TY  - JOUR
A1  - Gong, Tongqing
A1  - Zhang, Chunchao
A1  - Ni, Xiaotian
A1  - Li, Xianju
A1  - Li, Jin'e
A1  - Liu, Mingwei
A1  - Zhan, Dongdong
A1  - Xia, Xia
A1  - Song, Lei
A1  - Zhou, Quan
A1  - Ding, Chen
A1  - Qin, Jun
A1  - Wang, Yi
T1  - A time-resolved multi-omic atlas of the developing mouse liver
Y1  - 2020/02/12 
JF  - Genome Research 
JO  - Genome Research 
DO  - 10.1101/gr.253328.119 
UR  - http://genome.cshlp.org/content/early/2020/02/11/gr.253328.119.abstract 
N2  - Liver organogenesis and development are composed of a series of complex, well-orchestrated events. Identifying key factors and pathways governing liver development will help elucidate the physiological and pathological processes including those of cancer. We conducted multidimensional omics measurements including protein, mRNA, and transcription factor (TF) DNA-binding activity for mouse liver tissues collected from embryonic day 12.5 (E12.5) to postnatal week 8 (W8), encompassing major developmental stages. These data sets reveal dynamic changes of core liver functions and canonical signaling pathways governing development at both mRNA and protein levels. The TF DNA-binding activity data set highlights the importance of TF activity in early embryonic development. A comparison between mouse liver development and human hepatocellular carcinoma (HCC) proteomic profiles reveal that more aggressive tumors are characterized with the activation of early embryonic development pathways, whereas less aggressive ones maintain liver function–related pathways that are elevated in the mature liver. This work offers a panoramic view of mouse liver development and provides a rich resource to explore in-depth functional characterization. 
ER  -