ࡱ> OBDY  !"#$%&'()*+,-./0123456789:;<=>?@ACDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~R F<;P@WorkbookSummaryInformation(pDocumentSummaryInformation8> S?\p Gene Cutler Ba==pSF8@"1HVerdana1HVerdana1HVerdana1HVerdana1HVerdana"$"#,##0_);\("$"#,##0\)!"$"#,##0_);[Red]\("$"#,##0\)""$"#,##0.00_);\("$"#,##0.00\)'""$"#,##0.00_);[Red]\("$"#,##0.00\)7*2_("$"* #,##0_);_("$"* \(#,##0\);_("$"* "-"_);_(@_).))_(* #,##0_);_(* \(#,##0\);_(* "-"_);_(@_)?,:_("$"* #,##0.00_);_("$"* \(#,##0.00\);_("$"* "-"??_);_(@_)6+1_(* #,##0.00_);_(* \(#,##0.00\);_(* "-"??_);_(@_)                + ) , *  8dq:Fc-2NWgFSWc-2NWgFSW̙̙3f3fff3f3f33333f33333\`;Sheet1]Sheet2oSheet3߮ perinuclear region of cytoplasmGPI anchor bindingrhythmic processblood vessel morphogenesislymph node developmentneuron fate commitmentneuron development!branching morphogenesis of a tubeinner ear development!unspecific monooxygenase activity FAD binding NADP bindingcoenzyme binding4positive regulation of epithelial cell proliferationandrogen receptor binding/regulation of peptidyl-tyrosine phosphorylation8positive regulation of peptidyl-tyrosine phosphorylation(low-density lipoprotein receptor binding#positive regulation of phagocytosisregulation of axonogenesis#positive regulation of axonogenesisregulation of immune response&positive regulation of immune response#regulation of developmental processactivated T cell proliferation#synapse organization and biogenesis1positive regulation of calcium-mediated signaling!T cell receptor signaling pathway!B cell receptor signaling pathway(positive regulation of T cell activationregulation of balanceresponse to stimulussensory perception of tastenegative chemotaxisactin filament binding!barbed-end actin filament cappingactin filament bundle formationGTPase bindingmRNA transport7regulation of small GTPase mediated signal transductionunfolded protein binding,activation of NF-kappaB transcription factorcartilage developmentprotein polymerizationprotein homooligomerizationprotein tetramerization NAD binding cell divisioniron-sulfur cluster binding 2 iron, 2 sulfur cluster binding 4 iron, 4 sulfur cluster bindingGO id+neurotransmitter receptor metabolic processsarcomere organizationfat cell differentiationregulation of transcriptioncell redox homeostasis-positive regulation of B cell differentiation"regulation of cell differentiation+negative regulation of cell differentiation+positive regulation of cell differentiation-negative regulation of neuron differentiation?negative regulation of cyclin-dependent protein kinase activityregulation of angiogenesis%positive regulation of anti-apoptosis$positive regulation of cell adhesion5negative regulation of progression through cell cycle(negative regulation of heart contraction.positive regulation of protein kinase activity3negative regulation of transcription, DNA-dependent3positive regulation of transcription, DNA-dependent$positive regulation of transcriptionDpositive regulation of transcription from RNA polymerase II promoter#regulation of embryonic developmentdUTP metabolic processregulation of JNK cascade"positive regulation of JNK cascade SMAD binding6positive regulation of Ras protein signal transductionintercellular canaliculusanchored to plasma membrane&protein amino acid autophosphorylationphospholipid dephosphorylationfilopodium formationmetal ion transporter activitytransition metal ion bindingEhydrogen ion transporting ATP synthase activity, rotational mechanism7phosphatidylinositol-4,5-bisphosphate 3-kinase activity?hydrogen ion transporting ATPase activity, rotational mechanism#protein heterodimerization activityprotein dimerization activity)mitochondrion transport along microtubule5insulin-like growth factor receptor signaling pathway#phosphoinositide-mediated signalingfocal adhesion formationpigmentation during development!regulation of synaptic plasticity*regulation of neuronal synaptic plasticityactivin bindingcell developmentcell maturation+positive regulation of T cell proliferationT cell activationB cell activation regulation of cell proliferation+negative regulation of T cell proliferationlipoprotein metabolic processSH2 domain binding ribosome biogenesis and assembly sarcolemma"eye photoreceptor cell development melanosomeinner ear morphogenesis odontogenesis (sensu Vertebrata)mechanoreceptor differentiation&auditory receptor cell differentiationresponse to drug myelinationglucose