
seed used = 140002533

K12                                  ATG CGG TTG TTT ATT GCC GAA AAA CCG AGT CTG GCG CGC GCC ATT GCT GAT GTC CTG CCC AAA CCG CAC CGG AAA GGC GAT GGC TTT ATC GAG TGC GGT AAT GGT CAG GTG GTG ACC TGG TGT ATC GGT CAC CTG CTT GAG CAG GCG CAG CCA GAC GCC TAC GAC AGC CGC TAT GCG CGC TGG AAT CTT GCG GAT TTG CCG ATT GTC CCG GAA AAG TGG CAA TTA CAG CCC CGA CCC TCC GTG ACC AAA CAA CTT AAC GTC ATC AAA CGG TTC CTG CAT GAA GCC AGC GAA ATC GTT CAC GCC GGG GAC CCG GAT CGT GAA GGG CAA TTG CTG GTG GAT GAA GTG CTG GAC TAT CTG CAA CTG GCA CCG GAA AAG CGC CAG CAG GTA CAG CGT TGC TTG ATA AAC GAC CTG AAC CCG CAG GCG GTT GAG CGG GCG ATC GAC CGT CTT CGT TCC AAC AGT GAG TTT GTA CCG CTG TGC GTT TCT GCG CTG GCG CGA GCG CGT GCC GAC TGG CTG TAC GGC ATC AAT ATG ACC CGT GCG TAT ACC ATT CTC GGT CGC AAT GCC GGT TAT CAG GGC GTA CTT TCC GTG GGA CGC GTG CAG ACG CCC GTG CTT GGG CTG GTG GTG CGC CGC GAT GAA GAG ATT GAA AAC TTC GTG GCG AAA GAC TTC TTT GAA GTC AAA GCA CAT ATC GTG ACA CCT GCC GAT GAG CGG TTT ACC GCT ATC TGG CAA CCG AGC GAA GCG TGT GAA CCG TAC CAG GAT GAA GAA GGG CGC TTG TTA CAT CGT CCA CTG GCG GAG CAT GTG GTT AAC CGC ATT AGT GGT CAA CCG GCT ATT GTC ACC AGC TAT AAC GAT AAA CGG GAA TCA GAA TCC GCG CCG CTG CCT TTT TCG CTT TCA GCG TTG CAG ATT GAA GCG GCA AAA CGT TTT GGT CTG AGT GCG CAG AAC GTG CTT GAT ATC TGC CAG AAA CTG TAC GAA ACG CAC AAG CTA ATC ACT TAT CCG CGT TCT GAT TGT CGC TAT TTG CCA GAA GAA CAT TTT GCC GGA CGC CAC GCG GTG ATG AAT GCC ATC AGT GTT CAT GCA CCG GAT CTG TTG CCG CAG CCA GTG GTA GAT CCA GAT ATA CGC AAC CGC TGT TGG GAT GAC AAA AAG GTC GAT GCG CAC CAC GCC ATC ATT CCG ACC GCA CGG AGT TCT GCG ATC AAC CTG ACG GAG AAC GAA GCG AAG GTC TAT AAC CTG ATT GCC CGT CAG TAT CTG ATG CAA TTC TGC CCG GAT GCG GTG TTC CGC AAG TGT GTT ATC GAA CTG GAC ATT GCC AAA GGC AAA TTT GTC GCT AAA GCG CGT TTT CTT GCT GAA GCA GGC TGG CGC ACG CTG TTA GGC AGC AAA GAG CGC GAT GAA GAA AAC GAC GGC ACG CCA CTG CCT GTG GTG GCG AAA GGC GAT GAG TTG CTG TGT GAA AAA GGT GAA GTG GTA GAG CGG CAA ACC CAG CCG CCG CGC CAT TTT ACC GAT GCA ACA CTG CTT TCG GCG ATG ACC GGG ATC GCG CGC TTT GTG CAG GAT AAA GAT CTG AAA AAG ATC CTC CGT GCG ACC GAT GGT CTG GGG ACA GAG GCA ACG CGT GCC GGG ATT ATT GAA CTG TTG TTC AAG CGT GGT TTC CTG ACC AAA AAA GGG CGC TAT ATC CAC TCC ACC GAC GCC GGA AAA GCG CTA TTC CAT TCG CTG CCG GAG ATG GCG ACG CGA CCG GAC ATG ACC GCG CAC TGG GAA TCG GTG CTG ACG CAA ATC AGC GAA AAG CAG TGT CGC TAT CAG GAC TTT ATG CAG CCG CTG GTG GGG ACG CTA TAT CAG CTT ATT GAT CAA GCC AAA CGT ACG CCG GTG CGG CAG TTT CGC GGC ATT GTG GCT CCG GGC AGT GGT GGC AGT GCT GAT AAG AAA AAG GCT GCA CCG CGT AAA CGT AGT GCG AAA AAA AGT CCG CCA GCA GAT GAA GTC GGA AGC GGG GCG 
S2457T                               ATG CGG TTG TTT ATT GCC GAA AAA CCG AGT CTG GCG CGC GCC ATT GCT GAT GTC CTG CCC AAA CCG CAC CGG AAA GGC GAT GGC TTT ATC GAG TGC GGT AAT GGT CAG GTG GTG ACT TGG TGT ATC GGT CAC CTG CTT GAG CAG GCG CAG CCA GAC GCC TAC GAC AGC CGC TAT GCG CGC TGG AAT CTT GCG GAT TTG CCG ATT GTC CCG GAA AAG TGG CAA TTA CAG CCA CGA CCC TCC GTG ACC AAA CAA CTT AAC GTC ATC AAA CGC TTC CTG CAT GAA GCC AGC GAA ATC GTT CAC GCC GGG GAC CCG GAT CGT GAA GGG CAA TTG CTG GTG GAT GAA GTG CTG GAC TAT