RT Journal
A1 Garg, Kavita
A1 Green, Phil
T1 Differing patterns of selection in alternative and constitutive splice sites
JF Genome Research 
JO Genome Research 
YR 2007 
FD June 01 
VO 17 
IS 7 
SP 000 
OP 000 
DO 10.1101/gr.6347907 
UL http://genome.cshlp.org/content/early/2007/06/01/gr.6347907.abstract 
AB In addition to allowing identification of putative functional elements as regions having reduced substitution rates, comparison of genome sequences can also provide insights into these elements at the nucleotide level, by indicating the pattern of tolerated substitutions. We created data sets of orthologous alternative and constitutive splice sites in mouse, rat, and human and analyzed the substitutions occurring within them. Our results illuminate differences between alternative and constitutive sites and, in particular, strongly support the idea that alternative sites are under selection to be weak.