TY  - JOUR
A1  - Akagi, Keiko
A1  - Li, Jingfeng
A1  - Broutian, Tatevik R
A1  - Padilla-Nash, Hesed
A1  - Xiao, Weihong
A1  - Jiang, Bo
A1  - Rocco, James W
A1  - Teknos, Theodoros N
A1  - Kumar, Bhavna
A1  - Wangsa, Danny
A1  - He, Dandan
A1  - Ried, Thomas
A1  - Symer, David E
A1  - Gillison, Maura L
T1  - Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability
Y1  - 2013/11/07 
JF  - Genome Research 
JO  - Genome Research 
DO  - 10.1101/gr.164806.113 
SP  - gr.164806.113 
UR  - http://genome.cshlp.org/content/early/2013/11/05/gr.164806.113.abstract 
N2  - Genomic instability is a hallmark of human cancers, including the 5% caused by human papillomavirus (HPV). Here we report a striking association between HPV integration and adjacent host genomic structural variation in human cancer cell lines and primary tumors. Whole genome sequencing revealed HPV integrants flanking and bridging extensive host genomic amplifications and rearrangements, including deletions, inversions and chromosomal translocations. We present a model of 'looping' by which HPV integrant-mediated DNA replication and recombination may result in viral-host DNA concatemers, frequently disrupting genes involved in oncogenesis and amplifying HPV oncogenes E6 and E7. Our high-resolution results shed new light on a catastrophic process, distinct from chromothripsis and other mutational processes, by which HPV directly promotes genomic instability. 
ER  -