CTG CAA CTG GCA CCG GAA AAG CGC CAG CAG GTG CAG CGT TGC TTG ATA AAC GAC CTG AAC CCG CAG GCG GTT GAG CGG GCG ATC GAC CGT CTT CGT TCC AAC AGT GAG TTT GTG CCA TTG TGC GTT TCT GCG CTG GCG CGA GCG CGT GCC GAC TGG CTG TAC GGC ATC AAT ATG ACC CGT GCG TAT ACC ATT CTC GGT CGC AAT GCC GGT TAT CAG GGC GTA CTT TCC GTG GGA CGC GTG CAG ACA CCC GTG CTC GGG CTG GTG GTG CGC CGC GAT GAA GAG ATT GAA AAC TTC GTG GCG AAA GAC TTC TTT GAA GTC AAA GCA CAT ATC GTG ACA CCT GCC GAT GAG CGG TTT ACC GCT ATC TGG CAA CCG AGC GAA GCG TGT GAA CCG TAC CAG GAT GAA GAA GGG CGC TTG TTA CAT CGT CCA CTG GCG GAG CAT GTG GTT AAC CGC ATT AGT GGT CAA CCG GCT ATT GTC ACC AGC TAT AAC GAT AAA CGG GAA TCA GAA TCC GCG CCG CTG CCG TTT TCG CTT TCG GCG TTG CAG ATT GAA GCG GCA AAA CGC TTC GGT CTG AGC GCG CAG AAC GTG CTT GAT ATC TGC CAG AAG CTG TAC GAA ACG CAC AAG CTA ATC ACT TAT CCG CGT TCC GAT TGT CGC TAT TTG CCA GAA GAA CAT TTT GCC GGA CGC CAC GCG GTG ATG AAT GCC ATC AGC GTT CAT GCA CCG GAT CTG TTG CCG CAG CCA GTG GTA GAT CCA GAT ATA CGC AAC CGC TGT TGG GAT GAC AAA AAG GTC GAT GCG CAC CAC GCC ATC ATC CCG ACC GCA CGG AGT TCT GCG ATC AAC CTG ACG GAG AAC GAA GCG AAG GTC TAT AAC CTG ATT GCC CGT CAA TAC CTG ATG CAG TTC TGC CCG GAT GCG GTG TTC CGC AAG TGT GTT ATC GAA CTG GAC ATT GCC AAA GGC AAA TTT GTC GCT AAA GCC CGT TTT CTT GCT GAA GCA GGC TGG CGC ACG CTG TTA GGC AGC AAA GAG CGC GAT GAA GAA AAC GAC GGC ACG CCA TTG CCT GTG GTG GCG AAA GGC GAT GAG TTG CTG TGT GAA AAA GGT GAA GTG GTA GAG CGG CAA ACC CAG CCG CCG CGC CAT TTT ACC GAT GCA ACA CTG CTT TCG GCG ATG ACC GGG ATC GCG CGC TTT GTG CAG GAC AAA GAT CTG AAA AAG GTC CTT CGT GCG ACC GAT GGT CTG GGG ACA GAA GCA ACC CGT GCC GGG ATT ATT GAA CTG CTG TTC AAG CGT GGT TTT CTG ACC AAA AAA GGG CGC TAT ATC CAC TCC ACC GAC GCC GGA AAA GCG TTA TTC CAT TCG CTG CCA GAA ATG GCG ACG CGA CCG GAC ATG ACC GCG CAC TGG GAA TCG GTG CTG ACG CAA ATC AGC GAA AAG CAG TGT CGC TAT CAG GAC TTT ATG CAG CCG CTG GTG GGG ACG CTA TAT CAG CTT ATT GAT CAA GCC AAA CGT ACG CCG GTG CGG CAG TTT CGC GGC ATT GTG GCT CCG GGC AGT GGT GGC AGT GCT GAT AAG AAA AAG GCT GCA CCG CGT AAA CGT AGT GCG AAA AAA AGT CCG CCA GCA GAT GAA GCT GGA AGC GGG GCG 
Shig4337                             ATG CGG TTG TTT ATT GCC GAA AAA CCG AGT CTG GCG CGC GCC ATT GCT GAT GTC CTG CCC AAA CCG CAC CGG AAA GGC GAT GGC TTT ATC GAG TGC GGT AAT GGT CAG GTG GTG ACT TGG TGT ATC GGT CAC CTG CTT GAG CAG GCG CAG CCA GAC GCC TAC GAC AGC CGC TAT GCG CGC TGG AAT CTT GCG GAT TTG CCG ATT GTC CCG GAA AAG TGG CAA TTA CAG CCA CGA CCC TCC GTG ACC AAA CAA CTT AAC GTC ATC AAA CGC TTC CTG CAT GAA GCC AGC GAA ATC GTT CAC GCC GGG GAC CCG GAT CGT GAA GGG CAA TTG CTG GTG GAT GAA GTG CTG GAC TAT CTG CAA CTG GCA CCG GAA AAG CGC CAG CAG GTG CAG CGT TGC TTG ATA AAC GAC CTG AAC CCG CAG GCG GTT GAG CGG GCG ATC GAC CGT CTT CGT TCC AAC AGT GAG TTT GTG CCA TTG TGC GTT TCT GCG CTG GCG CGA GCG CGT GCC GAC TGG CTG TAC GGC ATC AAT ATG ACC CGT GCG TAT ACC ATT CTC GGT CGC AAT GCC GGT TAT CAG GGC GTA CTT TCC GTG GGG CGC GTG CAG ACA CCC GTG CTC GGG CTG GTG GTG CGC CGC GAT GAA GAG ATT GAA AAC TTC GTG GCG AAA GAC TTC TTT GAA GTC AAA GCA CAT ATC GTG ACA CCT GCC GAT GAG CGG TTT ACC GCT ATC TGG CAA CCG AGC GAA GCG TGT GAA CCG TAC CAG GAT GAA