TY  - JOUR
A1  - Centola, Michael
A1  - Chen, Xiaoguang
A1  - Sood, Raman
A1  - Deng, Zuoming
A1  - Aksentijevich, Ivona
A1  - Blake, Trevor
A1  - Ricke, Darrell O.
A1  - Chen, Xiang
A1  - Wood, Geryl
A1  - Zaks, Nurit
A1  - Richards, Neil
A1  - Krizman, David
A1  - Mansfield, Elizabeth
A1  - Apostolou, Sinoula
A1  - Liu, Jingmei
A1  - Shafran, Neta
A1  - Vedula, Anil
A1  - Hamon, Melanie
A1  - Cercek, Andrea
A1  - Kahan, Tanaz
A1  - Gumucio, Deborah
A1  - Callen, David F.
A1  - Richards, Robert I.
A1  - Moyzis, Robert K.
A1  - Doggett, Norman A.
A1  - Collins, Francis S.
A1  - Liu, P. Paul
A1  - Fischel-Ghodsian, Nathan
A1  - Kastner, Daniel L.
T1  - Construction of an ∼700-kb Transcript Map Around the Familial Mediterranean Fever Locus on Human Chromosome 16p13.3
Y1  - 1998/11/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1172 
EP  - 1191 
DO  - 10.1101/gr.8.11.1172 
VL  - 8 
IS  - 11 
UR  - http://genome.cshlp.org/content/8/11/1172.abstract 
N2  - We used a combination of cDNA selection, exon amplification, and computational prediction from genomic sequence to isolate transcribed sequences from genomic DNA surrounding the familial Mediterranean fever (FMF) locus. Eighty-seven kb of genomic DNA around D16S3370, a marker showing a high degree of linkage disequilibrium with FMF, was sequenced to completion, and the sequence annotated. A transcript map reflecting the minimal number of genes encoded within the ∼700 kb of genomic DNA surrounding the FMF locus was assembled. This map consists of 27 genes with discreet messages detectable on Northerns, in addition to three olfactory-receptor genes, a cluster of 18 tRNA genes, and two putative transcriptional units that have typical intron–exon splice junctions yet do not detect messages on Northerns. Four of the transcripts are identical to genes described previously, seven have been independently identified by the French FMF Consortium, and the others are novel. Six related zinc-finger genes, a cluster of tRNAs, and three olfactory receptors account for the majority of transcribed sequences isolated from a 315-kb FMF central region (betweenD16S468/D16S3070 and cosmid 377A12). Interspersed among them are several genes that may be important in inflammation. This transcript map not only has permitted the identification of the FMF gene (MEFV), but also has provided us an opportunity to probe the structural and functional features of this region of chromosome 16. 
ER  -