homeostasisMHC class II protein complexATPase activity, coupled@ATPase activity, coupled to transmembrane movement of substancescholesterol homeostasisanagenmenstrual cycleembryonic digit morphogenesispresynaptic membraneidentical protein binding!protein homodimerization activityhistone deacetylase bindingregulation of apoptosisneuron projection cell soma positive regulation of apoptosis negative regulation of apoptosisregulation of GTPase activityreceptor clustering8positive regulation of I-kappaB kinase/NF-kappaB cascadecation bindingterminal buttondendritic spineprotein complexcontractile fiber pigmentation'negative regulation of neuron apoptosis ADP binding!phosphoinositide 3-kinase binding9positive regulation of phosphoinositide 3-kinase activity"insulin receptor substrate bindingsequence-specific DNA bindingcellular metabolic process"cellular protein metabolic process:purinergic nucleotide receptor activity, G-protein coupled negative thymic T cell selection<positive regulation of interferon-gamma biosynthetic process9positive regulation of interleukin-2 biosynthetic processinnate immune responsekeratin filament>intermediate filament cytoskeleton organization and biogenesis lipid raftcell fate commitmentapical part of cellsynapsepostsynaptic membraneregulation of cell migration%positive regulation of cell migration%negative regulation of cell migration"phosphoinositide metabolic process3RNA interference, targeting of mRNA for destructionaxondendrite growth cone'ER-associated protein catabolic processBMP signaling pathway,negative regulation of BMP signaling pathway#androgen receptor signaling pathway transcription regulator activityribonucleoprotein complex cAMP bindingcollagen catabolic processneutrophil chemotaxis"neurotransmitter receptor activityprotein binding, bridging.Rac guanyl-nucleotide exchange factor activitycaspase activity+regulation of actin filament polymerization4positive regulation of actin filament polymerizationepithelial cell differentiation-regulation of epithelial cell differentiationcortical cytoskeletoncortical actin cytoskeleton7cortical actin cytoskeleton organization and biogenesismammary gland developmentactin-dependent ATPase activityforebrain developmenthindbrain developmentpotassium ion bindingunfolded protein responseextracellular matrixhair follicle morphogenesisheat shock protein bindingneurite development;RNA splicing factor activity, transesterification mechanism leading edgesodium ion bindingchloride ion bindingcytoplasmic vesicleL-ascorbic acid bindingkeratinizationM line!actin cytoskeleton reorganizationneuromuscular junction-regulation of ARF protein signal transductionintegrator complex single guanine insertion binding single thymine insertion bindingoxidized purine DNA binding-regulation of Rho protein signal transductionphosphoinositide binding embryonic hindlimb morphogenesisciliary rootletgrowthregulation of body size positive regulation of body size wound healingT cell receptor complexresponse to pheromone leukotriene biosynthetic processprotein metabolic process synaptosomecalcium-mediated signalingoxygen bindingstem cell maintenance cytolysisgrowth factor binding rRNA bindingouter membraneQantigen processing and presentation of endogenous peptide antigen via MHC class IQantigen processing and presentation of exogenous peptide antigen via MHC class IIextrinsic to plasma membraneextrinsic to membraneenzyme bindingprotein kinase bindingcAMP-mediated signalingdiacylglycerol binding heme bindingmetal ion transportZ discGextracellular matrix structural constituent conferring tensile strength lamellipodiumcell projection biogenesislamellipodium biogenesis.actin cytoskeleton organization and biogenesisactin filament polymerizationactin filament-based movement cell junction desmosomeinsulin secr< etion hemopoiesismyeloid cell differentiationregulation of endocytosis membrane coatclathrin vesicle coatCOPII vesicle coat,clathrin coat of trans-Golgi network vesicletransport vesicleendocytic vesiclesecretory granulemanganese ion bindingmolybdenum ion bindingcell differentiationregulation of cell adhesionprotein catabolic processPDZ domain bindingplatelet activationintegral to Golgi membrane filopodium*integral to endoplasmic reticulum membrane5negative regulation of Wnt receptor signaling pathwayneuron differentiationB cell differentiation0extracellular matrix organization and