RT Journal
A1 Murphy, William J.
A1 Sun, Shan
A1 Chen, Zhang-Qun
A1 Pecon-Slattery, Jill
A1 O'Brien, Stephen J.
T1 Extensive Conservation of Sex Chromosome Organization Between Cat and Human Revealed by Parallel Radiation Hybrid Mapping
JF Genome Research 
JO Genome Research 
YR 1999 
FD December 01 
VO 9 
IS 12 
SP 1223 
OP 1230 
DO 10.1101/gr.9.12.1223 
UL http://genome.cshlp.org/content/9/12/1223.abstract 
AB A radiation hybrid (RH)-derived physical map of 25 markers on the feline X chromosome (including 19 Type I coding loci and 6 Type II microsatellite markers) was compared to homologous marker order on the human and mouse X chromosome maps. Complete conservation of synteny and marker order was observed between feline and human X chromosomes, whereas the same markers identified a minimum of seven rearranged syntenic segments between mouse and cat/human X chromosome marker order. Within the blocks, the feline, human, and mouse marker order was strongly conserved. Similarly, Y chromosome locus order was remarkably conserved between cat and human Y chromosomes, with only one marker (SMCY) position rearranged between the species. Tight linkage and a conserved gene order for a segment encoding three genes,DFFRY–DBY–UTY in human, mouse, and cat Y chromosomes, coupled with demonstrated deletion effects of these genes on reproductive impairment in both human and mouse, implicates the region as critical for Y-mediated sperm production.[The sequence data described in this paper have been submitted to the GenBank data library under accession numbers AF197956–AF197962 andAF197964–AF197972.]