TY - JOUR A1 - Earl, Dent A. A1 - Bradnam, Keith A1 - St. John, John A1 - Darling, Aaron A1 - Lin, Dawei A1 - Faas, Joseph A1 - Yu, Hung On Ken A1 - Vince, Buffalo A1 - Zerbino, Daniel R. A1 - Diekhans, Mark A1 - Nguyen, Ngan A1 - Nuwantha, Pramila A1 - Sung, Ariyaratne Wing-Kin A1 - Ning, Zemin A1 - Haimel, Matthias A1 - Simpson, Jared T. A1 - Fronseca, Nuno A. A1 - Birol, İnanç A1 - Docking, T. Roderick A1 - Ho, Isaac Y. A1 - Rokhsar, Daniel S A1 - Chikhi, Rayan A1 - Lavenier, Dominique A1 - Chapuis, Guillaume A1 - Naquin, Delphine A1 - Maillet, Nicolas A1 - Schatz, Michael C. A1 - Kelly, David R. A1 - Phillippy, Adam M. A1 - Koren, Sergey A1 - Yang, Shiaw-Pyng A1 - Wu, Wei A1 - Chou, Wen-Chi A1 - Srivastava, Anuj A1 - Shaw, Timothy I. A1 - Ruby, J. Graham A1 - Skewes-Cox, Peter A1 - Betegon, Miguel A1 - Dimon, Michelle T. A1 - Solovyev, Victor A1 - Kosarev, Petr A1 - Vorobyev, Denis A1 - Ramirez-Gonzalez, Ricardo A1 - Leggett, Richard A1 - MacLean, Dan A1 - Xia, Fangfang A1 - Luo, Ruibang A1 - L, Zhenyu A1 - Xie, Yinlong A1 - Liu, Binghang A1 - Gnerre, Sante A1 - MacCallum, Iain A1 - Przybylski, Dariusz A1 - Ribeiro, Filipe J. A1 - Yin, Shuangye A1 - Sharpe, Ted A1 - Hall, Giles A1 - Kersey, Paul J. A1 - Durbin, Richard A1 - Jackman, Shaun D. A1 - Chapman, Jarrod A. A1 - Huang, Xiaoqiu A1 - DeRisi, Joseph L. A1 - Caccamo, Mario A1 - Li, Yingrui A1 - Jaffe, David B. A1 - Green, Richard A1 - Haussler, David A1 - Korf, Ian A1 - Paten, Benedict T1 - Assemblathon 1: A competitive assessment of de novo short read assembly methods Y1 - 2011/09/16 JF - Genome Research JO - Genome Research DO - 10.1101/gr.126599.111 SP - gr.126599.111 UR - http://genome.cshlp.org/content/early/2011/09/16/gr.126599.111.abstract N2 - Low cost short read sequencing technology has revolutionised genomics, though it is only just becoming practical for the high quality de novo assembly of a novel large genome. We describe the Assemblathon 1 competition, which aimed to comprehensively assess the state of the art in de novo assembly methods when applied to current sequencing technologies. In a collaborative effort teams were asked to assemble a simulated Illumina HiSeq dataset of an unknown, simulated diploid genome. A total of 41 assemblies from 17 different groups were received. Novel haplotype aware assessments of coverage, contiguity, structure, base calling and copy number were made. We establish that within this benchmark (1) it is possible to assemble the genome to a high level of coverage and accuracy, and that (2) large differences exist between the assemblies, suggesting room for further improvements in current methods. ER -