biogenesiscollagen fibril organizationkeratinocyte differentiationT cell differentiationerythrocyte differentiationbone mineralizationdynein complex"negative regulation of cell growthjunctional membrane complexsperm motilitymelanocyte differentiationlung developmentembryonic limb morphogenesis<oxidoreductase activity, acting on the CH-CH group of donors}oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donorsoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygentransferase activity2transferase activity, transferring glycosyl groups1transferase activity, transferring hexosyl groups5transferase activity, transferring nitrogenous groups?transferase activity, transferring phosphorus-containing groups6phosphotransferase activity, alcohol group as acceptornucleotidyltransferase activity)hydrolase activity, acting on ester bonds#carboxylic ester hydrolase activity,hydrolase activity, acting on glycosyl bondsdipeptidase activityRhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides^hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substanceslyase activitycarboxy-lyase activity phosphorus-oxygen lyase activityisomerase activityligase activityATPase activitycell wall catabolic processMAP kinase phosphatase activityRho GTPase binding"nucleoside-triphosphatase activity)wide-spectrum protease inhibitor activitySH3 domain bindingRab GTPase binding3negative regulation of protein biosynthetic processsemaphorin receptor activity+histone-lysine N-methyltransferase activitypeptidyl-serine phosphorylation!peptidyl-tyrosine phosphorylationpeptide cross-linkingprotein-chromophore linkageguanyl nucleotide binding GDP binding1cytokine and chemokine mediated signaling pathwaytubulin bindingUATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism%monovalent inorganic cation transportglucose transportlarge ribosomal subunitsmall ribosomal subunit&ATP synthesis coupled proton transport'ATP hydrolysis coupled proton transportproton transport"cytoplasmic membrane-bound vesiclelipid catabolic process.cellular component organization and biogenesisdetection of bacterium cell growthWnt receptor signaling pathway'immunoglobulin mediated immune responsemRNA metabolic processsterol biosynthetic processvesicle-mediated transportendosome transportantioxidant activity7general RNA polymerase II transcription factor activity(1-phosphatidylinositol-3-kinase activityphosphorylationbasolateral plasma membraneapical plasma membrane%morphogenesis of embryonic epitheliumcell-cell adhesion&calcium-independent cell-cell adhesion$calcium-dependent cell-cell adhesiondendrite developmentnuclear matrixacetyltransferase activity$tRNA-pseudouridine synthase activitymyosin complex-proton-transporting two-sector ATPase complexcell migration$negative regulation of transcriptionprotein processingoxidoreductase activityC-C chemokine receptor activitySWI/SNF complexlatrotoxin receptor activity#negative regulation of angiogenesissarcoplasmic reticulum2cyclin-dependent protein kinase regulator activity"transcriptional activator activity"transcriptional repressor activity+specific transcriptional repressor activityprotein ubiquitinationchromatin modificationhistone methylationhistone acetylation NuRD complexchromatin remodeling complexRac protein signal transductionPML body nuclear speckUoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor/induction of apoptosis by extracellular signals/induction of apoptosis by intracellular signalsLDNA damage response, signal transduction resulting in induction of apoptosisapoptotic programcarbohydrate transportamino acid biosynthetic process!phospholipid biosynthetic process9S-adenosylmethionine-dependent methyltransferase activityelectron carrier activitybiosynthetic processmethionine biosynthetic processnucleotide metabolic process&cyclic nucleotide biosynthetic processprotein secretionresponse to radiationbiotin binding=phosphoenolpyruvate-dependent sugar phosphotransferase systemresponse to heatresponse to UVmicrotubule-based flagellumresponse to woundingresponse to virusresponse to toxin"anatomical structure morphogenesisresponse to hormone stimulushormone-mediated signalingembryonic developmentorgan morphogenesistissue development external side of plasma membrane internal side of plasma membranebasal plasma membrane$anterior/posterior pattern formation dorsal/ventral pattern formation!regulation of signal transduction*negative regulation