TY  - JOUR
A1  - Murphy, William J.
A1  - Sun, Shan
A1  - Chen, Zhang-Qun
A1  - Pecon-Slattery, Jill
A1  - O'Brien, Stephen J.
T1  - Extensive Conservation of Sex Chromosome Organization Between Cat and Human Revealed by Parallel Radiation Hybrid Mapping
Y1  - 1999/12/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1223 
EP  - 1230 
DO  - 10.1101/gr.9.12.1223 
VL  - 9 
IS  - 12 
UR  - http://genome.cshlp.org/content/9/12/1223.abstract 
N2  - A radiation hybrid (RH)-derived physical map of 25 markers on the feline X chromosome (including 19 Type I coding loci and 6 Type II microsatellite markers) was compared to homologous marker order on the human and mouse X chromosome maps. Complete conservation of synteny and marker order was observed between feline and human X chromosomes, whereas the same markers identified a minimum of seven rearranged syntenic segments between mouse and cat/human X chromosome marker order. Within the blocks, the feline, human, and mouse marker order was strongly conserved. Similarly, Y chromosome locus order was remarkably conserved between cat and human Y chromosomes, with only one marker (SMCY) position rearranged between the species. Tight linkage and a conserved gene order for a segment encoding three genes,DFFRY–DBY–UTY in human, mouse, and cat Y chromosomes, coupled with demonstrated deletion effects of these genes on reproductive impairment in both human and mouse, implicates the region as critical for Y-mediated sperm production.[The sequence data described in this paper have been submitted to the GenBank data library under accession numbers AF197956–AF197962 andAF197964–AF197972.] 
ER  -