
seed used = 141369837

K12                                  ATG AAT AGA ATC TAT CGC GTG ATA TGG AAT TGC ACT CTA CAG GTA TTT CAG GCC TGC TCG GAA TTA ACT CGC AGG GCA GGT AAA ACA TCG ACG --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- GTT AAT TTG CGT AAA TCC TCT GGA CTG ACA ACG AAA TTC AGT AGA TTG ACG CTG GGT GTT TTG CTG GCA CTA AGC GGT --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- TCA GCG TCT GGT GCA AGT CTG GAA GTT GAT AAT GAT CAG ATT ACC AAT ATT GAT ACT GAT GTT GCT TAT GAT GCC TAC CTG GTT GGC TGG TAT GGC ACT GGA GTG CTT AAT ATT TTG GCT GGC GGT AAT GCC TCC TTA ACC --- --- --- --- --- --- --- --- --- ACT ATT ACT ACC AGC GTC ATT GGC GCT AAT GAG GAC TCA GAG GGC ACC GTT AAT GTT TTG GGT GGC ACC TGG CGA TTG TAT GAT AGC --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- GGA AAT AAT GCA AGG CCT TTA AAT GTG GGT CAA TCC GGA ACG GGG ACG CTG AAT --- --- --- --- --- --- --- --- --- --- --- --- ATT AAA CAG AAG GGT CAC GTC GAT GGA GGC TAT TTA AGA TTA GGT TCT TCG ACA GGA GGC GTC GGG ACG GTC AAT GTT GAG GGA GAG GAC TCT GTT CTG ACG ACC GAA --- --- --- --- --- --- --- --- --- --- --- --- TTA TTC GAA ATA GGT AGC TAT GGC ACA GGT TCA TTA AAT ATT ACG GAT AAG GGT TAC GTC ACG AGT TCA ATC GTC GCC ATT TTA GGC TAT CAG GCG GGC AGT AAT GGC CAG GTT GTC GTT GAA AAG GGT GGC GAG TGG CTA ATA AAA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- AAT AAT GAT TCC TCA ATT GAA TTT CAA ATT GGT AAT CAA GGA ACT GGG GAG GCG ACT ATT CGC GAG GGG GGG TTG GTT ACG GCT GAA AAT ACG --- --- --- --- --- --- --- ATT ATC GGT GGC AAT GCC ACC GGT ATC GGA ACC CTG AAT GTG CAG GAT CAA GAC TCT GTC ATC ACG GTA CGC AGA CTC TAT AAT GGA TAT TTC GGT AAT GGC ACA GTC AAT ATT TCC AAT AAT GGA CTG ATT AAT AAC AAA GAA TAT TCA TTG GTG GGC GTT CAG GAC GGT TCC CAC GGT GTC GTC AAC GTG ACC GAT AAA GGG CAT TGG AAT TTC CTC GGA ACG GGC GAA GCT --- --- --- --- --- TTC CGC TAT ATC TAT ATC GGT GAT GCT GGC GAC GGT GAA CTT AAT GTC TCG AGT GAA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- GGC AAA GTA GAT TCG GGA ATT ATC ACT GCG GGG ATG AAA GAA ACA GGC ACA GGC AAC ATT ACT GTT AAG GAT AAG AAC TCC --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- GTT ATC ACT AAT CTC GGA ACT AAT CTT GGT TAT GAC GGC CAC GGC GAA ATG AAT ATC AGT AAT CAG GGG CTT GTT GTC AGC AAC GGA GGA AGT TCA CTC GGT --- --- --- --- --- --- --- --- --- --- --- --- TAT GGA GAA ACC GGC GTC GGG AAT GTC AGC ATC ACC ACG GGG GGA ATG TGG GAG GTC AAT AAG AAT GTC TAT ACC ACC ATT GGT GTT GCG GGC GTC GGA AAC CTC AAT ATT AGC GAT GGC GGT AAG TTC GTA TCG CAA AAT ATT ACT TTT TTG GGC GAT AAA GCA AGC GGT ATC GGC ACA CTG AAC CTG ATG GAT GCG ACA