of signal transduction cell surfacecellular processglial cell differentiationgastrulation (sensu Mammalia)endosome membrane FMN bindingvesicle membranecoreceptor activity)protein disulfide oxidoreductase activity!disulfide oxidoreductase activityion transporter activity0monovalent inorganic cation transporter activity!hydrogen ion transporter activity calcium ion transporter activityamino acid transporter activity,calcium-activated potassium channel activity'store-operated calcium channel activityconnexon channel activityporin activitysymporter activityantiporter activity$potassium channel regulator activityacetylcholine receptor activityactin cytoskeletonmicrotubule cytoskeletonsynaptic vesicleprotein C-terminus bindingATP-dependent helicase activitytRNA processingaxon guidance receptor activityenzyme activator activity'voltage-gated potassium channel complexN-acetyltransferase activitygrowth factor activityretrograde axon cargo transportcytoskeletal protein bindingDNA-dependent ATPase activityprotein localizationcollagenase activitytranscription factor binding(NADH dehydrogenase (ubiquinone) activity6protein tyrosine/serine/threonine phosphatase activitysulfotransferase activitybiological_processmetabolic processmethyltransferase activityN-methyltransferase activityferric iron bindingheparin bindingsteroid metabolic processcholesterol metabolic processblood pressure regulationbioluminescence cell deathpeptidase activity cysteine-type peptidase activityserine-type peptidase activitymetallopeptidase activitysulfate transportBregulation of G-protein coupled receptor protein signaling pathwaycell proliferation"insulin receptor signaling pathway lipid bindingintegrin complex structural constituent of muscle"protein prenyltransferase activitycation transporter activityadult locomotory behaviorregulation of cell shapesialyltransferase activitygalactosyltransferase activity RNA splicing3'-5' exonuclease activityacyltransferase activityselenium bindingtransaminase activity"organic anion transporter activitytaste receptor activit< yastacin activity3fibroblast growth factor receptor signaling pathwayepidermis development=hydrogen-exporting ATPase activity, phosphorylative mechanismprotein transporter activity7regulation of synaptic growth at neuromuscular junctionmale gonad development0cAMP-dependent protein kinase regulator activitylipid biosynthetic processneuropeptide signaling pathwayNotch signaling pathway:Wnt receptor signaling pathway, calcium modulating pathwaysmoothened signaling pathway#integrin-mediated signaling pathwayintracellular signaling cascadeprotein kinase cascade!I-kappaB kinase/NF-kappaB cascade JNK cascadeactivation of JNK activityJAK-STAT cascade)small GTPase mediated signal transductionRas protein signal transductionRho protein signal transductioncell-cell signalingsynaptic transmissionneurotransmitter secretion"synaptic transmission, cholinergicgamete generationgerm cell developmentspermatogenesisspermatid developmentfemale gamete generationsingle fertilization"binding of sperm to zona pellucidaacrosome reaction$determination of left/right symmetrypattern specification processectoderm developmentnervous system developmentneuroblast proliferation axonogenesis axon guidanceaxonal fasciculationsynaptogenesis"central nervous system developmentbrain development%peripheral nervous system developmentsalivary gland morphogenesisendoderm developmentmesoderm developmentheart developmentadult heart developmentmuscle developmentstriated muscle developmentmyoblast fusion"neuromuscular junction developmentsex differentiation pregnancyembryo implantation cell agingrespiratory gaseous exchange digestion excretion lactationblood coagulationsensory perceptionvisual perceptionphototransductionsensory perception of sound'sensory perception of chemical stimulussensory perception of smellbehaviorlearning and/or memorylearningmemorycircadian rhythmlocomotory behavioradult walking behaviorfeeding behaviorchemokine activitybeta-catenin binding circulationregulation of heart contractionmicrotubule binding(complement activation, classical pathwayhumoral immune responsecellular defense responseresponse to DNA damage stimulusresponse to oxidative stressresponse to unfolded protein8chromosome organization and biogenesis (sensu Eukaryota))mitochondrion organization and biogenesis(cytoskeleton organization and biogenesisactin filament