TY  - JOUR
A1  - Kadotani, Hiroshi
A1  - Faraco, Juliette
A1  - Mignot, Emmanuel
T1  - Genetic Studies in the Sleep Disorder Narcolepsy
Y1  - 1998/05/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 427 
EP  - 434 
DO  - 10.1101/gr.8.5.427 
VL  - 8 
IS  - 5 
UR  - http://genome.cshlp.org/content/8/5/427.abstract 
N2  - Narcolepsy is a chronic neurologic disorder characterized by excessive daytime sleepiness and abnormal manifestations of REM sleep including cataplexy, sleep paralysis, and hypnagogic hallucinations. Narcolepsy is both a significant medical problem and a unique disease model for the study of sleep. Research in human narcolepsy has led to the identification of specific HLA alleles (DQB1*0602 andDQA1*0102) that predispose to the disorder. This has suggested the possibility that narcolepsy may be an autoimmune disorder, a hypothesis that has not been confirmed to date. Genetic factors other than HLA are also likely to be involved. In a canine model of narcolepsy, the disorder is transmitted as a non-MHC single autosomal recessive trait with full penetrance (canarc-1). A tightly linked marker for canarc-1 has been identified, and positional cloning studies are under way to isolate canarc-1 from a newly developed canine genomic BAC library. The molecular cloning of this gene may lead to a better understanding of sleep mechanisms, as has been the case for circadian rhythms following the cloning of frq, per, and Clock.
 
ER  -