RT Journal
A1 Baran, Yael
A1 Subramaniam, Meena
A1 Biton, Anne
A1 Tukiainen, Taru
A1 Tsang, Emily K
A1 Rivas, Manuel A
A1 Pirinen, Matti
A1 Gutierrez-Arcelus, Maria
A1 Smith, Kevin S
A1 Kukurba, Kim R
A1 Zhang, Rui
A1 Eng, Celeste
A1 Torgerson, Dara G
A1 Urbanek, Cydney
A1 GTEx Consortium
A1 Li, Jin Billy
A1 Rodriguez-Santana, Jose R
A1 Burchard, Esteban G
A1 Seibold, Max A
A1 MacArthur, Daniel G
A1 Montgomery, Stephen B
A1 Zaitlen, Noah A
A1 Lappalainen, Tuuli
T1 The landscape of genomic imprinting across diverse adult human tissues
JF Genome Research 
JO Genome Research 
YR 2015 
FD May 07 
DO 10.1101/gr.192278.115 
SP gr.192278.115 
UL http://genome.cshlp.org/content/early/2015/05/07/gr.192278.115.abstract 
AB Genomic imprinting is an important regulatory mechanism that silences one of the parental copies of a gene. To systematically characterize this phenomenon, we analyze tissue-specificity of imprinting from allelic expression data in 1582 primary tissue samples from 178 individuals from the Genotype Tissue Expression (GTEx) project. We characterize imprinting in 42 genes, including both novel and previously identified genes. Tissue-specificity of imprinting is widespread, and gender-specific effects are revealed in a small number of genes in muscle with stronger imprinting in males. IGF2 shows maternal expression in the brain instead of the canonical paternal expression elsewhere. Imprinting appears to have only a subtle impact on tissue-specific expression levels, with genes lacking a systematic expression difference between tissues with imprinted and biallelic expression. In summary, our systematic characterization of imprinting in adult tissues highlights variation in imprinting between genes, individuals, and tissues.