ontology node name node id #windows in node #windows in node with low theta p overrepresentation of low theta windows #windows in node with high theta p overrepresentation of high theta windows biological_process reproduction GO:0000003 259 13 0.325223 23 0.21803 biological_process transition metal ion transport GO:0000041 13 0 1 1 0.635998 biological_process protein import into nucleus. translocation GO:0000060 13 0 1 2 0.25295 biological_process mitotic sister chromatid segregation GO:0000070 16 0 1 1 0.711833 biological_process regulation of progression through cell cycle GO:0000074 283 20 0.0188385 20 0.639354 biological_process cell cycle checkpoint GO:0000075 42 3 0.270978 4 0.384697 biological_process DNA damage checkpoint GO:0000077 17 2 0.16505 1 0.73343 biological_process regulation of cyclin-dependent protein kinase activity GO:0000079 33 3 0.168433 2 0.71835 biological_process G1 phase of mitotic cell cycle GO:0000080 13 2 0.105696 1 0.635998 biological_process G1/S transition of mitotic cell cycle GO:0000082 24 3 0.0822737 0 1 biological_process M phase of mitotic cell cycle GO:0000087 81 5 0.270247 7 0.402056 biological_process sulfur amino acid metabolic process GO:0000096 10 0 1 1 0.540277 biological_process negative regulation of transcription from RNA polymerase II promoter GO:0000122 74 2 0.836136 9 0.0980678 biological_process MAPKKK cascade GO:0000165 99 11 0.00329746 9 0.319388 biological_process activation of MAPK activity GO:0000187 33 1 0.767711 1 0.923533 biological_process inactivation of MAPK activity GO:0000188 16 3 0.0292268 3 0.11214 biological_process microtubule cytoskeleton organization and biogenesis GO:0000226 36 3 0.201402 3 0.510896 biological_process spliceosome assembly GO:0000245 24 1 0.653766 5 0.0294809 biological_process mitotic cell cycle GO:0000278 136 10 0.0677309 9 0.697335 biological_process M phase GO:0000279 110 5 0.518052 9 0.439086 biological_process RNA splicing. via transesterification reactions GO:0000375 58 2 0.72159 9 0.0266195 biological_process RNA splicing. via transesterification reactions with bulged adenosine as nucleophile GO:0000377 57 2 0.712573 9 0.0240088 biological_process nuclear mRNA splicing. via spliceosome GO:0000398 57 2 0.712573 9 0.0240088 biological_process telomere maintenance GO:0000723 17 2 0.16505 1 0.73343 biological_process sister chromatid segregation GO:0000819 16 0 1 1 0.711833 biological_process cell morphogenesis GO:0000902 189 13 0.0631123 17 0.244303 biological_process cellular morphogenesis during differentiation GO:0000904 58 3 0.460109 3 0.81943 biological_process cytokinesis GO:0000910 21 0 1 2 0.472477 biological_process skeletal development GO:0001501 105 8 0.0821243 10 0.256858 biological_process ossification GO:0001503 25 2 0.293602 3 0.28581 biological_process regulation of neurotransmitter levels GO:0001505 33 0 1 1 0.923533 biological_process regulation of action potential GO:0001508 17 0 1 1 0.73343 biological_process angiogenesis GO:0001525 47 4 0.142883 4 0.470457 biological_process ovarian follicle development GO:0001541 11 2 0.0788061 1 0.57469 biological_process regulation of cell growth GO:0001558 65 3 0.536816 10 0.0211262 biological_process blood vessel development GO:0001568 50 4 0.167576 4 0.519799 biological_process eye development GO:0001654 10 1 0.356787 1 0.540277 biological_process urogenital system development GO:0001655 12 2 0.0919606 1 0.606533 biological_process response to hypoxia GO:0001666 13 3 0.0164134 2 0.25295 biological_process in utero embryonic development GO:0001701 10 1 0.356787 0 1 biological_process formation of primary germ layer GO:0001704 10 1 0.356787 0 1 biological_process mesoderm formation GO:0001707 10 1 0.356787 0 1 biological_process cell fate determination GO:0001709 11 0 1 1 0.57469 biological_process cell activation GO:0001775 109 10 0.0183933 11 0.188636 biological_process cytokine production GO:0001816 56 5 0.0921351 8 0.0543701 biological_process regulation of cytokine production GO:0001817 12 0 1 4 0.0093609 biological_process positive regulation of cytokine production GO:0001819 11 0 1 3 0.0434662 biological_process kidney development GO:0001822 11 2 0.0788061 1 0.57469 biological_process release of cytochrome c from mitochondria GO:0001836 10 0 1 0 1 biological_process tissue homeostasis GO:0001894 11 1 0.384585 3 0.0434662 biological_process regulation of protein amino acid phosphorylation GO:0001932 24 1 0.653766 1 0.845557 biological_process positive regulation of protein amino acid phosphorylation GO:0001934 16 0 1 1 0.711833 biological_process vasculature development GO:0001944 52 4 0.184822 4 0.551463 biological_process morphogenesis of an epithelium GO:0002009 14 0 1 2 0.281562 biological_process adaptive immune response GO:0002250 25 2 0.293602 4 0.111699 biological_process immune effector process GO:0002252 29 2 0.357803 5 0.0608025 biological_process activation of immune response GO:0002253 23 0 1 3 0.244224 biological_process myeloid leukocyte activation GO:0002274 14 0 1 1 0.663263 biological_process immune system process GO:0002376 361 20 0.145344 30 0.292843 biological_process immune response-activating cell surface receptor signaling pathway GO:0002429 17 0 1 2 0.36627 biological_process production of molecular mediator of immune response GO:0002440 15 2 0.134621 3 0.0962019 biological_process leukocyte mediated immunity GO:0002443 19 2 0.196524 4 0.0484504 biological_process lymphocyte mediated immunity GO:0002449 19 2 0.196524 4 0.0484504 biological_process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 24 2 0.277366 3 0.264917 biological_process immune system development GO:0002520 101 9 0.0292096 12 0.0717885 biological_process leukocyte differentiation GO:0002521 58 6 0.0374979 8 0.0645602 biological_process acute inflammatory response GO:0002526 13 1 0.436645 0 1 biological_process myeloid leukocyte differentiation GO:0002573 20 2 0.21253 3 0.184164 biological_process regulation of immune system process GO:0002682 38 1 0.813969 3 0.548131 biological_process positive regulation of immune system process GO:0002684 32 1 0.757168 3 0.431998 biological_process immune response-activating signal transduction GO:0002757 18 0 1 3 0.146689 biological_process regulation of myeloid leukocyte differentiation GO:0002761 12 1 0.411187 3 0.0548347 biological_process immune response-regulating signal transduction GO:0002764 18 0 1 3 0.146689 biological_process immune response-regulating cell surface receptor signaling pathway GO:0002768 17 0 1 2 0.36627 biological_process peptide secretion GO:0002790 11 0 1 1 0.57469 biological_process generation of a signal involved in cell-cell signaling GO:0003001 34 2 0.434842 3 0.472113 biological_process regionalization GO:0003002 15 1 0.48432 3 0.0962019 biological_process reproductive developmental process GO:0003006 36 2 0.46427 7 0.0154303 biological_process carbohydrate metabolic process GO:0005975 192 13 0.069713 16 0.360639 biological_process polysaccharide metabolic process GO:0005976 15 2 0.134621 0 1 biological_process monosaccharide metabolic process GO:0005996 57 4 0.230204 5 0.423526 biological_process fucose metabolic process GO:0006004 13 1 0.436645 1 0.635998 biological_process glucose metabolic process GO:0006006 31 1 0.74615 3 0.411527 biological_process glucose catabolic process GO:0006007 11 0 1 0 1 biological_process aminoglycan metabolic process GO:0006022 24 3 0.0822737 2 0.544771 biological_process aminoglycan biosynthetic process GO:0006023 18 2 0.180682 2 0.393718 biological_process glycosaminoglycan biosynthetic process GO:0006024 17 1 0.527978 2 0.36627 biological_process proteoglycan metabolic process GO:0006029 25 1 0.668773 2 0.56729 biological_process amino sugar metabolic process GO:0006040 16 1 0.506629 2 0.338356 biological_process glucosamine metabolic process GO:0006041 10 0 1 1 0.540277 biological_process alcohol metabolic process GO:0006066 107 9 0.0402564 9 0.406226 biological_process organic acid metabolic process GO:0006082 223 9 0.631439 22 0.106235 biological_process generation of precursor metabolites and energy GO:0006091 151 8 0.326162 16 0.0963485 biological_process tricarboxylic acid cycle intermediate metabolic process GO:0006100 13 0 1 0 1 biological_process energy reserve metabolic process GO:0006112 10 0 1 0 1 biological_process electron transport GO:0006118 82 4 0.474686 10 0.0828775 biological_process oxidative phosphorylation GO:0006119 37 0 1 4 0.297579 biological_process mitochondrial electron transport. NADH to ubiquinone GO:0006120 31 0 1 3 0.411527 biological_process nucleobase. nucleoside. nucleotide and nucleic acid metabolic process GO:0006139 1257 68 0.0175725 109 0.0357516 biological_process purine nucleotide metabolic process GO:0006163 12 1 0.411187 2 0.224414 biological_process DNA metabolic process GO:0006259 317 22 0.0170366 25 0.417825 biological_process DNA replication GO:0006260 91 8 0.0414285 3 0.971129 biological_process DNA-dependent DNA replication GO:0006261 49 5 0.0583161 1 0.97816 biological_process DNA replication initiation GO:0006270 15 0 1 1 0.68849 biological_process regulation of DNA replication GO:0006275 18 2 0.180682 1 0.753413 biological_process DNA repair GO:0006281 121 9 0.0761924 12 0.190605 biological_process base-excision repair GO:0006284 15 1 0.48432 3 0.0962019 biological_process nucleotide-excision repair GO:0006289 18 1 0.548407 2 0.393718 biological_process mismatch repair GO:0006298 11 0 1 0 1 biological_process double-strand break repair GO:0006302 13 0 1 1 0.635998 biological_process DNA modification GO:0006304 11 1 0.384585 1 0.57469 biological_process DNA alkylation GO:0006305 10 1 0.356787 0 1 biological_process DNA methylation GO:0006306 10 1 0.356787 0 1 biological_process DNA catabolic process GO:0006308 14 0 1 3 0.0812802 biological_process DNA recombination GO:0006310 42 2 0.546854 6 0.0894594 biological_process DNA packaging GO:0006323 103 8 0.0752326 9 0.362501 biological_process establishment and/or maintenance of chromatin architecture GO:0006325 98 7 0.128882 9 0.308773 biological_process chromatin assembly or disassembly GO:0006333 39 3 0.235726 6 0.0669202 biological_process nucleosome assembly GO:0006334 23 2 0.261108 2 0.52145 biological_process chromatin remodeling GO:0006338 33 2 0.419807 7 0.00957681 biological_process transcription GO:0006350 777 45 0.019779 71 0.0340974 biological_process transcription. DNA-dependent GO:0006351 666 37 0.0585806 64 0.0166669 biological_process transcription initiation GO:0006352 28 3 0.117743 1 0.88698 biological_process regulation of transcription. DNA-dependent GO:0006355 497 25 0.233191 52 0.00637427 biological_process regulation of transcription from RNA polymerase II promoter GO:0006357 256 10 0.674737 27 0.0405741 biological_process rRNA processing GO:0006364 23 3 0.0742541 0 1 biological_process transcription from RNA polymerase II promoter GO:0006366 429 21 0.301298 39 0.109154 biological_process transcription initiation from RNA polymerase II promoter GO:0006367 23 3 0.0742541 0 1 biological_process mRNA splice site selection GO:0006376 11 0 1 4 0.00662546 biological_process transcription from RNA polymerase III promoter GO:0006383 23 1 0.638083 1 0.833024 biological_process RNA processing GO:0006396 184 14 0.0266238 19 0.0910727 biological_process mRNA processing GO:0006397 91 5 0.355861 12 0.0368874 biological_process tRNA metabolic process GO:0006399 15 0 1 1 0.68849 biological_process RNA catabolic process GO:0006401 25 2 0.293602 1 0.857151 biological_process RNA localization GO:0006403 18 1 0.548407 2 0.393718 biological_process RNA export from nucleus GO:0006405 16 1 0.506629 2 0.338356 biological_process mRNA export from nucleus GO:0006406 13 1 0.436645 2 0.25295 biological_process translation GO:0006412 182 14 0.0245 11 0.811282 biological_process translational initiation GO:0006413 36 3 0.201402 1 0.939525 biological_process translational elongation GO:0006414 10 2 0.0663126 1 0.540277 biological_process regulation of translation GO:0006417 90 8 0.0391787 7 0.513579 biological_process regulation of translational initiation GO:0006446 31 3 0.147432 1 0.910594 biological_process protein folding GO:0006457 61 1 0.933224 8 0.0819335 biological_process protein complex assembly GO:0006461 172 8 0.465694 19 0.053342 biological_process protein modification process GO:0006464 592 33 0.0697304 45 0.474443 biological_process protein amino acid phosphorylation GO:0006468 242 13 0.243662 15 0.813775 biological_process negative regulation of protein kinase activity GO:0006469 30 4 0.0382538 3 0.390834 biological_process protein amino acid dephosphorylation GO:0006470 56 4 0.220902 2 0.929696 biological_process protein amino acid ADP-ribosylation GO:0006471 12 1 0.411187 1 0.606533 biological_process protein amino acid acetylation GO:0006473 14 1 0.461007 0 1 biological_process protein amino acid methylation GO:0006479 10 1 0.356787 1 0.540277 biological_process protein amino acid glycosylation GO:0006486 75 4 0.406644 4 0.822613 biological_process protein amino acid N-linked glycosylation GO:0006487 33 0 1 2 0.71835 biological_process protein amino acid O-linked glycosylation GO:0006493 20 2 0.21253 2 0.446885 biological_process protein amino acid lipidation GO:0006497 22 3 0.0666051 1 0.819477 biological_process GPI anchor metabolic process GO:0006505 17 3 0.034389 1 0.73343 biological_process GPI anchor biosynthetic process GO:0006506 17 3 0.034389 1 0.73343 biological_process proteolysis GO:0006508 202 12 0.160826 18 0.248517 biological_process membrane protein ectodomain proteolysis GO:0006509 10 0 1 2 0.16839 biological_process ubiquitin-dependent protein catabolic process GO:0006511 66 2 0.785461 2 0.963222 biological_process ubiquitin cycle GO:0006512 58 4 0.239603 6 0.2635 biological_process misfolded or incompletely synthesized protein catabolic process GO:0006515 11 0 1 1 0.57469 biological_process glycoprotein catabolic process GO:0006516 10 0 1 1 0.540277 biological_process peptide metabolic process GO:0006518 11 1 0.384585 1 0.57469 biological_process amino acid and derivative metabolic process GO:0006519 128 5 0.653985 12 0.2462 biological_process amino acid metabolic process GO:0006520 106 3 0.843407 12 0.095335 biological_process regulation of amino acid metabolic process GO:0006521 25 1 0.668773 1 0.857151 biological_process amino acid derivative metabolic process GO:0006575 25 2 0.293602 0 1 biological_process biogenic amine metabolic process GO:0006576 16 1 0.506629 0 1 biological_process protein targeting GO:0006605 110 5 0.518052 6 0.841311 biological_process protein import into nucleus GO:0006606 48 2 0.620175 3 0.707029 biological_process NLS-bearing substrate import into nucleus GO:0006607 13 0 1 1 0.635998 biological_process protein export from nucleus GO:0006611 10 1 0.356787 0 1 biological_process protein targeting to membrane GO:0006612 15 0 1 1 0.68849 biological_process protein targeting to mitochondrion GO:0006626 14 1 0.461007 0 1 biological_process lipid metabolic process GO:0006629 341 21 0.0598946 31 0.142015 biological_process fatty acid metabolic process GO:0006631 83 6 0.147023 7 0.427181 biological_process fatty acid biosynthetic process GO:0006633 12 2 0.0919606 0 1 biological_process fatty acid beta-oxidation GO:0006635 12 2 0.0919606 0 1 biological_process neutral lipid metabolic process GO:0006638 14 1 0.461007 0 1 biological_process acylglycerol metabolic process GO:0006639 14 1 0.461007 0 1 biological_process triacylglycerol metabolic process GO:0006641 11 1 0.384585 0 1 biological_process membrane lipid metabolic process GO:0006643 98 8 0.0595899 11 0.112144 biological_process phospholipid metabolic process GO:0006644 65 6 0.0598903 8 0.108999 biological_process glycerophospholipid metabolic process GO:0006650 40 3 0.247394 7 0.0266812 biological_process glycerol ether metabolic process GO:0006662 14 1 0.461007 0 1 biological_process glycolipid metabolic process GO:0006664 18 2 0.180682 1 0.753413 biological_process sphingolipid metabolic process GO:0006665 35 5 0.0160664 2 0.748409 biological_process ceramide metabolic process GO:0006672 15 3 0.0245086 1 0.68849 biological_process glycosphingolipid metabolic process GO:0006687 13 2 0.105696 1 0.635998 biological_process icosanoid metabolic process GO:0006690 19 3 0.046022 1 0.771902 biological_process prostanoid metabolic process GO:0006692 14 3 0.0202374 1 0.663263 biological_process prostaglandin metabolic process GO:0006693 14 3 0.0202374 1 0.663263 biological_process steroid biosynthetic process GO:0006694 32 2 0.404572 4 0.213638 biological_process isoprenoid metabolic process GO:0006720 14 1 0.461007 3 0.0812802 biological_process aromatic compound metabolic process GO:0006725 29 0 1 5 0.0608025 biological_process one-carbon compound metabolic process GO:0006730 26 2 0.309788 1 0.867877 biological_process coenzyme metabolic process GO:0006732 38 1 0.813969 5 0.150277 biological_process vitamin metabolic process GO:0006766 25 2 0.293602 2 0.56729 biological_process water-soluble vitamin metabolic process GO:0006767 10 0 1 2 0.16839 biological_process fat-soluble vitamin metabolic process GO:0006775 11 1 0.384585 0 1 biological_process vitamin A metabolic process GO:0006776 11 1 0.384585 0 1 biological_process porphyrin metabolic process GO:0006778 13 1 0.436645 2 0.25295 biological_process porphyrin biosynthetic process GO:0006779 10 1 0.356787 2 0.16839 biological_process sulfur metabolic process GO:0006790 43 2 0.559732 3 0.633504 biological_process phosphorus metabolic process GO:0006793 373 19 0.254498 27 0.6012 biological_process phosphate metabolic process GO:0006796 373 19 0.254498 