CLUSTAL X (1.81) multiple sequence alignment sp_P13205_ANFB_RATBrainnatriur ------MDLQKVLPQMILLLLFLNLSPLGGHS------------------ sp_P16860_ANFB_HUMANBrainnatri ------MDPQTAPSRALLLLLFLHLAFLGGRS------------------ Q9PW56Bradykinin_potentiating/ ------MVLSRLAASGLLLLALLALSVDGKPVQQWAQGGWPRPGPEIPPL tr_Q8QG91Bradykinin_potentiati ------MVLSRLAASGLLLLALLALSVDGKPVQQWAQGGWPRPGPEIPPL tn_BAA12879Bradykinin_potentia ------MVLSRLAASGLLLLALLALSVDGKPVQQWAQS---WPGPNIPPL tr_Q90Y11Bradykininpotentiatin ------MFVSRLAASGLLLLALLAVSLDGKPLQQWSHR------------ tr_Q90Y12Bradykininpotentiatin ------MFVSRLAASGLLLLALLAVSLDGKPLQQWSQR------------ tr_Q9PT52BPP_CNPhomolog_Agkist ------MFVSRLAASGLLLLALMALSLDGKPVQQWSQGR--PPGPPIPRL sp_P40756_ANFD_RANCAC_typenatr ------MHFCHIVGWGLVLAVLYLR-TEAKPV------------------ sp_P23582_ANFC_HUMANC_typenatr ------MHLSQLLACALLLTLLSLRPSEAKPG------------------ tr_Q805D3C_typenatriureticpept ------MNLSYLVACGLMITLLSVR-MGAKPL------------------ tr_Q800I8C_typenatriureticpept ------MSLRAFMLC--VCLLLQSVGARPAS------------------- sp_P41319_ANFC_SQUACC_typenatr ------MSGHTSFYCGLLLLLLIQVQARPRADD----------------- tr_Q805E8B_typenatriureticpept ------MRLSSMWLC---SLLLILKLQLSSTYPIS--------------- tr_Q7T1Q2B_typenatriureticpept MSRCSSHRSSHMFFIPFWGLLFILNVQRSTSVPIS--------------- tr_Q805D7B_typenatriureticpept ------MVVSFVSIC---GLLLIFNLPLSTSFPV---------------- tr_Q7T2I6Ventricularnatriureti ------MAKLHIFLG---YIVLITTLSVSCGTPYA--------------- tr_Q9PSV2Ventricularnatriureti ------MAKSGIYLG---CFILILIQNMVAANPLF--------------- tn_BAD02837Ventricularnatriure ----MRMGKIAVGYG---FLLLLVFQLGVRASTLF--------------- tr_Q9PSV1Atrialnatriureticpept ------MRKIILTGL---LLVLLCQQAMVAAHVLS--------------- tr_Q7T2I7Atrialnatriureticpept ------MVRTAVSWG---LLLLLCQQTLVAAHVLG--------------- tr_Q805D8Atrialnatriureticpept -------MTALVLWG---LLLLLGQHTQVNSHVLG--------------- sp_P01160_ANF_HUMANAtrialnatri ------MSSFSTTTVSFLLLLAFQLLGQTRANPMY--------------- sp_P01161_ANF_RATAtrialnatriur ------MGSFSITKG-FFLFLAFWLPGHIGANPVY--------------- sp_P18909_ANF_RANCAAtrialnatri --------MGTSFVGYLTFVLLLLALTKVRGGPAY--------------- tr_Q9DGK8Atrialnatriureticfact --------MQTSFVGYFTLIFFLLSLMKAKGSPAY--------------- sp_P18908_ANF_CHICKAtrialnatri ------MDTRGSFSCGFLLLLLIQLQPSRANPIY---------------- tn_BAD02836Brainnatriureticpep ------MLGSRLTFCYGFLHLLLQTHVLVCAYPN---------------- tn_BAD02838C_typenatriureticpe ---MSISSSSSSSSSSSSCLLLISLMLLAASCQGR--------------- tr_Q8AXR2C_typenatriureticpept ------MLYPALLCAALLLIAPLGHTEGRTLYP----------------- tr_Q805D5C_typenatriureticpept ------MAASSSSFVPLVLLFLAIPVEPRPSMT----------------- tr_Q7YZU5Natriureticpeptide_Ep ------MERCTAPFFMILLLMPCWPFALANPVTLHAQN------------ tr_P79799Natriureticpeptide_Mi ------MVGLSRLRGGGLLLVLALLPLALDGKPLE--------------- sp_P13205_ANFB_RATBrainnatriur -------------------------------------------------- sp_P16860_ANFB_HUMANBrainnatri -------------------------------------------------- Q9PW56Bradykinin_potentiating/ KVQQWAQGGWPRPGPEIPPLTVQQWAQNWP-HPQIPPLTVQQWAQWGRPP tr_Q8QG91Bradykinin_potentiati KVQQWAQGGWPRPGPEIPPLTVQQWAQNWP-HPQIPPLTVQQWAQLGPPP tn_BAA12879Bradykinin_potentia KVQQWAQGGWPRPGPEIPPLTVQQWAQNWP-HPQIPPLTVQQWAQG-RAP tr_Q90Y11Bradykininpotentiatin ------------------------WP------------------------ tr_Q90Y12Bradykininpotentiatin ------------------------WP------------------------ tr_Q9PT52BPP_CNPhomolog_Agkist VVQQWSQG--LPPGPPIPRLVVQQWSQGLPPGPPIPPLVVQQWSQG-LPP sp_P40756_ANFD_RANCAC_typenatr -------------------------------------------------- sp_P23582_ANFC_HUMANC_typenatr -------------------------------------------------- tr_Q805D3C_typenatriureticpept -------------------------------------------------- tr_Q800I8C_typenatriureticpept -------------------------------------------------- sp_P41319_ANFC_SQUACC_typenatr -------------------------------------------------- tr_Q805E8B_typenatriureticpept -------------------------------------------------- tr_Q7T1Q2B_typenatriureticpept -------------------------------------------------- tr_Q805D7B_typenatriureticpept -------------------------------------------------- tr_Q7T2I6Ventricularnatriureti -------------------------------------------------- tr_Q9PSV2Ventricularnatriureti -------------------------------------------------- tn_BAD02837Ventricularnatriure -------------------------------------------------- tr_Q9PSV1Atrialnatriureticpept -------------------------------------------------- tr_Q7T2I7Atrialnatriureticpept -------------------------------------------------- tr_Q805D8Atrialnatriureticpept -------------------------------------------------- sp_P01160_ANF_HUMANAtrialnatri -------------------------------------------------- sp_P01161_ANF_RATAtrialnatriur -------------------------------------------------- sp_P18909_ANF_RANCAAtrialnatri -------------------------------------------------- tr_Q9DGK8Atrialnatriureticfact -------------------------------------------------- sp_P18908_ANF_CHICKAtrialnatri -------------------------------------------------- tn_BAD02836Brainnatriureticpep -------------------------------------------------- tn_BAD02838C_typenatriureticpe -------------------------------------------------- tr_Q8AXR2C_typenatriureticpept -------------------------------------------------- tr_Q805D5C_typenatriureticpept -------------------------------------------------- tr_Q7YZU5Natriureticpeptide_Ep -------------------------------------------------- tr_P79799Natriureticpeptide_Mi -------------------------------------------------- sp_P13205_ANFB_RATBrainnatriur -----------------------------------------HPLGSP--S sp_P16860_ANFB_HUMANBrainnatri -----------------------------------------HPLGSPGSA Q9PW56Bradykinin_potentiating/ GPPIPPLTVQQWAQARPPHPPIPPAPLQKWAPVQKWAP-LLQPHESPASG tr_Q8QG91Bradykinin_potentiati RPQIPPLEVQQWAQGRAPHPPIPPAPLQKWAPVQKWAP-LLQPHESPASG tn_BAA12879Bradykinin_potentia GPPIPPLTVQQWAQGRAPHPPIPPAPLQKWAPLQKWAP-LLQPHESPASG tr_Q90Y11Bradykininpotentiatin HPEIPPLVVQNWKS-----------------------PTQLQARESPAGG tr_Q90Y12Bradykininpotentiatin HLEIPPLVVQNWKS-----------------------PTQLQARESPAGG tr_Q9PT52BPP_CNPhomolog_Agkist RPKIPPLVVQQWSQGLPPRPKIPPLVVQKWDPPPVSPPLLLQPHESPAGG sp_P40756_ANFD_RANCAC_typenatr ------------------------------------------AQAHQKSL sp_P23582_ANFC_HUMANC_typenatr ------------------------------------------APP--KVP tr_Q805D3C_typenatriureticpept ------------------------------------------SQAQQKSF tr_Q800I8C_typenatriureticpept ---------------------------------------------ELQNL sp_P41319_ANFC_SQUACC_typenatr ---------------------------------------------SLQVL tr_Q805E8B_typenatriureticpept -------------------------------------------TGLTDTD tr_Q7T1Q2B_typenatriureticpept -------------------------------------------MGLTNAD tr_Q805D7B_typenatriureticpept ---------------------------------------------LSDTD tr_Q7T2I6Ventricularnatriureti -------------------------------------------SRN-VQE tr_Q9PSV2Ventricularnatriureti -------------------------------------------NRNNVQE tn_BAD02837Ventricularnatriure -------------------------------------------NKYNVQE tr_Q9PSV1Atrialnatriureticpept -------------------------------------------RPYSAND tr_Q7T2I7Atrialnatriureticpept -------------------------------------------RPYPESD tr_Q805D8Atrialnatriureticpept -------------------------------------------RPFSASD sp_P01160_ANF_HUMANAtrialnatri -------------------------------------------NAVSNAD sp_P01161_ANF_RATAtrialnatriur -------------------------------------------SAVSNTD sp_P18909_ANF_RANCAAtrialnatri -------------------------------------------NSPLSSD tr_Q9DGK8Atrialnatriureticfact -------------------------------------------SSVLSSD sp_P18908_ANF_CHICKAtrialnatri -------------------------------------------NLSPAKE tn_BAD02836Brainnatriureticpep -------------------------------------------SDAVVRD tn_BAD02838C_typenatriureticpe ------------------------------------------PDLQHRNH tr_Q8AXR2C_typenatriureticpept ----------------------------------------------SPDA tr_Q805D5C_typenatriureticpept -------------------------------------------RDEAQVL tr_Q7YZU5Natriureticpeptide_Ep ----------------------------------------MELPYVDEFS tr_P79799Natriureticpeptide_Mi ------------------------------------------EAPTAPSR