@article{Alekseyev01052009,
author = {Alekseyev, Max A. and Pevzner, Pavel A.}, 
title = {Breakpoint graphs and ancestral genome reconstructions},
year = {2009}, 
doi = {10.1101/gr.082784.108}, 
abstract ={Recently completed whole-genome sequencing projects marked the transition from gene-based phylogenetic studies to phylogenomics analysis of entire genomes. We developed an algorithm MGRA for reconstructing ancestral genomes and used it to study the rearrangement history of seven mammalian genomes: human, chimpanzee, macaque, mouse, rat, dog, and opossum. MGRA relies on the notion of the multiple breakpoint graphs to overcome some limitations of the existing approaches to ancestral genome reconstructions. MGRA also generates the rearrangement-based characters guiding the phylogenetic tree reconstruction when the phylogeny is unknown.}, 
URL = {http://genome.cshlp.org/content/early/2009/04/03/gr.082784.108.abstract}, 
eprint = {http://genome.cshlp.org/content/early/2009/04/03/gr.082784.108.full.pdf+html}, 
journal = {Genome Research} 
}