006626857	0.002273353	0.005844521	0.003892328	0.020927364
glucose homeostasis	17	0.07219641	0.005906492	0.003630468	0.005946081	0.00357161	0.00587536	0.005405797
detection of chemical stimulus	17	0.281839153	0.003007021	0.01814728	0.000858528	0.004635369	0.000941951	0.013531441
negative regulation of locomotion	17	0.57439337	0.023300086	0.001957858	0.001390646	0.000604024	0.001349186	0.00151299
peptide cross linking	17	0.13080824	0.041314742	0.061650074	0.047932701	0.065012596	0.03520522	0.024103469
response to inorganic substance	17	0.206559138	0.000696485	0.006761759	0.00591899	0.006476003	0.006101373	0.001107536
axis specification	16	0.251462728	0.001519585	0.00292835	0.003320585	0.001905425	0.003700429	0.001340759
determination of symmetry	16	0.714133586	0.002671551	0.023504803	0.020956555	0.022724613	0.018297234	0.001291687
response to toxin	16	0.226674498	1.00E-10	0.006267713	0.004531375	0.006470156	0.004632486	0.001276785
gas transport	16	0.133083625	0.007479479	0.021830959	0.012235327	0.01978096	0.011775627	0.007693748
protein chromophore linkage	15	0.029925979	0.005744288	0.003415335	0.002192488	0.003281379	0.003118233	0.002059741
fat cell differentiation	15	0.211519548	0.015841917	0.02022178	0.012318891	0.020213567	0.011844137	0.000236455
RNA 3' end processing	15	0.127991453	7.12E-05	8.77E-05	0.000393291	0.000228657	0.000489378	0.000827183
detection of biotic stimulus	15	0.03428486	0.013213936	0.006943975	0.006528468	0.006882834	0.007045661	0.006135675
aldehyde metabolism	14	0.912697182	0.002409599	0.101483669	0.038998945	0.063737546	0.016064931	0.002106476
protein amino acid deacetylation	14	0.052197802	0.019119769	0.018052229	0.011674274	0.018024122	0.011724497	0.002475042
RNA elongation	14	0.042402948	0.003279139	0.005182655	0.002495	0.004945921	0.00245431	0.002414343
mechanoreceptor differentiation	13	0.002339054	1.00E-10	1.00E-10	0.0002777	1.00E-10	0.000196961	0.000531436
vitamin transport	13	0.646523743	0.00085253	0.001385186	0.001463945	0.000894269	0.001134625	0.001069173
regulation of membrane potential	13	0.066410701	0.015823136	0.010107686	0.007776085	0.009720074	0.007564189	0.001272719
response to mechanical stimulus	13	0.181627948	0.000207292	0.004735731	0.004377104	0.004084339	0.004728101	0.005852026
pigmentation	13	0.030972052	1.00E-10	0.002278302	0.002755342	0.002203061	0.002898112	0.002535176
response to carbohydrate stimulus	13	0.040499773	0.009664224	0.007371097	0.008407992	0.007816447	0.008187959	0.006011672
placenta development	13	0.715255482	0.000643711	0.000528784	0.000691452	0.000628328	0.000278133	0.000349466
endothelial cell differentiation	13	0.207722072	4.09E-05	0.012898983	0.012442183	0.013944701	0.011720186	0.002382887
cell wall catabolism	13	0.029442039	7.55E-05	0.002906339	0.001652485	0.002925975	0.00115032	3.36E-05
behavioral interaction between organisms	12	0.382150282	1.00E-10	0.002619355	0.001466688	0.002052863	0.001429104	0.007078796
regulation of protein catabolism	12	0.240923962	9.06E-05	0.00044448	0.000988994	0.000691445	0.001468141	0.001377424
adult locomotory behavior	12	1.00E-10	1.00E-10	1.00E-10	1.00E-10	1.00E-10	1.00E-10	1.00E-10
cholesterol homeostasis	12	0.626262626	0.000168967	0.000355114	0.001020772	0.000523582	0.00102715	0.000478266
drug transport	12	0.089305103	1.00E-10	3.98E-05	0.000182919	3.09E-05	0.000144659	0.000333589
snRNA metabolism	11	0.039926311	1.00E-10	0.009741641	0.010947117	0.010329634	0.011521802	0.008688571
sperm motility	11	0.207863853	0.039374304	0.107375724	0.036310628	0.04277586	0.036696527	0.01224154
plasma membrane organization and biogenesis	11	0.489020071	0.000300415	0.061070795	0.088590693	0.031795106	0.055240389	0.025571744
pancreas development	10	0.02086743	1.00E-10	0.001540544	0.000905209	0.000642045	0.002114645	0.000684846
negative regulation of transcription factor activity	10	0.009306318	0.002123066	0.000994332	0.000997932	0.000837622	0.000993208	0.002660123
two component signal transduction system, phosphorelay 	10	0.02554799	0.008630568	0.016408008	0.011153148	0.015497813	0.011108627	0.003364913
endothelial cell proliferation	10	0.533571837	0.000803793	0.048109402	0.025921925	0.048316679	0.030811192	0.000407148
collagen fibril organization	10	0.014888337	0.002414404	0.004667431	0.00424602	0.004516741	0.004209233	0.000331591
protein stabilization	10	1.00E-10	1.00E-10	1.00E-10	1.00E-10	1.00E-10	1.00E-10	1.00E-10
Golgi organization and biogenesis	10	0.008844147	0.000188663	0.002700113	0.001161815	0.002701183	0.002906368	0.004862819
defense response to virus	10	0.321429378	0.021360359	0.317177346	0.31770537	0.318630936	0.317049037	0.158609361
fluid transport	10	0.09236394	0.002920803	0.012335306	0.010217431	0.013472713	0.009517826	0.004098892
nucleotide sugar metabolism	10	0.098423395	1.00E-10	0.001563399	0.000518528	0.00103636	0.000564863	0.005248444