TY  - JOUR
A1  - Takada, Toyoyuki
A1  - Ebata, Toshinobu
A1  - Noguchi, Hideki
A1  - Keane, Thomas
A1  - Adams, David
A1  - Narita, Takanori
A1  - Shin-I, Tadasu
A1  - Fujisawa, Hironori
A1  - Toyoda, Atsushi
A1  - Abe, Kuniya
A1  - Obata, Yuichi
A1  - Sakaki, Yoshiyuki
A1  - Moriwaki, Kazuo
A1  - Fujiyama, Asao
A1  - Kohara, Yuji
A1  - Shiroishi, Toshihiko
T1  - The ancestor of extant Japanese fancy mice contributed to the mosaic genomes of classical inbred strains
Y1  - 2013/04/19 
JF  - Genome Research 
JO  - Genome Research 
DO  - 10.1101/gr.156497.113 
SP  - gr.156497.113 
UR  - http://genome.cshlp.org/content/early/2013/04/19/gr.156497.113.abstract 
N2  - Commonly used classical inbred mouse strains have mosaic genomes with sequences from different subspecific origins. Their genomes are derived predominantly from the Western European subspecies Mus musculus domesticus, with the remaining sequences derived mostly from the Japanese subspecies M. m. molossinus. However, it remains unknown how this intersubspecific genome introgression occurred during the establishment of classical inbred strains. In this study, we resequenced the genomes of M. m. molossinus -derived two inbred strains, MSM/Ms and JF1/Ms. MSM/Ms originated from Japanese wild mice, and ancestry of JF1/Ms was originally found in Europe and then transferred to Japan. We compared the characteristics of these sequences to those of the C57BL/6J reference sequence and the recent datasets from the resequencing of 17 inbred strains in the Mouse Genome Project (MGP), and the results unequivocally show that genome introgression from M. m. molossinus  into M. m. domesticus  provided the primary framework for the mosaic genomes of classical inbred strains. Furthermore, the genomes of C57BL/6J and other classical inbred strains have long consecutive segments with extremely high similarity (>99.998%) to the JF1/Ms strain. In the early 20th century, Japanese waltzing mice with a morphological phenotype resembling that of JF1/Ms mice were often crossed with European fancy mice for early studies of "Mendelism" which suggests that that the ancestor of the extant JF1/Ms strain provided the origin of the M. m. molossinus  genome in classical inbred strains and largely contributed to its intersubspecific genome diversity. 
ER  -