TY - JOUR A1 - Vilella, Albert J A1 - Severin, Jessica A1 - Ureta-Vidal, Abel A1 - Durbin, Richard A1 - Heng, Li A1 - Birney, Ewan T1 - EnsemblCompara GeneTrees: Analysis of complete, duplication aware phylogenetic trees in vertebrates. Y1 - 2008/01/01 JF - Genome Research JO - Genome Research DO - 10.1101/gr.073585.107 SP - gr.073585.107 UR - http://genome.cshlp.org/content/early/2008/11/24/gr.073585.107.abstract N2 - We have developed a comprehensive gene orientated phylogenetic resource, EnsemblCompara GeneTrees based on a computational pipeline to handle clustering, multiple alignment and tree generation, including the handling of large gene families. We developed two novel non-sequence based metrics of gene tree correctness and benchmarked a number of tree methods. The TreeBeST method from TreeFam shows the best performance in our hands. We also compared this phylogenetic approach to clustering approaches for ortholog prediction, showing a large increase in coverage using the phylogenetic approach. All data is made available in a number of formats and will be kept up to date with the Ensembl project. ER -