GAA GGG CGC TTG TTA CAT CGT CCA CTG GCG GAG CAT GTG GTT AAC CGC ATT AGT GGT CAA CCG GCT ATT GTC ACC AGC TAT AAC GAT AAA CGG GAA TCA GAA TCC GCG CCG CTG CCG TTT TCG CTT TCG GCG TTG CAG ATT GAA GCG GCA AAA CGC TTC GGT CTG AGC GCG CAG AAC GTG CTT GAT ATC TGC CAG AAG CTG TAC GAA ACG CAC AAG CTA ATC ACT TAT CCG CGT TCC GAT TGT CGC TAT TTG CCA GAA GAA CAT TTT GCC GGA CGC CAC GCG GTG ATG AAT GCC ATC AGC GTT CAT GCA CCG GAT CTG TTG CCG CAG CCA GTG GTA GAT CCA GAT ATA CGC AAC CGC TGT TGG GAT GAC AAA AAG GTC GAT GCG CAC CAC GCC ATC ATC CCG ACC GCA CGG AGT TCT GCG ATC AAC CTG ACG GAG AAC GAA GCG AAG GTC TAT AAC CTG ATT GCC CGT CAA TAC CTG ATG CAG TTC TGC CCG GAT GCG GTG TTC CGC AAG TGT GTT ATC GAA CTG GAC ATT GCC AAA GGC AAA TTT GTC GCT AAA GCC CGT TTT CTT GCT GAA GCA GGC TGG CGC ACG CTG TTA GGC AGC AAA GAG CGC GAT GAA GAA AAC GAC GGC ACG CCA TTG CCT GTG GTG GCG AAA GGC GAT GAG TTG CTG TGT GAA AAA GGT GAA GTG GTA GAG CGG CAA ACC CAG CCG CCG CGC CAT TTT ACC GAT GCA ACA CTG CTT TCG GCG ATG ACC GGG ATC GCG CGC TTT GTG CAG GAC AAA GAT CTG AAA AAG GTC CTT CGT GCG ACC GAT GGT CTG GGG ACA GAA GCA ACC CGT GCC GGG ATT ATT GAA CTG CTG TTC AAG CGT GGT TTT CTG ACC AAA AAA GGG CGC TAT ATC CAC TCC ACC GAC GCC GGA AAA GCG TTA TTC CAT TCG CTG CCA GAA ATG GCG ACG CGA CCG GAC ATG ACC GCG CAC TGG GAA TCG GTG CTG ACG CAA ATC AGC GAA AAG CAG TGT CGC TAT CAG GAC TTT ATG CAG CCG CTG GTG GGG ACG CTA TAT CAG CTT ATT GAT CAA GCC AAA CGT ACG CCG GTG CGG CAG TTT CGC GGC ATT GTG GCT CCG GGC AGT GGT GGC AGT GCT GAT AAG AAA AAG GCT GCA CCG CGT AAA CGT AGT GCG AAA AAA AGT CCG CCA GCA GAT GAA GCC GGA AGC GGG GCG 
CFT073                               ATG CGG TTG TTT ATT GCC GAA AAA CCG AGT CTG GCG CGC GCC ATT GCT GAT GTC CTG CCT AAA CCG CAC CGG AAA GGC GAT GGC TTT ATC GAG TGC GGT AAT GGT CAG GTG GTG ACC TGG TGT ATC GGT CAC CTG CTT GAG CAG GCG CAG CCA GAC GCC TAC GAC AGC CGC TAT GCG CGC TGG AAT CTT GCG GAT TTG CCA ATT GTC CCG GAA AAG TGG CAA TTA CAG CCC CGA CCC TCC GTG ACT AAA CAA CTT AAT GTC ATC AAA CAC TTC CTG CAT GAA GCC AGC GAA ATC GTT CAC GCC GGA GAC CCG GAT CGC GAA GGG CAA CTG CTG GTG GAT GAA GTG CTG GAC TAC CTG CAA CTA GCA CCG GAA AAG CGC CAG CAG GTA CAG CGT TGT TTG ATA AAC GAC CTG AAC CCG CAG GCG GTT GAG CGG GCG ATC GAT CGT CTT CGC TCC AAT AGC GAG TTT GTA CCG CTG TGC GTT TCT GCA CTG GCG CGG GCG CGG GCT GAC TGG CTG TAC GGC ATT AAT ATG ACC CGT GCG TAT ACC ATT CTC GGC CGC AAT GCC GGT TAT CAG GGC GTG CTT TCC GTG GGA CGC GTG CAG ACG CCC GTA CTC GGA CTG GTG GTG CGC CGC GAC GAA GAG ATT GAA AAC TTC GTG GCG AAA GAC TTC TTT GAA GTC AAA GCA CAT ATC GTG ACA CCT GCA GAT GAG CGG TTT ACC GCT ATC TGG CAA CCG AGC GAA GCG TGT GAA CCG TAC CAG GAT GAA GAA GGG CGC TTG TTA CAT CGT CCA CTG GCG GAG CAT GTG GTT AAC CGC ATT AGT GGT CAA CCA GCT ATT GTC ACC AGC TAT AAC GAT AAA CGG GAA TCA GAA TCC GCG CCG CTG CCT TTT TCG CTT TCG GCG TTG CAG ATT GAA GCG GCT AAA CGT TTT GGT CTG AGC GCG CAG AAC GTG CTT GAT ATC TGC CAG AAG CTG TAC GAA ACG CAC AAG CTA ATC ACT TAT CCG CGT TCC GAT TGC CGC TAT TTG CCA GAA GAA CAT TTT GCC GGA CGC CAC GCG GTG ATG AAT GCT ATC AGC GTT CAT GCA CCG GAT CTG TTG CCG CAG CCA GTG GTA GAT CCA GAT ATA CGC AAC CGC TGT TGG GAT GAC AAA AAG GTC GAT GCG CAC CAC GCC ATC ATT