organizationmicrotubule-based processmicrotubule-based movement3negative regulation of microtubule depolymerization&peroxisome organization and biogenesis$lysosome organization and biogenesis cell-substrate junction assemblycell cycle arrestchromosome segregationmitosismitotic chromosome condensationnuclear migrationmeiosismeiotic recombinationcell communication cell adhesionhomophilic cell adhesionheterophilic cell adhesionleukocyte adhesioncell-matrix adhesion$negative regulation of cell adhesion1establishment and/or maintenance of cell polaritysignal transduction0cell surface receptor linked signal transduction@transmembrane receptor protein tyrosine kinase signaling pathway2epidermal growth factor receptor signaling pathwayHtransmembrane receptor protein serine/threonine kinase signaling pathway:transforming growth factor beta receptor signaling pathwayEtransmembrane receptor protein tyrosine phosphatase signaling pathway4G-protein coupled receptor protein signaling pathwayBG-protein signaling, coupled to cyclic nucleotide second messenger@G-protein signaling, coupled to cAMP nucleotide second messenger9G-protein signaling, adenylate cyclase activating pathwayadenylate cyclase activation9G-protein signaling, adenylate cyclase inhibiting pathwayQG-protein signaling, coupled to IP3 second messenger (phospholipase C activating)0elevation of cytosolic calcium ion concentrationprotein kinase C activation)gamma-aminobutyric acid signaling pathwayprotein targetingprotein import into nucleusprotein export from nucleus/posttranslational protein targeting to membranelipid metabolic processfatty acid metabolic processfatty acid biosynthetic processfatty acid beta-oxidationacyl-CoA metabolic processphospholipid metabolic processleukotriene metabolic processsteroid biosynthetic process cholesterol biosynthetic process#aromatic compound metabolic process%one-carbon compound metabolic processglutathione metabolic processATP biosynthetic processheme biosynthetic processsulfur metabolic processphosphate metabolic process4oxygen and reactive oxygen species metabolic processsuperoxide metabolic processxenobiotic metabolic process#nitrogen compound metabolic process!nitric oxide biosynthetic processcation transportpotassium ion transportsodium ion transportcalcium ion transportphosphate transportanion transportchloride transportiron ion transportneurotransmitter transportmitochondrial transportamino acid transportlipid transportcalcium ion homeostasiscopper ion homeostasisiron ion homeostasiszinc ion homeostasisregulation of pHintracellular protein transport exocytosis&ER to Golgi vesicle-mediated transport&intra-Golgi vesicle-mediated transport endocytosisreceptor-mediated endocytosis!vesicle docking during exocytosis phagocytosisphagocytosis, recognitionphagocytosis, engulfment autophagy apoptosisanti-apoptosisinduction of apoptosiscaspase activation cell motility chemotaxismuscle contraction regulation of muscle contractionsmooth muscle contractionstriated muscle contractionmembrane fusionresponse to stressacute-phase responseinflammatory responseimmune responsecomplement activation*complement activation, alternative pathwayEnucleobase, nucleoside, nucleotide and nucleic acid metabolic process&purine nucleotide biosynthetic processcAMP biosynthetic processcGMP biosynthetic process.'de novo' pyrimidine base biosynthetic processCTP biosynthetic processDNA metabolic processDNA replicationDNA topological change DNA unwinding during replicationDNA replication initiation DNA repairbase-excision repairnucleotide-excision repairmismatch repairdouble-strand break repair8double-strand break repair via nonhomologous end joiningDNA methylationDNA recombination DNA packaging:establishment and/or maintenance of chromatin architecture!chromatin assembly or disassemblynucleosome assemblychromatin remodelingtranscription initiation*regulation of transcription, DNA-dependent;regulation of transcription from RNA polymerase II promoterrRNA processing-transcription from RNA polymerase II promoter8transcription initiation from RNA polymerase II promotermRNA splice site selectionRNA processingmRNA processingmRNA catabolic processtranslational initiationtranslational elongationregulation of translation+tRNA aminoacylation for protein translation&regulation of translational initiationprotein complex assemblyprotein modification process"protein amino acid phosphorylation.negative