27 0.6012 biological_process oxygen and reactive oxygen species metabolic process GO:0006800 58 2 0.72159 8 0.0645602 biological_process superoxide metabolic process GO:0006801 11 0 1 1 0.57469 biological_process xenobiotic metabolic process GO:0006805 13 0 1 0 1 biological_process nitrogen compound metabolic process GO:0006807 180 9 0.372891 17 0.18622 biological_process nitric oxide biosynthetic process GO:0006809 11 1 0.384585 1 0.57469 biological_process transport GO:0006810 799 36 0.414147 73 0.0318171 biological_process ion transport GO:0006811 190 10 0.303241 17 0.251181 biological_process cation transport GO:0006812 155 8 0.352485 13 0.373045 biological_process potassium ion transport GO:0006813 62 3 0.504665 5 0.497923 biological_process sodium ion transport GO:0006814 23 3 0.0742541 3 0.244224 biological_process calcium ion transport GO:0006816 27 4 0.0270673 1 0.8778 biological_process hydrogen transport GO:0006818 20 2 0.21253 2 0.446885 biological_process anion transport GO:0006820 29 2 0.357803 4 0.167012 biological_process chloride transport GO:0006821 11 0 1 1 0.57469 biological_process neurotransmitter transport GO:0006836 11 1 0.384585 0 1 biological_process mitochondrial transport GO:0006839 26 1 0.683132 2 0.588995 biological_process amino acid transport GO:0006865 24 0 1 6 0.00706475 biological_process lipid transport GO:0006869 24 2 0.277366 1 0.845557 biological_process cell ion homeostasis GO:0006873 105 5 0.47652 11 0.158441 biological_process calcium ion homeostasis GO:0006874 65 1 0.944152 6 0.357347 biological_process metal ion homeostasis GO:0006875 90 1 0.981784 10 0.132191 biological_process iron ion homeostasis GO:0006879 12 0 1 2 0.224414 biological_process intracellular protein transport GO:0006886 161 10 0.155704 15 0.220063 biological_process exocytosis GO:0006887 32 0 1 3 0.431998 biological_process ER to Golgi vesicle-mediated transport GO:0006888 19 0 1 1 0.771902 biological_process retrograde vesicle-mediated transport. Golgi to ER GO:0006890 13 1 0.436645 1 0.635998 biological_process intra-Golgi vesicle-mediated transport GO:0006891 15 1 0.48432 3 0.0962019 biological_process post-Golgi vesicle-mediated transport GO:0006892 12 1 0.411187 2 0.224414 biological_process endocytosis GO:0006897 87 6 0.171651 9 0.199482 biological_process receptor-mediated endocytosis GO:0006898 31 5 0.00966368 3 0.411527 biological_process phagocytosis GO:0006909 16 0 1 1 0.711833 biological_process nucleocytoplasmic transport GO:0006913 82 6 0.141135 4 0.871795 biological_process autophagy GO:0006914 10 0 1 2 0.16839 biological_process apoptosis GO:0006915 424 24 0.099081 41 0.0475226 biological_process anti-apoptosis GO:0006916 124 7 0.286543 12 0.213689 biological_process induction of apoptosis GO:0006917 152 12 0.0301811 18 0.0330464 biological_process caspase activation GO:0006919 30 1 0.734633 5 0.0686961 biological_process cell structure disassembly during apoptosis GO:0006921 14 1 0.461007 1 0.663263 biological_process cell motility GO:0006928 213 14 0.0744498 23 0.0448056 biological_process chemotaxis GO:0006935 72 4 0.376925 3 0.913936 biological_process muscle contraction GO:0006936 112 3 0.869076 8 0.606068 biological_process regulation of muscle contraction GO:0006937 24 1 0.653766 4 0.0993747 biological_process smooth muscle contraction GO:0006939 23 1 0.638083 2 0.52145 biological_process striated muscle contraction GO:0006941 16 0 1 3 0.11214 biological_process membrane fusion GO:0006944 28 0 1 5 0.0534531 biological_process response to stress GO:0006950 484 30 0.0250261 51 0.00599801 biological_process defense response GO:0006952 257 17 0.0500902 25 0.101011 biological_process inflammatory response GO:0006954 130 7 0.32841 12 0.263114 biological_process immune response GO:0006955 249 9 0.756603 21 0.310496 biological_process humoral immune response GO:0006959 33 0 1 3 0.452206 biological_process cellular defense response GO:0006968 53 2 0.674054 7 0.0971261 biological_process response to DNA damage stimulus GO:0006974 152 11 0.0625559 14 0.243341 biological_process response to oxidative stress GO:0006979 41 2 0.533717 6 0.0815355 biological_process ER-nuclear signaling pathway GO:0006984 11 0 1 2 0.196151 biological_process response to unfolded protein GO:0006986 30 0 1 4 0.182138 biological_process organelle organization and biogenesis GO:0006996 480 25 0.182625 41 0.196166 biological_process nuclear organization and biogenesis GO:0006997 20 1 0.586663 2 0.446885 biological_process chromosome organization and biogenesis (sensu Eukaryota) GO:0007001 149 9 0.192624 12 0.436955 biological_process mitochondrion organization and biogenesis GO:0007005 24 1 0.653766 3 0.264917 biological_process mitochondrial membrane organization and biogenesis GO:0007006 12 1 0.411187 2 0.224414 biological_process plasma membrane organization and biogenesis GO:0007009 10 0 1 2 0.16839 biological_process cytoskeleton organization and biogenesis GO:0007010 229 10 0.531582 23 0.0863184 biological_process actin filament organization GO:0007015 23 1 0.638083 1 0.833024 biological_process microtubule-based process GO:0007017 67 3 0.557584 5 0.568422 biological_process microtubule-based movement GO:0007018 17 0 1 0 1 biological_process cytoplasm organization and biogenesis GO:0007028 13 1 0.436645 0 1 biological_process peroxisome organization and biogenesis GO:0007031 11 0 1 2 0.196151 biological_process vacuole organization and biogenesis GO:0007033 17 1 0.527978 0 1 biological_process vacuolar transport GO:0007034 15 0 1 1 0.68849 biological_process lysosome organization and biogenesis GO:0007040 16 1 0.506629 0 1 biological_process lysosomal transport GO:0007041 12 0 1 0 1 biological_process intercellular junction assembly GO:0007043 10 1 0.356787 0 1 biological_process cell cycle GO:0007049 396 28 0.00571791 25 0.844971 biological_process cell cycle arrest GO:0007050 55 5 0.0867902 5 0.393139 biological_process spindle organization and biogenesis GO:0007051 18 3 0.0399899 2 0.393718 biological_process mitotic spindle organization and biogenesis GO:0007052 12 2 0.0919606 1 0.606533 biological_process chromosome segregation GO:0007059 29 0 1 2 0.649211 biological_process mitosis GO:0007067 80 5 0.261921 7 0.389478 biological_process regulation of mitosis GO:0007088 37 3 0.212714 4 0.297579 biological_process mitotic checkpoint GO:0007093 14 1 0.461007 2 0.281562 biological_process centrosome cycle GO:0007098 10 1 0.356787 0 1 biological_process meiosis GO:0007126 33 0 1 2 0.71835 biological_process meiosis I GO:0007127 19 0 1 1 0.771902 biological_process meiotic recombination GO:0007131 16 0 1 1 0.711833 biological_process cell communication GO:0007154 1695 89 0.011943 130 0.368999 biological_process cell adhesion GO:0007155 324 14 0.53855 26 0.378933 biological_process homophilic cell adhesion GO:0007156 21 0 1 0 1 biological_process heterophilic cell adhesion GO:0007157 20 2 0.21253 2 0.446885 biological_process leukocyte adhesion GO:0007159 10 2 0.0663126 2 0.16839 biological_process cell-matrix adhesion GO:0007160 38 1 0.813969 3 0.548131 biological_process negative regulation of cell adhesion GO:0007162 15 0 1 1 0.68849 biological_process establishment and/or maintenance of cell polarity GO:0007163 16 1 0.506629 1 0.711833 biological_process signal transduction GO:0007165 1501 82 0.00583506 113 0.479834 biological_process cell surface receptor linked signal transduction GO:0007166 606 35 0.0407247 45 0.543623 biological_process enzyme linked receptor protein signaling pathway GO:0007167 140 12 0.016965 12 0.352632 biological_process transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 92 10 0.00586106 6 0.694703 biological_process epidermal growth factor receptor signaling pathway GO:0007173 19 0 1 1 0.771902 biological_process transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 40 2 0.520324 5 0.17518 biological_process transforming growth factor beta receptor signaling pathway GO:0007179 32 2 0.404572 4 0.213638 biological_process G-protein coupled receptor protein signaling pathway GO:0007186 307 15 0.344985 20 0.776002 biological_process G-protein signaling. coupled to cyclic nucleotide second messenger GO:0007187 90 4 0.548582 8 0.357885 biological_process G-protein signaling. coupled to cAMP nucleotide second messenger GO:0007188 58 3 0.460109 6 0.2635 biological_process G-protein signaling. adenylate cyclase activating pathway GO:0007189 20 1 0.586663 2 0.446885 biological_process adenylate cyclase activation GO:0007190 16 0 1 1 0.711833 biological_process G-protein signaling. adenylate cyclase inhibiting pathway GO:0007193 10 0 1 0 1 biological_process negative regulation of adenylate cyclase activity GO:0007194 14 0 1 2 0.281562 biological_process G-protein signaling. coupled to IP3 second messenger (phospholipase C activating) GO:0007200 41 3 0.259149 1 0.959111 biological_process phospholipase C activation GO:0007202 15 0 1 0 1 biological_process elevation of cytosolic calcium ion concentration GO:0007204 38 0 1 3 0.548131 biological_process glutamate signaling pathway GO:0007215 14 2 0.11994 0 1 biological_process neuropeptide signaling pathway GO:0007218 20 0 1 2 0.446885 biological_process Notch signaling pathway GO:0007219 15 0 1 2 0.310079 biological_process integrin-mediated signaling pathway GO:0007229 18 0 1 0 1 biological_process intracellular signaling cascade GO:0007242 633 37 0.0303507 49 0.415597 biological_process protein kinase cascade GO:0007243 269 18 0.0404857 23 0.276227 biological_process I-kappaB kinase/NF-kappaB cascade GO:0007249 111 6 0.345369 11 0.204657 biological_process activation of NF-kappaB-inducing kinase GO:0007250 14 1 0.461007 3 0.0812802 biological_process JNK cascade GO:0007254 46 4 0.134997 4 0.453594 biological_process activation of JNK activity GO:0007257 14 1 0.461007 1 0.663263 biological_process JAK-STAT cascade GO:0007259 27 2 0.3259 1 0.8778 biological_process tyrosine phosphorylation of STAT protein GO:0007260 15 1 0.48432 1 0.68849 biological_process small GTPase mediated signal transduction GO:0007264 85 5 0.304078 3 0.958871 biological_process Ras protein signal transduction GO:0007265 61 2 0.747223 3 0.845078 biological_process Rho protein signal transduction GO:0007266 30 0 1 2 0.667666 biological_process cell-cell signaling GO:0007267 430 19 0.491964 39 0.11196 biological_process synaptic transmission GO:0007268 172 7 0.618442 16 0.212229 biological_process neurotransmitter secretion GO:0007269 17 0 1 1 0.73343 biological_process ensheathment of neurons GO:0007272 12 0 1 1 0.606533 biological_process multicellular organismal development GO:0007275 959 53 0.0264488 95 0.00115985 biological_process gamete generation GO:0007276 122 5 0.611409 12 0.198167 biological_process germ cell development GO:0007281 12 0 1 0 1 biological_process spermatogenesis GO:0007283 97 5 0.407997 11 0.106252 biological_process spermatid development GO:0007286 13 1 0.436645 0 1 biological_process female gamete generation GO:0007292 17 1 0.527978 1 0.73343 biological_process single fertilization GO:0007338 23 0 1 2 0.52145 biological_process regulation of progression through mitotic cell cycle GO:0007346 17 1 0.527978 1 0.73343 biological_process gastrulation GO:0007369 12 1 0.411187 0 1 biological_process pattern specification process GO:0007389 25 1 0.668773 5 0.03467 biological_process ectoderm development GO:0007398 67 3 0.557584 6 0.384763 biological_process nervous system development GO:0007399 336 18 0.19785 27 0.372592 biological_process axonogenesis GO:0007409 52 2 0.663796 3 0.757304 biological_process axon guidance GO:0007411 25 1 0.668773 2 0.56729 biological_process synaptogenesis GO:0007416 13 0 1 0 1 biological_process central nervous system development GO:0007417 110 6 0.337596 10 0.305341 biological_process brain development GO:0007420 43 2 0.559732 4 0.402084 biological_process peripheral nervous system development GO:0007422 11 0 1 3 0.0434662 biological_process sensory organ development GO:0007423 13 1 0.436645 1 0.635998 biological_process mesoderm development GO:0007498 27 2 0.3259 2 0.609882 biological_process heart development GO:0007507 32 0 1 5 0.086093 biological_process muscle development GO:0007517 97 7 0.123933 12 0.0559383 biological_process striated muscle development GO:0007519 47 3 0.330736 6 0.134982 biological_process neuromuscular junction development GO:0007528 10 0 1 2 0.16839 biological_process sex differentiation GO:0007548 34 2 0.434842 6 0.0376202 biological_process pregnancy GO:0007565 42 3 0.270978 1 0.962192 biological_process aging GO:0007568 11 1 0.384585 1 0.57469 biological_process response to nutrient GO:0007584 13 1 0.436645 1 0.635998 biological_process respiratory gaseous exchange GO:0007585 12 0 1 1 0.606533 biological_process digestion GO:0007586 46 4 0.134997 4 0.453594 biological_process excretion GO:0007588 44 6 0.0107318 8 0.0147193 biological_process fluid secretion GO:0007589 12 2 0.0919606 4 0.0093609 biological_process blood coagulation GO:0007596 46 1 0.869665 7 0.0523389 biological_process hemostasis GO:0007599 50 1 0.890931 7 0.0759303 biological_process sensory perception GO:0007600 175 11 0.133113 21 0.019598 biological_process visual perception GO:0007601 103 6 0.283966 8 0.508491 biological_process phototransduction GO:0007602 16 1 0.506629 0 1 biological_process sensory perception of sound GO:0007605 41 3 0.259149 6 0.0815355 biological_process sensory perception of chemical stimulus GO:0007606 28 3 0.117743 6 0.0153527 biological_process sensory perception of smell GO:0007608 20 3 0.0524761 5 0.0137454 biological_process behavior GO:0007610 125 5 0.633069 8 0.727249 biological_process learning and/or memory GO:0007611 12 1 0.411187 1 0.606533 biological_process circadian rhythm GO:0007623 16 0 1 1 0.711833 biological_process locomotory behavior GO:0007626 76 4 0.416497 4 0.830478 biological_process feeding behavior GO:0007631 24 0 1 4 0.0993747 biological_process circulation GO:0008015 94 4 0.583458 10 0.16168 biological_process regulation of heart contraction GO:0008016 24 0 1 3 0.264917 biological_process cell recognition GO:0008037 27 3 0.1084 1 0.8778 biological_process neuron recognition GO:0008038 14 2 0.11994 0 1 biological_process regulation of actin polymerization and/or depolymerization GO:0008064 13 0 1 2 0.25295 biological_process protein localization GO:0008104 225 15 0.0600621 23 0.074138 biological_process biological_process GO:0008150 4846 209 1 362 1 biological_process metabolic process GO:0008152 2650 125 0.073087 213 0.054908 biological_process actin polymerization and/or depolymerization GO:0008154 21 0 1 4 0.0665768 biological_process negative regulation of DNA replication GO:0008156 10 1 0.356787 1 0.540277 biological_process steroid metabolic process GO:0008202 77 5 0.237338 7 0.35184 biological_process cholesterol metabolic process GO:0008203 36 3 0.201402 3 0.510896 biological_process protein amino acid alkylation GO:0008213 10 1 0.356787 1 0.540277 biological_process blood pressure regulation GO:0008217 26 1 0.683132 3 0.306829 biological_process cell death GO:0008219 437 26 0.0549249 43 0.0335148 biological_process regulation of G-protein coupled receptor protein signaling pathway GO:0008277 24 3 0.0822737 0 1 biological_process cell proliferation GO:0008283 466 33 0.00261177 43 0.0798559 biological_process positive regulation of cell proliferation GO:0008284 135 11 0.0303835 12 0.307 biological_process negative regulation of cell proliferation GO:0008285 143 13 0.00825191 16 0.0658352 biological_process insulin receptor signaling pathway GO:0008286 19 3 0.046022 2 0.420613 biological_process regulation of cell shape GO:0008360 14 2 0.11994 1 0.663263 biological_process regulation of cell size GO:0008361 83 5 0.287068 11 0.0432079 biological_process axon ensheathment GO:0008366 12 0 1 1 0.606533 biological_process RNA splicing GO:0008380 110 7 0.195476 16 0.0070933 biological_process gonad development GO:0008406 24 2 0.277366 5 0.0294809 biological_process fibroblast growth factor receptor signaling pathway GO:0008543 10 1 0.356787 0 1 biological_process epidermis development GO:0008544 62 3 0.504665 6 0.316541 biological_process male gonad development GO:0008584 11 0 1 4 0.00662546 biological_process female gonad development GO:0008585 12 2 0.0919606 1 0.606533 biological_process lipid biosynthetic process GO:0008610 108 8 0.0931423 9 0.417187 biological_process induction of apoptosis by extracellular signals GO:0008624 27 2 0.3259 4 0.138233 biological_process induction of apoptosis via death domain receptors GO:0008625 10 2 0.0663126 2 0.16839 biological_process induction of apoptosis by intracellular signals GO:0008629 23 3 0.0742541 1 0.833024 biological_process DNA damage response. signal transduction resulting in induction of apoptosis GO:0008630 12 2 0.0919606 1 0.606533 biological_process apoptotic program GO:0008632 62 4 0.278001 7 0.177617 biological_process apoptotic mitochondrial changes GO:0008637 11 0 1 0 1 biological_process carbohydrate transport GO:0008643 25 3 0.0906487 4 0.111699 biological_process hexose transport GO:0008645 18 3 0.0399899 3 0.146689 biological_process amino acid biosynthetic process GO:0008652 11 0 1 1 0.57469 biological_process phospholipid biosynthetic process GO:0008654 37 4 0.0731922 2 0.775676 biological_process catabolic process GO:0009056 222 14 0.0966443 14 0.786467 biological_process macromolecule catabolic process GO:0009057 155 11 0.0699412 6 0.979025 biological_process biosynthetic process GO:0009058 488 30 0.0276602 40 0.285284 biological_process macromolecule biosynthetic process GO:0009059 321 22 0.0194314 21 0.774293 biological_process