CCG ACC GCA CGG AGT TCT GCG ATC AAC CTG ACG GAG AAC GAA GCG AAG GTC TAT AAC CTG ATT GCC CGT CAG TAT TTG ATG CAG TTC TGC CCG GAT GCG GTG TTC CGC AAG TGT GTT ATC GAA CTG GAC ATT GCC AAA GGC AAA TTT GTC GCT AAA GCC CGT TTT CTT GCT GAA GCA GGC TGG CGC ACG CTG TTA GGC AGC AAA GAG CGC GAT GAA GAA AAC GAC GGC ACG CCG CTG CCT GTG GTG GCG AAA GGC GAT GAA TTG TTG TGC GAA AAA GGT GAA GTG GTA GAG CGG CAA ACC CAG CCG CCA CGC CAT TTT ACC GAT GCA ACA CTG CTT TCG GCG ATG ACC GGG ATC GCA CGC TTT GTG CAG GAC AAA GAT CTG AAA AAG ATC CTT CGT GCG ACC GAT GGT CTG GGG ACA GAA GCG ACT CGC GCC GGG ATT ATT GAA CTG CTG TTC AAG CGA GGC TTC CTG ACC AAA AAA GGG CGC TAT ATC CAC TCC ACC GAC GCC GGA AAA GCG CTA TTC CAT TCG CTG CCA GAA ATG GCG ACG CGA CCG GAC ATG ACC GCG CAC TGG GAA TCG GTG CTG ACG CAA ATC AGC GAA AAG CAG TGT CGC TAT CAG GAC TTT ATG CAG CCG CTG GTG GGG ACA TTG TAC CAG TTG ATT GAT CAG GCT CGT AGC ACT CCG GTC AGA CGG TTT AAA GGA ATT GTG GTA CCA AGG AAC GGA --- --- --- GAC GAG AAA AAT AAA GAC GTG AAA AAA AGG GTC AAA AAA ACT GCG CAG AAA AAG GAT GCT ACA GTT AAG CGT GAC 
O157                                 ATG CGG TTG TTT ATT GCC GAA AAA CCG AGT CTG GCG CGC GCC ATT GCT GAT GTC CTG CCC AAA CCG CAC CGG AAA GGC GAT GGC TTT ATC GAG TGC GGT AAT GGT CAG GTG GTG ACC TGG TGT ATC GGT CAC CTG CTT GAG CAG GCG CAG CCA GAC GCC TAC GAC AGC CGC TAT GCG CGC TGG AAT CTT GCG GAT TTG CCG ATT GTC CCG GAA AAG TGG CAA TTA CAG CCC CGA CCC TCC GTG ACC AAA CAA CTT AAC GTC ATC AAA CGG TAC CTG CAT GAA GCC AGC GAA ATC GTT CAC GCC GGG GAC CCG GAT CGC GAA GGG CAA CTG CTG GTG GAT GAA GTG CTG GAC TAT CTA CAA CTG GCA CCG GAA AAG CGC CAG CAG GTG CAG CGT TGC TTG ATA AAC GAC CTG AAC CCG CAG GCG GTT GAG CGG GCG ATC GAC CGT CTT CGT TCC AAC AGT GAG TTT GTA CCG CTG TGC GTT TCT GCG CTG GCG CGA GCG CGT GCC GAC TGG CTG TAC GGC ATC AAT ATG ACC CGT GCG TAT ACC ATT CTC GGT CGC AAT GCC GGT TAT CAG GGC GTG CTT TCC GTG GGA CGC GTG CAG ACG CCC GTG CTT GGG CTG GTG GTG CGC CGC GAT GAA GAG ATT GAA AAC TTC GTG GCG AAA GAC TTC TTT GAA GTC AAA GCA CAT ATC GTG ACA CCT GCC GAT GAG CGG TTT ACC GCT ATC TGG CAA CCG AGC GAA GCG TGT GAA CCG TAC CAG GAT GAA GAA GGG CGC TTG TTA CAT CGT CCA CTG GCG GAG CAT GTG GTT AAC CGC ATT AGT GGT CAA CCG GCT ATT GTC ACC AGC TAT AAC GAT AAA CGG GAA TCA GAA TCC GCG CCG CTG CCG TTT TCG CTT TCG GCG TTG CAG ATT GAA GCG GCA AAA CGC TTT GGT CTG AGC GCG CAG AAC GTG CTT GAT ATC TGC CAG AAG CTG TAC GAA ACG CAC AAG CTA ATC ACT TAT CCG CGT TCC GAT TGT CGC TAT TTG CCA GAA GAA CAT TTT GCC GGA CGC CAC GCG GTG ATG AAT GCC ATC AGC GTT CAT GCA CCA GAT CTG TTG CCG CAG CCA GTG GTA GAT CCA GAT ATA CGC AAC CGC TGT TGG GAT GAC AAA AAG GTC GAT GCG CAC CAC GCC ATC ATT CCG ACC GCA CGG AGT TCT GCG ATC AAC CTG ACG GAG AAC GAA GCG AAG GTC TAT AAC CTG ATT TCC CGT CAG TAT CTG ATG CAG TTC TGC CCG GAT GCG GTG TTC CGC AAG TGT GTT ATC GAA CTG GAC ATT GCC AAA GGC AAA TTT GTC GCT AAA GCG CGT TTT CTT GCT GAA GCA GGC TGG CGC ACG CTG TTA GGC AGC AAA GAG CGC GAT GAA GAA AAC GAC GGT ACG CCA TTG CCT GTG GTG GCG AAA GGC GAT GAG TTG CTG TGT GAA AAA GGT GAA GTG GTA GAG CGG CAA ACC CAG CCG CCG CGC CAT TTT ACC GAT GCA ACA CTG CTT TCG GCG ATG ACC GGG ATC GCG CGC TTT GTG CAG GAC AAA GAT CTG AAA AAG ATC CTT CGT GCG