TY  - JOUR
A1  - Bollenbach, Tobias
A1  - Vetsigian, Kalin
A1  - Kishony, Roy
T1  - Evolution and multilevel optimization of the genetic code
Y1  - 2007/04/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 000 
EP  - 000 
DO  - 10.1101/gr.6144007 
VL  - 17 
IS  - 4 
UR  - http://genome.cshlp.org/content/early/2007/03/09/gr.6144007.abstract 
N2  - The discovery of the genetic code was one of the most important advances of modern biology. But there is more to a DNA code than protein sequence; DNA carries signals for splicing, localization, folding, and regulation that are often embedded within the protein-coding sequence. In this issue, Itzkovitz and Alon show that the specific 64-to-20 mapping found in the genetic code may have been optimized for permitting protein-coding regions to carry this extra information and suggest that this property may have evolved as a side benefit of selection to minimize the negative effects of frameshift errors. 
ER  -