RT Journal
A1 Tripodis, Nicos
A1 Mason, Ruth
A1 Humphray, Sean J.
A1 Davies, Angela F.
A1 Herberg, Jethro A.
A1 Trowsdale, John
A1 Nizetic, Dean
A1 Senger, Gabriele
A1 Ragoussis, Jiannis
T1 Physical Map of Human 6p21.2–6p21.3: Region Flanking the Centromeric End of the Major Histocompatibility Complex
JF Genome Research 
JO Genome Research 
YR 1998 
FD June 01 
VO 8 
IS 6 
SP 631 
OP 643 
DO 10.1101/gr.8.6.631 
UL http://genome.cshlp.org/content/8/6/631.abstract 
AB We have physically mapped and cloned a 2.5-Mb chromosomal segment flanking the centromeric end of the major histocompatibility complex (MHC). We characterized in detail 27 YACs, 144 cosmids, 51 PACs, and 5 BACs, which will facilitate the complete genomic sequencing of this region of chromosome 6. The contig contains the genes encoding CSBP, p21, HSU09564 serine kinase, ZNF76, TCP-11, RPS10, HMGI(Y), BAK, and the human homolog of Tctex-7 (HSET). The GLO1 gene was mapped further centromeric in the 6p21.2–6p21.1 region towardTCTE-1. The gene order of the GLO1–HMGI(Y) segment in respect to the centromere is similar to the gene order in the mouset-chromosome distal inversion, indicating that there is conservation in gene content but not gene order between humans and mice in this region. The close linkage of the BAK and CSBPgenes to the MHC is of interest because of their possible involvement in autoimmune disease.