TCA TCG TTC GAT ACT GTG GGT ATC AAT GTC GGT --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- AAT TTT GGT AGC GGT ATC GTA AAT GTC AGT AAT GGT GCC ACC CTT AAT TCA ACG GGC TAT GGA TTT ATC GGA GGA AAT GCC TCC GGT AAG GGG ATA GTT AAT --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ATT TCA ACG GAC AGT CTC TGG AAT TTA AAG ACA TCA TCT ACT AAC GCA CAA TTG CTA CAG GTC GGT GTA TTA GGC ACG GGT GAA CTG AAT ATT ACC ACC GGA GGT ATA GTT AAA GCG CGT GAT ACA CAG ATA GCT CTC AAT GAC AAA AGT AAG GGC GAC GTG AGG GTG GAT GGG CAG AAC TCT CTT --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- CTT GAA ACA TTC AAT ATG TAC GTA GGG ACA TCT GGT ACG GGT ACG TTA ACC CTG ACG AAT AAC GGT ACG CTG AAT GTC GAA GGT GGA GAA GTT TAC TTA GGT GTT TTT GAG CCT GCT GTA GGA ACG CTA AAC ATT GGT GCT GCT CAC GGT GAG GCG GCG --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- GCA GAT GCC GGA TTT ATC ACC AAT GCG ACG AAA GTG GAG TTT GGT CTT GGC GAA GGC GTT TTT GTC TTT AAT CAT ACC AAT AAC AGT GAT GCC GGC TAC CAG GTC GAT ATG CTG ATT ACA GGT GAC GAT AAA GAC GGA AAA GTG ATC CAT GAT GCA GGC CAT ACG GTG TTC AAT GCA GGG --- --- --- --- --- --- --- --- --- AAT ACT TAT AGC GGT AAA ACG CTG GTC AAT GAC GGC CTC CTG ACC ATT GCG TCT CAT ACG GCA GAT GGG GTA ACG GGC ATG GGG TCG AGT GAA GTA ACC ATT GCA AAC CCC GGT ACG CTC GAC ATT CTC GCA TCA ACG AAC AGT --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- GCA GGA GAT TAC ACG CTG ACC AAT GCG CTC AAA GGC GAT GGC TTG ATG CGA GTG CAG CTG TCA TCC TCC GAC AAG ATG TTT GGC TTT ACC CAT GCA ACA GGG ACT GAA TTC GCC GGT GTT GCC CAA CTG AAA GAC AGT ACC TTC ACT CTG GAA CGC GAC AAC ACC GCT GCG CTT ACT CAC GCG ATG TTG CAG TCT GAC AGT GAA AAT ACC ACA TCG GTA AAA GTT GGA GAG CAA TCC ATT GGT GGA CTG GCC ATG AAT GGA GGT ACC ATC ATT TTC GAT ACG GAT ATT CCT GCT GCG ACG CTC GCG GAG GGA TAT ATC AGC GTC GAT ACG CTG GTT GTC GGC GCG GGT GAC TAC ACC TGG AAA GGC CGT AAC TAT CAG GTA AAC GGG ACG GGC GAC GTG CTT ATC GAC GTG CCT AAA CCG TGG AAT GAT CCC ATG GCG AAT AAC CCT CTG ACG ACG CTC AAT TTG CTG GAA CAC GAC GAT AGC CAT GTC GGC GTT CAA CTG GTG AAG GCG CAA ACG GTT ATT GGG TCG GGT GGC TCA TTA ACG TTA CGT GAT TTA CAG GGC GAC GAG GTG GAA GCG GAC AAA ACG TTA CAC ATT GCG CAA AAC GGA ACG GTG GTC GCC GAG GGT GAT TAT GGA TTC CGC CTC ACG ACC GCA CCA --- --- --- --- GGT AAT GGT TTG TAC GTT AAC TAT GGG CTG AAA GCG CTG AAC ATC CAT --- --- GGT GGG CAA AAG CTG ACG TTA GCC GAA CAT GGC GGA GCC TAT GGC GCA ACG GCC GAT ATG TCG GCA AAA ATC GGT GGT GAA GGG GAT CTG GCA ATC AAT ACG GTG --- CGA CAG GTT TCG CTT TCC AAC GGT CAG AAC GAC TAT CAG GGG GCA ACC TAC GTT CAG ATG GGG ACA TTA CGT ACC