ACC GAT GGT CTG GGG ACA GAA GCA ACG CGT GCC GGG ATT ATT GAA CTG TTG TTC AAG CGT GGT TTC CTC ATC AAA AAA GGG CGC TAT ATC CAC TCC ACC GAC GCC GGA AAA GCG TTA TTC CAT TCG CTG CCA GAA ATG GCT ACG CGA CCG GAC ATG ACC GCG CAC TGG GAA TCG GTG CTG ACG CAA ATC AGC GAA AAG CAG TGT CGC TAT CAG GAC TTT ATG CAG CCG CTG GTG GGG ACG CTA TAT CAG CTT ATT GAT CAA GCC AAA CGT ACT CCG GTG CGG CAG TTT CGC GGC ATT GTG GCT CCG GGC AGT GGT GGC AGT GCT GAT AAG AAA AAG GCT GCA CCG CGT AAA CGT AGT GCG AAA AAA AGT CCG CCA GCA GAT GAA GCC GGA AGC GGG GCG 
EDL933                               ATG CGG TTG TTT ATT GCC GAA AAA CCG AGT CTG GCG CGC GCC ATT GCT GAT GTC CTG CCC AAA CCG CAC CGG AAA GGC GAT GGC TTT ATC GAG TGC GGT AAT GGT CAG GTG GTG ACC TGG TGT ATC GGT CAC CTG CTT GAG CAG GCG CAG CCA GAC GCC TAC GAC AGC CGC TAT GCG CGC TGG AAT CTT GCG GAT TTG CCG ATT GTC CCG GAA AAG TGG CAA TTA CAG CCC CGA CCC TCC GTG ACC AAA CAA CTT AAC GTC ATC AAA CGG TAC CTG CAT GAA GCC AGC GAA ATC GTT CAC GCC GGG GAC CCG GAT CGC GAA GGG CAA CTG CTG GTG GAT GAA GTG CTG GAC TAT CTA CAA CTG GCA CCG GAA AAG CGC CAG CAG GTG CAG CGT TGC TTG ATA AAC GAC CTG AAC CCG CAG GCG GTT GAG CGG GCG ATC GAC CGT CTT CGT TCC AAC AGT GAG TTT GTA CCG CTG TGC GTT TCT GCG CTG GCG CGA GCG CGT GCC GAC TGG CTG TAC GGC ATC AAT ATG ACC CGT GCG TAT ACC ATT CTC GGT CGC AAT GCC GGT TAT CAG GGC GTG CTT TCC GTG GGA CGC GTG CAG ACG CCC GTG CTT GGG CTG GTG GTG CGC CGC GAT GAA GAG ATT GAA AAC TTC GTG GCG AAA GAC TTC TTT GAA GTC AAA GCA CAT ATC GTG ACA CCT GCC GAT GAG CGG TTT ACC GCT ATC TGG CAA CCG AGC GAA GCG TGT GAA CCG TAC CAG GAT GAA GAA GGG CGC TTG TTA CAT CGT CCA CTG GCG GAG CAT GTG GTT AAC CGC ATT AGT GGT CAA CCG GCT ATT GTC ACC AGC TAT AAC GAT AAA CGG GAA TCA GAA TCC GCG CCG CTG CCG TTT TCG CTT TCG GCG TTG CAG ATT GAA GCG GCA AAA CGC TTT GGT CTG AGC GCG CAG AAC GTG CTT GAT ATC TGC CAG AAG CTG TAC GAA ACG CAC AAG CTA ATC ACT TAT CCG CGT TCC GAT TGT CGC TAT TTG CCA GAA GAA CAT TTT GCC GGA CGC CAC GCG GTG ATG AAT GCC ATC AGC GTT CAT GCA CCA GAT CTG TTG CCG CAG CCA GTG GTA GAT CCA GAT ATA CGC AAC CGC TGT TGG GAT GAC AAA AAG GTC GAT GCG CAC CAC GCC ATC ATT CCG ACC GCA CGG AGT TCT GCG ATC AAC CTG ACG GAG AAC GAA GCG AAG GTC TAT AAC CTG ATT TCC CGT CAG TAT CTG ATG CAG TTC TGC CCG GAT GCG GTG TTC CGC AAG TGT GTT ATC GAA CTG GAC ATT GCC AAA GGC AAA TTT GTC GCT AAA GCG CGT TTT CTT GCT GAA GCA GGC TGG CGC ACG CTG TTA GGC AGC AAA GAG CGC GAT GAA GAA AAC GAC GGT ACG CCA TTG CCT GTG GTG GCG AAA GGC GAT GAG TTG CTG TGT GAA AAA GGT GAA GTG GTA GAG CGG CAA ACC CAG CCG CCG CGC CAT TTT ACC GAT GCA ACA CTG CTT TCG GCG ATG ACC GGG ATC GCG CGC TTT GTG CAG GAC AAA GAT CTG AAA AAG ATC CTT CGT GCG ACC GAT GGT CTG GGG ACA GAA GCA ACG CGT GCC GGG ATT ATT GAA CTG TTG TTC AAG CGT GGT TTC CTC ATC AAA AAA GGG CGC TAT ATC CAC TCC ACC GAC GCC GGA AAA GCG TTA TTC CAT TCG CTG CCA GAA ATG GCT ACG CGA CCG GAC ATG ACC GCG CAC TGG GAA TCG GTG CTG ACG CAA ATC AGC GAA AAG CAG TGT CGC TAT CAG GAC TTT ATG CAG CCG CTG GTG GGG ACG CTA TAT CAG CTT ATT GAT CAA GCC AAA CGT ACT CCG GTG CGG CAG TTT CGC GGC ATT GTG GCT CCG GGC AGT GGT GGC AGT GCT GAT AAG AAA AAG GCT GCA CCG CGT AAA CGT AGT GCG AAA AAA AGT CCG CCA GCA GAT GAA GCC GGA AGC GGG GCG 