regulation of protein kinase activity$protein amino acid dephosphorylation#protein amino acid ADP-ribosylation protein amino acid glycosylation)protein amino acid N-linked glycosylation)protein amino acid O-linked glycosylationGPI anchor biosynthetic process proteolysis'membrane protein ectodomain proteolysis-ubiquitin-dependent protein catabolic processubiquitin cycleamino acid metabolic processarginine biosynthetic processglutamine metabolic processhistidine catabolic processcatecholamine metabolic processU12-dependent spliceosomenuclear heterochromatin nucleolus)small nucleolar ribonucleoprotein complex mitochondrionmitochondrial envelopemitochondrial outer membranemitochondrial inner membranemitochondrial respiratory chain< )mitochondrial respiratory chain complex Imitochondrial matrixmitochondrial ribosome%mitochondrial large ribosomal subunitlysosomelysosomal membraneendosomeearly endosome late endosome peroxisomeendoplasmic reticulum<signal recognition particle, endoplasmic reticulum targetingendoplasmic reticulum lumenendoplasmic reticulum membrane microsome!ER-Golgi intermediate compartmentGolgi apparatus Golgi stacktrans-Golgi network centrosomespindlecytosol$cytosolic ribosome (sensu Eukaryota) heterotrimeric G-protein complex)proteasome core complex (sensu Eukaryota)ribosome3cytosolic small ribosomal subunit (sensu Eukaryota) cytoskeletonaxonemal dynein complexmuscle myosin complexstriated muscle thick filamentstriated muscle thin filamentkinesin complex microtubulemicrotubule associated complexintermediate filamentactin filamentplasma membrane%voltage-gated calcium channel complex microvillus brush border coated pitintercellular junctionadherens junctioncell-cell adherens junction gap junctionconnexon complextight junctionfocal adhesioncilium cell cortex!phosphoinositide 3-kinase complex%cAMP-dependent protein kinase complexcarbohydrate metabolic processglycogen metabolic processglucose metabolic processgalactose metabolic processproteoglycan metabolic process.generation of precursor metabolites and energygluconeogenesis glycolysistricarboxylic acid cycleelectron transport4mitochondrial electron transport, NADH to ubiquinone&structural constituent of cytoskeleton+extracellular matrix structural constituent"structural constituent of eye lenstransporter activityion channel activity4ryanodine-sensitive calcium-release channel activity/extracellular ligand-gated ion channel activity$glutamate-gated ion channel activity%gap-junction forming channel activity"voltage-gated ion channel activity&voltage-gated calcium channel activity"calcium channel regulator activity'voltage-gated chloride channel activity%voltage-gated sodium channel activity(voltage-gated potassium channel activity,delayed rectifier potassium channel activitychloride channel activitycation channel activitycalcium channel activitypotassium channel activitysodium channel activity)amino acid-polyamine transporter activitylipid transporter activity*neurotransmitter:sodium symporter activitysugar porter activityglucose transporter activitycarrier activity$calcium-transporting ATPase activity+sodium:potassium-exchanging ATPase activity"inorganic anion exchanger activitybindingsteroid bindingiron ion bindingcopper ion bindingcalcium ion bindingcalmodulin bindingcollagen binding"insulin-like growth factor binding ATP binding GTP binding sugar bindinghyaluronic acid bindingphospholipid binding&calcium-dependent phospholipid bindingphosphatidylinositol binding/phosphatidylinositol-3,4,5-triphosphate bindingcellular_componentextracellular region"proteinaceous extracellular matrixcollagenbasement membrane basal laminalaminin-1 complex intracellularmembrane fractionsoluble fractioninsoluble fractionnuclear envelope nuclear pore nucleoplasmreplication fork,DNA-directed RNA polymerase II, core complex"transcription factor TFIID complexanaphase-promoting complex spliceosome endopeptidase inhibitor activity,serine-type endopeptidase inhibitor activity$cysteine protease inhibitor activitysignal transducer activityreceptor activity*ligand-dependent nuclear receptor activity!thyroid hormone receptor activitytransmembrane receptor activityCnicotinic acetylcholine-activated cation-selective channel activityGABA-A receptor activityGhematopoietin/interferon-class (D200-domain) cytokine receptor activityinterleukin receptor activity+non-G-protein coupled 7TM receptor