aerobic respiration GO:0009060 12 0 1 2 0.224414 biological_process amino acid catabolic process GO:0009063 23 1 0.638083 3 0.244224 biological_process glutamine family amino acid metabolic process GO:0009064 12 0 1 2 0.224414 biological_process glycoprotein metabolic process GO:0009100 96 4 0.600308 7 0.583777 biological_process glycoprotein biosynthetic process GO:0009101 81 4 0.465122 6 0.570328 biological_process coenzyme biosynthetic process GO:0009108 13 0 1 3 0.0674637 biological_process nucleoside metabolic process GO:0009116 11 0 1 0 1 biological_process nucleotide metabolic process GO:0009117 49 1 0.885962 6 0.155756 biological_process purine ribonucleotide metabolic process GO:0009150 10 1 0.356787 1 0.540277 biological_process nucleotide biosynthetic process GO:0009165 27 1 0.696872 3 0.327904 biological_process cyclic nucleotide metabolic process GO:0009187 14 0 1 2 0.281562 biological_process glycolipid biosynthetic process GO:0009247 12 1 0.411187 1 0.606533 biological_process ribonucleotide metabolic process GO:0009259 17 1 0.527978 3 0.129001 biological_process ribonucleotide biosynthetic process GO:0009260 12 1 0.411187 1 0.606533 biological_process response to temperature stimulus GO:0009266 14 1 0.461007 2 0.281562 biological_process protein secretion GO:0009306 27 4 0.0270673 3 0.327904 biological_process amine metabolic process GO:0009308 168 8 0.439146 16 0.186392 biological_process amine biosynthetic process GO:0009309 19 1 0.567956 1 0.771902 biological_process amine catabolic process GO:0009310 26 1 0.683132 3 0.306829 biological_process oligosaccharide metabolic process GO:0009311 13 0 1 1 0.635998 biological_process response to radiation GO:0009314 47 2 0.608614 2 0.876499 biological_process response to xenobiotic stimulus GO:0009410 17 2 0.16505 1 0.73343 biological_process response to UV GO:0009411 14 1 0.461007 1 0.663263 biological_process response to light stimulus GO:0009416 37 2 0.478644 1 0.944076 biological_process RNA modification GO:0009451 12 1 0.411187 2 0.224414 biological_process fertilization GO:0009566 24 0 1 2 0.544771 biological_process detection of external stimulus GO:0009581 26 2 0.309788 0 1 biological_process detection of abiotic stimulus GO:0009582 21 1 0.604564 1 0.804835 biological_process detection of light stimulus GO:0009583 17 1 0.527978 0 1 biological_process detection of visible light GO:0009584 17 1 0.527978 0 1 biological_process detection of chemical stimulus GO:0009593 16 0 1 0 1 biological_process detection of biotic stimulus GO:0009595 12 1 0.411187 0 1 biological_process response to external stimulus GO:0009605 290 14 0.369837 26 0.186522 biological_process response to biotic stimulus GO:0009607 103 2 0.941678 12 0.0807035 biological_process response to wounding GO:0009611 191 7 0.725577 19 0.119559 biological_process response to virus GO:0009615 42 0 1 5 0.201528 biological_process response to bacterium GO:0009617 25 2 0.293602 2 0.56729 biological_process response to abiotic stimulus GO:0009628 73 4 0.386852 6 0.466554 biological_process anatomical structure morphogenesis GO:0009653 431 24 0.113501 48 0.00257892 biological_process response to endogenous stimulus GO:0009719 177 11 0.140749 16 0.24665 biological_process response to hormone stimulus GO:0009725 24 0 1 1 0.845557 biological_process response to carbohydrate stimulus GO:0009743 11 0 1 1 0.57469 biological_process embryonic development GO:0009790 70 4 0.357036 5 0.608193 biological_process embryonic development ending in birth or egg hatching GO:0009792 17 1 0.527978 1 0.73343 biological_process embryonic pattern specification GO:0009880 10 0 1 4 0.00447697 biological_process organ morphogenesis GO:0009887 132 8 0.208684 13 0.184756 biological_process tissue development GO:0009888 131 7 0.335489 13 0.177783 biological_process regulation of biosynthetic process GO:0009889 105 9 0.036301 9 0.384322 biological_process negative regulation of biosynthetic process GO:0009890 19 2 0.196524 1 0.771902 biological_process positive regulation of biosynthetic process GO:0009891 39 3 0.235726 6 0.0669202 biological_process negative regulation of metabolic process GO:0009892 215 11 0.322575 19 0.2523 biological_process positive regulation of metabolic process GO:0009893 190 13 0.0652641 24 0.00707646 biological_process regulation of catabolic process GO:0009894 12 1 0.411187 1 0.606533 biological_process anterior/posterior pattern formation GO:0009952 11 0 1 3 0.0434662 biological_process regulation of signal transduction GO:0009966 187 12 0.107574 12 0.752098 biological_process positive regulation of signal transduction GO:0009967 96 7 0.119083 8 0.42787 biological_process negative regulation of signal transduction GO:0009968 34 1 0.777798 2 0.73374 biological_process cellular process GO:0009987 4222 192 0.0190736 306 0.943896 biological_process response to extracellular stimulus GO:0009991 32 1 0.757168 5 0.086093 biological_process response to organic substance GO:0010033 24 1 0.653766 1 0.845557 biological_process response to inorganic substance GO:0010035 15 0 1 0 1 biological_process response to metal ion GO:0010038 14 0 1 0 1 biological_process membrane invagination GO:0010324 87 6 0.171651 9 0.199482 biological_process programmed cell death GO:0012501 426 24 0.103072 41 0.0505924 biological_process induction of programmed cell death GO:0012502 153 12 0.0315467 18 0.0349803 biological_process mesenchymal cell development GO:0014031 11 2 0.0788061 2 0.196151 biological_process protein transport GO:0015031 175 12 0.0737639 17 0.15729 biological_process monovalent inorganic cation transport GO:0015672 98 4 0.616746 8 0.451144 biological_process di-. tri-valent inorganic cation transport GO:0015674 33 4 0.0517224 2 0.71835 biological_process inorganic anion transport GO:0015698 20 1 0.586663 3 0.184164 biological_process monosaccharide transport GO:0015749 18 3 0.0399899 3 0.146689 biological_process glucose transport GO:0015758 18 3 0.0399899 3 0.146689 biological_process neutral amino acid transport GO:0015804 12 0 1 3 0.0548347 biological_process peptide transport GO:0015833 16 1 0.506629 2 0.338356 biological_process amine transport GO:0015837 36 1 0.796682 6 0.0481076 biological_process organic acid transport GO:0015849 37 1 0.805517 6 0.0539641 biological_process nucleobase. nucleoside. nucleotide and nucleic acid transport GO:0015931 25 1 0.668773 2 0.56729 biological_process energy derivation by oxidation of organic compounds GO:0015980 32 1 0.757168 3 0.431998 biological_process proton transport GO:0015992 19 2 0.196524 2 0.420613 biological_process viral reproduction GO:0016032 44 3 0.294798 4 0.419381 biological_process lipid catabolic process GO:0016042 24 1 0.653766 2 0.544771 biological_process cellular component organization and biogenesis GO:0016043 1146 62 0.0241984 88 0.400371 biological_process membrane organization and biogenesis GO:0016044 145 7 0.435755 19 0.0108367 biological_process cell growth GO:0016049 83 5 0.287068 11 0.0432079 biological_process carbohydrate biosynthetic process GO:0016051 50 3 0.366636 4 0.519799 biological_process carbohydrate catabolic process GO:0016052 32 2 0.404572 0 1 biological_process organic acid biosynthetic process GO:0016053 17 2 0.16505 1 0.73343 biological_process Wnt receptor signaling pathway GO:0016055 18 1 0.548407 0 1 biological_process RNA metabolic process GO:0016070 866 50 0.0146146 81 0.0136359 biological_process mRNA metabolic process GO:0016071 110 6 0.337596 13 0.0647933 biological_process rRNA metabolic process GO:0016072 26 4 0.0238395 0 1 biological_process sterol metabolic process GO:0016125 37 3 0.212714 3 0.529718 biological_process sterol biosynthetic process GO:0016126 10 0 1 1 0.540277 biological_process vesicle-mediated transport GO:0016192 214 8 0.713328 23 0.0468595 biological_process endosome transport GO:0016197 23 1 0.638083 1 0.833024 biological_process regulation of striated muscle development GO:0016202 11 2 0.0788061 1 0.57469 biological_process death GO:0016265 437 26 0.0549249 43 0.0335148 biological_process phosphorylation GO:0016310 299 15 0.307868 20 0.734688 biological_process dephosphorylation GO:0016311 64 4 0.29757 4 0.715191 biological_process cell-cell adhesion GO:0016337 111 3 0.865072 13 0.0686661 biological_process calcium-independent cell-cell adhesion GO:0016338 18 1 0.548407 4 0.0405588 biological_process calcium-dependent cell-cell adhesion GO:0016339 11 0 1 1 0.57469 biological_process gene silencing GO:0016458 14 0 1 1 0.663263 biological_process cell migration GO:0016477 91 6 0.197865 4 0.917447 biological_process negative regulation of transcription GO:0016481 168 6 0.740099 15 0.271431 biological_process protein processing GO:0016485 41 3 0.259149 4 0.367252 biological_process negative regulation of angiogenesis GO:0016525 11 2 0.0788061 0 1 biological_process protein autoprocessing GO:0016540 26 2 0.309788 1 0.867877 biological_process protein ubiquitination GO:0016567 46 2 0.59679 3 0.679062 biological_process chromatin modification GO:0016568 61 5 0.121295 7 0.167531 biological_process covalent chromatin modification GO:0016569 20 1 0.586663 0 1 biological_process histone modification GO:0016570 19 1 0.567956 0 1 biological_process protein import GO:0017038 56 2 0.703315 3 0.800396 biological_process negative regulation of protein biosynthetic process GO:0017148 16 2 0.149678 1 0.711833 biological_process peptidyl-tyrosine phosphorylation GO:0018108 29 1 0.722598 2 0.649211 biological_process peptide cross-linking GO:0018149 10 0 1 1 0.540277 biological_process peptidyl-amino acid modification GO:0018193 60 3 0.482612 3 0.836901 biological_process peptidyl-tyrosine modification GO:0018212 29 1 0.722598 2 0.649211 biological_process virus-host interaction GO:0019048 10 2 0.0663126 1 0.540277 biological_process viral infectious cycle GO:0019058 32 2 0.404572 3 0.431998 biological_process initiation of viral infection GO:0019059 11 1 0.384585 2 0.196151 biological_process viral genome replication GO:0019079 21 2 0.228655 1 0.804835 biological_process regulation of lipid metabolic process GO:0019216 15 0 1 2 0.310079 biological_process regulation of nucleobase. nucleoside. nucleotide and nucleic acid metabolic process GO:0019219 627 31 0.229679 64 0.00440299 biological_process regulation of phosphate metabolic process GO:0019220 37 2 0.478644 2 0.775676 biological_process cytokine and chemokine mediated signaling pathway GO:0019221 22 2 0.24486 0 1 biological_process regulation of metabolic process GO:0019222 769 42 0.0564979 70 0.0380724 biological_process transmission of nerve impulse GO:0019226 190 7 0.720487 17 0.251181 biological_process hexose metabolic process GO:0019318 55 4 0.211704 5 0.393139 biological_process hexose biosynthetic process GO:0019319 10 0 1 0 1 biological_process hexose catabolic process GO:0019320 20 1 0.586663 0 1 biological_process fatty acid oxidation GO:0019395 21 2 0.228655 1 0.804835 biological_process protein metabolic process GO:0019538 1141 65 0.00647093 84 0.584723 biological_process calcium-mediated signaling GO:0019722 19 1 0.567956 1 0.771902 biological_process B cell mediated immunity GO:0019724 10 2 0.0663126 1 0.540277 biological_process cell homeostasis GO:0019725 134 5 0.693501 15 0.0730747 biological_process secondary metabolic process GO:0019748 26 2 0.309788 6 0.0106456 biological_process carboxylic acid metabolic process GO:0019752 222 9 0.626012 22 0.102514 biological_process antigen processing and presentation GO:0019882 11 2 0.0788061 1 0.57469 biological_process second-messenger-mediated signaling GO:0019932 165 9 0.281353 11 0.698916 biological_process cAMP-mediated signaling GO:0019933 59 3 0.471414 6 0.276557 biological_process cyclic-nucleotide-mediated signaling GO:0019935 91 4 0.557442 8 0.369506 biological_process modification-dependent protein catabolic process GO:0019941 66 2 0.785461 2 0.963222 biological_process sexual reproduction GO:0019953 143 5 0.746824 14 0.179049 biological_process developmental maturation GO:0021700 22 1 0.621692 0 1 biological_process neurogenesis GO:0022008 88 3 0.739366 4 0.904148 biological_process cell cycle process GO:0022402 378 24 0.0339304 25 0.773702 biological_process cell cycle phase GO:0022403 152 9 0.20827 11 0.590221 biological_process cellular component disassembly GO:0022411 25 2 0.293602 2 0.56729 biological_process reproductive process GO:0022414 151 9 0.202997 14 0.235775 biological_process viral reproductive process GO:0022415 39 3 0.235726 3 0.566115 biological_process menstrual cycle phase GO:0022601 11 2 0.0788061 1 0.57469 biological_process menstrual cycle process GO:0022602 11 2 0.0788061 1 0.57469 biological_process regulation of anatomical structure morphogenesis GO:0022603 14 2 0.11994 1 0.663263 biological_process regulation of cell morphogenesis GO:0022604 14 2 0.11994 1 0.663263 biological_process cellular component assembly GO:0022607 299 17 0.145164 29 0.0842368 biological_process biological adhesion GO:0022610 324 14 0.53855 26 0.378933 biological_process ribonucleoprotein complex biogenesis and assembly GO:0022613 92 7 0.100708 8 0.381159 biological_process protein-RNA complex assembly GO:0022618 66 4 0.317304 7 0.22036 biological_process metal ion transport GO:0030001 122 8 0.155008 9 0.566651 biological_process cation homeostasis GO:0030003 100 4 0.632761 11 0.124478 biological_process monovalent inorganic cation homeostasis GO:0030004 16 3 0.0292268 3 0.11214 biological_process di-. tri-valent inorganic cation homeostasis GO:0030005 81 1 0.972716 8 0.256514 biological_process actin filament-based process GO:0030029 117 5 0.573742 13 0.0950742 biological_process cell projection organization and biogenesis GO:0030030 80 4 0.455499 6 0.557864 biological_process cell projection biogenesis GO:0030031 20 1 0.586663 1 0.789008 biological_process actin cytoskeleton organization and biogenesis GO:0030036 106 5 0.484925 10 0.266349 biological_process actin filament polymerization GO:0030041 11 0 1 2 0.196151 biological_process actin filament-based movement GO:0030048 12 0 1 3 0.0548347 biological_process peptide hormone secretion GO:0030072 11 0 1 1 0.57469 biological_process hemopoiesis GO:0030097 96 8 0.0539621 11 0.100547 biological_process lymphocyte differentiation GO:0030098 41 5 0.0301431 5 0.188186 biological_process myeloid cell differentiation GO:0030099 39 3 0.235726 5 0.162535 biological_process regulation of endocytosis GO:0030100 15 0 1 2 0.310079 biological_process regulation of Wnt receptor signaling pathway GO:0030111 14 1 0.461007 0 1 biological_process sphingolipid biosynthetic process GO:0030148 14 2 0.11994 1 0.663263 biological_process cell differentiation GO:0030154 926 50 0.0454277 81 0.0596366 biological_process regulation of cell adhesion GO:0030155 34 2 0.434842 5 0.105571 biological_process protein catabolic process GO:0030163 87 7 0.0801113 3 0.963416 biological_process proteoglycan biosynthetic process GO:0030166 18 1 0.548407 2 0.393718 biological_process neuron differentiation GO:0030182 76 3 0.643812 4 0.830478 biological_process B cell differentiation GO:0030183 21 4 0.0112854 4 0.0665768 biological_process extracellular matrix organization and biogenesis GO:0030198 16 0 1 0 1 biological_process heparan sulfate proteoglycan metabolic process GO:0030201 11 1 0.384585 1 0.57469 biological_process glycosaminoglycan metabolic process GO:0030203 23 2 0.261108 2 0.52145 biological_process keratinocyte differentiation GO:0030216 20 1 0.586663 1 0.789008 biological_process T cell differentiation GO:0030217 22 2 0.24486 1 0.819477 biological_process erythrocyte differentiation GO:0030218 13 1 0.436645 2 0.25295 biological_process entry into host cell GO:0030260 11 1 0.384585 2 0.196151 biological_process chromosome condensation GO:0030261 12 0 1 1 0.606533 biological_process apoptotic nuclear changes GO:0030262 13 1 0.436645 2 0.25295 biological_process negative regulation of cell growth GO:0030308 35 2 0.449666 6 0.0426614 biological_process DNA damage response. signal transduction by p53 class mediator GO:0030330 12 2 0.0919606 2 0.224414 biological_process regulation of cell migration GO:0030334 23 0 1 1 0.833024 biological_process negative regulation of cell migration GO:0030336 11 0 1 1 0.57469 biological_process phosphoinositide metabolic process GO:0030384 29 3 0.127374 4 0.167012 biological_process ER-associated protein catabolic process GO:0030433 11 0 1 1 0.57469 biological_process steroid hormone receptor signaling pathway GO:0030518 33 2 0.419807 1 0.923533 biological_process androgen receptor signaling pathway GO:0030521 25 1 0.668773 1 0.857151 biological_process intracellular receptor-mediated signaling pathway GO:0030522 35 2 0.449666 1 0.934604 biological_process leukocyte chemotaxis GO:0030595 13 3 0.0164134 0 1 biological_process hydrogen ion homeostasis GO:0030641 10 3 0.00757767 1 0.540277 biological_process cytoskeleton-dependent intracellular transport GO:0030705 29 0 1 3 0.369964 biological_process regulation of actin filament length GO:0030832 16 0 1 2 0.338356 biological_process microtubule organizing center organization and biogenesis GO:0031023 14 1 0.461007 0 1 biological_process stress-activated protein kinase signaling pathway GO:0031098 47 4 0.142883 4 0.470457 biological_process neurite development GO:0031175 58 3 0.460109 4 0.639318 biological_process biomineral formation GO:0031214 25 2 0.293602 3 0.28581 biological_process regulation of cyclase activity GO:0031279 30 0 1 3 0.390834 biological_process negative regulation of cyclase activity GO:0031280 14 0 1 2 0.281562 biological_process positive regulation of cyclase activity GO:0031281 16 0 1 