RT Journal
A1 Alekseyev, Max A.
A1 Pevzner, Pavel A.
T1 Breakpoint graphs and ancestral genome reconstructions
JF Genome Research 
JO Genome Research 
YR 2009 
FD May 01 
DO 10.1101/gr.082784.108 
UL http://genome.cshlp.org/content/early/2009/04/03/gr.082784.108.abstract 
AB Recently completed whole-genome sequencing projects marked the transition from gene-based phylogenetic studies to phylogenomics analysis of entire genomes. We developed an algorithm MGRA for reconstructing ancestral genomes and used it to study the rearrangement history of seven mammalian genomes: human, chimpanzee, macaque, mouse, rat, dog, and opossum. MGRA relies on the notion of the multiple breakpoint graphs to overcome some limitations of the existing approaches to ancestral genome reconstructions. MGRA also generates the rearrangement-based characters guiding the phylogenetic tree reconstruction when the phylogeny is unknown.