TY  - JOUR
A1  - Thorrez, Lieven
A1  - Laudadio, Ilaria
A1  - Van Deun, Katrijn
A1  - Quintens, Roel
A1  - Hendrickx, Nico
A1  - Granvik, Mikaela
A1  - Lemaire, Katleen
A1  - Schraenen, Anica
A1  - Van Lommel, Leentje
A1  - Lehnert, Stefan
A1  - Aguayo-Mazzucato, Cristina
A1  - Cheng-Xue, Rui
A1  - Gilon, Patrick
A1  - Van Mechelen, Iven
A1  - Bonner-Weir, Susan
A1  - Lemaigre, Frédéric
A1  - Schuit, Frans
T1  - Tissue-specific disallowance of housekeeping genes: The other face of cell differentiation
Y1  - 2010/11/18 
JF  - Genome Research 
JO  - Genome Research 
DO  - 10.1101/gr.109173.110 
UR  - http://genome.cshlp.org/content/early/2010/12/10/gr.109173.110.abstract 
N2  - We report on a hitherto poorly characterized class of genes that are expressed in all tissues, except in one. Often, these genes have been classified as housekeeping genes, based on their nearly ubiquitous expression. However, the specific repression in one tissue defines a special class of “disallowed genes.” In this paper, we used the intersection-union test to screen for such genes in a multi-tissue panel of genome-wide mRNA expression data. We propose that disallowed genes need to be repressed in the specific target tissue to ensure correct tissue function. We provide mechanistic data of repression with two metabolic examples, exercise-induced inappropriate insulin release and interference with ketogenesis in liver. Developmentally, this repression is established during tissue maturation in the early postnatal period involving epigenetic changes in histone methylation. In addition, tissue-specific expression of microRNAs can further diminish these repressed mRNAs. Together, we provide a systematic analysis of tissue-specific repression of housekeeping genes, a phenomenon that has not been studied so far on a genome-wide basis and, when perturbed, can lead to human disease. 
ER  -