@article{Luo01022022,
author = {Luo, Zhengyu and Zhang, Ran and Hu, Tengfei and Zhu, Yuting and Wu, Yueming and Li, Wenfei and Zhang, Zhi and Yao, Xuebiao and Liang, Haiyi and Song, Xiaoyuan}, 
title = {NicE-C efficiently reveals open chromatin-associated chromosome interactions at high resolution},
year = {2022}, 
doi = {10.1101/gr.275986.121}, 
elocation-id = {gr.275986.121}, 
abstract ={Enhancer-promoter communication is known to regulate spatiotemporal dynamics of gene expression. Several methods are available to capture enhancer-promoter interactions, but they either require large amounts of starting materials and are costly, or provide a relative low-resolution in chromatin contact maps. Here, we present nicking enzyme-assisted open chromatin interaction capture (NicE-C), a method that leverages nicking enzyme mediated open chromatin profiling and chromosome conformation capture to enable robust and cost-effective detection of open chromatin interactions at high resolution, especially enhancer-promoter interactions. Using TNF stimulation and mouse kidney aging as models, we applied NicE-C to reveal characteristics of dynamic enhancer-promoter interactions.}, 
URL = {http://genome.cshlp.org/content/early/2022/02/01/gr.275986.121.abstract}, 
eprint = {http://genome.cshlp.org/content/early/2022/02/01/gr.275986.121.full.pdf+html}, 
journal = {Genome Research} 
}