1 0.711833 biological_process regulation of cellular metabolic process GO:0031323 731 40 0.0607764 68 0.0268172 biological_process negative regulation of cellular metabolic process GO:0031324 203 10 0.378762 18 0.255227 biological_process positive regulation of cellular metabolic process GO:0031325 177 11 0.140749 23 0.00589423 biological_process regulation of cellular biosynthetic process GO:0031326 99 8 0.0625379 9 0.319388 biological_process negative regulation of cellular biosynthetic process GO:0031327 18 2 0.180682 1 0.753413 biological_process positive regulation of cellular biosynthetic process GO:0031328 35 2 0.449666 6 0.0426614 biological_process chromatin assembly GO:0031497 31 2 0.38915 3 0.411527 biological_process DNA integrity checkpoint GO:0031570 21 2 0.228655 2 0.472477 biological_process cell-substrate adhesion GO:0031589 40 2 0.520324 3 0.583655 biological_process regulation of neurological process GO:0031644 15 0 1 2 0.310079 biological_process regulation of protein stability GO:0031647 12 1 0.411187 2 0.224414 biological_process response to nutrient levels GO:0031667 28 1 0.710018 5 0.0534531 biological_process activation of protein kinase activity GO:0032147 37 1 0.805517 7 0.0178488 biological_process telomere organization and biogenesis GO:0032200 17 2 0.16505 1 0.73343 biological_process methylation GO:0032259 21 2 0.228655 1 0.804835 biological_process regulation of intracellular transport GO:0032386 16 2 0.149678 1 0.711833 biological_process protein modification by small protein conjugation GO:0032446 48 2 0.620175 3 0.707029 biological_process multicellular organismal process GO:0032501 1527 78 0.0395408 144 0.000331526 biological_process developmental process GO:0032502 1663 80 0.123789 160 3.23E-05 biological_process multicellular organism reproduction GO:0032504 61 6 0.0463017 3 0.845078 biological_process maintenance of cellular protein localization GO:0032507 15 0 1 1 0.68849 biological_process interferon-gamma production GO:0032609 12 2 0.0919606 1 0.606533 biological_process RNA biosynthetic process GO:0032774 668 38 0.0409098 64 0.017719 biological_process monocarboxylic acid metabolic process GO:0032787 106 6 0.306748 8 0.541992 biological_process secretion by cell GO:0032940 129 7 0.321355 12 0.254606 biological_process mononuclear cell proliferation GO:0032943 23 2 0.261108 1 0.833024 biological_process regulation of mononuclear cell proliferation GO:0032944 18 1 0.548407 1 0.753413 biological_process positive regulation of mononuclear cell proliferation GO:0032946 15 1 0.48432 0 1 biological_process macromolecular complex disassembly GO:0032984 11 1 0.384585 1 0.57469 biological_process cellular structure morphogenesis GO:0032989 189 13 0.0631123 17 0.244303 biological_process cell part morphogenesis GO:0032990 80 4 0.455499 6 0.557864 biological_process tetrapyrrole metabolic process GO:0033013 13 1 0.436645 2 0.25295 biological_process tetrapyrrole biosynthetic process GO:0033014 10 1 0.356787 2 0.16839 biological_process macromolecule localization GO:0033036 241 16 0.0548516 24 0.0872773 biological_process regulation of intracellular protein transport GO:0033157 14 2 0.11994 1 0.663263 biological_process regulation of Rho protein signal transduction GO:0035023 12 0 1 2 0.224414 biological_process tube development GO:0035295 10 0 1 2 0.16839 biological_process growth GO:0040007 109 5 0.509849 13 0.0610684 biological_process regulation of growth GO:0040008 79 3 0.669797 11 0.0315228 biological_process locomotion GO:0040011 30 0 1 2 0.667666 biological_process regulation of locomotion GO:0040012 30 0 1 2 0.667666 biological_process negative regulation of locomotion GO:0040013 14 0 1 2 0.281562 biological_process positive regulation of locomotion GO:0040017 11 0 1 0 1 biological_process regulation of gene expression. epigenetic GO:0040029 32 4 0.0469792 3 0.431998 biological_process regulation of cytokine biosynthetic process GO:0042035 36 4 0.0674556 5 0.127015 biological_process wound healing GO:0042060 56 1 0.916529 7 0.121254 biological_process cytokine biosynthetic process GO:0042089 39 4 0.0853811 5 0.162535 biological_process interferon-gamma biosynthetic process GO:0042095 12 2 0.0919606 1 0.606533 biological_process T cell proliferation GO:0042098 16 1 0.506629 0 1 biological_process positive regulation of T cell proliferation GO:0042102 13 1 0.436645 0 1 biological_process cytokine metabolic process GO:0042107 39 4 0.0853811 5 0.162535 biological_process positive regulation of cytokine biosynthetic process GO:0042108 24 2 0.277366 4 0.0993747 biological_process T cell activation GO:0042110 52 5 0.0717731 3 0.757304 biological_process B cell activation GO:0042113 33 5 0.0125908 6 0.0329768 biological_process regulation of cell proliferation GO:0042127 276 22 0.00350062 26 0.126349 biological_process regulation of T cell proliferation GO:0042129 15 1 0.48432 0 1 biological_process neurotransmitter metabolic process GO:0042133 13 0 1 0 1 biological_process lipoprotein metabolic process GO:0042157 30 4 0.0382538 2 0.667666 biological_process lipoprotein biosynthetic process GO:0042158 22 3 0.0666051 1 0.819477 biological_process heme metabolic process GO:0042168 10 1 0.356787 2 0.16839 biological_process response to chemical stimulus GO:0042221 267 12 0.484949 17 0.792628 biological_process ribosome biogenesis and assembly GO:0042254 27 4 0.0270673 0 1 biological_process regulation of protein import into nucleus GO:0042306 14 2 0.11994 1 0.663263 biological_process regulation of phosphorylation GO:0042325 34 2 0.434842 2 0.73374 biological_process positive regulation of phosphorylation GO:0042327 19 0 1 2 0.420613 biological_process taxis GO:0042330 72 4 0.376925 3 0.913936 biological_process regulation of NF-kappaB import into nucleus GO:0042345 10 1 0.356787 0 1 biological_process NF-kappaB import into nucleus GO:0042348 10 1 0.356787 0 1 biological_process L-fucose metabolic process GO:0042354 11 1 0.384585 0 1 biological_process regulation of membrane potential GO:0042391 15 0 1 3 0.0962019 biological_process amino acid derivative biosynthetic process GO:0042398 11 1 0.384585 0 1 biological_process pigment metabolic process GO:0042440 17 1 0.527978 5 0.00660447 biological_process hormone metabolic process GO:0042445 38 2 0.492782 5 0.150277 biological_process hormone biosynthetic process GO:0042446 15 1 0.48432 3 0.0962019 biological_process response to drug GO:0042493 26 3 0.0993629 3 0.306829 biological_process regulation of tyrosine phosphorylation of STAT protein GO:0042509 11 1 0.384585 0 1 biological_process homeostatic process GO:0042592 169 8 0.445801 22 0.0068632 biological_process response to starvation GO:0042594 10 0 1 3 0.0334188 biological_process muscle cell differentiation GO:0042692 20 1 0.586663 0 1 biological_process menstrual cycle GO:0042698 14 2 0.11994 2 0.281562 biological_process defense response to bacterium GO:0042742 20 1 0.586663 1 0.789008 biological_process DNA damage response. signal transduction GO:0042770 29 2 0.357803 3 0.369964 biological_process ATP synthesis coupled electron transport GO:0042773 33 0 1 4 0.229922 biological_process organelle ATP synthesis coupled electron transport GO:0042775 33 0 1 4 0.229922 biological_process regulation of apoptosis GO:0042981 329 18 0.174361 33 0.0468092 biological_process regulation of transcription factor import into nucleus GO:0042990 13 1 0.436645 1 0.635998 biological_process transcription factor import into nucleus GO:0042991 13 1 0.436645 1 0.635998 biological_process chordate embryonic development GO:0043009 17 1 0.527978 1 0.73343 biological_process extracellular structure organization and biogenesis GO:0043062 34 0 1 2 0.73374 biological_process positive regulation of apoptosis GO:0043065 172 13 0.0335763 20 0.0303286 biological_process negative regulation of apoptosis GO:0043066 147 8 0.300227 14 0.206525 biological_process regulation of programmed cell death GO:0043067 332 18 0.184241 33 0.0520453 biological_process positive regulation of programmed cell death GO:0043068 173 13 0.0349657 20 0.0320175 biological_process negative regulation of programmed cell death GO:0043069 149 8 0.313138 14 0.220941 biological_process positive regulation of enzyme activity GO:0043085 149 3 0.959912 16 0.0880062 biological_process negative regulation of enzyme activity GO:0043086 50 5 0.0626265 6 0.166641 biological_process regulation of GTPase activity GO:0043087 15 0 1 1 0.68849 biological_process regulation of I-kappaB kinase/NF-kappaB cascade GO:0043122 81 6 0.13536 8 0.256514 biological_process positive regulation of I-kappaB kinase/NF-kappaB cascade GO:0043123 76 6 0.108261 7 0.33937 biological_process proteasomal ubiquitin-dependent protein catabolic process GO:0043161 16 0 1 1 0.711833 biological_process macromolecule metabolic process GO:0043170 2121 107 0.0163898 170 0.111752 biological_process protein complex disassembly GO:0043241 11 1 0.384585 1 0.57469 biological_process positive regulation of caspase activity GO:0043280 34 1 0.777798 6 0.0376202 biological_process regulation of caspase activity GO:0043281 39 1 0.822056 6 0.0669202 biological_process biopolymer metabolic process GO:0043283 1627 90 0.00219145 137 0.0425975 biological_process biopolymer biosynthetic process GO:0043284 17 3 0.034389 1 0.73343 biological_process biopolymer catabolic process GO:0043285 128 10 0.0484853 6 0.925184 biological_process regulation of MAPK activity GO:0043405 60 5 0.115148 4 0.665986 biological_process positive regulation of MAPK activity GO:0043406 38 1 0.813969 1 0.948286 biological_process negative regulation of MAPK activity GO:0043407 18 3 0.0399899 3 0.146689 biological_process biopolymer modification GO:0043412 617 35 0.0508589 50 0.284097 biological_process biopolymer glycosylation GO:0043413 75 4 0.406644 4 0.822613 biological_process biopolymer methylation GO:0043414 21 2 0.228655 1 0.804835 biological_process regulation of JNK activity GO:0043506 16 1 0.506629 1 0.711833 biological_process positive regulation of JNK activity GO:0043507 14 1 0.461007 1 0.663263 biological_process regulation of neuron apoptosis GO:0043523 11 0 1 1 0.57469 biological_process protein amino acid acylation GO:0043543 15 1 0.48432 0 1 biological_process regulation of kinase activity GO:0043549 141 9 0.153625 12 0.361907 biological_process cellular protein complex assembly GO:0043623 33 1 0.767711 4 0.229922 biological_process cellular protein complex disassembly GO:0043624 10 1 0.356787 1 0.540277 biological_process modification-dependent macromolecule catabolic process GO:0043632 66 2 0.785461 2 0.963222 biological_process post-translational protein modification GO:0043687 439 26 0.0574662 34 0.437959 biological_process cellular metabolic process GO:0044237 2465 119 0.0421705 202 0.0287613 biological_process primary metabolic process GO:0044238 2494 120 0.0453818 198 0.110404 biological_process cellular lipid catabolic process GO:0044242 21 1 0.604564 1 0.804835 biological_process cellular catabolic process GO:0044248 199 8 0.633681 13 0.7357 biological_process cellular biosynthetic process GO:0044249 244 16 0.0600686 25 0.0631388 biological_process cellular lipid metabolic process GO:0044255 270 16 0.119746 27 0.0699611 biological_process cellular protein catabolic process GO:0044257 67 2 0.792472 2 0.965566 biological_process cellular macromolecule metabolic process GO:0044260 1052 62 0.00364214 78 0.553042 biological_process cellular carbohydrate metabolic process GO:0044262 137 10 0.0704368 10 0.578973 biological_process cellular polysaccharide metabolic process GO:0044264 14 2 0.11994 0 1 biological_process cellular macromolecule catabolic process GO:0044265 123 6 0.439107 3 0.996065 biological_process cellular protein metabolic process GO:0044267 1036 61 0.00406495 77 0.542958 biological_process nitrogen compound catabolic process GO:0044270 27 1 0.696872 3 0.327904 biological_process nitrogen compound biosynthetic process GO:0044271 30 2 0.373555 2 0.667666 biological_process sulfur compound biosynthetic process GO:0044272 21 1 0.604564 3 0.203762 biological_process cellular carbohydrate catabolic process GO:0044275 31 2 0.38915 0 1 biological_process symbiosis. encompassing mutualism through parasitism GO:0044403 23 2 0.261108 2 0.52145 biological_process entry into host GO:0044409 11 1 0.384585 2 0.196151 biological_process interspecies interaction between organisms GO:0044419 23 2 0.261108 2 0.52145 biological_process maintenance of fidelity during DNA-dependent DNA replication GO:0045005 11 0 1 0 1 biological_process secretory pathway GO:0045045 102 3 0.823979 9 0.351643 biological_process regulated secretory pathway GO:0045055 19 0 1 1 0.771902 biological_process regulation of interferon-gamma biosynthetic process GO:0045072 11 2 0.0788061 1 0.57469 biological_process innate immune response GO:0045087 28 1 0.710018 4 0.152362 biological_process development of primary sexual characteristics GO:0045137 27 2 0.3259 6 0.0128487 biological_process cell fate commitment GO:0045165 16 0 1 1 0.711833 biological_process establishment of protein localization GO:0045184 203 15 0.0279532 21 0.0773535 biological_process maintenance of protein localization GO:0045185 15 0 1 1 0.68849 biological_process intercellular junction assembly and maintenance GO:0045216 12 1 0.411187 0 1 biological_process leukocyte activation GO:0045321 99 9 0.0260566 11 0.11822 biological_process cellular respiration GO:0045333 18 0 1 3 0.146689 biological_process myoblast differentiation GO:0045445 18 1 0.548407 0 1 biological_process regulation of transcription GO:0045449 595 31 0.148818 60 0.00764994 biological_process regulation of cell differentiation GO:0045595 61 4 0.268297 7 0.167531 biological_process negative regulation of cell differentiation GO:0045596 22 2 0.24486 2 0.497344 biological_process positive regulation of cell differentiation GO:0045597 23 1 0.638083 3 0.244224 biological_process regulation of myeloid cell differentiation GO:0045637 23 2 0.261108 4 0.0877257 biological_process negative regulation of myeloid cell differentiation GO:0045638 13 2 0.105696 1 0.635998 biological_process positive regulation of protein biosynthetic process GO:0045727 32 2 0.404572 5 0.086093 biological_process regulation of adenylate cyclase activity GO:0045761 30 0 1 3 0.390834 biological_process positive regulation of adenylate cyclase activity GO:0045762 16 0 1 1 0.711833 biological_process positive regulation of amino acid metabolic process GO:0045764 16 0 1 1 0.711833 biological_process regulation of angiogenesis GO:0045765 24 3 0.0822737 1 0.845557 biological_process regulation of anti-apoptosis GO:0045767 10 0 1 0 1 biological_process negative regulation of progression through cell cycle GO:0045786 74 6 0.0982869 7 0.314627 biological_process positive regulation of progression through cell cycle GO:0045787 10 0 1 0 1 biological_process negative regulation of cell size GO:0045792 35 2 0.449666 6 0.0426614 biological_process regulation of protein kinase activity GO:0045859 139 9 0.144543 12 0.343399 biological_process positive regulation of protein kinase activity GO:0045860 78 2 0.857204 7 0.364357 biological_process negative regulation of transcription. DNA-dependent GO:0045892 111 2 0.95667 10 0.31531 biological_process positive regulation of transcription. DNA-dependent GO:0045893 104 6 0.291519 16 0.00406999 biological_process negative regulation of growth GO:0045926 39 2 0.506677 6 0.0669202 biological_process positive regulation of growth GO:0045927 11 1 0.384585 3 0.0434662 biological_process negative regulation of nucleobase. nucleoside. nucleotide and nucleic acid metabolic process GO:0045934 181 6 0.801624 17 0.192307 biological_process positive regulation of nucleobase. nucleoside. nucleotide and nucleic acid metabolic process GO:0045935 135 9 0.127238 20 0.00220649 biological_process positive regulation of phosphate metabolic process GO:0045937 19 0 1 2 0.420613 biological_process positive regulation of transcription GO:0045941 130 9 0.107276 18 0.0074405 biological_process positive regulation of transcription from RNA polymerase II promoter GO:0045944 42 3 0.270978 8 0.0111662 biological_process cAMP metabolic process GO:0046058 11 0 1 2 0.196151 biological_process pigment biosynthetic process GO:0046148 15 1 0.48432 5 0.00362948 biological_process alcohol catabolic process GO:0046164 21 1 0.604564 0 1 biological_process alcohol biosynthetic process GO:0046165 10 0 1 0 1 biological_process nitric oxide metabolic process GO:0046209 11 1 0.384585 1 0.57469 biological_process monosaccharide biosynthetic process GO:0046364 10 0 1 0 1 biological_process monosaccharide catabolic process GO:0046365 21 1 0.604564 0 1 biological_process carboxylic acid biosynthetic process GO:0046394 17 2 0.16505 1 0.73343 biological_process regulation of JAK-STAT cascade GO:0046425 11 1 0.384585 0 1 biological_process membrane lipid biosynthetic process GO:0046467 51 5 0.0671125 3 0.745428 biological_process glycerophospholipid biosynthetic process GO:0046474 27 3 0.1084 2 0.609882 biological_process heterocycle metabolic process GO:0046483 27 1 0.696872 4 0.138233 biological_process glycerolipid metabolic process GO:0046486 14 1 0.461007 0 1 biological_process phosphoinositide biosynthetic process GO:0046489 24 3 0.0822737 1 0.845557 biological_process sphingoid metabolic process GO:0046519 17 3 0.034389 1 0.73343 biological_process development of primary female sexual characteristics GO:0046545 13 2 0.105696 1 0.635998 biological_process development of primary male sexual characteristics GO:0046546 14 0 1 5 0.00257535 biological_process regulation of Ras protein signal