GAT GCG GAT GGT GCA CTT GGC AAC ACC CGG GAA CTG AAC ATC AGC AAC GCG GCC ATC GTC GAT CTT AAT GGA TCG ACG CAG ACG GTA GAG ACA TTC ACC GGG CAG ATG GGT TCG ACT GTT TTG TTC AAA GAG GGG GCG CTG ACG GTA AAT AAA GGT GGG --- --- --- --- --- --- --- --- --- --- --- ATC AGT CAG GGT GAA CTG ACA GGT GGC GGA AAC CTG AAT GTT ACA GGG GGA ACG CTG GCT ATC GAG GGG CTT AAT GCA CGC TAC AAT GCG TTA ACC AGC ATT AGC CCA AAT GCG GAA GTC AGC CTC GAT AAT ACT CAG GGG TTA GGC --- AGA GGA AAT ATT GCC AAT GAC GGT CTG --- --- --- TTA ACG CTA AAA AAC GTG ACT GGC --- --- --- --- --- GAA CTG CGT AAT AGC ATA AGC GGG AAG GGT ATC GTG AGC GCA ACC GCC AGG ACA GAT GTA GAG TTG GAT GGC GAT AAT AGC CGC TTT GTG GGG CAA TTC AAC ATT GAT ACA GGC AGC GCG CTC AGC GTC AAC GAG CAG AAA AAC CTG GGT GAT GCT TCC GTT ATC AAT AAT GGC CTG CTC ACC ATC TCC ACT GAG CGT AGC TGG GCG ATG ACG CAC AGT ATC AGC GGT AGC GGT GAT GTG ACA AAA CTG GGT ACC GGG ATC CTG ACT CTT AAC AAC GAT TCC GCG GCG TAT CAG GGT ACG ACG GAT ATC GTG GGG GGG GAA ATT GCT TTC GGT TCC GAC TCT GCC ATT AAT ATG GCA --- --- --- --- --- --- AGT CAA CAC ATT AAT ATC CAT AAC AGC GGT GTG ATG TCG GGA AAT GTC ACC ACT GCA GGT GAT ATG AAC --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- GTT ATG CCT GGG GGG --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- GGC ACT GCG TGT CGC 
O157                                 ATG AAT AGA ATC TAT CGC GTG ATA TGG AAT TGC ACT CTA CAG GTA TTT CAG GCC TGC TCG GAA TTA ACT CGC AGG GTA GGT AAA ACA TCA ACG --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- GTT AAT TTG CGA AAG TCC TCT GGA CTG ACA ACG AAA TTC AGT AGA TTG ACG CTG GGT GTT TTG CTG GCA CTA AGC GGT --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- TCA GTG TCT GGT GCG AGT CTG GAA GTT GAT AAT GGT CAG ATT ACC AAT ATT GAT ACT GAT GTT GCT TAT GAT GCC TAC CTG GTT GGC TGG TAT GGC ACT GGA GTG CTT AAT ATT TTG GCT GGC GGT AAT GCC TCC TTA ACC --- --- --- --- --- --- --- --- --- ACT ATT ACT ACC AGC GTC ATT GGC GGT AAT GAG GAT TCG GAG GGT ACC GTT AAT GTT TTG GGT GGC ACC TGG CGA TTG TAT GAT AGC --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- GGA AAT AAT GCA AGG CCT TTA AAT GTG GGT CAA TCC GGA ACG GGG ACG CTG AAT --- --- --- --- --- --- --- --- --- --- --- --- ATT AAA CAG AAG GGT CAC GTC GAT GGA GGC TAT TTA AGA TTA GGT ACT CAA GCT GCA GGC GTC GGG ACG GTT AAT GTT GAG GGA GAG GAC TCG GTT TTG ACG ACC GAA --- --- --- --- --- --- --- --- --- --- --- --- TTA TTC GAA ATA GGG AGT TAC GGT ACG GGC TCA TTA AAT ATT ACG GAT AAG GGT TAC GTC ACG AGT TCA ATA GTC GCC ATT TTA GGA TAT CAA GCG AAC AGT AAT GGT AAG GTT GTC GTT GAA AAG GGT GGC GAG TGG CTA ATA