TY  - JOUR
A1  - Mackiewicz, Pawel
A1  - Gierlik, Agnieszka
A1  - Kowalczuk, Maria
A1  - Dudek, Miroslaw R.
A1  - Cebrat, Stanislaw
T1  - How Does Replication-Associated Mutational Pressure Influence Amino Acid Composition of Proteins?
Y1  - 1999/05/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 409 
EP  - 416 
DO  - 10.1101/gr.9.5.409 
VL  - 9 
IS  - 5 
UR  - http://genome.cshlp.org/content/9/5/409.abstract 
N2  - We have performed detrended DNA walks on whole prokaryotic genomes, on noncoding sequences and, separately, on each position in codons of coding sequences. Our method enables us to distinguish between the mutational pressure associated with replication and the mutational pressure associated with transcription and other mechanisms that introduce asymmetry into prokaryotic chromosomes. In many prokaryotic genomes, each component of mutational pressure affects coding sequences not only in silent positions but also in positions in which changes cause amino acid substitutions in coded proteins. Asymmetry in the silent positions of codons differentiates the rate of translation of mRNA produced from leading and lagging strands. Asymmetry in the amino acid composition of proteins resulting from replication-associated mutational pressure also corresponds to leading and lagging roles of DNA strands, whereas asymmetry connected with transcription and coding function corresponds to the distance of genes from the origin or terminus of chromosome replication. 
ER  -