transduction GO:0046578 18 1 0.548407 2 0.393718 biological_process lymphocyte activation GO:0046649 83 9 0.00892667 10 0.0883117 biological_process lymphocyte proliferation GO:0046651 23 2 0.261108 1 0.833024 biological_process female sex differentiation GO:0046660 13 2 0.105696 1 0.635998 biological_process male sex differentiation GO:0046661 16 0 1 5 0.0049607 biological_process entry of virus into host cell GO:0046718 11 1 0.384585 2 0.196151 biological_process protein amino acid autophosphorylation GO:0046777 24 2 0.277366 0 1 biological_process regulation of nucleocytoplasmic transport GO:0046822 19 2 0.196524 1 0.771902 biological_process bone remodeling GO:0046849 33 2 0.419807 6 0.0329768 biological_process regulation of bone remodeling GO:0046850 14 1 0.461007 1 0.663263 biological_process hormone secretion GO:0046879 19 2 0.196524 3 0.165109 biological_process secretion GO:0046903 158 11 0.0778674 18 0.0459183 biological_process intracellular transport GO:0046907 286 12 0.583845 24 0.302622 biological_process transition metal ion homeostasis GO:0046916 19 0 1 2 0.420613 biological_process carboxylic acid transport GO:0046942 36 1 0.796682 6 0.0481076 biological_process phosphoinositide-mediated signaling GO:0048015 63 4 0.287761 2 0.955237 biological_process Golgi vesicle transport GO:0048193 50 2 0.642507 5 0.317064 biological_process male gamete generation GO:0048232 97 5 0.407997 11 0.106252 biological_process mesoderm morphogenesis GO:0048332 11 1 0.384585 0 1 biological_process cell development GO:0048468 811 43 0.0795975 73 0.0428069 biological_process cell maturation GO:0048469 20 1 0.586663 0 1 biological_process rhythmic process GO:0048511 30 2 0.373555 3 0.390834 biological_process organ development GO:0048513 541 31 0.0577919 59 0.00136068 biological_process blood vessel morphogenesis GO:0048514 50 4 0.167576 4 0.519799 biological_process spermatid differentiation GO:0048515 15 1 0.48432 0 1 biological_process positive regulation of biological process GO:0048518 590 42 0.000564171 63 0.00158143 biological_process negative regulation of biological process GO:0048519 594 30 0.199123 61 0.0047668 biological_process positive regulation of cellular process GO:0048522 550 38 0.00188922 58 0.00330334 biological_process negative regulation of cellular process GO:0048523 577 28 0.2783 59 0.00606937 biological_process hemopoietic or lymphoid organ development GO:0048534 98 9 0.0245743 11 0.112144 biological_process regulation of response to stimulus GO:0048583 18 2 0.180682 2 0.393718 biological_process developmental growth GO:0048589 12 0 1 1 0.606533 biological_process embryonic morphogenesis GO:0048598 17 1 0.527978 1 0.73343 biological_process reproductive structure development GO:0048608 24 2 0.277366 5 0.0294809 biological_process reproductive process in a multicellular organism GO:0048609 61 6 0.0463017 3 0.845078 biological_process skeletal muscle development GO:0048637 30 1 0.734633 2 0.667666 biological_process anatomical structure formation GO:0048646 58 6 0.0374979 4 0.639318 biological_process neuron development GO:0048666 65 3 0.536816 4 0.726626 biological_process neuron morphogenesis during differentiation GO:0048667 54 2 0.684058 3 0.779714 biological_process generation of neurons GO:0048699 84 3 0.709986 4 0.883498 biological_process tissue morphogenesis GO:0048729 18 1 0.548407 0 1 biological_process system development GO:0048731 773 44 0.0278578 76 0.00502289 biological_process gland development GO:0048732 10 0 1 1 0.540277 biological_process skeletal muscle fiber development GO:0048741 28 1 0.710018 2 0.629952 biological_process muscle fiber development GO:0048747 28 1 0.710018 2 0.629952 biological_process mesenchymal cell differentiation GO:0048762 11 2 0.0788061 2 0.196151 biological_process tissue remodeling GO:0048771 33 2 0.419807 6 0.0329768 biological_process neurite morphogenesis GO:0048812 54 2 0.684058 3 0.779714 biological_process anatomical structure development GO:0048856 958 53 0.0259666 103 2.26E-05 biological_process cell projection morphogenesis GO:0048858 80 4 0.455499 6 0.557864 biological_process cellular developmental process GO:0048869 926 50 0.0454277 81 0.0596366 biological_process multicellular organismal homeostasis GO:0048871 11 1 0.384585 3 0.0434662 biological_process chemical homeostasis GO:0048878 123 6 0.439107 14 0.0730805 biological_process beta-amyloid metabolic process GO:0050435 10 0 1 2 0.16839 biological_process nucleic acid transport GO:0050657 18 1 0.548407 2 0.393718 biological_process RNA transport GO:0050658 18 1 0.548407 2 0.393718 biological_process regulation of lymphocyte proliferation GO:0050670 18 1 0.548407 1 0.753413 biological_process positive regulation of lymphocyte proliferation GO:0050671 15 1 0.48432 0 1 biological_process epithelial cell proliferation GO:0050673 11 0 1 0 1 biological_process regulation of epithelial cell proliferation GO:0050678 11 0 1 0 1 biological_process regulation of protein secretion GO:0050708 14 1 0.461007 1 0.663263 biological_process positive regulation of protein secretion GO:0050714 10 1 0.356787 1 0.540277 biological_process regulation of peptidyl-tyrosine phosphorylation GO:0050730 21 1 0.604564 1 0.804835 biological_process positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 14 0 1 1 0.663263 biological_process regulation of neurogenesis GO:0050767 16 1 0.506629 0 1 biological_process regulation of axonogenesis GO:0050770 13 1 0.436645 0 1 biological_process regulation of immune response GO:0050776 38 1 0.813969 3 0.548131 biological_process positive regulation of immune response GO:0050778 32 1 0.757168 3 0.431998 biological_process regulation of biological process GO:0050789 1645 82 0.0586229 139 0.0366176 biological_process regulation of catalytic activity GO:0050790 244 11 0.485124 24 0.0970571 biological_process regulation of viral life cycle GO:0050792 11 0 1 2 0.196151 biological_process regulation of developmental process GO:0050793 89 7 0.0880286 8 0.346306 biological_process regulation of cellular process GO:0050794 1502 75 0.0698616 129 0.0280605 biological_process ion homeostasis GO:0050801 107 5 0.493283 12 0.100549 biological_process regulation of synaptic transmission GO:0050804 12 0 1 1 0.606533 biological_process synapse organization and biogenesis GO:0050808 19 0 1 2 0.420613 biological_process coagulation GO:0050817 48 1 0.880769 8 0.0241744 biological_process protein stabilization GO:0050821 10 1 0.356787 1 0.540277 biological_process antigen receptor-mediated signaling pathway GO:0050851 17 0 1 2 0.36627 biological_process T cell receptor signaling pathway GO:0050852 12 0 1 1 0.606533 biological_process regulation of T cell activation GO:0050863 32 2 0.404572 2 0.70222 biological_process regulation of B cell activation GO:0050864 11 3 0.0100918 1 0.57469 biological_process regulation of cell activation GO:0050865 44 4 0.119789 4 0.419381 biological_process positive regulation of T cell activation GO:0050870 24 2 0.277366 1 0.845557 biological_process neurological process GO:0050877 359 17 0.379491 38 0.0159883 biological_process regulation of body fluids GO:0050878 63 3 0.51551 11 0.00624958 biological_process regulation of blood vessel size GO:0050880 13 1 0.436645 1 0.635998 biological_process response to stimulus GO:0050896 955 49 0.0985291 78 0.197764 biological_process leukocyte migration GO:0050900 15 3 0.0245086 0 1 biological_process detection of stimulus during sensory perception GO:0050906 19 1 0.567956 0 1 biological_process detection of light stimulus during visual perception GO:0050908 16 1 0.506629 0 1 biological_process sensory perception of light stimulus GO:0050953 103 6 0.283966 8 0.508491 biological_process sensory perception of mechanical stimulus GO:0050954 41 3 0.259149 6 0.0815355 biological_process detection of light stimulus during sensory perception GO:0050962 16 1 0.506629 0 1 biological_process actin filament bundle formation GO:0051017 12 0 1 1 0.606533 biological_process mRNA transport GO:0051028 13 1 0.436645 2 0.25295 biological_process regulation of secretion GO:0051046 31 3 0.147432 4 0.197694 biological_process positive regulation of secretion GO:0051047 14 3 0.0202374 1 0.663263 biological_process regulation of transport GO:0051049 55 2 0.693811 4 0.596808 biological_process positive regulation of transport GO:0051050 16 1 0.506629 0 1 biological_process negative regulation of transport GO:0051051 18 0 1 3 0.146689 biological_process regulation of DNA metabolic process GO:0051052 32 2 0.404572 5 0.086093 biological_process negative regulation of DNA metabolic process GO:0051053 10 1 0.356787 1 0.540277 biological_process regulation of small GTPase mediated signal transduction GO:0051056 20 1 0.586663 2 0.446885 biological_process regulation of transcription factor activity GO:0051090 28 1 0.710018 4 0.152362 biological_process positive regulation of transcription factor activity GO:0051091 22 1 0.621692 4 0.076784 biological_process activation of NF-kappaB transcription factor GO:0051092 15 1 0.48432 2 0.310079 biological_process negative regulation of developmental process GO:0051093 25 2 0.293602 2 0.56729 biological_process positive regulation of developmental process GO:0051094 32 2 0.404572 3 0.431998 biological_process regulation of binding GO:0051098 19 1 0.567956 2 0.420613 biological_process regulation of cellular component organization and biogenesis GO:0051128 29 1 0.722598 4 0.167012 biological_process negative regulation of cell organization and biogenesis GO:0051129 11 0 1 1 0.57469 biological_process nuclear export GO:0051168 27 2 0.3259 2 0.609882 biological_process nuclear transport GO:0051169 76 5 0.229292 4 0.830478 biological_process nuclear import GO:0051170 51 3 0.378543 3 0.745428 biological_process regulation of phosphorus metabolic process GO:0051174 37 2 0.478644 2 0.775676 biological_process localization GO:0051179 1043 49 0.269444 97 0.00770741 biological_process vitamin transport GO:0051180 11 1 0.384585 2 0.196151 biological_process cofactor metabolic process GO:0051186 55 2 0.693811 7 0.112893 biological_process cofactor biosynthetic process GO:0051188 23 1 0.638083 5 0.0248108 biological_process regulation of protein transport GO:0051223 17 2 0.16505 1 0.73343 biological_process negative regulation of protein transport GO:0051224 10 0 1 1 0.540277 biological_process establishment of localization GO:0051234 845 41 0.222446 80 0.0105868 biological_process maintenance of localization GO:0051235 27 0 1 2 0.609882 biological_process establishment of RNA localization GO:0051236 18 1 0.548407 2 0.393718 biological_process sequestering of metal ion GO:0051238 11 0 1 1 0.57469 biological_process regulation of multicellular organismal process GO:0051239 146 8 0.29382 14 0.199482 biological_process positive regulation of multicellular organismal process GO:0051240 39 2 0.506677 3 0.566115 biological_process negative regulation of multicellular organismal process GO:0051241 11 2 0.0788061 1 0.57469 biological_process regulation of protein metabolic process GO:0051246 147 12 0.0239888 10 0.669158 biological_process positive regulation of protein metabolic process GO:0051247 54 3 0.413948 7 0.104849 biological_process negative regulation of protein metabolic process GO:0051248 35 5 0.0160664 3 0.491686 biological_process regulation of lymphocyte activation GO:0051249 40 4 0.091824 4 0.349783 biological_process positive regulation of lymphocyte activation GO:0051251 28 3 0.117743 2 0.629952 biological_process regulation of RNA metabolic process GO:0051252 10 0 1 1 0.540277 biological_process protein polymerization GO:0051258 14 0 1 3 0.0812802 biological_process protein oligomerization GO:0051259 38 1 0.813969 5 0.150277 biological_process protein homooligomerization GO:0051260 19 0 1 2 0.420613 biological_process protein depolymerization GO:0051261 10 0 1 1 0.540277 biological_process protein tetramerization GO:0051262 12 1 0.411187 1 0.606533 biological_process regulation of cell motility GO:0051270 30 0 1 2 0.667666 biological_process negative regulation of cell motility GO:0051271 14 0 1 2 0.281562 biological_process positive regulation of cell motility GO:0051272 11 0 1 0 1 biological_process chromosome organization and biogenesis GO:0051276 156 10 0.134789 14 0.274509 biological_process centrosome organization and biogenesis GO:0051297 13 1 0.436645 0 1 biological_process cell division GO:0051301 26 0 1 3 0.306829 biological_process G1 phase GO:0051318 15 2 0.134621 1 0.68849 biological_process meiotic cell cycle GO:0051321 34 0 1 2 0.73374 biological_process interphase GO:0051325 54 5 0.0816136 2 0.920176 biological_process M phase of meiotic cell cycle GO:0051327 33 0 1 2 0.71835 biological_process interphase of mitotic cell cycle GO:0051329 52 5 0.0717731 2 0.909455 biological_process regulation of hydrolase activity GO:0051336 75 1 0.964298 7 0.326961 biological_process regulation of transferase activity GO:0051338 146 9 0.177517 14 0.199482 biological_process regulation of lyase activity GO:0051339 30 0 1 3 0.390834 biological_process positive regulation of hydrolase activity GO:0051345 56 1 0.916529 6 0.237906 biological_process positive regulation of transferase activity GO:0051347 83 2 0.880066 9 0.164475 biological_process negative regulation of transferase activity GO:0051348 30 4 0.0382538 3 0.390834 biological_process positive regulation of lyase activity GO:0051349 16 0 1 1 0.711833 biological_process negative regulation of lyase activity GO:0051350 14 0 1 2 0.281562 biological_process neuron apoptosis GO:0051402 17 0 1 3 0.129001 biological_process cytosolic calcium ion homeostasis GO:0051480 38 0 1 3 0.548131 biological_process proteolysis involved in cellular protein catabolic process GO:0051603 66 2 0.785461 2 0.963222 biological_process protein maturation GO:0051604 10 0 1 2 0.16839 biological_process detection of stimulus GO:0051606 48 2 0.620175 1 0.976377 biological_process defense response to virus GO:0051607 10 0 1 2 0.16839 biological_process organelle localization GO:0051640 23 1 0.638083 2 0.52145 biological_process cellular localization GO:0051641 379 16 0.575316 33 0.195068 biological_process establishment of cellular localization GO:0051649 359 16 0.484096 30 0.282034 biological_process maintenance of cellular localization GO:0051651 16 0 1 1 0.711833 biological_process establishment of organelle localization GO:0051656 16 0 1 1 0.711833 biological_process localization within membrane GO:0051668 10 0 1 2 0.16839 biological_process localization of cell GO:0051674 213 14 0.0744498 23 0.0448056 biological_process interaction with host GO:0051701 20 2 0.21253 2 0.446885 biological_process multi-organism process GO:0051704 73 5 0.205673 3 0.918563 biological_process response to other organism GO:0051707 68 2 0.799282 7 0.242993 biological_process cellular response to stimulus GO:0051716 13 0 1 3 0.0674637 biological_process regulation of cell cycle GO:0051726 286 20 0.0208862 20 0.658418 biological_process response to protein stimulus GO:0051789 30 0 1 4 0.182138 biological_process entry into cell of other organism during symbiotic interaction GO:0051806 11 1 0.384585 2 0.196151 biological_process entry into other organism during symbiotic interaction GO:0051828 11 1 0.384585 2 0.196151 biological_process regulation of transmission of nerve impulse GO:0051969 15 0 1 2 0.310079 biological_process movement in host environment GO:0052126 11 1 0.384585 2 0.196151 biological_process movement in environment of other organism during symbiotic interaction GO:0052192 11 1 0.384585 2 0.196151 biological_process heart contraction GO:0060047 24 0 1 3 0.264917 biological_process intracellular protein transport across a membrane GO:0065002 13 0 1 2 0.25295 biological_process macromolecular complex assembly GO:0065003 281 17 0.0965292 28 0.0681981 biological_process protein-DNA complex assembly GO:0065004 49 5 0.0583161 2 0.890828 biological_process biological regulation GO:0065007 1812 87 0.111589 158 0.00652642 biological_process regulation of biological quality GO:0065008 266 14 0.256202 34 0.0011701 biological_process regulation of a molecular function GO:0065009 259 12 0.441885 26 0.0717354 molecular_function microfilament motor activity GO:0000146 12 0 1 3 0.0626949 molecular_function nucleotide binding GO:0000166 253 10 0.627247 23 0.264411 molecular_function magnesium ion binding GO:0000287 58 4 0.225771 4 0.682024 molecular_function rhodopsin-like receptor activity GO:0001584 140 7 0.374184 14 0.211845 molecular_function peptide receptor activity GO:0001653 54 3 0.397675 4 0.625849 molecular_function G-protein-coupled receptor binding GO:0001664 37 2 0.464939 4 0.333212 molecular_function lipid kinase activity GO:0001727 19 1 0.558354 0 1 molecular_function pattern binding GO:0001871 43 3 0.26983 5 0.248614 molecular_function molecular_function GO:0003674 4997 210 1 394 1 molecular_function nucleic acid binding GO:0003676 874 42 0.186868 83 0.0322501 molecular_function DNA binding GO:0003677 634 27 0.502488 65 0.0129665 molecular_function DNA helicase activity GO:0003678 20 2 0.204364 0 1 molecular_function chromatin binding GO:0003682 24 1 0.644006 2 0.57511 molecular_function damaged DNA binding GO:0003684 21 2 0.220011 1 0.822419 molecular_function double-stranded DNA binding GO:0003690 26 1 0.67344 3 0.33726 molecular_function single-stranded DNA binding GO:0003697 35 2 0.436312 3 0.529009 molecular_function transcription factor activity GO:0003700 410 20 0.27271 51 0.000526034 molecular_function RNA polymerase II transcription factor activity GO:0003702 189 14 0.0268937 17 0.319799 molecular_function specific RNA polymerase