RT Journal
A1 Robbins, Christiane
A1 Torres, Jada Benn
A1 Hooker, Stanley
A1 Bonilla, Carolina
A1 Hernandez, Wenndy
A1 Candreva, Angela
A1 Ahaghotu, Chiledum
A1 Kittles, Rick
A1 Carpten, John
T1 Confirmation study of prostate cancer risk variants at 8q24 in African Americans identifies a novel risk locus
JF Genome Research 
JO Genome Research 
YR 2007 
FD December 01 
VO 17 
IS 12 
SP 000 
OP 000 
DO 10.1101/gr.6782707 
UL http://genome.cshlp.org/content/early/2007/10/31/gr.6782707.abstract 
AB Prostate cancer is a common complex disease that disproportionately affects men of African descent. Recently, several different common variants on chromosome 8q24 have been shown to be associated with prostate cancer in multiple studies and ethnic groups. The objective of this study was to confirm the association of 8q24 markers with prostate cancer in African Americans. We genotyped 24 markers along 8q24 and 80 unlinked ancestry informative markers in a hospital-based case-control sample of 1057 African American men (490 prostate cancer cases and 567 controls). Association analyses of 8q24 markers with prostate cancer risk were adjusted for both global and local 8q24 admixture stratification using estimates from ancestry informative markers. We report that rs7008482, which maps to the 8q24.13 region, is an additional independent prostate cancer risk variant (P = 5 × 10−4), and we also replicate the association of rs16901979 with prostate cancer (P = 0.002). Other published risk variants in the region such as rs1447295 and rs6983267 showed a similar direction and magnitude of effect, but were not significant in our population. Both rs7008482 and rs16901979 independently predicted risk and remained significant (P < 0.001) after controlling for each other. Our data combined with additional replications of 8q24 markers provide compelling support for multiple regions of risk for prostate cancer on 8q24.