RT Journal
A1 Michaud, Joëlle
A1 Praz, Viviane
A1 Faresse, Nicole James
A1 JnBaptiste, Courtney K.
A1 Tyagi, Shweta
A1 Schütz, Frédéric
A1 Herr, Winship
T1 HCFC1 is a common component of active human CpG-island promoters and coincides with ZNF143, THAP11, YY1, and GABP transcription factor occupancy
JF Genome Research 
JO Genome Research 
YR 2013 
FD March 28 
DO 10.1101/gr.150078.112 
UL http://genome.cshlp.org/content/early/2013/04/24/gr.150078.112.abstract 
AB In human transcriptional regulation, DNA-sequence-specific factors can associate with intermediaries that orchestrate interactions with a diverse set of chromatin-modifying enzymes. One such intermediary is HCFC1 (also known as HCF-1). HCFC1, first identified in herpes simplex virus transcription, has a poorly defined role in cellular transcriptional regulation. We show here that, in HeLa cells, HCFC1 is observed bound to 5400 generally active CpG-island promoters. Examination of the DNA sequences underlying the HCFC1-binding sites revealed three sequence motifs associated with the binding of (1) ZNF143 and THAP11 (also known as Ronin), (2) GABP, and (3) YY1 sequence-specific transcription factors. Subsequent analysis revealed colocalization of HCFC1 with these four transcription factors at ∼90% of the 5400 HCFC1-bound promoters. These studies suggest that a relatively small number of transcription factors play a major role in HeLa-cell transcriptional regulation in association with HCFC1.