II transcription factor activity GO:0003704 40 4 0.0853535 4 0.388592 molecular_function RNA polymerase II transcription factor activity. enhancer binding GO:0003705 14 0 1 1 0.683798 molecular_function steroid hormone receptor activity GO:0003707 11 0 1 3 0.0498498 molecular_function transcription cofactor activity GO:0003712 243 18 0.0129258 22 0.276984 molecular_function transcription coactivator activity GO:0003713 142 10 0.0743795 10 0.693189 molecular_function transcription corepressor activity GO:0003714 95 7 0.103357 13 0.0343402 molecular_function RNA binding GO:0003723 259 18 0.0233735 25 0.166309 molecular_function RNA helicase activity GO:0003724 28 2 0.33042 4 0.175001 molecular_function single-stranded RNA binding GO:0003727 11 1 0.376718 1 0.595202 molecular_function mRNA binding GO:0003729 27 1 0.687236 4 0.159246 molecular_function structural constituent of ribosome GO:0003735 69 6 0.0685378 3 0.918126 molecular_function translation initiation factor activity GO:0003743 19 0 1 1 0.790576 molecular_function motor activity GO:0003774 38 1 0.805571 3 0.585975 molecular_function microtubule motor activity GO:0003777 24 1 0.644006 0 1 molecular_function actin binding GO:0003779 77 6 0.103491 10 0.0787401 molecular_function antigen binding GO:0003823 24 4 0.0166212 2 0.57511 molecular_function catalytic activity GO:0003824 1701 83 0.0517468 140 0.274522 molecular_function DNA-directed DNA polymerase activity GO:0003887 13 1 0.42812 1 0.656656 molecular_function DNA-directed RNA polymerase activity GO:0003899 16 2 0.143547 0 1 molecular_function GTPase activity GO:0003924 104 5 0.445371 9 0.436637 molecular_function NADH dehydrogenase activity GO:0003954 29 0 1 3 0.403621 molecular_function ATP-dependent DNA helicase activity GO:0004003 10 0 1 0 1 molecular_function ATP-dependent RNA helicase activity GO:0004004 19 1 0.558354 4 0.057222 molecular_function cyclic-nucleotide phosphodiesterase activity GO:0004112 16 0 1 3 0.126689 molecular_function 3'.5'-cyclic-nucleotide phosphodiesterase activity GO:0004114 15 0 1 3 0.109004 molecular_function cytochrome-c oxidase activity GO:0004129 12 0 1 2 0.243338 molecular_function endopeptidase activity GO:0004175 97 8 0.0501348 11 0.139828 molecular_function aminopeptidase activity GO:0004177 14 0 1 2 0.303805 molecular_function carboxypeptidase activity GO:0004180 11 0 1 2 0.213231 molecular_function cysteine-type endopeptidase activity GO:0004197 33 2 0.406883 2 0.746585 molecular_function metalloendopeptidase activity GO:0004222 25 2 0.283217 4 0.12946 molecular_function serine-type endopeptidase activity GO:0004252 35 4 0.0573671 4 0.296471 molecular_function helicase activity GO:0004386 50 4 0.156974 5 0.35918 molecular_function histone deacetylase activity GO:0004407 11 1 0.376718 1 0.595202 molecular_function inositol or phosphatidylinositol kinase activity GO:0004428 26 1 0.67344 1 0.882457 molecular_function inositol or phosphatidylinositol phosphodiesterase activity GO:0004434 14 0 1 2 0.303805 molecular_function phosphoinositide phospholipase C activity GO:0004435 14 0 1 2 0.303805 molecular_function monooxygenase activity GO:0004497 29 1 0.713111 3 0.403621 molecular_function nuclease activity GO:0004518 57 4 0.216758 5 0.471119 molecular_function endonuclease activity GO:0004519 27 1 0.687236 3 0.359511 molecular_function endoribonuclease activity GO:0004521 15 1 0.475301 2 0.333774 molecular_function exonuclease activity GO:0004527 22 2 0.235754 2 0.52714 molecular_function deoxyribonuclease activity GO:0004536 17 1 0.518607 1 0.753042 molecular_function ribonuclease activity GO:0004540 28 2 0.33042 3 0.381653 molecular_function hydrolase activity. hydrolyzing O-glycosyl compounds GO:0004553 27 1 0.687236 1 0.891774 molecular_function oligosaccharyl transferase activity GO:0004576 11 0 1 1 0.595202 molecular_function phospholipase activity GO:0004620 34 0 1 2 0.761429 molecular_function phospholipase A2 activity GO:0004623 12 0 1 0 1 molecular_function phospholipase C activity GO:0004629 15 0 1 2 0.333774 molecular_function protein kinase activity GO:0004672 274 12 0.484864 21 0.589853 molecular_function protein serine/threonine kinase activity GO:0004674 192 8 0.562642 16 0.446767 molecular_function receptor signaling protein serine/threonine kinase activity GO:0004702 36 2 0.450731 4 0.314794 molecular_function MAP kinase activity GO:0004707 12 1 0.402969 1 0.62719 molecular_function MAP kinase kinase kinase activity GO:0004709 12 1 0.402969 3 0.0626949 molecular_function protein-tyrosine kinase activity GO:0004713 78 4 0.416511 6 0.586917 molecular_function transmembrane receptor protein tyrosine kinase activity GO:0004714 44 4 0.111697 2 0.872676 molecular_function phosphoprotein phosphatase activity GO:0004721 76 4 0.397293 5 0.726924 molecular_function protein serine/threonine phosphatase activity GO:0004722 23 0 1 3 0.270558 molecular_function protein tyrosine phosphatase activity GO:0004725 49 2 0.617105 3 0.754545 molecular_function retinol dehydrogenase activity GO:0004745 10 0 1 2 0.183525 molecular_function aminoacyl-tRNA ligase activity GO:0004812 14 1 0.452216 0 1 molecular_function ubiquitin-protein ligase activity GO:0004842 55 0 1 1 0.989356 molecular_function enzyme inhibitor activity GO:0004857 114 9 0.0493329 9 0.549674 molecular_function protein kinase inhibitor activity GO:0004860 21 2 0.220011 1 0.822419 molecular_function protein phosphatase inhibitor activity GO:0004864 10 0 1 1 0.560478 molecular_function endopeptidase inhibitor activity GO:0004866 37 3 0.202078 3 0.567478 molecular_function serine-type endopeptidase inhibitor activity GO:0004867 22 1 0.611933 1 0.83648 molecular_function signal transducer activity GO:0004871 775 54 6.45E-05 69 0.142218 molecular_function receptor activity GO:0004872 528 39 0.000261923 41 0.569384 molecular_function ligand-dependent nuclear receptor activity GO:0004879 23 2 0.251558 3 0.270558 molecular_function transmembrane receptor activity GO:0004888 392 29 0.00172798 32 0.444984 molecular_function hematopoietin/interferon-class (D200-domain) cytokine receptor activity GO:0004896 29 0 1 1 0.908255 molecular_function interleukin receptor activity GO:0004907 18 0 1 1 0.77258 molecular_function G-protein coupled receptor activity GO:0004930 170 10 0.176672 15 0.362706 molecular_function ionotropic glutamate receptor activity GO:0004970 11 3 0.00939958 0 1 molecular_function olfactory receptor activity GO:0004984 21 2 0.220011 6 0.00452151 molecular_function serotonin receptor activity GO:0004993 11 1 0.376718 1 0.595202 molecular_function transmembrane receptor protein tyrosine phosphatase activity GO:0005001 17 1 0.518607 0 1 molecular_function scavenger receptor activity GO:0005044 10 1 0.349318 1 0.560478 molecular_function signal sequence binding GO:0005048 15 0 1 1 0.7088 molecular_function receptor signaling protein activity GO:0005057 90 7 0.0829533 11 0.0946933 molecular_function SH3/SH2 adaptor activity GO:0005070 41 1 0.829245 8 0.0131693 molecular_function small GTPase regulator activity GO:0005083 67 3 0.539705 5 0.61776 molecular_function guanyl-nucleotide exchange factor activity GO:0005085 54 2 0.669996 3 0.810588 molecular_function Ras guanyl-nucleotide exchange factor activity GO:0005088 20 1 0.576986 1 0.807152 molecular_function Rho guanyl-nucleotide exchange factor activity GO:0005089 10 0 1 1 0.560478 molecular_function GTPase inhibitor activity GO:0005095 10 1 0.349318 0 1 molecular_function GTPase activator activity GO:0005096 59 3 0.454242 6 0.320139 molecular_function Ras GTPase activator activity GO:0005099 27 1 0.687236 3 0.359511 molecular_function Rho GTPase activator activity GO:0005100 16 0 1 3 0.126689 molecular_function receptor binding GO:0005102 373 28 0.00167466 26 0.779838 molecular_function cytokine activity GO:0005125 105 8 0.0730799 7 0.732857 molecular_function hematopoietin/interferon-class (D200-domain) cytokine receptor binding GO:0005126 25 0 1 2 0.597731 molecular_function integrin binding GO:0005178 27 2 0.314757 0 1 molecular_function hormone activity GO:0005179 52 6 0.0208126 4 0.595519 molecular_function neuropeptide hormone activity GO:0005184 12 0 1 0 1 molecular_function structural molecule activity GO:0005198 279 13 0.390818 19 0.785129 molecular_function structural constituent of cytoskeleton GO:0005200 64 4 0.281584 9 0.0618229 molecular_function extracellular matrix structural constituent GO:0005201 54 2 0.669996 4 0.625849 molecular_function transporter activity GO:0005215 483 26 0.109662 53 0.00683187 molecular_function ion channel activity GO:0005216 139 6 0.533418 13 0.300299 molecular_function extracellular ligand-gated ion channel activity GO:0005230 19 1 0.558354 3 0.184931 molecular_function excitatory extracellular ligand-gated ion channel activity GO:0005231 17 0 1 3 0.145315 molecular_function inward rectifier potassium channel activity GO:0005242 12 0 1 2 0.243338 molecular_function voltage-gated ion channel activity GO:0005244 67 2 0.780147 5 0.61776 molecular_function voltage-gated calcium channel activity GO:0005245 14 1 0.452216 1 0.683798 molecular_function voltage-gated sodium channel activity GO:0005248 11 0 1 0 1 molecular_function voltage-gated potassium channel activity GO:0005249 37 1 0.796975 4 0.333212 molecular_function delayed rectifier potassium channel activity GO:0005251 13 1 0.42812 1 0.656656 molecular_function anion channel activity GO:0005253 22 1 0.611933 2 0.52714 molecular_function chloride channel activity GO:0005254 19 0 1 2 0.448647 molecular_function cation channel activity GO:0005261 109 3 0.844213 10 0.356283 molecular_function calcium channel activity GO:0005262 24 2 0.267388 1 0.861357 molecular_function potassium channel activity GO:0005267 49 1 0.879264 5 0.343074 molecular_function sodium channel activity GO:0005272 15 0 1 1 0.7088 molecular_function amine transporter activity GO:0005275 40 2 0.506233 7 0.0345704 molecular_function lipid transporter activity GO:0005319 40 4 0.0853535 6 0.090862 molecular_function organic acid transporter activity GO:0005342 39 2 0.492697 7 0.0305081 molecular_function carrier activity GO:0005386 79 4 0.426071 10 0.0901313 molecular_function intracellular transporter activity GO:0005478 18 0 1 2 0.420888 molecular_function binding GO:0005488 3720 162 0.202878 293 0.542164 molecular_function steroid binding GO:0005496 13 0 1 1 0.656656 molecular_function fatty acid binding GO:0005504 13 2 0.10116 1 0.656656 molecular_function copper ion binding GO:0005507 18 1 0.538907 1 0.77258 molecular_function calcium ion binding GO:0005509 115 7 0.208206 9 0.560535 molecular_function protein binding GO:0005515 3061 139 0.0759344 244 0.409739 molecular_function calmodulin binding GO:0005516 41 0 1 5 0.218713 molecular_function collagen binding GO:0005518 15 1 0.475301 1 0.7088 molecular_function ATP binding GO:0005524 183 8 0.507012 16 0.369859 molecular_function GTP binding GO:0005525 43 0 1 4 0.443326 molecular_function sugar binding GO:0005529 37 4 0.0678725 4 0.333212 molecular_function glycosaminoglycan binding GO:0005539 33 3 0.159557 5 0.113853 molecular_function phospholipid binding GO:0005543 45 0 1 4 0.478999 molecular_function phospholipid transporter activity GO:0005548 17 3 0.0321848 2 0.39243 molecular_function chemokine activity GO:0008009 25 2 0.283217 2 0.597731 molecular_function microtubule binding GO:0008017 25 2 0.283217 1 0.872341 molecular_function protein C-terminus binding GO:0008022 41 0 1 4 0.406957 molecular_function ATP-dependent helicase activity GO:0008026 30 2 0.361429 4 0.207976 molecular_function lipoprotein binding GO:0008034 17 2 0.158395 0 1 molecular_function enzyme activator activity GO:0008047 125 7 0.271623 13 0.184094 molecular_function glutamate receptor activity GO:0008066 20 3 0.0492284 1 0.807152 molecular_function N-acetyltransferase activity GO:0008080 12 2 0.0879526 0 1 molecular_function phosphoric diester hydrolase activity GO:0008081 42 2 0.532594 6 0.109094 molecular_function growth factor activity GO:0008083 63 5 0.123847 5 0.561847 molecular_function cytoskeletal protein binding GO:0008092 157 9 0.213632 17 0.110484 molecular_function cytoskeletal adaptor activity GO:0008093 11 0 1 1 0.595202 molecular_function DNA-dependent ATPase activity GO:0008094 14 0 1 0 1 molecular_function transcription factor binding GO:0008134 302 21 0.0147661 26 0.346378 molecular_function translation factor activity. nucleic acid binding GO:0008135 33 0 1 1 0.934083 molecular_function NADH dehydrogenase (ubiquinone) activity GO:0008137 29 0 1 3 0.403621 molecular_function drug binding GO:0008144 13 0 1 1 0.656656 molecular_function sulfotransferase activity GO:0008146 29 0 1 3 0.403621 molecular_function methyltransferase activity GO:0008168 31 2 0.376737 2 0.714518 molecular_function N-methyltransferase activity GO:0008170 11 2 0.0753187 1 0.595202 molecular_function RNA-dependent ATPase activity GO:0008186 20 1 0.576986 4 0.067253 molecular_function neuropeptide receptor activity GO:0008188 23 1 0.628314 1 0.84943 molecular_function UDP-glycosyltransferase activity GO:0008194 49 3 0.339681 5 0.343074 molecular_function heparin binding GO:0008201 24 3 0.0774197 3 0.292705 molecular_function amine receptor activity GO:0008227 29 1 0.713111 3 0.403621 molecular_function peptidase activity GO:0008233 152 12 0.0253606 18 0.0519017 molecular_function cysteine-type peptidase activity GO:0008234 47 4 0.133539 4 0.513756 molecular_function metalloexopeptidase activity GO:0008235 11 0 1 1 0.595202 molecular_function serine-type peptidase activity GO:0008236 42 4 0.0981084 6 0.109094 molecular_function metallopeptidase activity GO:0008237 45 3 0.293015 6 0.139645 molecular_function exopeptidase activity GO:0008238 30 0 1 5 0.0826249 molecular_function zinc ion binding GO:0008270 118 1 0.99407 12 0.217829 molecular_function lipid binding GO:0008289 81 4 0.445071 5 0.777007 molecular_function structural constituent of muscle GO:0008307 36 1 0.788001 4 0.314794 molecular_function cation transporter activity GO:0008324 206 7 0.77163 20 0.192221 molecular_function O-acyltransferase activity GO:0008374 14 0 1 2 0.303805 molecular_function acetylglucosaminyltransferase activity GO:0008375 19 3 0.04314 2 0.448647 molecular_function acetylgalactosaminyltransferase activity GO:0008376 14 0 1 2 0.303805 molecular_function galactosyltransferase activity GO:0008378 17 0 1 4 0.0397701 molecular_function 3'-5' exonuclease activity GO:0008408 17 1 0.518607 1 0.753042 molecular_function acyltransferase activity GO:0008415 43 2 0.545412 4 0.443326 molecular_function fucosyltransferase activity GO:0008417 10 1 0.349318 0 1 molecular_function transaminase activity GO:0008483 10 0 1 0 1 molecular_function anion transporter activity GO:0008509 61 4 0.253351 8 0.10419 molecular_function peptide receptor activity. G-protein coupled GO:0008528 54 3 0.397675 4 0.625849 molecular_function protein transporter activity GO:0008565 26 1 0.67344 4 0.144049 molecular_function protein phosphatase type 2A regulator activity GO:0008601 10 1 0.349318 1 0.560478 molecular_function small protein conjugating enzyme activity GO:0008639 57 0 1 2 0.946463 molecular_function caspase activator activity GO:0008656 14 1 0.452216 4 0.0201738 molecular_function S-adenosylmethionine-dependent methyltransferase activity GO:0008757 20 1 0.576986 1 0.807152 molecular_function electron carrier activity GO:0009055 97 3 0.781975 8 0.50165 molecular_function cyclase activity GO:0009975 14 2 0.114871 0 1 molecular_function heme-copper terminal oxidase activity GO:0015002 12 0 1 2 0.243338 molecular_function coreceptor activity GO:0015026 14 0 1 1 0.683798 molecular_function ion transporter activity GO:0015075 256 12 0.390336 25 0.152161 molecular_function monovalent inorganic cation transporter activity GO:0015077 32 1 0.747982 2 0.730956 molecular_function hydrogen ion transporter activity GO:0015078 25 0 1 2 0.597731 molecular_function di-. tri-valent inorganic cation transporter activity GO:0015082 19 0 1 1 0.790576 molecular_function inorganic anion transporter activity GO:0015103 16 2 0.143547 3 0.126689 molecular_function carbohydrate transporter activity GO:0015144 18 3 0.0374562 3 0.164767 molecular_function amino acid transporter activity GO:0015171 28 1 0.700451 7 0.00496254 molecular_function neutral amino acid transporter activity GO:0015175 13 0 1 3 0.0768999 molecular_function L-amino acid transporter activity GO:0015179 18 0 1 4 0.0480568 molecular_function channel or pore class transporter activity GO:0015267 155 6 0.64113 13 0.450588 molecular_function alpha-type channel activity GO:0015268 149 6 0.602445 13 0.393393 molecular_function ligand-gated ion channel activity GO:0015276 45 2 0.570308 6 0.139645 molecular_function electrochemical potential-driven transporter activity GO:0015290 50 2 0.628178 6 0.198121 molecular_function porter activity GO:0015291 49 2 0.617105 6 0.185753 molecular_function symporter activity GO:0015293 29 1 0.713111 4 0.191262 molecular_function solute:cation symporter activity GO:0015294 13 1 0.42812 1 0.656656 molecular_function anion:cation symporter activity GO:0015296 18 1 0.538907 3 0.164767 molecular_function antiporter activity GO:0015297 10 1 0.349318 0 1 molecular_function solute:sodium symporter activity GO:0015370 10 1 0.349318 1 0.560478 molecular_function primary active transporter activity GO:0015399 22 2 0.235754 3 0.248612 molecular_function P-P-bond-hydrolysis-driven transporter activity GO:0015405 22 2 0.235754 3 0.248612 molecular_function auxiliary transport protein activity GO:0015457 29 0 1 2 0.679121 molecular_function potassium channel regulator activity GO:0015459 17 0 