AAA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- AAT AAT GAT TCC TCA ATT GAA TTT CAA ATT GGT AAT CAA GGA ACT GGG GAG GCG ACT ATT CGC GAG GGT GGG CTG ATT ACG GCT GAA AAT ACG --- --- --- --- --- --- --- ATT ATC GGT GGC AAT GCC ACC GGT GTC GGA ACC CTG AAT GTG CAG GAT CAA GAC TCT GTC ATC ACG GTA CGC AGA CTC TAT AAT GGA TAT TTC GGT AAT GGC GCA GTC AAT ATT TCC AAT AAT GGA CTA ATT AAT AAC AAA GAA TAT TCA TTG GTG GGC GTT CAG GAC GGT TCC CAC GGT GTC GTC AAC GTG ACC GAT AAA GGG CAT TGG AAT TTC CTC GGA ACG GGC GAA GCT --- --- --- --- --- TTC CGC TAT ATC TAT ATC GGT GAT GCT GGC GAC GGT GAA CTT AAT GTC TCG CGT GAA --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- GGT AAA GTA GAT TCG GGA ATT ATC ACT GCG GGG ATG AAA GAA ACA GGC ACA GGC AAC CTT ACT GTT AAG GAT AAG AAC TCC --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- GTT ATC ACT AAT CTC GGA ACT AAT CTT GGT TAT GAC GGC CAC GGC GAA ATG AAT ATC AGT AAT GAG GGG CTT GTT GTC AGC AAC GGA GGA AGC TCT CTC GGT --- --- --- --- --- --- --- --- --- --- --- --- TAT GGA GAA ACC GGC GTC GGG AAG GTT AGC ATC ACC ACG GGG GGG ATA TGG GAG GTC AAT AAG AAT GTC TAT ACC ACC ATT GGT GTT GCG GGC GTC GGA AAC CTC AAT ATT AGC GAT GGC GGT AAG TTC GTA TCG CAA AAT ATT ACT TTT TTG GGC GAT AAA GCA AGC GGT ATC GGC ACA CTG AAC CTG ATG GAT GCG ACA TCG TCG TTC GAT ACT GTG GGT ATC AAT GTC GGT --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- AAT TTT GGT AGC GGT ATC GTA AAT GTC AGT AAT GGT GCC ACC CTT AAT TCA ACG GGC TAT GGA TTT ATC GGA GGA AAT GCC TCC GGT AAG GGA ATA GTT AAT --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ATT TCA ACG GAT AGT CTC TGG AAT TTA AAG ACG TCT TCT ACT AAC GCC CAA TTG CTA CAG GTC GGT GTA TTA GGC ACG GGT GAA CTG AAT ATT ACC ACC GGA GGT ATA GTT AAA GCG CGT GAT ACA CAG ATA GCT CTC AAT GAC AAA AGT AAG GGC GAC GTG AGG GTG GAT GGG CAG AAC TCT CTT --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- CTT GAA ACA TTC AAT ATG TAC GTA GGG ACA TCT GGT ACG GGT ACG TTA ACC CTG ACG AAT AGC GGC ACG CTG AAT GTC GAA GGT GGA GAA GTT TAC TTA GGT GTT TTT GAA CCT GCT GTA GGA ACG CTA AAC ATT GGT GCA GCT CAC GGT GAG GCG GCG --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- GCA GAT GCC GGA TTT ATC ACC AAC GCG ACG AAA GTA GAG TTT GGC TCT GGC GAA GGT GTT TTT GTC TTT AAT CAT ACT AAT AAC AGT GAT GCC GGC TAC CAG GTC GAT ATG CTG ATT ACA GGT GAC GAT AAA GAC GGA AAA GTG ATC CAT GAT GCA GGC CAT ACG GTG TTC AAT GCA GGG --- --- --- --- --- --- --- --- --- AAT ACT TAT AGC GGT AAA ACG CTG GTC AAT GAC GGC CTC CTG ACC ATT GCG TCT CAT ACG GCA GAT GGG GTA ACG GGC ATG GGG TCG AGT GAA GTA ACC ATT GCA AGC CCC GGT ACG CTC GAC ATT CTC