activity#G-protein coupled receptor activityadrenoceptor activity&ionotropic glutamate receptor activity neuropeptide Y receptor activityolfactory receptor activity<transmembrane receptor protein tyrosine phosphatase activityephrin receptor activity&transmembrane-ephrin receptor activity)epidermal growth factor receptor activity*fibroblast growth factor receptor activity4vascular endothelial growth factor receptor activity1transforming growth factor beta receptor activity)low-density lipoprotein receptor activityscavenger receptor activity#receptor signaling protein activitySH3/SH2 adaptor activityprotein kinase C bindingsmall GTPase regulator activity*guanyl-nucleotide exchange factor activity.ARF guanyl-nucleotide exchange factor activity.Ras guanyl-nucleotide exchange factor activity.Rho guanyl-nucleotide exchange factor activityGTPase activator activityRas GTPase activator activityRho GTPase activator activityreceptor binding Notch bindingcytokine activityFhematopoietin/interferon-class (D200-domain) cytokine receptor bindinginterleukin-1 receptor binding(epidermal growth factor receptor bindinginsulin receptor binding+insulin-like growth factor receptor binding&tumor necrosis factor receptor bindingintegrin bindinghormone activityneuropeptide hormone activitystructural molecule activity$aspartic-type endopeptidase activitypepsin A activity$cysteine-type endopeptidase activitycalpain activity ubiquitin thiolesterase activitymetalloendopeptidase activity"serine-type endopeptidase activitychymotrypsin activitysubtilase activitytrypsin activity threonine endopeptidase activity glutathione transferase activityCglyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activityguanylate cyclase activityguanylate kinase activityhelicase activity"histone acetyltransferase activityhistone deacetylase activity0inositol or phosphatidylinositol kinase activity)phosphoinositide phospholipase C activity5inositol or phosphatidylinositol phosphatase activitymonooxygenase activitynuclease activityendonuclease activity pancreatic ribonuclease activityribonuclease III activityexonuclease activityribonuclease activity4hydrolase activity, hydrolyzing O-glycosyl compoundsperoxidase activityphospholipase A2 activityphospholipase C activity6polypeptide N-acetylgalactosaminyltransferase activityprotein kinase activity(protein serine/threonine kinase activity?transmembrane receptor protein serine/threonine kinase activity;receptor signaling protein serine/threonine kinase activityMAP kinase activity protein-tyrosine kinase activity7transmembrane receptor protein tyrosine kinase activity6non-membrane spanning protein tyrosine kinase activity3receptor signaling protein tyrosine kinase activity!protein-lysine 6-oxidase activity#phosphoprotein phosphatase activity-protein serine/threonine phosphatase activity%protein tyrosine phosphatase activity0prenylated protein tyrosine phosphatase activityserine esterase activityaminoacyl-tRNA ligase activity!ubiquitin-protein ligase activityenzyme inhibitor activity!protein kinase inhibitor activity&protein phosphatase inhibitor activity$morphogenesis of an epithelial sheetcardiac inotropyFantigen processing and presentation of peptide antigen via MHC class IYantigen processing and presentation of peptide or polysaccharide antigen via MHC class IImolecular_functionnucleic acid bindingDNA helicase activitychromatin bindingdamaged DNA bindingdouble-stranded DNA bindingsingle-stranded DNA binding/RNA polymerase II transcription factor activity8specific RNA polymerase II transcription factor activityARNA polymerase II transcription factor activity, enhancer binding!steroid hormone receptor activitytranscription cofactor activity"transcription coactivator activity"transcription corepressor activity RNA bindingRNA helicase activitydouble-stranded RNA bindingsingle-stranded RNA binding mRNA binding"structural constituent of ribosome<l&translation initiation factor activity&translation elongation factor activity,peptidyl-prolyl cis-trans isomerase activitymotor activitymicrotubule motor activity actin binding4protein-glutamine gamma-glutamyltransferase activitycatalytic activity$DNA-directed DNA polymerase activity$DNA-directed RNA polymerase activityDNA ligase (ATP) activity,DNA topoisomerase (ATP-hydrolyzing) activityGTPase activity$NAD+ ADP-ribosyltransferase activityNADH dehydrogenase activityacid phosphatase activityacyl-CoA