@article{Jehan01122006,
author = {Jehan, Zeenath and Vallinayagam, Sambandam and Tiwari, Shrish and Pradhan, Suman and Singh, Lalji and Suresh, Amritha and Reddy, Hemakumar M. and Ahuja, Y.R. and Jesudasan, Rachel A.}, 
title = {Novel noncoding RNA from human Y distal heterochromatic block (Yq12) generates testis-specific chimeric CDC2L2},
volume = {16}, 
number = {12}, 
pages = {000}, 
year = {2006}, 
doi = {10.1101/gr.5155706}, 
abstract ={The human Y chromosome, because it is enriched in repetitive DNA, has been very intractable to genetic and molecular analyses. There is no previous evidence for developmental stage- and testis-specific transcription from the male-specific region of the Y (MSY). Here, we present evidence for the first time for a developmental stage- and testis-specific transcription from MSY distal heterochromatic block. We isolated two novel RNAs, which localize to Yq12 in multiple copies, show testis-specific expression, and lack active X-homologs. Experimental evidence shows that one of the above Yq12 noncoding RNAs (ncRNAs) trans-splices with CDC2L2 mRNA from chromosome 1p36.3 locus to generate a testis-specific chimeric β sv13 isoform. This 67-nt 5′UTR provided by the Yq12 transcript contains within it a Y box protein-binding CCAAT motif, indicating translational regulation of the β sv13 isoform in testis. This is also the first report of trans-splicing between a Y chromosomal and an autosomal transcript.}, 
URL = {http://genome.cshlp.org/content/early/2006/11/09/gr.5155706.abstract}, 
eprint = {http://genome.cshlp.org/content/early/2006/11/09/gr.5155706.full.pdf+html}, 
journal = {Genome Research} 
}