GCA TCA ACG AAC AGT --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- GCA GGA GAT TAC ACG CTG ACC AAT GCG CTC AAA GGC GAT GGC TTG ATG CGA GTT CAG CTG TCA TCC TCC GAC AAG ATG TTT GGC TTT ACA CAT GCA ACA GGG ACT GAA TTC GCC GGT GTT GCC CAA CTG AAA GAC AGT ACC TTC ACT CTG GAA CGC GAC AAC ACC GCT GCG CTT ACT CAC GCG ATG TTG CAG TCT GAC ATT GAA AAT ACC ACA TCG GTA AAC GTG GGA GAG CAA TCC ATT GGT GGA CTG GCC ATG AAT GGC GGT ACG CTC ATT TTC GAT ACG GAT ATT CCT GCT GCG ACG CTT GCA GAG GGA TAT ATC AGC GTC GAT ACG CTG GTT GTC GGC GCG AGT GAC TAC ACC TGG AAA GGC CGT AAC TAT CAG GTA AAC GGG ACG GGC GAC GTG CTT ATC GGC GTG CCT AAA CCG TGG AAT GAT CCT ATG GCG AAT AAC CCT CTG ACG ACG CTC AAT TTG CTG GAA CAC GAT GAT AAC CAT GTC GGC GTT CAA CTG GTG AAG GCG CAA ACG GTT ATT GGG TCG GGT GGC TCA TTA ACG TTA CGT GAT TTA CAG GGC GAC GAG GTG GAA GCG GAC AAA ACG TTA CAC ATT GCG CAA AAC GGA ACG GTG GTC GCC GAG GGT GAT TAT GGA TTC CGC CTC ACG ACC GCA CCA --- --- --- --- GGT GAT GGT TTG TAC GTT AAC TAT GGG CTG AAA GCG CTG AAC ATC CAT --- --- GGA GGG CAA AAG CTG ACG TTA GCC GAA CAT GGC GGA GCC TAT GGC GCA ACG GCC GAT ATG TCG GCA AAA ATC GGT GGT GAA GGG GAT CTG GCA ATC AAT ACG GTG --- CGA CAG GTT TCG CTT TCC AAC GGT CAG AAC GAC TAT CAG GGG GCA ACC TAC GTT CAG ATG GGG ACA TTA CGT ACC GAT GCG GAT GGC GCG CTG GGC AAC ACC CGG GAA CTG AAC ATC AGC AAC GCA GCC ATC GTC GAT CTT AAT GGA TCG ACG CAG ACG GTA GAG ACA TTC ACC GGG CAG ATG GGT TCG ACT GTT TTG TTC AAA GAA GGG TCG CTG ACG GTA AAT AAA GGT GGG --- --- --- --- --- --- --- --- --- --- --- ATC AGT CAG GGT GAA CTG ACA GGT GGC GGA AAC CTG AAT GTT ACA GGG GGA ACG CTG GCT GTC GAG GGG CTT AAT GCA CGC TAC AAT GCG TTA ACC AGC GTT AGC CCA AAT GCG GAA GTC AGC CTC GAT AAT ACG CAG GGG TTA GGC --- AGA GGA AAT ATT GCC AAT GAC GGT CTG --- --- --- TTA ACG CTA AAA AAC GTG ACT GGC --- --- --- --- --- GAA CTG CGT AAT AGC ATA AGC GGG AAG GGT ATC GTG AGC GCA ACC GCC AGG ACA GAT GTA GAG CTG GAT GGC GAT AAT AGC CGC TTT GTG GGG CAA TTC AAC ATT GAT ACA GGC AGC GCG CTC AGC GTC AAC GAG CAG AAA AAC CTG GGT GAT GCT TCC GTT ATC AAT AAT GGC CTG CTC ACC ATC TCC ACT GAG CGT AGC TGG GCG ATG ACG CAC AGT ATC AGC GGT AGC GGT GAT TTG ACA AAA CTG GGT ACC GGG ATC CTG ACT CTT AAC AAC GAT TCC TCG GCG TAT CAG GGT ACG ACG GAT ATC GTG GGG GGG GAA ATT GCT TTC GGT TCC GAC TCT GCC ATT AAT ACG GCA --- --- --- --- --- --- AGT CAA CAC ATT AAT ATC CAT AAC AGC GGT GTG ATG TCG GGA AAT GTC ACC ACT GCA GGT GAT GTG AAC --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- GTT ATG TCT GGG GGG ACA CTG CGT GTC GCT AAA ACC ACA ATC GGC GAA TCG GCG GCA ACC TGG AGA ATG GCG GCA CGG 