sp_P13205_ANFB_RATBrainnatriur QSPEQSTMQKLLELIREKSEEMAQR------------------------- sp_P16860_ANFB_HUMANBrainnatri SDLETSGLQEQRNHLQGKLSELQVE------------------------- Q9PW56Bradykinin_potentiating/ TTALREELSLGPEAASGVPSAGAEVGRSGSK-APAAPHRLSKSKGAAATS tr_Q8QG91Bradykinin_potentiati TTALREELSLGPEAASGVPSAGAEVGRSGSK-APAAPHRLSKSKGAAATS tn_BAA12879Bradykinin_potentia TTALREELSLGPEAASGVPSAGAEVGRSGSK-APAAPHRLSKSKGAAAT- tr_Q90Y11Bradykininpotentiatin TTALREELSLGPEAALDTPPAGPDGGPRGSKAAAAAPQRLSKSKGASATS tr_Q90Y12Bradykininpotentiatin TTALREELSLGPEAALDTPPAGPDGGPRGSKAAAAAPQRLSKSKGASATS tr_Q9PT52BPP_CNPhomolog_Agkist TTALREELSLGPEAASGPAAAGADGGRSGSK-APAALHRLSKSKGASATS sp_P40756_ANFD_RANCAC_typenatr RALLGEELAEYLVSGERGERSIDPK---------TRARLLR--------- sp_P23582_ANFC_HUMANC_typenatr RTPPAEELAEPQAAGGGQKKGDKAPGGGGANLKGDRSRLLR--------- tr_Q805D3C_typenatriureticpept RSLLGEELAEFLESEEKERRLDAVR---------SRLRLLR--------- tr_Q800I8C_typenatriureticpept ERLLQDQLSSTEHPEEDRLDRTREEPQLGGSSSREAAD------------ sp_P41319_ANFC_SQUACC_typenatr SRLLEDEYGHFNSEELNNEAQEISPAASLPDLNTDQSD------------ tr_Q805E8B_typenatriureticpept MDILKVLLSRLEESVSEQMAVDQSAPGQRDLLDSLSTEDAGD-------- tr_Q7T1Q2B_typenatriureticpept VNTLKDLLHRLQESVPEQSSVDEEGAVERDTLNQLSTEEERE-------- tr_Q805D7B_typenatriureticpept VDVLEAILHKLEESMSEETEEDQMVPANSESLEPVGSMKQTA-------- tr_Q7T2I6Ventricularnatriureti LENLKDLIQRLEDKLTVNEENYAYPSESEDVDTAEMEDIDYS-------- tr_Q9PSV2Ventricularnatriureti LENLKDLIHQLEERVAVNEEPEVYPESEDMKMDAEEEDAGIS-------- tn_BAD02837Ventricularnatriure LSSLKDLLERLEEKLSPGEESDVYAGSEDLVNDPE-EDADLI-------- tr_Q9PSV1Atrialnatriureticpept LARLKSFLEQFEDTLAREEVADN-PGDYEDAKPEEAERGQPG-------- tr_Q7T2I7Atrialnatriureticpept LAQLKNLLERFEETLAAVATADDTVVDYEGPNPE-PEHSKAS-------- tr_Q805D8Atrialnatriureticpept SSQLKSLLERLEETISEADQEQNPELDQEVEYDIRDQDPGQR-------- sp_P01160_ANF_HUMANAtrialnatri LMDFKNLLDHLEEKMPLEDEVVPPQVLSEPNEEAGAALSPLP-------- sp_P01161_ANF_RATAtrialnatriur LMDFKNLLDHLEEKMPVEDEVMPPQALSEQTDEAGAALSSLS-------- sp_P18909_ANF_RANCAAtrialnatri LSDLKGLLERLEDRLPVEEVETPVQDIFAPNYDSADSSN----------- tr_Q9DGK8Atrialnatriureticfact LTDLKNILERLEDRVTAEEPMAPSQDLFAQNYDAADSSN----------- sp_P18908_ANF_CHICKAtrialnatri LASMEALLERLEDKFALIEALESNPDLQEPQTQEEIPPELTD-------- tn_BAD02836Brainnatriureticpep TDTLKTLLQRLEEAYLLTVRAESLERGQVADGMPEEQSYEAE-------- tn_BAD02838C_typenatriureticpe KSQLAGLFGAEVAALLEDAGAADGSSGEEAALSQRAPPSIRALHPRSGRL tr_Q8AXR2C_typenatriureticpept IQFVEQFLDRYNDLTLDDLENLVSSQPEEPSSAFTSGVKIAEYP------ tr_Q805D5C_typenatriureticpept RALFGARLSSIISTPVNTDDIAELLPRRPGPPRSFGASPGALR------- tr_Q7YZU5Natriureticpeptide_Ep GSDVDVQVDPQEAKLSPSSMLSDQYPLLGQETSPQLSVRYFG-------- tr_P79799Natriureticpeptide_Mi IIPFSRPVRKQSQAVLDPMVHPERPAGSGDDGDSRRLEGLAK-------- sp_P13205_ANFB_RATBrainnatriur ------------QLSKDQGPTKELLKRVLRSQDSAFR------------- sp_P16860_ANFB_HUMANBrainnatri ------------QTSLEPLQESPRPTGVWKSREVATEGIRGHRKMVL--- Q9PW56Bradykinin_potentiating/ A-----ASRPMRDLRPDGKQARQNWGRMVHHDHHAAVGGGGGGGGGG--- tr_Q8QG91Bradykinin_potentiati A-----ASRPMRDLRPDGKQARQNWGRMVHHDHHAAVGGGGGGGGGG--- tn_BAA12879Bradykinin_potentia --------RPMRDLRPDGKQARQNWGRMAHHDHHAAAGGGGGGGGG---- tr_Q90Y11Bradykininpotentiatin A--------ASRDLRTDGKQARQNWGRLVSPDHHSAAGGGGGGGGG---- tr_Q90Y12Bradykininpotentiatin A--------ASRDLRTDGKQARQNWGRLVSPDHHSAAGGGCGGGGG---- tr_Q9PT52BPP_CNPhomolog_Agkist AS----ASRPMRDLRTDGKQARQNWARMVNPDHHAVGGCCCGGGGGG--- sp_P40756_ANFD_RANCAC_typenatr ------------DIRADTR-SRAAWTRLLNEHPNSRKIK----------- sp_P23582_ANFC_HUMANC_typenatr ------------DLRVDTK-SRAAWARLLQEHPNARKYK----------- tr_Q805D3C_typenatriureticpept ------------DLRMDTR-ARGVWARLLNDQPVPRRHKT---------- tr_Q800I8C_typenatriureticpept ---------------------ESALTRLFADLLRTSKRS----------- sp_P41319_ANFC_SQUACC_typenatr --LELPWDRESREIGGRSFRQEALLARLLQDLSNNPLRFK---------- tr_Q805E8B_typenatriureticpept ----------------GPQPDAGLDEAEIREFLSAKN------------- tr_Q7T1Q2B_typenatriureticpept ----------------DEPGLSRMEEEVIRELLSSKN------------- tr_Q805D7B_typenatriureticpept ----------------NRDQIRPVEVEAIREFLSANT------------- tr_Q7T2I6Ventricularnatriureti -----------------PTAIRGQEERMTMNAPNRIAPES--------PV tr_Q9PSV2Ventricularnatriureti -----------------PGALRQSEENLLMNIVDRIAPES--------PL tn_BAD02837Ventricularnatriure -----------------LDNVRKQAEKEFYKPAG-FRDEN--------LQ tr_Q9PSV1Atrialnatriureticpept -----------------PEWDRERGGQGPASDLRGPGD-----G---YQA tr_Q7T2I7Atrialnatriureticpept -----------------PEWDRSPEAPQRLSDVRELAADESYSR---AQS tr_Q805D8Atrialnatriureticpept -----------------WNLDLGRDQDQVTATRSEIHS-----R---PSV sp_P01160_ANF_HUMANAtrialnatri -----------------EVPPWTGEVSPAQRDGGALGRGPWDSSDRSALL sp_P01161_ANF_RATAtrialnatriur -----------------EVPPWTGEVNPSQRDGGALGRGPWDPSDRSALL sp_P18909_ANF_RANCAAtrialnatri -----------------SAPSLTVEAARPGADMMYNRGS-WTQQEKSSPL tr_Q9DGK8Atrialnatriureticfact -----------------SAPSWTGEAIRPQSDIIYNKGSSWETPDKLSRL sp_P18908_ANF_CHICKAtrialnatri -----------------DSDEQKAEPKLASNTPLSYRNPFLKRLRG---- tn_BAD02836Brainnatriureticpep ----------------DGSQERLAEESAIGYITLDAEEARLPDR------ tn_BAD02838C_typenatriureticpe G------------LRDDLEAEPPAENKPRRRLLKDFMSSR---------- tr_Q8AXR2C_typenatriureticpept ---------------KWADIPAQGDSTWLRLLKGTLANQ----------- tr_Q805D5C_typenatriureticpept ----------------GLTRGSEGGSRFLLDFLQQQSKTTR--------- tr_Q7YZU5Natriureticpeptide_Ep ------------------LPVIQRTRRSMHSIRSDLLKSASDSWQELLGR tr_P79799Natriureticpeptide_Mi -----------------EALGDGCFGQRIDRICNVSGMGCN--------- sp_P13205_ANFB_RATBrainnatriur ----IQERLRNSKMAHSSSCFGQKIDRIGAVSRLGCDGLRLF-------- sp_P16860_ANFB_HUMANBrainnatri ---YTLRAPRSPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH-------- Q9PW56Bradykinin_potentiating/ ---ARRLKGLAKKGAAK-GCFGLKVDRIGTMSGLGC-------------- tr_Q8QG91Bradykinin_potentiati ---ARRLKGLAKKGAAK-GCFGLKLDRIGTMSGLGC-------------- tn_BAA12879Bradykinin_potentia ---ARRLKGLAKKGAAK-GCFGLKLDRIGTMSGLGC-------------- tr_Q90Y11Bradykininpotentiatin ---ARRLKGLAKKRAGN-GCFGLKLDRIGSMSGLGC-------------- tr_Q90Y12Bradykininpotentiatin ---ARRLKGLAKKRAGN-GCFGLKLDRIGSMSGLGC-------------- tr_Q9PT52BPP_CNPhomolog_Agkist ---ARRLKGLVKKGVAK-GCFGLKLDRIGTMSGLGC-------------- sp_P40756_ANFD_RANCAC_typenatr --------GINKKGTSK-GCFGLKLDRIGAMSGLGC-------------- sp_P23582_ANFC_HUMANC_typenatr --------GANKKGLSK-GCFGLKLDRIGSMSGLGC-------------- tr_Q805D3C_typenatriureticpept --------GIKKGGSSRSGCFGHKMDRIGTISGMGC-------------- tr_Q800I8C_typenatriureticpept -------WGRYKKGGMR-SCFGVRLERIGSFSGLGC-------------- sp_P41319_ANFC_SQUACC_typenatr --------GRSKKGPSR-SCFGLKLDRIGAMSGLGC-------------- tr_Q805E8B_typenatriureticpept ----LKSVRN-DSSRRSSGCFGRRMDRIGSMSSLGCNTVGRYNPKQR--- tr_Q7T1Q2B_typenatriureticpept ----LKSLRSGDSSRRSSGCFGRRMDRIGSMSSLGCNTVGRYNPK----- tr_Q805D7B_typenatriureticpept ----RKNVQN-DSSRRSSSCFGRRMDRIGSMSSLGCNTVGKYNPK----- tr_Q7T2I6Ventricularnatriureti VSRLKDLIGLTKTAKSFNSCFGNRIERIGSWSGLGCNNVKTGNKKRIFGN tr_Q9PSV2Ventricularnatriureti RSRFRDLAGLAKTAKSFNSCFGTRMDRIGSWSGLGCNSLKNGTKKKIFGN tn_BAD02837Ventricularnatriure RGRLR---SIATSARSMNGCFGNRIERIGSWSSLGCNNSRFGSKKRIF-- tr_Q9PSV1Atrialnatriureticpept QRSWLQDLLMSTRSKSSSPCFGGKLDRIGSYSGLGCNSRKG--------- tr_Q7T2I7Atrialnatriureticpept QRSRLQDLLMATRSKAVSGCFGARMDRIGTSSGLGCSPKRRS-------- tr_Q805D8Atrialnatriureticpept QRSHLQDLLMSLRKRASS-CFGARMDRIGNASGLGCNNGRG--------- sp_P01160_ANF_HUMANAtrialnatri KSKLRALLTAPRSLRRSS-CFGGRMDRIGAQSGLGCNSFRYRR------- sp_P01161_ANF_RATAtrialnatriur KSKLRALLAGPRSLRRSS-CFGGRIDRIGAQSGLGCNSFRYRR------- sp_P18909_ANF_RANCAAtrialnatri RNKLRELLNAPRSMRRSSDCFGSRIDRIGAQSGMGCG-RRF--------- tr_Q9DGK8Atrialnatriureticfact KSKLRELLNSPRSLRRSSDCFGGRIDRIGAQSGMGCNSHRF--------- sp_P18908_ANF_CHICKAtrialnatri --------VQMPRMMRDSGCFGRRIDRIGSLSGMGCNGSRKN-------- tn_BAD02836Brainnatriureticpep --NSNGFLNPLRNTKRYSGCFGRRLDRIGSMSALGCNGGSRLSYKRS--- tn_BAD02838C_typenatriureticpe ----KMFRGRTKKMQQGRGCFGMKLDRIGSMSGLGC-------------- tr_Q8AXR2C_typenatriureticpept ----KRAVTDRSRRGWNRGCFGLKLDRIGSMSGLGC-------------- tr_Q805D5C_typenatriureticpept --------RGRSSMVGGRGCFGMKIDRIGSISGLGC-------------- tr_Q7YZU5Natriureticpeptide_Ep QDMRRHRFSKTRLGSTSDGCFGVKMDRIGASTGLGCRGARRRTFSG---- tr_P79799Natriureticpeptide_Mi --HVRTDPAPTALARIIPFSRPVRKESRAALDRMQQPG------------ . : : . :