TY - JOUR A1 - Farahbod, Marjan A1 - Diab, Aboud A1 - Sud, Paul A1 - Kagda, Meenakshi S. A1 - Whaling, Ian A1 - Foroozandeh, Mehdi A1 - Goel, Ishan A1 - Daneshpajouh, Habib A1 - Hitz, Benjamin A1 - Cherry, J. Michael A1 - Libbrecht, Maxwell W. T1 - Integrative chromatin state annotation of 234 human ENCODE4 cell types using Segway Y1 - 2025/10/06 JF - Genome Research JO - Genome Research DO - 10.1101/gr.280633.125 SP - gr.280633.125 UR - http://genome.cshlp.org/content/early/2025/10/06/gr.280633.125.abstract N2 - The fourth and final phase of the ENCODE consortium has newly profiled epigenetic activity in hundreds of human tissues. Chromatin state annotations created by segmentation and genome annotation (SAGA) methods such as Segway have emerged as the predominant integrative summary of such data sets. Here, we present the ENCODE4 Catalog of Segway Annotations, a set of sample-specific genome-wide chromatin state annotations of 234 human biosamples inferred from 1,794 genomics experiments. This catalog identifies genomic elements, accurately captures cell type-specific regulatory patterns, and facilitates discovery of elements involved in phenotype and disease. ER -