TY  - JOUR
A1  - Kostic, Aleksandar D.
A1  - Gevers, Dirk
A1  - Pedamallu, Chandra Sekhar
A1  - Michaud, Monia
A1  - Duke, Fujiko
A1  - Earl, Ashlee M.
A1  - Ojesina, Akinyemi I.
A1  - Jung, Joonil
A1  - Bass, Adam J.
A1  - Tabernero, Josep
A1  - Baselga, José
A1  - Liu, Chen
A1  - Shivdasani, Ramesh A.
A1  - Ogino, Shuji
A1  - Birren, Bruce W.
A1  - Huttenhower, Curtis
A1  - Garrett, Wendy S.
A1  - Meyerson, Matthew
T1  - Genomic analysis identifies association of Fusobacterium with colorectal carcinoma
Y1  - 2011/10/18 
JF  - Genome Research 
JO  - Genome Research 
DO  - 10.1101/gr.126573.111 
UR  - http://genome.cshlp.org/content/early/2011/10/04/gr.126573.111.abstract 
N2  - The tumor microenvironment of colorectal carcinoma is a complex community of genomically altered cancer cells, nonneoplastic cells, and a diverse collection of microorganisms. Each of these components may contribute to carcinogenesis; however, the role of the microbiota is the least well understood. We have characterized the composition of the microbiota in colorectal carcinoma using whole genome sequences from nine tumor/normal pairs. Fusobacterium sequences were enriched in carcinomas, confirmed by quantitative PCR and 16S rDNA sequence analysis of 95 carcinoma/normal DNA pairs, while the Bacteroidetes and Firmicutes phyla were depleted in tumors. Fusobacteria were also visualized within colorectal tumors using FISH. These findings reveal alterations in the colorectal cancer microbiota; however, the precise role of Fusobacteria in colorectal carcinoma pathogenesis requires further investigation. 
ER  -