dehydrogenase activity#ATP-dependent DNA helicase activity#ATP-dependent RNA helicase activityadenylate cyclase activityadenylate kinase activity%carbamoyl-phosphate synthase activitycarbonate dehydratase activity23',5'-cyclic-nucleotide phosphodiesterase activitycytochrome-c oxidase activitydiacylglycerol kinase activityendopeptidase activity ATP-dependent peptidase activityaminopeptidase activitycarboxypeptidase activitycarboxypeptidase A activity3'-5'-exoribonuclease activityexosome (RNase complex)/mRNA catabolic process, nonsense-mediated decayactivation of MAPKK activityactivation of MAPK activityinactivation of MAPK activityprotein polyubiquitination4microtubule cytoskeleton organization and biogenesisnuclear chromosomepericentriolar materialspliceosome assemblypeptidoglycan metabolic processmagnesium ion binding)integral to membrane of membrane fraction&nuclear mRNA splicing, via spliceosomefour-way junction DNA binding$proteasome complex (sensu Eukaryota)telomere maintenancechromosome, pericentric region kinetochorechromosome, telomeric region chromatin nucleosomeheterochromatincondensed chromosomecondensed nuclear chromosomesynaptonemal complexcell morphogenesis cytokinesis spindle poleskeletal developmentcartilage condensation ossification$voltage-gated sodium channel complex angiogenesis microfibrilcornified envelopeovarian follicle developmentregulation of cell growthblood vessel developmentpatterning of blood vesselsvasculogenesisHdetection of chemical stimulus during sensory perception of bitter taste rhodopsin-like receptor activityosteoblast differentiationeye developmentmetanephros developmentureteric bud developmentureteric bud branchingresponse to hypoxiaacrosomein utero embryonic developmentmesoderm formationcell fate specificationcell fate determination stress fiberrufflephotoreceptor outer segmentneural crest cell migration somitogenesisinduction of an organneuron migrationimmunological synapseplasma membrane repaircytokine productionkidney development$epithelial to mesenchymal transitionneural tube closureliver developmentplacenta developmentblood vessel remodeling descriptionamp.foldamp.pvalamp.hitdel.folddel.pvaldel.hit changed.fold changed.pval changed.hitunchanged.foldunchanged.pval unchanged.hitpheromone binding TRUEantigen bindingMHC class I protein complex#antigen processing and presentation43-beta-hydroxy-delta5-steroid dehydrogenase activity steroid delta-isomerase activity(C21-steroid hormone biosynthetic processdefense response5metabotropic glutamate, GABA-B-like receptor activitypheromone receptor activitydefense response to bacteriumnucleotide binding DNA bindingtranscription factor activityprotein bindingextracellular spacenucleustranscription factor complex chromosome cytoplasmintegral to plasma membrane transcription translationprotein folding transport ion transport cell cycle$multicellular organismal developmentzinc ion binding)positive regulation of cell proliferation)negative regulation of cell proliferationprotein transportmembraneintegral to membranekinase activityhydrolase activitymetal ion binding tRNA binding$protein import into nucleus, docking*protein import into nucleus, translocation,regulation of progression through cell cyclecell cycle checkpointDNA damage checkpoint6regulation of cyclin-dependent protein kinase activity%G1/S transition of mitotic cell cycle%G2/M transition of mitotic cell cyclehistone deacetylase complexmediator complexDnegative regulation of transcription from RNA polymerase II promoter!histone acetyltransferase complexGolgi membranemicrofilament motor activityubiquitin ligase complextwo-component sensor activity#protein phosphatase type 2A complex7two-component signal transduction system (phosphorelay)MAPKKK cascade  Ox~ 's  + rH S y eY w'w,@d's~6%T J!'s"#$S%P&7',(P"*{O-h/^A0 1 2L ;4 ei567*8P:;?<9>l?rf@A'sBOC3DQFt2GgHI3J+'sK0OL2MONzOSP RO R0 US"WWeX¼YZO[\]^_a=SybcJeE's1ffng]hw.iH=jWk2k-mGnp6 pq 3rM Jsd s 9uS'svxz6_{y|}e1KvMgȃ*D>=܋U%$ގ ّ #" RQ=<@?ȦPHPPN"PN#JPP'spD" cHHC0A ""p"@ ZB PHUr4N"O JPP's"N#А)J!&translation initiation factor activity&translation elongation factor activity,peptidyl-prolyl cis-trans isomerase activitymotor activitymicrotubule motor activity actin binding4protein-glutamine gamma-glutamyltransferase activitycatalytic activity$DNA-directed DNA polymerase activity$DNA-directed RNA 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