CODONML (in paml 3.14, January 2004)    H:\users\mt269\runpaml\NEWdna80\b1763.phy   Model: One dN/dS ratio 
Codon frequencies: F3x4
Site-class models:  PositiveSelection

ns = 6  	ls = 651
# site patterns = 168
    8    7    8   13   14   11   30   24   17    3   26   26   21    5   23
    8    1    9    8   16   10    4    8    5   21   23    1    8    5    9
    5   13    4    6    9    4    9    8    3    1    2    2    5    1    2
    1    1    8    6    2    1    7    1    2    1    1    6    1    8    1
    2   11    1    2    1    1    1    1    2    2    1    1    3    1   11
    1    2    1    1    1    1    1    2    6    3    2    1    1    1    4
    1    1    1    1    2    1    6    1    1    1    2    2    1    2    1
    1    1    1    2    1    1    1    1    1    1    1    1    1    2    1
    1    1    1    1    1    1    1    1    1    1    1    1    1    1    1
    1    1    1    1    1    1    1    1    1    1    1    1    1    1    1
    1    1    1    1    1    1    1    1    1    1    1    1    1    1    1
    1    1    1

K12                                  ATG CGG TTG TTT ATT GCC GAA AAA CCG AGT CTG GCG CGC GCT GAT GTC CCC CAC GGC ATC GAG TGC GGT AAT CAG GTG ACC TGG TGT CTT CCA GAC TAC AGC TAT CCG AAG CAA TTA CCC CGA CCC TCC ACC AAC CGG TTC CAT GTT GGG CGT GGG TTG TAT CTG CTG GCA GTA CGT TGC ATA AAC GAC CGT AGT GTA CCG CTG TCT GCG CGA CGT GCC ATC ACC CTC GGT GTA GGA ACG GTG CTT GAT TTC ACA CCT GCC TCA CCT TCG TCA GCA CGT TTT AGT AAA ACG CTA ACT TCT TGT GGA CCG GTA ATT GCC CAG TAT CTG CAA GCG GGC CCA CTG GAG GAT ATC CTC GAG GCA ACG TTG CGT TTC CTG ACC CTA CCG GCG ACG CTA CTT CAA AAA CGT ACG GTG CGG CAG CGC GGC GCT GGC AGT GGT GGC AGT GCT AAG AAG GCT GCA CCG CGT CGT AGT GCG AAA AGT CCG CCA GCA GAA GTC GGA AGC GGG GCG 
S2457T                               ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ..T ... ... ... ... ... ... ... ... ... ... ... ... ..A ... ... ... ... ... ..C ... ... ... ... ... ... ... ... ... ... ... ..G ... ... ... ... ... ... ... ..G ..A T.. ... ... ... ... ... ... ... ... ... ... ... ..A ... ..C ... ... ... ... ... ... ..G ... ..G ... ..C ..C ..C ..G ... ... ... ..C ... ... ... ... ..C ... ..A ..C ... ..G ..C ... ... T.. ... ..C G.. ..T ..A ... ..C C.. ... ..T ... ... T.. ..A ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... .CT ... ... ... ... 
Shig4337                             ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ..T ... ... ... ... ... ... ... ... ... ... ... ... ..A ... ... ... ... ... ..C ... ... ... ... ... ... ... ... ... ... ... ..G ... ... ... ... ... ... ... ..G ..A T.. ... ... ... ... ... ... ... ... ... ... ..G ..A ... ..C ... ... ... ... ... ... ..G ... ..G ... ..C ..C ..C ..G ... ... ... ..C ... ... ... ... ..C ... ..A ..C ... ..G ..C ... ... T.. ... ..C G.. ..T ..A ... ..C C.. ... ..T ... ... T.. ..A ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... .C. ... ... ... ... 
CFT073                               ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ..T ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ..A ... ... ... ... ... ... ... ..T ..T .AC ... ... ... ..A ..C ... C.. ..C ... ..A ... ... ... ..T ... ... ..T ..C ..C ... ... ... ... ..A ..G ..G ..T ..T ... ... ..C ..G ... ... ..A ..C ..C ... ... ... ..A ... ... ... ..G ..T ... ... ..C ..G ... ... ... ..C ..C ... ... ... ... ... ... ... T.. ..G ..C ... ..G ... ..A ..C ... ..T ..A ..G ..T C.. ..A ... ... ... ... ..A ... ..A T.G T.G ..G CGT A.C ..T ..C A.A .G. AAA ..A .TA A.G .AC ..A --- --- --- G.. ..T AAA .AC GT. AAA A.G GTC AAA .CT GCG .A. AA. AAG .CT ACA .TT .AG C.T .AC 
O157                                 ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... .A. ... ... ... ..C ... C.. ... ..A ... ... ..G ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ..G ... ... ... ... ... ... ... ... ... ... ..G ... ..G ... ..C ... ..C ..G ... ... ... ..C ... ... ..A ... ... T.. ... ... ... ..G ... ..T ... T.. ... ..C ... ..T ..A ... ... ... ... ... ..C .T. T.. ..A ..T ... ... ... ... ... ... ..T ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... .C. ... ... ... ... 
EDL933                               ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... .A. ... ... ... ..C ... C.. ... ..A ... ... ..G ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ..G ... ... ... ... ... ... ... ... ... ... ..G ... ..G ... ..C ... ..C ..G ... ... ... ..C ... ... ..A ... ... T.. ... ... ... ..G ... ..T ... T.. ... ..C ... ..T ..A ... ... ... ... ... ..C .T. T.. ..A ..T ... ... ... ... ... ... ..T ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... .C. ... ... ... ... 



Codon usage in sequences
--------------------------------------------------------------------------------------------------------------
Phe TTT 14 14 14 14 14 14 | Ser TCT  3  2  2  2  2  2 | Tyr TAT 12 11 11 10 12 12 | Cys TGT  7  7  7  6  7  7
    TTC  8  8  8  8  7  7 |     TCC  5  6  6  6  7  7 |     TAC  4  5  5  6  5  5 |     TGC  5  5  5  6  5  5
Leu TTA  3  4  4  3  4  4 |     TCA  2  1  1  1  1  1 | *** TAA  0  0  0  0  0  0 | *** TGA  0  0  0  0  0  0
    TTG 10 11 11 12 10 10 |     TCG  4  5  5  5  5  5 |     TAG  0  0  0  0  0  0 | Trp TGG  8  8  8  8  8  8
--------------------------------------------------------------------------------------------------------------
Leu CTT 11 11 11 10 12 12 | Pro CCT  3  2  2  4  2  2 | His CAT  8  8  8  8  8  8 | Arg CGT 17 16 16 11 15 15
    CTC  2  2  2  2  2  2 |     CCC  4  3  3  3  4  4 |     CAC  9  9  9 10  9  9 |     CGC 22 24 24 24 24 24
    CTA  3  2  2  3  3  3 |     CCA  7 10 10 10  9  9 | Gln CAA 10 10 10  8  9  9 |     CGA  3  3  3  3  3  3
    CTG 33 32 32 32 31 31 |     CCG 26 25 25 20 25 25 |     CAG 23 23 23 25 24 24 |     CGG  9  8  8 10  9  9
--------------------------------------------------------------------------------------------------------------
Ile ATT 15 14 14 16 15 15 | Thr ACT  1  2  2  5  2  2 | Asn AAT  5  5  5  8  5  5 | Ser AGT 10  8  8  3  8  8
    ATC 18 18 18 17 19 19 |     ACC 14 14 14 13 13 13 |     AAC 13 13 13 12 13 13 |     AGC  7  9  9 10  9  9
    ATA  2  2  2  2  2  2 |     ACA  3  4  4  5  3  3 | Lys AAA 27 26 26 29 26 26 | Arg AGA  0  0  0  1  0  0
Met ATG  8  8  8  8  8  8 |     ACG 10  8  8  7  9  9 |     AAG 11 12 12 12 12 12 |     AGG  0  0  0  2  0  0
--------------------------------------------------------------------------------------------------------------
Val GTT  6  6  6  7  6  6 | Ala GCT  8  9  8 10  9  9 | Asp GAT 26 25 25 24 25 25 | Gly GGT 11 11 11  8 12 12
    GTC  9  9  9 10  8  8 |     GCC 16 17 18 13 16 16 |     GAC 14 15 15 18 15 15 |     GGC 12 12 12 11 11 11
    GTA  5  3  3  6  3  3 |     GCA 10 10 10  9 10 10 | Glu GAA 31 33 33 33 33 33 |     GGA  4  4  3  7  4  4
    GTG 25 27 27 25 27 27 |     GCG 32 31 31 29 31 31 |     GAG 13 11 11 11 11 11 |     GGG 10 10 11  7 10 10
--------------------------------------------------------------------------------------------------------------