CODONML (in paml 3.14, January 2004)    /home/melissa/melissashare/runpaml/NEWdna80/b1510.phy   Model: One dN/dS ratio 
Codon frequencies: F3x4
Site-class models:  PositiveSelection

ns = 2  	ls = 2227
# site patterns = 154
   18   79    5   30   23    9   22    7   10    2   24    6   24   15   13
   20   13   32   21    4    1   66   27   19    1   52  886   32   14    1
    1   16    9   37   39   17   15   20   24   10    1    2   49    1   35
   35   13   10   48   13   31    1   19    3    2    5    3    5   14   35
   14    9    1    1    1    1    2   22    1    1    1    1    1    2    4
    1    1    1   27    1    1    1    2    1    2   16    1    1   33   10
    1    1    1    1    2    1    1    1    1    1    6    2    2    1    1
    1    1    1    1    1    1    1    1    1    1    1    1    1    2    1
    1    1    1    1    2    1    1    1    1    2    1    1    1    1    1
    1    2    1    1    1    1    1    2    1    1    1    1    1    1    1
    1    1    1    1

K12                                  ATG AAT AGA ATC TAT CGC GTG ATA TGG TGC ACT CTA CAG GTA TTT GCC TCG GAA TTA AGG GCA GGT AAA ACA TCG ACG --- GTT TTG CGT AAA TCC TCT GGA CTG TTC AGT GCA AGC TCA GCG GCA GAT GAT ATT ACC GCT TAC GGC CTT GTC GCT GAG GAC TCA GGC CGA CCT CAA GGG AAG CAC TCT TCG ACA GGA GTC GAC TCT CTG GGT AGC TAT ACA GGT ATC GGC CAG GCG GGC CAG GGG TTG GTT ATC CTC ACA CTG AAC CAT AGT ATT CAG AGT TCA AAT GGA ATG GGG GCA CGT AAC GAG GCT AAT GTG CTT ACC CCC GTG ACC AGT AAA GTT GGA ACC ATC CTC GCG GGT GAC CCG CCC AGC CCA AAT GGT CTT CGG GCG ATT ACT GTG ATG ATG CCT --- --- --- --- --- --- --- --- --- --- --- --- --- --- GGC ACT TGT CGC 
O157                                 ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... .T. ... ... ... ..A ... --- ... ... ..A ..G ... ... ... ... ... ... ... ... ... .T. ..G ... .G. ... ... ... ... ... ... ... .G. ... ..T ..G ..T ... ... ... ... ... ... A.. CAA G.T .C. ..T ... ..G T.. ..G ..T ..C ..G ..C ..A ..A ..A ... AA. A.. ..T C.. A.. G.. ... G.. ..A ... ... C.. C.. G.. ..C ..T ..G ..G ..A ..A ..C ... .G. ..A ..A ..C ..A TC. ..T ... ..T ..A .T. ..C ..G ..C ..G C.. ..T ..A A.. .G. ... ..T .A. ... G.. ..A ..G ... T.. G.. ..G T.. .C. G.. T.. ACA CTG CGT GTC GCT AAA ACC ATC GGC GAA TCG GCG GCA TGG A.A .TG GCA ..G 



