TY  - JOUR
A1  - Duret, Laurent
A1  - Guex, Nicolas
A1  - Peitsch, Manuel C.
A1  - Bairoch, Amos
T1  - New Insulin-Like Proteins with Atypical Disulfide Bond Pattern Characterized  in Caenorhabditis elegans by Comparative Sequence Analysis and Homology Modeling
Y1  - 1998/04/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 348 
EP  - 353 
DO  - 10.1101/gr.8.4.348 
VL  - 8 
IS  - 4 
UR  - http://genome.cshlp.org/content/8/4/348.abstract 
N2  - We have identified three new families of insulin homologs inCaenorhabditis elegans. In two of these families, concerted mutations suggest that an additional disulfide bond links B and A domains, and that the A-domain internal disulfide bond is substituted by a hydrophobic interaction. Homology modeling remarkably confirms these predictions and shows that despite this atypical disulfide bond pattern and the absence of C-like peptide, all these proteins may adopt the same fold as the insulin. Interestingly, whereas we identified 10 insulin-like peptides, only one insulin-like-receptor (daf-2) has been found. We propose that these insulin-related peptides may correspond to different activators or inhibitors of the daf-2insulin-regulating pathway. 
ER  -