Codon position x base (3x4) table for each sequence.

#1: K12            
position  1:    T:0.13057    C:0.29186    A:0.22120    G:0.35637
position  2:    T:0.26421    C:0.22734    A:0.31644    G:0.19201
position  3:    T:0.24117    C:0.24885    A:0.16897    G:0.34101

#2: S2457T         
position  1:    T:0.13364    C:0.28879    A:0.21966    G:0.35791
position  2:    T:0.26267    C:0.22888    A:0.31644    G:0.19201
position  3:    T:0.23195    C:0.25960    A:0.17204    G:0.33641

#3: Shig4337       
position  1:    T:0.13364    C:0.28879    A:0.21966    G:0.35791
position  2:    T:0.26267    C:0.22888    A:0.31644    G:0.19201
position  3:    T:0.23041    C:0.26114    A:0.17051    G:0.33794

#4: CFT073         
position  1:    T:0.13426    C:0.28241    A:0.23148    G:0.35185
position  2:    T:0.27006    C:0.21914    A:0.33025    G:0.18056
position  3:    T:0.22531    C:0.26080    A:0.18519    G:0.32870

#5: O157           
position  1:    T:0.13364    C:0.29032    A:0.22120    G:0.35484
position  2:    T:0.26267    C:0.22734    A:0.31797    G:0.19201
position  3:    T:0.23656    C:0.25653    A:0.16897    G:0.33794

#6: EDL933         
position  1:    T:0.13364    C:0.29032    A:0.22120    G:0.35484
position  2:    T:0.26267    C:0.22734    A:0.31797    G:0.19201
position  3:    T:0.23656    C:0.25653    A:0.16897    G:0.33794

Sums of codon usage counts
------------------------------------------------------------------------------
Phe F TTT      84 | Ser S TCT      13 | Tyr Y TAT      68 | Cys C TGT      41
      TTC      46 |       TCC      37 |       TAC      30 |       TGC      31
Leu L TTA      22 |       TCA       7 | *** * TAA       0 | *** * TGA       0
      TTG      64 |       TCG      29 |       TAG       0 | Trp W TGG      48
------------------------------------------------------------------------------
Leu L CTT      67 | Pro P CCT      15 | His H CAT      48 | Arg R CGT      90
      CTC      12 |       CCC      21 |       CAC      55 |       CGC     142
      CTA      16 |       CCA      55 | Gln Q CAA      56 |       CGA      18
      CTG     191 |       CCG     146 |       CAG     142 |       CGG      53
------------------------------------------------------------------------------
Ile I ATT      89 | Thr T ACT      14 | Asn N AAT      33 | Ser S AGT      45
      ATC     109 |       ACC      81 |       AAC      77 |       AGC      53
      ATA      12 |       ACA      22 | Lys K AAA     160 | Arg R AGA       1
Met M ATG      48 |       ACG      51 |       AAG      71 |       AGG       2
------------------------------------------------------------------------------
Val V GTT      37 | Ala A GCT      53 | Asp D GAT     150 | Gly G GGT      65
      GTC      53 |       GCC      96 |       GAC      92 |       GGC      69
      GTA      23 |       GCA      59 | Glu E GAA     196 |       GGA      26
      GTG     158 |       GCG     185 |       GAG      68 |       GGG      58
------------------------------------------------------------------------------

(Ambiguity data are not used in the counts.)


Codon position x base (3x4) table, overall

position  1:    T:0.13323    C:0.28875    A:0.22239    G:0.35562
position  2:    T:0.26416    C:0.22649    A:0.31924    G:0.19011
position  3:    T:0.23367    C:0.25724    A:0.17243    G:0.33666

Codon frequencies under model, for use in evolver:
  0.00844329  0.00929502  0.00623063  0.01216500
  0.00723944  0.00796974  0.00534226  0.01043051
  0.01020401  0.01123336  0.00000000  0.00000000
  0.00607654  0.00668953  0.00000000  0.00875502
  0.01829920  0.02014517  0.01350368  0.02636529
  0.01569010  0.01727287  0.01157833  0.02260613
  0.02211523  0.02434615  0.01631968  0.03186339
  0.01316974  0.01449827  0.00971846  0.01897483
  0.01409379  0.01551553  0.01040035  0.02030619
  0.01208430  0.01330333  0.00891747  0.01741093
  0.01703285  0.01875107  0.01256919  0.02454075
  0.01014316  0.01116637  0.00748503  0.01461415
  0.02253708  0.02481055  0.01663098  0.03247118
  0.01932374  0.02127307  0.01425973  0.02784144
  0.02723686  0.02998443  0.02009913  0.03924258
  0.01621970  0.01785590  0.01196914  0.02336917



Nei & Gojobori 1986. dN/dS (dN, dS)
(Pairwise deletion)
(Note: This matrix is not used in later m.l. analysis.
Use runmode = -2 for ML pairwise comparison.)

