@article{Duret01041998,
author = {Duret, Laurent and Guex, Nicolas and Peitsch, Manuel C. and Bairoch, Amos}, 
title = {New Insulin-Like Proteins with Atypical Disulfide Bond Pattern Characterized  in Caenorhabditis elegans by Comparative Sequence Analysis and Homology Modeling},
volume = {8}, 
number = {4}, 
pages = {348-353}, 
year = {1998}, 
doi = {10.1101/gr.8.4.348}, 
abstract ={We have identified three new families of insulin homologs inCaenorhabditis elegans. In two of these families, concerted mutations suggest that an additional disulfide bond links B and A domains, and that the A-domain internal disulfide bond is substituted by a hydrophobic interaction. Homology modeling remarkably confirms these predictions and shows that despite this atypical disulfide bond pattern and the absence of C-like peptide, all these proteins may adopt the same fold as the insulin. Interestingly, whereas we identified 10 insulin-like peptides, only one insulin-like-receptor (daf-2) has been found. We propose that these insulin-related peptides may correspond to different activators or inhibitors of the daf-2insulin-regulating pathway.}, 
URL = {http://genome.cshlp.org/content/8/4/348.abstract}, 
eprint = {http://genome.cshlp.org/content/8/4/348.full.pdf+html}, 
journal = {Genome Research} 
}