TY  - JOUR
A1  - Liu, Siling
A1  - Wang, Zhengbo
A1  - Chen, Dong
A1  - Zhang, Bowen
A1  - Tian, Renrong
A1  - Wu, Jing
A1  - Zhang, Ying
A1  - Xu, Kaiyu
A1  - Yang, Liumeng
A1  - Cheng, Chao
A1  - Ma, Jian
A1  - Lv, Longbao
A1  - Zheng, Yongtang
A1  - Hu, Xintian
A1  - Zhang, Yi
A1  - Wang, Xiangting
A1  - Li, Jiali
T1  - Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in Rhesus macaque brain
Y1  - 2017/07/07 
JF  - Genome Research 
JO  - Genome Research 
DO  - 10.1101/gr.217463.116 
SP  - gr.217463.116 
UR  - http://genome.cshlp.org/content/early/2017/07/07/gr.217463.116.abstract 
N2  - Long noncoding RNA (lncRNA)-mediated epigenetic regulation plays important roles in wide range of biological processes and diseases. Here, we applied comprehensive analyses of RNA-seq and CAGE-seq (cap analysis of gene expression and sequencing) to characterize the dynamic changes in lncRNA expression in rhesus macaque brain in four age groups from postnatal to aged periods. We identified 18 anatomically diverse lncRNA modules and 14 mRNA modules representing spatial, age and sex specificities. Spatiotemporal- and sex-biased changes in lncRNA expression are in general higher than that observed in mRNA expression. A negative correlation between lncRNA and mRNA expression in cerebral cortex was observed, such relationship was further explored and functionally validated. Our findings offer an initial insight into spatial-, age- and sex-biased changes in lncRNA expression in macaque brain, and that the distinct classification of such changes might represent a previously unappreciated regulatory system which potentially contributes to brain development and ageing. 
ER  -