RT Journal
A1 Ranta, Susanna
A1 Lehesjoki, Anna-Elina
A1 Bonaldo, Maria de Fatima
A1 Knowles, James A.
A1 Hirvasniemi, Aune
A1 Ross, Barbara
A1 de Jong, Pieter J.
A1 Soares, Marcelo Bento
A1 de la Chapelle, Albert
A1 Gilliam, T. Conrad
T1 High-Resolution Mapping and Transcript Identification at the Progressive Epilepsy with Mental Retardation Locus on Chromosome 8p
JF Genome Research 
JO Genome Research 
YR 1997 
FD September 01 
VO 7 
IS 9 
SP 887 
OP 896 
DO 10.1101/gr.7.9.887 
UL http://genome.cshlp.org/content/7/9/887.abstract 
AB Progressive epilepsy with mental retardation (EPMR) is an autosomal recessive central nervous system disorder characterized by childhood onset epilepsy and subsequent mental retardation. The locus for EPMR has been mapped to human chromosome 8p23. We recently reported the construction of a YAC contig across the 4 centimorgan minimum genetic region that harbors the disease locus. We now report further delineation of the critical region to <700 kb. Our mapping strategy relied on the identification of nine novel microsatellite markers and the construction of a complete BAC contig across the critical region. Several partial gene sequences have been identified from the region and are being analyzed as candidate genes for EPMR.[The sequence data described in this paper have been submitted to the GenBank data library under accession nos. AF009188–AF009214.]