1 1 0.753042 molecular_function acetylcholine receptor activity GO:0015464 15 0 1 2 0.333774 molecular_function tubulin binding GO:0015631 38 3 0.213101 3 0.585975 molecular_function ATPase activity. coupled to transmembrane movement of ions. phosphorylative mechanism GO:0015662 15 2 0.12902 3 0.109004 molecular_function antioxidant activity GO:0016209 13 1 0.42812 0 1 molecular_function channel regulator activity GO:0016247 26 0 1 1 0.882457 molecular_function general RNA polymerase II transcription factor activity GO:0016251 29 3 0.120309 1 0.908255 molecular_function lipase activity GO:0016298 46 1 0.862496 3 0.71495 molecular_function kinase activity GO:0016301 354 19 0.159186 23 0.867439 molecular_function 1-phosphatidylinositol-3-kinase activity GO:0016303 11 1 0.376718 0 1 molecular_function acetyltransferase activity GO:0016407 16 2 0.143547 1 0.731829 molecular_function N-acyltransferase activity GO:0016410 13 2 0.10116 0 1 molecular_function RNA polymerase II transcription mediator activity GO:0016455 12 1 0.402969 1 0.62719 molecular_function pyrophosphatase activity GO:0016462 221 13 0.136501 24 0.0651385 molecular_function oxidoreductase activity GO:0016491 294 12 0.58614 30 0.0827896 molecular_function protease activator activity GO:0016504 16 1 0.497418 4 0.0323658 molecular_function apoptotic protease activator activity GO:0016505 16 1 0.497418 4 0.0323658 molecular_function transcriptional activator activity GO:0016563 196 15 0.017136 17 0.376435 molecular_function transcriptional repressor activity GO:0016564 146 10 0.0859454 15 0.173954 molecular_function oxidoreductase activity. acting on CH-OH group of donors GO:0016614 63 2 0.750207 6 0.377845 molecular_function oxidoreductase activity. acting on the CH-OH group of donors. NAD or NADP as acceptor GO:0016616 58 2 0.707944 6 0.305898 molecular_function oxidoreductase activity. acting on the aldehyde or oxo group of donors. NAD or NADP as acceptor GO:0016620 14 1 0.452216 0 1 molecular_function oxidoreductase activity. acting on the CH-CH group of donors GO:0016627 26 1 0.67344 3 0.33726 molecular_function oxidoreductase activity. acting on the CH-NH group of donors GO:0016645 10 0 1 1 0.560478 molecular_function oxidoreductase activity. acting on NADH or NADPH GO:0016651 44 1 0.850048 4 0.461264 molecular_function oxidoreductase activity. acting on NADH or NADPH. quinone or similar compound as acceptor GO:0016655 32 0 1 3 0.467948 molecular_function oxidoreductase activity. acting on heme group of donors GO:0016675 12 0 1 2 0.243338 molecular_function oxidoreductase activity. acting on heme group of donors. oxygen as acceptor GO:0016676 12 0 1 2 0.243338 molecular_function oxidoreductase activity. acting on paired donors. with incorporation or reduction of molecular oxygen GO:0016705 32 2 0.391893 3 0.467948 molecular_function transferase activity GO:0016740 640 33 0.12009 49 0.615314 molecular_function transferase activity. transferring one-carbon groups GO:0016741 32 2 0.391893 2 0.730956 molecular_function transferase activity. transferring acyl groups GO:0016746 54 2 0.669996 4 0.625849 molecular_function transferase activity. transferring groups other than amino-acyl groups GO:0016747 43 2 0.545412 4 0.443326 molecular_function transferase activity. transferring glycosyl groups GO:0016757 108 5 0.478459 12 0.141397 molecular_function transferase activity. transferring hexosyl groups GO:0016758 82 5 0.261183 9 0.195121 molecular_function transferase activity. transferring pentosyl groups GO:0016763 17 0 1 3 0.145315 molecular_function transferase activity. transferring alkyl or aryl (other than methyl) groups GO:0016765 21 2 0.220011 3 0.226959 molecular_function transferase activity. transferring nitrogenous groups GO:0016769 11 0 1 0 1 molecular_function transferase activity. transferring phosphorus-containing groups GO:0016772 402 23 0.0773895 27 0.842264 molecular_function phosphotransferase activity. alcohol group as acceptor GO:0016773 329 16 0.306856 23 0.763013 molecular_function phosphotransferase activity. phosphate group as acceptor GO:0016776 18 1 0.538907 1 0.77258 molecular_function nucleotidyltransferase activity GO:0016779 44 4 0.111697 3 0.685923 molecular_function transferase activity. transferring sulfur-containing groups GO:0016782 31 0 1 3 0.446817 molecular_function hydrolase activity GO:0016787 690 39 0.0294774 71 0.00862288 molecular_function hydrolase activity. acting on ester bonds GO:0016788 251 12 0.364226 23 0.251869 molecular_function carboxylic ester hydrolase activity GO:0016789 52 1 0.893996 5 0.391436 molecular_function thiolester hydrolase activity GO:0016790 13 1 0.42812 3 0.0768999 molecular_function phosphoric monoester hydrolase activity GO:0016791 104 5 0.445371 7 0.723609 molecular_function exonuclease activity. active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters GO:0016796 11 1 0.376718 1 0.595202 molecular_function hydrolase activity. acting on glycosyl bonds GO:0016798 40 1 0.821691 5 0.204206 molecular_function hydrolase activity. hydrolyzing N-glycosyl compounds GO:0016799 13 0 1 4 0.0153447 molecular_function hydrolase activity. acting on carbon-nitrogen (but not peptide) bonds GO:0016810 48 3 0.328007 6 0.173702 molecular_function hydrolase activity. acting on carbon-nitrogen (but not peptide) bonds. in linear amides GO:0016811 21 2 0.220011 2 0.501819 molecular_function hydrolase activity. acting on carbon-nitrogen (but not peptide) bonds. in cyclic amidines GO:0016814 17 1 0.518607 2 0.39243 molecular_function hydrolase activity. acting on acid anhydrides GO:0016817 223 13 0.143283 25 0.0443487 molecular_function hydrolase activity. acting on acid anhydrides. in phosphorus-containing anhydrides GO:0016818 223 13 0.143283 25 0.0443487 molecular_function hydrolase activity. acting on acid anhydrides. catalyzing transmembrane movement of substances GO:0016820 43 4 0.104801 7 0.0488528 molecular_function lyase activity GO:0016829 68 5 0.156145 6 0.450108 molecular_function carbon-carbon lyase activity GO:0016830 19 3 0.04314 3 0.184931 molecular_function carboxy-lyase activity GO:0016831 15 2 0.12902 3 0.109004 molecular_function carbon-oxygen lyase activity GO:0016835 29 1 0.713111 3 0.403621 molecular_function hydro-lyase activity GO:0016836 24 1 0.644006 1 0.861357 molecular_function phosphorus-oxygen lyase activity GO:0016849 12 1 0.402969 0 1 molecular_function isomerase activity GO:0016853 33 2 0.406883 4 0.260297 molecular_function intramolecular oxidoreductase activity GO:0016860 18 2 0.173512 0 1 molecular_function ligase activity GO:0016874 106 3 0.830277 4 0.972716 molecular_function ligase activity. forming carbon-oxygen bonds GO:0016875 14 1 0.452216 0 1 molecular_function ligase activity. forming aminoacyl-tRNA and related compounds GO:0016876 14 1 0.452216 0 1 molecular_function ligase activity. forming carbon-nitrogen bonds GO:0016879 74 1 0.959281 3 0.93912 molecular_function acid-amino acid ligase activity GO:0016881 63 0 1 2 0.96461 molecular_function ATPase activity GO:0016887 108 7 0.167666 14 0.0430356 molecular_function endoribonuclease activity. producing 5'-phosphomonoesters GO:0016891 11 0 1 1 0.595202 molecular_function endonuclease activity. active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters GO:0016893 11 0 1 1 0.595202 molecular_function oxidoreductase activity. acting on the aldehyde or oxo group of donors GO:0016903 19 2 0.18885 2 0.448647 molecular_function GABA receptor activity GO:0016917 10 0 1 2 0.183525 molecular_function Ras GTPase binding GO:0017016 25 2 0.283217 1 0.872341 molecular_function purine nucleotide binding GO:0017076 239 9 0.682612 22 0.251073 molecular_function nucleoside-triphosphatase activity GO:0017111 210 12 0.171497 22 0.101188 molecular_function SH3 domain binding GO:0017124 16 2 0.143547 0 1 molecular_function guanyl nucleotide binding GO:0019001 44 0 1 4 0.461264 molecular_function DNA N-glycosylase activity GO:0019104 12 0 1 3 0.0626949 molecular_function transmembrane receptor protein phosphatase activity GO:0019198 17 1 0.518607 0 1 molecular_function transmembrane receptor protein kinase activity GO:0019199 52 4 0.173389 2 0.924883 molecular_function carbohydrate kinase activity GO:0019200 13 1 0.42812 1 0.656656 molecular_function nucleotide kinase activity GO:0019201 12 1 0.402969 1 0.62719 molecular_function nucleobase. nucleoside. nucleotide kinase activity GO:0019205 23 2 0.251558 1 0.84943 molecular_function kinase regulator activity GO:0019207 45 3 0.293015 3 0.700704 molecular_function phosphatase regulator activity GO:0019208 25 1 0.659039 2 0.597731 molecular_function kinase inhibitor activity GO:0019210 25 2 0.283217 1 0.872341 molecular_function phosphatase inhibitor activity GO:0019212 11 0 1 1 0.595202 molecular_function deacetylase activity GO:0019213 14 1 0.452216 2 0.303805 molecular_function deaminase activity GO:0019239 16 1 0.497418 1 0.731829 molecular_function small conjugating protein-specific protease activity GO:0019783 10 2 0.0633334 2 0.183525 molecular_function small conjugating protein ligase activity GO:0019787 57 0 1 1 0.990986 molecular_function oxygen binding GO:0019825 18 0 1 1 0.77258 molecular_function growth factor binding GO:0019838 27 3 0.102236 2 0.640231 molecular_function vitamin binding GO:0019842 11 0 1 0 1 molecular_function protein kinase regulator activity GO:0019887 34 3 0.16992 1 0.939315 molecular_function protein phosphatase regulator activity GO:0019888 24 1 0.644006 2 0.57511 molecular_function enzyme binding GO:0019899 167 8 0.40396 14 0.446239 molecular_function kinase binding GO:0019900 63 4 0.272113 4 0.74357 molecular_function protein kinase binding GO:0019901 52 2 0.649579 3 0.7896 molecular_function phosphatase binding GO:0019902 13 1 0.42812 1 0.656656 molecular_function protein domain specific binding GO:0019904 67 4 0.310276 8 0.154779 molecular_function cytokine binding GO:0019955 47 2 0.594208 3 0.728668 molecular_function chemokine binding GO:0019956 10 0 1 1 0.560478 molecular_function interleukin binding GO:0019965 22 0 1 2 0.52714 molecular_function receptor signaling complex scaffold activity GO:0030159 17 1 0.518607 1 0.753042 molecular_function PDZ domain binding GO:0030165 10 0 1 1 0.560478 molecular_function low-density lipoprotein binding GO:0030169 11 2 0.0753187 0 1 molecular_function enzyme regulator activity GO:0030234 327 20 0.0559419 27 0.429578 molecular_function carbohydrate binding GO:0030246 75 7 0.0370301 10 0.0682882 molecular_function polysaccharide binding GO:0030247 35 3 0.180472 5 0.137376 molecular_function ligand-dependent nuclear receptor transcription coactivator activity GO:0030374 15 2 0.12902 2 0.333774 molecular_function protease inhibitor activity GO:0030414 39 3 0.224251 4 0.370153 molecular_function transcription regulator activity GO:0030528 751 45 0.0070307 77 0.00675021 molecular_function adenyl nucleotide binding GO:0030554 198 9 0.453901 19 0.214346 molecular_function neurotransmitter receptor activity GO:0030594 49 1 0.879264 5 0.343074 molecular_function protein binding. bridging GO:0030674 66 1 0.942308 9 0.0724745 molecular_function GTPase regulator activity GO:0030695 134 7 0.332503 9 0.741075 molecular_function RNA splicing factor activity. transesterification mechanism GO:0031202 20 2 0.204364 3 0.205698 molecular_function small GTPase binding GO:0031267 32 2 0.391893 2 0.730956 molecular_function protein complex binding GO:0032403 46 5 0.042319 1 0.977535 molecular_function protein complex scaffold GO:0032947 17 1 0.518607 1 0.753042 molecular_function phosphoinositide 3-kinase activity GO:0035004 12 1 0.402969 0 1 molecular_function phosphoinositide binding GO:0035091 22 0 1 2 0.52714 molecular_function nuclear hormone receptor binding GO:0035257 39 3 0.224251 2 0.824822 molecular_function steroid hormone receptor binding GO:0035258 21 1 0.594834 1 0.822419 molecular_function telomeric DNA binding GO:0042162 10 1 0.349318 0 1 molecular_function neurotransmitter binding GO:0042165 52 1 0.893996 5 0.391436 molecular_function acetylcholine binding GO:0042166 16 0 1 2 0.363358 molecular_function SH2 domain binding GO:0042169 16 2 0.143547 1 0.731829 molecular_function peptide binding GO:0042277 89 4 0.518837 9 0.266433 molecular_function chemokine receptor binding GO:0042379 26 2 0.299014 2 0.619437 molecular_function histone binding GO:0042393 13 1 0.42812 2 0.2736 molecular_function hormone binding GO:0042562 13 0 1 2 0.2736 molecular_function phosphoric ester hydrolase activity GO:0042578 145 7 0.409154 13 0.355591 molecular_function peptide antigen binding GO:0042605 10 1 0.349318 2 0.183525 molecular_function ATPase activity. coupled GO:0042623 93 6 0.195429 13 0.0294428 molecular_function ATPase activity. coupled to transmembrane movement of ions GO:0042625 20 2 0.204364 3 0.205698 molecular_function ATPase activity. coupled to transmembrane movement of substances GO:0042626 43 4 0.104801 7 0.0488528 molecular_function identical protein binding GO:0042802 220 14 0.0777377 21 0.206437 molecular_function protein homodimerization activity GO:0042803 93 7 0.0948924 10 0.195198 molecular_function neuropeptide binding GO:0042923 24 1 0.644006 1 0.861357 molecular_function ribonucleoprotein binding GO:0043021 10 0 1 0 1 molecular_function caspase regulator activity GO:0043028 20 2 0.204364 4 0.067253 molecular_function ion binding GO:0043167 309 13 0.541072 23 0.649259 molecular_function cation binding GO:0043169 253 9 0.745924 19 0.625366 molecular_function amine binding GO:0043176 22 0 1 3 0.248612 molecular_function ATPase activity. coupled to movement of substances GO:0043492 44 4 0.111697 7 0.054336 molecular_function sequence-specific DNA binding GO:0043565 41 2 0.519533 2 0.845639 molecular_function structure-specific DNA binding GO:0043566 53 2 0.65991 5 0.407531 molecular_function translation regulator activity GO:0045182 45 1 0.856406 1 0.975593 molecular_function metal ion binding GO:0046872 309 13 0.541072 23 0.649259 molecular_function metal ion transporter activity GO:0046873 24 1 0.644006 1 0.861357 molecular_function transition metal ion binding GO:0046914 144 2 0.985852 12 0.465106 molecular_function transition metal ion transporter activity GO:0046915 10 0 1 1 0.560478 molecular_function carboxylic acid transporter activity GO:0046943 38 2 0.47893 7 0.0267797 molecular_function thyroid hormone receptor binding GO:0046966 17 1 0.518607 1 0.753042 molecular_function protein heterodimerization activity GO:0046982 72 4 0.358612 11 0.0241664 molecular_function protein dimerization activity GO:0046983 148 11 0.0459582 17 0.0727417 molecular_function protein N-terminus binding GO:0047485 18 1 0.538907 3 0.164767 molecular_function monosaccharide binding GO:0048029 14 2 0.114871 1 0.683798 molecular_function cofactor binding GO:0048037 21 1 0.594834 2 0.501819 molecular_function NADH dehydrogenase (quinone) activity GO:0050136 29 0 1 3 0.403621 molecular_function coenzyme binding GO:0050662 15 1 0.475301 2 0.333774 molecular_function androgen receptor binding GO:0050681 15 0 1 1 0.7088 molecular_function actin filament binding GO:0051015 19 1 0.558354 3 0.184931 molecular_function GTPase binding GO:0051020 34 2 0.421693 2 0.761429 molecular_function unfolded protein binding GO:0051082 50 3 0.351343 8 0.0399281 molecular_function hormone receptor binding GO:0051427 40 3 0.235513 2 0.835527 molecular_function molecular transducer activity GO:0060089 775 54 6.45E-05 69 0.142218 molecular_function molecular adaptor activity GO:0060090 55 1 0.906939 9 0.026521 cellular_component histone deacetylase complex GO:0000118 18 1 0.557582 1 0.756826 cellular_component mediator complex GO:0000119 18 1 0.557582 0 1 cellular_component Golgi membrane GO:0000139 57 2 0.725675 7 0.134522 cellular_component ubiquitin ligase complex GO:0000151 40 0 1 3 0.590299 cellular_component nuclear ubiquitin ligase complex GO:0000152 13 0 1 1 0.639625 cellular_component nuclear chromosome GO:0000228 46 3 0.33258 3 0.685485 cellular_component cell fraction GO:0000267 593 33 0.0915079 69 8.29E-05 cellular_component organellar ribosome GO:0000313 37 3 0.223248 3 0.536304 cellular_component organellar small ribosomal subunit GO:0000314 13 1 0.444915 0 1 cellular_component organellar large ribosomal subunit GO:0000315 11 1 0.392231 1 0.57827 cellular_component lytic vacuole GO:0000323 52 1 0.906066 4 0.559188 cellular_component DNA-directed RNA polymerase complex GO:0000428 23 1 0.647473 1 0.835987 cellular_component proteasome complex (sensu Eukaryota) GO:0000502 22 3 0.0706446 1 0.822539 cellular_component chromosome. pericentric region GO:0000775 27 1 0.706101 4 0.141658 cellular_component kinetochore GO:0000776 19 1 0.577221 3 0.16839 cellular_component chromatin GO:0000785 45 4 0.135838 1 0.971165 cellular_component nucleosome GO:0000786 19 1 0.577221 0 1 cellular_component nuclear chromatin GO:0000790 10 1 0.364052 0 1 cellular_component condensed chromosome GO:0000793 21 2 0.237157 2 0.477552 cellular_component condensed nuclear chromosome GO:0000794 17 2 0.171619 1 0.736912 cellular_component spindle pole GO:0000922 13 1 0.444915 0 1 cellular_component cornified envelope GO:0001533 14 0 1 1 0.666878 cellular_component stress fiber GO:0001725 10 0 1 1 0.543793 cellular_component ruffle GO:0001726 24 0 1 3 0.269584 cellular_component immunological synapse GO:0001772 13 1 0.444915 2 0.25644 cellular_component cellular_component GO:0005575 4456 197 1 336 1 cellular_component extracellular region GO:0005576 546 28 0.224089 48 0.137357 cellular_component proteinaceous extracellular matrix GO:0005578 109 5 0.532323 12 0.117067 cellular_component collagen GO:0005581 