TY  - JOUR
A1  - Luo, Zhengyu
A1  - Zhang, Ran
A1  - Hu, Tengfei
A1  - Zhu, Yuting
A1  - Wu, Yueming
A1  - Li, Wenfei
A1  - Zhang, Zhi
A1  - Yao, Xuebiao
A1  - Liang, Haiyi
A1  - Song, Xiaoyuan
T1  - NicE-C efficiently reveals open chromatin-associated chromosome interactions at high resolution
Y1  - 2022/02/01 
JF  - Genome Research 
JO  - Genome Research 
DO  - 10.1101/gr.275986.121 
SP  - gr.275986.121 
UR  - http://genome.cshlp.org/content/early/2022/02/01/gr.275986.121.abstract 
N2  - Enhancer-promoter communication is known to regulate spatiotemporal dynamics of gene expression. Several methods are available to capture enhancer-promoter interactions, but they either require large amounts of starting materials and are costly, or provide a relative low-resolution in chromatin contact maps. Here, we present nicking enzyme-assisted open chromatin interaction capture (NicE-C), a method that leverages nicking enzyme mediated open chromatin profiling and chromosome conformation capture to enable robust and cost-effective detection of open chromatin interactions at high resolution, especially enhancer-promoter interactions. Using TNF stimulation and mouse kidney aging as models, we applied NicE-C to reveal characteristics of dynamic enhancer-promoter interactions. 
ER  -