@article{Symmons07012014,
author = {Symmons, Orsolya and Uslu, Veli Vural and Tsujimura, Taro and Ruf, Sandra and Nassari, Sonya and Schwarzer, Wibke and Ettwiller, Laurence and Spitz, Francois}, 
title = {Functional and topological characteristics of mammalian regulatory domains},
year = {2014}, 
doi = {10.1101/gr.163519.113}, 
elocation-id = {gr.163519.113}, 
abstract ={Long-range regulatory interactions have an important role in shaping gene expression programs. However, the genomic features that organize these activities are still poorly characterized. We conducted a large operational analysis to chart the distribution of gene regulatory activities along the mouse genome, using hundreds of insertions of a regulatory sensor. We found that enhancers distribute their activities along broad regions and not in a gene-centric manner, defining large regulatory domains. Remarkably, these domains correlate strongly with the recently described TADs, which partition the genome into distinct self-interacting blocks. Different features, including specific repeats and CTCF-binding sites, correlate with the transition zones separating regulatory domains, and may help to further organize promiscuously distributed regulatory influences within large domains. These findings support a model of genomic organisation where TADs confine regulatory activities to specific but large regulatory domains, contributing to the establishment of specific gene expression profiles.}, 
URL = {http://genome.cshlp.org/content/early/2014/01/07/gr.163519.113.abstract}, 
eprint = {http://genome.cshlp.org/content/early/2014/01/07/gr.163519.113.full.pdf+html}, 
journal = {Genome Research} 
}