24 1 0.663139 2 0.550064 cellular_component fibrillar collagen GO:0005583 10 0 1 1 0.543793 cellular_component basement membrane GO:0005604 36 1 0.804929 2 0.767163 cellular_component basal lamina GO:0005605 22 1 0.631083 2 0.502512 cellular_component extracellular space GO:0005615 240 11 0.496535 21 0.266291 cellular_component intracellular GO:0005622 3006 140 0.152002 238 0.0939471 cellular_component cell GO:0005623 4160 186 0.332534 315 0.436699 cellular_component membrane fraction GO:0005624 427 19 0.525123 49 0.00142854 cellular_component soluble fraction GO:0005625 180 13 0.0537243 21 0.0282623 cellular_component insoluble fraction GO:0005626 15 2 0.140161 4 0.0222613 cellular_component nucleus GO:0005634 1312 73 0.0112932 114 0.0360425 cellular_component nuclear envelope GO:0005635 82 5 0.295943 9 0.162352 cellular_component nuclear pore GO:0005643 30 3 0.144767 3 0.396734 cellular_component nucleoplasm GO:0005654 230 13 0.215566 20 0.282438 cellular_component replication fork GO:0005657 14 1 0.469527 1 0.666878 cellular_component DNA-directed RNA polymerase II. core complex GO:0005665 16 0 1 1 0.715373 cellular_component transcription factor complex GO:0005667 80 7 0.0620244 4 0.864264 cellular_component transcription factor TFIID complex GO:0005669 11 1 0.392231 1 0.57827 cellular_component anaphase-promoting complex GO:0005680 10 0 1 1 0.543793 cellular_component spliceosome GO:0005681 49 2 0.64525 7 0.0722844 cellular_component chromosome GO:0005694 122 9 0.0891434 9 0.578473 cellular_component nucleolus GO:0005730 93 10 0.00744966 8 0.403049 cellular_component cytoplasm GO:0005737 1890 90 0.190224 156 0.0683417 cellular_component mitochondrion GO:0005739 344 19 0.182302 33 0.0846908 cellular_component mitochondrial envelope GO:0005740 120 4 0.785494 14 0.0657307 cellular_component mitochondrial outer membrane GO:0005741 20 1 0.595992 1 0.792257 cellular_component mitochondrial inner membrane GO:0005743 86 2 0.900337 11 0.0566311 cellular_component mitochondrial respiratory chain GO:0005746 44 0 1 5 0.234852 cellular_component mitochondrial respiratory chain complex I GO:0005747 32 0 1 3 0.438178 cellular_component mitochondrial proton-transporting ATP synthase complex GO:0005753 11 2 0.0822671 3 0.0444983 cellular_component mitochondrial matrix GO:0005759 70 7 0.033719 8 0.154394 cellular_component mitochondrial ribosome GO:0005761 37 3 0.223248 3 0.536304 cellular_component mitochondrial large ribosomal subunit GO:0005762 11 1 0.392231 1 0.57827 cellular_component mitochondrial small ribosomal subunit GO:0005763 13 1 0.444915 0 1 cellular_component lysosome GO:0005764 52 1 0.906066 4 0.559188 cellular_component lysosomal membrane GO:0005765 10 1 0.364052 1 0.543793 cellular_component endosome GO:0005768 64 3 0.543347 3 0.871887 cellular_component early endosome GO:0005769 18 0 1 0 1 cellular_component vacuole GO:0005773 61 1 0.937801 5 0.491806 cellular_component vacuolar membrane GO:0005774 14 1 0.469527 2 0.285332 cellular_component peroxisome GO:0005777 56 1 0.921784 5 0.416389 cellular_component peroxisomal membrane GO:0005778 16 0 1 2 0.342619 cellular_component integral to peroxisomal membrane GO:0005779 11 0 1 2 0.199021 cellular_component endoplasmic reticulum GO:0005783 279 12 0.584199 28 0.0691757 cellular_component endoplasmic reticulum lumen GO:0005788 17 1 0.537036 2 0.370743 cellular_component endoplasmic reticulum membrane GO:0005789 81 4 0.484615 6 0.579896 cellular_component microsome GO:0005792 54 2 0.697483 6 0.21921 cellular_component ER-Golgi intermediate compartment GO:0005793 24 1 0.663139 3 0.269584 cellular_component Golgi apparatus GO:0005794 203 12 0.185334 23 0.03026 cellular_component Golgi-associated vesicle GO:0005798 35 3 0.19993 4 0.268864 cellular_component trans-Golgi network GO:0005802 14 0 1 1 0.666878 cellular_component centrosome GO:0005813 50 2 0.656235 3 0.739182 cellular_component microtubule organizing center GO:0005815 59 3 0.488085 5 0.461983 cellular_component spindle GO:0005819 33 2 0.432383 2 0.723404 cellular_component cytosol GO:0005829 279 18 0.0656847 23 0.356481 cellular_component cytosolic ribosome (sensu Eukaryota) GO:0005830 65 6 0.0658503 6 0.365698 cellular_component heterotrimeric G-protein complex GO:0005834 10 0 1 2 0.170926 cellular_component ribosome GO:0005840 113 9 0.0609503 10 0.346175 cellular_component cytosolic large ribosomal subunit (sensu Eukaryota) GO:0005842 39 5 0.0272195 2 0.804788 cellular_component cytosolic small ribosomal subunit (sensu Eukaryota) GO:0005843 27 2 0.336801 4 0.141658 cellular_component cytoskeleton GO:0005856 382 21 0.172285 37 0.0629825 cellular_component kinesin complex GO:0005871 13 1 0.444915 0 1 cellular_component microtubule GO:0005874 28 1 0.719174 1 0.889429 cellular_component microtubule associated complex GO:0005875 56 1 0.921784 4 0.619002 cellular_component spindle microtubule GO:0005876 12 0 1 1 0.610149 cellular_component intermediate filament GO:0005882 37 5 0.022118 3 0.536304 cellular_component actin filament GO:0005884 14 1 0.469527 1 0.666878 cellular_component plasma membrane GO:0005886 1227 65 0.0489465 103 0.103294 cellular_component integral to plasma membrane GO:0005887 864 48 0.0459353 68 0.363801 cellular_component voltage-gated calcium channel complex GO:0005891 14 1 0.469527 2 0.285332 cellular_component brush border GO:0005903 14 3 0.0215939 3 0.0830891 cellular_component coated pit GO:0005905 12 1 0.419167 0 1 cellular_component intercellular junction GO:0005911 55 2 0.707136 8 0.0519269 cellular_component adherens junction GO:0005912 25 1 0.678113 1 0.85991 cellular_component tight junction GO:0005923 23 1 0.647473 4 0.0900741 cellular_component cell-substrate adherens junction GO:0005924 16 1 0.515541 1 0.715373 cellular_component focal adhesion GO:0005925 14 1 0.469527 1 0.666878 cellular_component axoneme GO:0005930 12 0 1 0 1 cellular_component cell cortex GO:0005938 35 1 0.795831 3 0.498158 cellular_component synaptic vesicle GO:0008021 15 1 0.493053 0 1 cellular_component voltage-gated potassium channel complex GO:0008076 37 1 0.813623 3 0.536304 cellular_component protein serine/threonine phosphatase complex GO:0008287 15 1 0.493053 2 0.314107 cellular_component integrin complex GO:0008305 21 2 0.237157 2 0.477552 cellular_component external side of plasma membrane GO:0009897 19 2 0.204086 4 0.0498468 cellular_component cell surface GO:0009986 81 3 0.702812 10 0.0814003 cellular_component endomembrane system GO:0012505 234 14 0.15123 23 0.110927 cellular_component vesicle membrane GO:0012506 37 5 0.022118 5 0.142372 cellular_component trans-Golgi network transport vesicle membrane GO:0012510 12 2 0.0959348 3 0.0561092 cellular_component actin cytoskeleton GO:0015629 144 8 0.304006 19 0.0109946 cellular_component microtubule cytoskeleton GO:0015630 150 7 0.497898 10 0.705554 cellular_component large ribosomal subunit GO:0015934 50 6 0.0217272 3 0.739182 cellular_component small ribosomal subunit GO:0015935 41 3 0.271264 4 0.373996 cellular_component dystrophin-associated glycoprotein complex GO:0016010 10 0 1 1 0.543793 cellular_component membrane GO:0016020 1869 94 0.0547032 153 0.0920115 cellular_component integral to membrane GO:0016021 1292 70 0.0248802 109 0.083958 cellular_component cytoplasmic membrane-bound vesicle GO:0016023 110 10 0.0226289 11 0.204697 cellular_component eukaryotic 43S preinitiation complex GO:0016282 39 2 0.520208 4 0.33871 cellular_component eukaryotic 48S initiation complex GO:0016283 27 2 0.336801 4 0.141658 cellular_component basolateral plasma membrane GO:0016323 28 1 0.719174 3 0.354523 cellular_component apical plasma membrane GO:0016324 13 0 1 2 0.25644 cellular_component apicolateral plasma membrane GO:0016327 29 1 0.731668 5 0.0627841 cellular_component nuclear matrix GO:0016363 12 0 1 2 0.227603 cellular_component myosin complex GO:0016459 17 0 1 5 0.00686263 cellular_component proton-transporting two-sector ATPase complex GO:0016469 18 2 0.187753 4 0.0417489 cellular_component chromatin remodeling complex GO:0016585 15 1 0.493053 2 0.314107 cellular_component DNA-directed RNA polymerase II. holoenzyme GO:0016591 64 4 0.313351 5 0.535345 cellular_component nuclear body GO:0016604 25 2 0.303781 4 0.114578 cellular_component nuclear speck GO:0016607 10 0 1 3 0.0342291 cellular_component organelle inner membrane GO:0019866 94 3 0.79347 11 0.0941563 cellular_component outer membrane GO:0019867 26 2 0.320339 1 0.870533 cellular_component extrinsic to plasma membrane GO:0019897 16 2 0.155735 3 0.114527 cellular_component extrinsic to membrane GO:0019898 30 2 0.385388 3 0.396734 cellular_component myofibril GO:0030016 18 0 1 4 0.0417489 cellular_component sarcomere GO:0030017 15 0 1 3 0.098296 cellular_component lamellipodium GO:0030027 16 0 1 2 0.342619 cellular_component cell junction GO:0030054 71 3 0.614622 9 0.0837267 cellular_component cell-matrix junction GO:0030055 16 1 0.515541 1 0.715373 cellular_component membrane coat GO:0030117 30 3 0.144767 4 0.186387 cellular_component clathrin coat GO:0030118 15 2 0.140161 3 0.098296 cellular_component membrane coat adaptor complex GO:0030119 15 2 0.140161 3 0.098296 cellular_component vesicle coat GO:0030120 27 3 0.114559 4 0.141658 cellular_component clathrin vesicle coat GO:0030125 15 2 0.140161 3 0.098296 cellular_component clathrin coat of trans-Golgi network vesicle GO:0030130 11 2 0.0822671 3 0.0444983 cellular_component clathrin adaptor complex GO:0030131 12 2 0.0959348 3 0.0561092 cellular_component transport vesicle GO:0030133 41 4 0.105413 5 0.193174 cellular_component coated vesicle GO:0030135 53 4 0.205465 5 0.370235 cellular_component clathrin-coated vesicle GO:0030136 40 3 0.259128 4 0.356355 cellular_component endocytic vesicle GO:0030139 13 1 0.444915 1 0.639625 cellular_component trans-Golgi network transport vesicle GO:0030140 18 2 0.187753 3 0.149672 cellular_component secretory granule GO:0030141 14 2 0.124957 1 0.666878 cellular_component integral to Golgi membrane GO:0030173 14 0 1 2 0.285332 cellular_component integral to endoplasmic reticulum membrane GO:0030176 25 2 0.303781 2 0.572616 cellular_component dynein complex GO:0030286 18 0 1 1 0.756826 cellular_component axon GO:0030424 12 0 1 1 0.610149 cellular_component dendrite GO:0030425 11 1 0.392231 1 0.57827 cellular_component ribonucleoprotein complex GO:0030529 211 16 0.0231428 19 0.23891 cellular_component heterogeneous nuclear ribonucleoprotein complex GO:0030530 13 1 0.444915 0 1 cellular_component small nuclear ribonucleoprotein complex GO:0030532 22 3 0.0706446 4 0.0788784 cellular_component transport vesicle membrane GO:0030658 15 2 0.140161 3 0.098296 cellular_component cytoplasmic vesicle membrane GO:0030659 34 4 0.0610257 5 0.108738 cellular_component Golgi-associated vesicle membrane GO:0030660 15 2 0.140161 3 0.098296 cellular_component coated vesicle membrane GO:0030662 28 3 0.124343 4 0.156064 cellular_component clathrin coated vesicle membrane GO:0030665 16 2 0.155735 3 0.114527 cellular_component cortical cytoskeleton GO:0030863 16 1 0.515541 1 0.715373 cellular_component cortical actin cytoskeleton GO:0030864 11 1 0.392231 1 0.57827 cellular_component RNA polymerase complex GO:0030880 23 1 0.647473 1 0.835987 cellular_component NADH dehydrogenase complex (quinone) GO:0030964 32 0 1 3 0.438178 cellular_component extracellular matrix GO:0031012 111 6 0.367059 12 0.129117 cellular_component organelle membrane GO:0031090 336 18 0.227505 32 0.0954177 cellular_component intrinsic to membrane GO:0031224 1310 72 0.0161449 111 0.073238 cellular_component anchored to membrane GO:0031225 11 1 0.392231 2 0.199021 cellular_component intrinsic to plasma membrane GO:0031226 876 49 0.0392696 70 0.308127 cellular_component intrinsic to endoplasmic reticulum membrane GO:0031227 25 2 0.303781 2 0.572616 cellular_component intrinsic to Golgi membrane GO:0031228 21 0 1 2 0.477552 cellular_component intrinsic to peroxisomal membrane GO:0031231 11 0 1 2 0.199021 cellular_component leading edge GO:0031252 32 0 1 4 0.21842 cellular_component intrinsic to organelle membrane GO:0031300 68 3 0.585002 8 0.137188 cellular_component integral to organelle membrane GO:0031301 58 2 0.734569 7 0.143739 cellular_component cytoplasmic vesicle GO:0031410 111 10 0.0239434 11 0.213011 cellular_component microbody membrane GO:0031903 16 0 1 2 0.342619 cellular_component nuclear membrane GO:0031965 49 4 0.169369 4 0.5112 cellular_component mitochondrial membrane GO:0031966 111 4 0.731463 14 0.0379448 cellular_component organelle envelope GO:0031967 197 9 0.509749 22 0.0387042 cellular_component organelle outer membrane GO:0031968 24 2 0.287153 1 0.848418 cellular_component membrane-enclosed lumen GO:0031974 411 30 0.00369208 34 0.30539 cellular_component envelope GO:0031975 197 9 0.509749 22 0.0387042 cellular_component mitochondrial lumen GO:0031980 70 7 0.033719 8 0.154394 cellular_component nuclear lumen GO:0031981 319 23 0.0125479 26 0.366141 cellular_component vesicle GO:0031982 115 11 0.012061 11 0.247608 cellular_component membrane-bound vesicle GO:0031988 113 11 0.0106408 11 0.230052 cellular_component actin filament bundle GO:0032432 10 0 1 1 0.543793 cellular_component macromolecular complex GO:0032991 952 52 0.0495847 84 0.0542444 cellular_component nuclear envelope-endoplasmic reticulum network GO:0042175 86 5 0.331166 6 0.639344 cellular_component microbody GO:0042579 56 1 0.921784 5 0.416389 cellular_component vesicular fraction GO:0042598 56 2 0.716532 6 0.244459 cellular_component cell projection GO:0042995 101 7 0.157757 10 0.228461 cellular_component neuron projection GO:0043005 27 2 0.336801 2 0.615223 cellular_component organelle GO:0043226 2374 118 0.0330594 197 0.0231085 cellular_component membrane-bound organelle GO:0043227 2061 104 0.0353213 172 0.0336805 cellular_component non-membrane-bound organelle GO:0043228 667 44 0.00312537 60 0.073835 cellular_component intracellular organelle GO:0043229 2372 118 0.0321214 197 0.0221888 cellular_component intracellular membrane-bound organelle GO:0043231 2060 104 0.0348195 172 0.0330413 cellular_component intracellular non-membrane-bound organelle GO:0043232 667 44 0.00312537 60 0.073835 cellular_component organelle lumen GO:0043233 411 30 0.00369208 34 0.30539 cellular_component protein complex GO:0043234 846 45 0.0954894 72 0.132971 cellular_component receptor complex GO:0043235 54 2 0.697483 7 0.108723 cellular_component contractile fiber GO:0043292 25 0 1 4 0.114578 cellular_component apical junction complex GO:0043296 29 1 0.731668 5 0.0627841 cellular_component extracellular matrix part GO:0044420 58 2 0.734569 4 0.646936 cellular_component extracellular region part GO:0044421 336 14 0.633964 31 0.134528 cellular_component organelle part GO:0044422 1153 67 0.00578935 93 0.234411 cellular_component intracellular part GO:0044424 2917 138 0.0943355 238 0.0172739 cellular_component membrane part GO:0044425 1586 81 0.0580216 136 0.030452 cellular_component chromosomal part GO:0044427 102 8 0.0803163 6 0.792718 cellular_component nuclear part GO:0044428 503 35 0.00376079 39 0.451466 cellular_component mitochondrial part GO:0044429 185 11 0.193767 20 0.0625112 cellular_component cytoskeletal part GO:0044430 238 12 0.360778 20 0.337654 cellular_component Golgi apparatus part GO:0044431 96 3 0.805165 9 0.297095 cellular_component endoplasmic reticulum part GO:0044432 95 5 0.411351 7 0.582775 cellular_component cytoplasmic vesicle part GO:0044433 34 4 0.0610257 5 0.108738 cellular_component vacuolar part GO:0044437 14 1 0.469527 2 0.285332 cellular_component microbody part GO:0044438 17 0 1 2 0.370743 cellular_component peroxisomal part GO:0044439 17 0 1 2 0.370743 cellular_component cytoplasmic part GO:0044444 1288 60 0.337401 110 0.0618053 cellular_component cytosolic part GO:0044445 82 8 0.027338 9 0.162352 cellular_component intracellular organelle part GO:0044446 1149 66 0.00826698 93 0.222481 cellular_component axoneme part GO:0044447 10 0 1 0 1 cellular_component cell cortex part GO:0044448 22 1 0.631083 1 0.822539 cellular_component contractile fiber part GO:0044449 24 0 1 4 0.101985 cellular_component microtubule organizing center part GO:0044450 17 1 0.537036 2 0.370743 cellular_component nucleoplasm part GO:0044451 183 12 0.109047 13 0.632466 cellular_component nucleolar part GO:0044452 17 2 0.171619 0 1 cellular_component nuclear membrane part GO:0044453 41 4 0.105413 3 0.607375 cellular_component nuclear chromosome part GO:0044454 29 2 0.369346 2 0.654504 cellular_component mitochondrial membrane part GO:0044455 71 3 0.614622 11 0.0161588 cellular_component plasma membrane part GO:0044459 1011 54 0.0649334 88 0.0650726 cellular_component cell projection part GO:0044463 25 1 0.678113 3 0.290722 cellular_component cell part GO:0044464 4159 186 0.327931 315 0.429979 cellular_component intermediate filament cytoskeleton GO:0045111 37 5 0.022118 3 0.536304 cellular_component lipid raft GO:0045121 16 0 1 0 1 cellular_component apical part of cell GO:0045177 14 0 1 2 0.285332 cellular_component synapse GO:0045202 15 1 0.493053 0 1 cellular_component proton-transporting ATP synthase complex GO:0045259 11 2 0.0822671 3 0.0444983 cellular_component respiratory chain complex I GO:0045271 32 0 1 3 0.438178 cellular_component anchored to plasma membrane GO:0046658 11 1 0.392231 2 0.199021 cellular_component pore complex GO:0046930 36 4 0.0724682 3 0.517433 cellular_component perinuclear region of cytoplasm GO:0048471 39 2 0.520208 5 0.167003 cellular_component coated membrane GO:0048475 30 3 0.144767 4 0.186387 cellular_component nuclear DNA-directed RNA polymerase complex GO:0055029 23 1 0.647473 1 0.835987