RT Journal
A1 Gong, Tongqing
A1 Zhang, Chunchao
A1 Ni, Xiaotian
A1 Li, Xianju
A1 Li, Jin'e
A1 Liu, Mingwei
A1 Zhan, Dongdong
A1 Xia, Xia
A1 Song, Lei
A1 Zhou, Quan
A1 Ding, Chen
A1 Qin, Jun
A1 Wang, Yi
T1 A time-resolved multi-omic atlas of the developing mouse liver
JF Genome Research 
JO Genome Research 
YR 2020 
FD February 12 
DO 10.1101/gr.253328.119 
UL http://genome.cshlp.org/content/early/2020/02/11/gr.253328.119.abstract 
AB Liver organogenesis and development are composed of a series of complex, well-orchestrated events. Identifying key factors and pathways governing liver development will help elucidate the physiological and pathological processes including those of cancer. We conducted multidimensional omics measurements including protein, mRNA, and transcription factor (TF) DNA-binding activity for mouse liver tissues collected from embryonic day 12.5 (E12.5) to postnatal week 8 (W8), encompassing major developmental stages. These data sets reveal dynamic changes of core liver functions and canonical signaling pathways governing development at both mRNA and protein levels. The TF DNA-binding activity data set highlights the importance of TF activity in early embryonic development. A comparison between mouse liver development and human hepatocellular carcinoma (HCC) proteomic profiles reveal that more aggressive tumors are characterized with the activation of early embryonic development pathways, whereas less aggressive ones maintain liver function–related pathways that are elevated in the mature liver. This work offers a panoramic view of mouse liver development and provides a rich resource to explore in-depth functional characterization.