@article{Murphy01121999,
author = {Murphy, William J. and Sun, Shan and Chen, Zhang-Qun and Pecon-Slattery, Jill and O'Brien, Stephen J.}, 
title = {Extensive Conservation of Sex Chromosome Organization Between Cat and Human Revealed by Parallel Radiation Hybrid Mapping},
volume = {9}, 
number = {12}, 
pages = {1223-1230}, 
year = {1999}, 
doi = {10.1101/gr.9.12.1223}, 
abstract ={A radiation hybrid (RH)-derived physical map of 25 markers on the feline X chromosome (including 19 Type I coding loci and 6 Type II microsatellite markers) was compared to homologous marker order on the human and mouse X chromosome maps. Complete conservation of synteny and marker order was observed between feline and human X chromosomes, whereas the same markers identified a minimum of seven rearranged syntenic segments between mouse and cat/human X chromosome marker order. Within the blocks, the feline, human, and mouse marker order was strongly conserved. Similarly, Y chromosome locus order was remarkably conserved between cat and human Y chromosomes, with only one marker (SMCY) position rearranged between the species. Tight linkage and a conserved gene order for a segment encoding three genes,DFFRY–DBY–UTY in human, mouse, and cat Y chromosomes, coupled with demonstrated deletion effects of these genes on reproductive impairment in both human and mouse, implicates the region as critical for Y-mediated sperm production.[The sequence data described in this paper have been submitted to the GenBank data library under accession numbers AF197956–AF197962 andAF197964–AF197972.]}, 
URL = {http://genome.cshlp.org/content/9/12/1223.abstract}, 
eprint = {http://genome.cshlp.org/content/9/12/1223.full.pdf+html}, 
journal = {Genome Research} 
}