K12                 
S2457T               0.0188 (0.0014 0.0721)
Shig4337             0.0188 (0.0014 0.0721) 0.0000 (0.0000 0.0042)
CFT073               0.1567 (0.0322 0.2058) 0.1516 (0.0319 0.2103) 0.1496 (0.0319 0.2131)
O157                 0.0504 (0.0027 0.0540) 0.0483 (0.0027 0.0563) 0.0483 (0.0027 0.0563) 0.1750 (0.0337 0.1924)
EDL933               0.0504 (0.0027 0.0540) 0.0483 (0.0027 0.0563) 0.0483 (0.0027 0.0563) 0.1750 (0.0337 0.1924)-1.0000 (0.0000 0.0000)


TREE #  1:  ((1, (2, 3)), (4, (5, 6)));   MP score: -1
This is a rooted tree.  Please check!
check convergence..
lnL(ntime: 10  np: 15):  -3415.383083     +0.000000
   7..8     8..1     8..9     9..2     9..3     7..10   10..4    10..11   11..5    11..6  
  0.00500  0.02736  0.02794  0.00156  0.00159  0.00078  0.24578  0.01414  0.00000  0.00000  2.86614  0.94519  0.00000  0.00526  4.34443
Note: Branch length is defined as number of nucleotide substitutions per codon (not per neucleotide site).

tree length =   0.32414

((1: 0.027356, (2: 0.001564, 3: 0.001585): 0.027936): 0.004998, (4: 0.245779, (5: 0.000004, 6: 0.000004): 0.014135): 0.000780);

((K12: 0.027356, (S2457T: 0.001564, Shig4337: 0.001585): 0.027936): 0.004998, (CFT073: 0.245779, (O157: 0.000004, EDL933: 0.000004): 0.014135): 0.000780);

Detailed output identifying parameters

kappa (ts/tv) =  2.86614


dN/dS for site classes (K=3)

p:   0.94519  0.00000  0.05481
w:   0.00526  1.00000  4.34443

dN & dS for each branch

 branch           t        S        N    dN/dS       dN       dS   S*dS   N*dN

   7..8       0.005    552.5   1400.5   0.2431   0.0009   0.0036    2.0    1.2
   8..1       0.027    552.5   1400.5   0.2431   0.0048   0.0199   11.0    6.8
   8..9       0.028    552.5   1400.5   0.2431   0.0050   0.0204   11.3    6.9
   9..2       0.002    552.5   1400.5   0.2431   0.0003   0.0011    0.6    0.4
   9..3       0.002    552.5   1400.5   0.2431   0.0003   0.0012    0.6    0.4
   7..10      0.001    552.5   1400.5   0.2431   0.0001   0.0006    0.3    0.2
  10..4       0.246    552.5   1400.5   0.2431   0.0436   0.1792   99.0   61.0
  10..11      0.014    552.5   1400.5   0.2431   0.0025   0.0103    5.7    3.5
  11..5       0.000    552.5   1400.5   0.2431   0.0000   0.0000    0.0    0.0
  11..6       0.000    552.5   1400.5   0.2431   0.0000   0.0000    0.0    0.0


Positively selected sites (*: P>95%; **: P>99%)

            Pr(w>1)     post mean +- SE for w

    90 R      0.982*        4.268
    91 F      0.897         3.896
   407 A      0.902         3.919
   515 I      0.869         3.776
   542 T      0.907         3.939
   607 K      1.000**       4.343
   608 R      0.926         4.025
   613 Q      0.848         3.686
   615 R      1.000**       4.343
   619 A      0.909         3.951
   621 G      0.956*        4.156
   622 S      0.893         3.878
   628 K      0.764         3.319
   630 K      0.810         3.519
   631 A      1.000**       4.344
   632 A      0.983*        4.271
   633 P      1.000**       4.344
   634 R      1.000**       4.343
   637 S      1.000**       4.344
   638 A      1.000**       4.344
   640 K      0.990*        4.301
   641 S      1.000**       4.344
   642 P      0.898         3.904
   643 P      1.000**       4.344
   644 A      1.000**       4.344
   646 E      0.988*        4.291
   647 V      1.000**       4.344
   648 G      0.956*        4.154
   649 S      1.000**       4.343
   650 G      0.915         3.977
   651 A      0.981*        4.263


Bayes Empirical Bayes (BEB) analysis
Positively selected sites (*: P>95%; **: P>99%)

            Pr(w>1)     post mean +- SE for w

    90 R      0.571         4.058 +- 3.265
   607 K      0.968*        6.590 +- 1.882
   615 R      0.966*        6.583 +- 1.889
   631 A      0.960*        6.551 +- 1.927
   632 A      0.667         4.698 +- 3.232
   633 P      0.784         5.479 +- 2.779
   634 R      0.969*        6.596 +- 1.873
   637 S      0.881         6.085 +- 2.414
   638 A      0.835         5.802 +- 2.617
   640 K      0.744         5.197 +- 3.039
   641 S      0.954*        6.517 +- 1.975
   643 P      0.924         6.346 +- 2.180
   644 A      0.875         6.051 +- 2.449
   646 E      0.686         4.816 +- 3.159
   647 V      0.867         6.011 +- 2.489
   648 G      0.515         3.700 +- 3.424
   649 S      0.749         5.258 +- 2.873
   651 A      0.567         4.039 +- 3.276



The grid (see ternary graph for p0-p1)

w0:   0.050  0.150  0.250  0.350  0.450  0.550  0.650  0.750  0.850  0.950
w2:   1.500  2.500  3.500  4.500  5.500  6.500  7.500  8.500  9.500 10.500


Posterior on the grid

w0:   1.000  0.000  0.000  0.000  0.000  0.000  0.000  0.000  0.000  0.000
w2:   0.000  0.001  0.022  0.105  0.212  0.245  0.196  0.123  0.065  0.031

Posterior for p0-p1 (see the ternary graph)

 0.000
 0.000 0.000 0.000
 0.000 0.000 0.000 0.000 0.000
 0.000 0.000 0.000 0.000 0.000 0.000 0.000
 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000
 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000
 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000
 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000
 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000
 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 1.000

sum of density on p0-p1 =   1.000000