Codon usage in sequences
--------------------------------------------------------------
Phe TTT 13 13 | Ser TCT 11 13 | Tyr TAT 24 23 | Cys TGT  1  0
    TTC 17 17 |     TCC 16 16 |     TAC 10 11 |     TGC  2  2
Leu TTA 21 21 |     TCA 14 11 | *** TAA  0  0 | *** TGA  0  0
    TTG 16 16 |     TCG 15 19 |     TAG  0  0 | Trp TGG 10 11
--------------------------------------------------------------
Leu CTT 15 15 | Pro CCT  6  6 | His CAT 10 10 | Arg CGT  7  8
    CTC 17 17 |     CCC  2  1 |     CAC  9  9 |     CGC 10  9
    CTA  6  7 |     CCA  2  2 | Gln CAA 14 16 |     CGA  3  4
    CTG 41 43 |     CCG  1  1 |     CAG 27 24 |     CGG  1  2
--------------------------------------------------------------
Ile ATT 37 37 | Thr ACT 26 26 | Asn AAT 82 79 | Ser AGT 18 17
    ATC 34 31 |     ACC 38 37 |     AAC 35 37 |     AGC 26 27
    ATA  7  9 |     ACA 23 22 | Lys AAA 29 28 | Arg AGA  5  6
Met ATG 21 19 |     ACG 52 57 |     AAG 14 17 |     AGG  4  4
--------------------------------------------------------------
Val GTT 34 36 | Ala GCT 15 15 | Asp GAT 50 53 | Gly GGT 73 74
    GTC 33 34 |     GCC 20 21 |     GAC 26 22 |     GGC 56 55
    GTA 15 17 |     GCA 24 27 | Glu GAA 32 35 |     GGA 40 40
    GTG 25 25 |     GCG 32 30 |     GAG 21 20 |     GGG 37 37
--------------------------------------------------------------

Codon position x base (3x4) table for each sequence.

#1: K12            
position  1:    T:0.12830    C:0.12906    A:0.34038    G:0.40226
position  2:    T:0.26566    C:0.22415    A:0.28906    G:0.22113
position  3:    T:0.31849    C:0.26491    A:0.17736    G:0.23925

#2: O157           
position  1:    T:0.12901    C:0.12975    A:0.33781    G:0.40343
position  2:    T:0.26622    C:0.22670    A:0.28635    G:0.22073
position  3:    T:0.31693    C:0.25802    A:0.18270    G:0.24236

Sums of codon usage counts
------------------------------------------------------------------------------
Phe F TTT      26 | Ser S TCT      24 | Tyr Y TAT      47 | Cys C TGT       1
      TTC      34 |       TCC      32 |       TAC      21 |       TGC       4
Leu L TTA      42 |       TCA      25 | *** * TAA       0 | *** * TGA       0
      TTG      32 |       TCG      34 |       TAG       0 | Trp W TGG      21
------------------------------------------------------------------------------
Leu L CTT      30 | Pro P CCT      12 | His H CAT      20 | Arg R CGT      15
      CTC      34 |       CCC       3 |       CAC      18 |       CGC      19
      CTA      13 |       CCA       4 | Gln Q CAA      30 |       CGA       7
      CTG      84 |       CCG       2 |       CAG      51 |       CGG       3
------------------------------------------------------------------------------
Ile I ATT      74 | Thr T ACT      52 | Asn N AAT     161 | Ser S AGT      35
      ATC      65 |       ACC      75 |       AAC      72 |       AGC      53
      ATA      16 |       ACA      45 | Lys K AAA      57 | Arg R AGA      11
Met M ATG      40 |       ACG     109 |       AAG      31 |       AGG       8
------------------------------------------------------------------------------
Val V GTT      70 | Ala A GCT      30 | Asp D GAT     103 | Gly G GGT     147
      GTC      67 |       GCC      41 |       GAC      48 |       GGC     111
      GTA      32 |       GCA      51 | Glu E GAA      67 |       GGA      80
      GTG      50 |       GCG      62 |       GAG      41 |       GGG      74
------------------------------------------------------------------------------

(Ambiguity data are not used in the counts.)


Codon position x base (3x4) table, overall

position  1:    T:0.12866    C:0.12941    A:0.33908    G:0.40285
position  2:    T:0.26594    C:0.22543    A:0.28770    G:0.22093
position  3:    T:0.31770    C:0.26144    A:0.18005    G:0.24081

Codon frequencies under model, for use in evolver:
  0.01110006  0.00913429  0.00629047  0.00841351
  0.00940922  0.00774289  0.00533226  0.00713190
  0.01200811  0.00988153  0.00000000  0.00000000
  0.00922135  0.00758829  0.00000000  0.00698950
  0.01116479  0.00918755  0.00632715  0.00846257
  0.00946409  0.00778804  0.00536335  0.00717349
  0.01207813  0.00993914  0.00684475  0.00915485
  0.00927512  0.00763254  0.00525627  0.00703026
  0.02925498  0.02407405  0.01657897  0.02217438
  0.02479865  0.02040692  0.01405354  0.01879662
  0.03164819  0.02604344  0.01793522  0.02398836
  0.02430350  0.01999946  0.01377294  0.01842131
  0.03475647  0.02860125  0.01969670  0.02634434
  0.02946211  0.02424450  0.01669636  0.02233138
  0.03759973  0.03094099  0.02130800  0.02849944
  0.02887385  0.02376042  0.01636299  0.02188549



