RT Journal
A1 Lin, Jimmy
A1 Gan, Christine M.
A1 Zhang, Xiaosong
A1 Jones, Siân
A1 Sjöblom, Tobias
A1 Wood, Laura D.
A1 Parsons, D. Williams
A1 Papadopoulos, Nickolas
A1 Kinzler, Kenneth W.
A1 Vogelstein, Bert
A1 Parmigiani, Giovanni
A1 Velculescu, Victor E.
T1 A multidimensional analysis of genes mutated in breast and colorectal cancers
JF Genome Research 
JO Genome Research 
YR 2007 
FD September 01 
VO 17 
IS 9 
SP 000 
OP 000 
DO 10.1101/gr.6431107 
UL http://genome.cshlp.org/content/early/2007/08/10/gr.6431107.abstract 
AB A recent study of a large number of genes in a panel of breast and colorectal cancers identified somatic mutations in 1149 genes. To identify potential biological processes affected by these genes, we examined their putative roles based on sequence similarity, membership in known functional groups and pathways, and predicted interactions with other proteins. These analyses identified functional groups and pathways that were enriched for mutated genes in both tumor types. Additionally, the results pointed to differences in molecular mechanisms that underlie breast and colorectal cancers, including various intracellular signaling and metabolic pathways. These studies provide a multidimensional framework to guide further research and help identify cellular processes critical for malignant progression and therapeutic intervention.