Nei & Gojobori 1986. dN/dS (dN, dS)
(Pairwise deletion)
(Note: This matrix is not used in later m.l. analysis.
Use runmode = -2 for ML pairwise comparison.)

K12                 
O157                 0.2224 (0.0149 0.0671)


TREE #  1:  (1, 2);   MP score: -1
check convergence..
lnL(ntime:  2  np:  7):  -5913.561996     +0.000000
   3..1     3..2  
  0.21736  0.00000  2.59303  0.76701  0.22929  0.00000 302.88457
Note: Branch length is defined as number of nucleotide substitutions per codon (not per neucleotide site).

tree length =   0.21736

(1: 0.217356, 2: 0.000004);

(K12: 0.217356, O157: 0.000004);

Detailed output identifying parameters

kappa (ts/tv) =  2.59303


dN/dS for site classes (K=3)

p:   0.76701  0.22929  0.00370
w:   0.00000  1.00000302.88457

dN & dS for each branch

 branch           t        S        N    dN/dS       dN       dS   S*dS   N*dN

   3..1       0.217   1838.0   4843.0   1.3508   0.0780   0.0578  106.2  377.9
   3..2       0.000   1838.0   4843.0   1.3508   0.0000   0.0000    0.0    0.0


Positively selected sites (*: P>95%; **: P>99%)

            Pr(w>1)     post mean +- SE for w

   450 S      0.997**       302.102
  2226 C      0.995**       301.507


Bayes Empirical Bayes (BEB) analysis
Positively selected sites (*: P>95%; **: P>99%)

            Pr(w>1)     post mean +- SE for w

    26 A      0.572         4.519 +- 3.835
   302 A      0.533         4.227 +- 3.833
   365 A      0.556         4.401 +- 3.838
   449 S      0.574         4.537 +- 3.835
   450 S      0.951*        7.119 +- 2.482
   451 T      0.535         4.255 +- 3.843
   452 G      0.614         4.834 +- 3.812
   514 G      0.917         6.912 +- 2.695
   518 Q      0.566         4.477 +- 3.835
   605 I      0.507         4.032 +- 3.820
   631 T      0.571         4.512 +- 3.835
   697 S      0.558         4.419 +- 3.838
   762 I      0.566         4.474 +- 3.837
   806 Q      0.558         4.417 +- 3.837
  1334 L      0.936         7.030 +- 2.579
  1631 S      0.527         4.189 +- 3.834
  1654 I      0.585         4.622 +- 3.831
  1911 A      0.600         4.730 +- 3.824
  1950 I      0.507         4.032 +- 3.820
  2084 V      0.588         4.641 +- 3.829
  2099 A      0.600         4.730 +- 3.824
  2204 P      0.577         4.557 +- 3.832
  2223 G      0.849         6.475 +- 3.114
  2224 T      0.843         6.430 +- 3.135
  2226 C      0.955*        7.145 +- 2.454



The grid (see ternary graph for p0-p1)

w0:   0.050  0.150  0.250  0.350  0.450  0.550  0.650  0.750  0.850  0.950
w2:   1.500  2.500  3.500  4.500  5.500  6.500  7.500  8.500  9.500 10.500


Posterior on the grid

w0:   0.863  0.136  0.001  0.000  0.000  0.000  0.000  0.000  0.000  0.000
w2:   0.009  0.024  0.048  0.071  0.109  0.149  0.171  0.165  0.142  0.112

Posterior for p0-p1 (see the ternary graph)

 0.000
 0.000 0.000 0.000
 0.000 0.000 0.000 0.000 0.000
 0.000 0.000 0.000 0.000 0.000 0.000 0.000
 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000
 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000
 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000
 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.003
 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.003 0.189
 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.001 0.005 0.056 0.742

sum of density on p0-p1 =   1.000000
