TY - JOUR A1 - Byrd, P J A1 - Stankovic, T A1 - McConville, C M A1 - Smith, A D A1 - Cooper, P R A1 - Taylor, A M T1 - Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23. Y1 - 1997/01/01 JF - Genome Research JO - Genome Research SP - 71 EP - 75 DO - 10.1101/gr.7.1.71 VL - 7 IS - 1 UR - http://genome.cshlp.org/content/7/1/71.abstract N2 - We have localized the human homolog of the rabbit vasopressin-activated calcium-mobilizing receptor VACM-1 to a region close to the gene for ataxia telangiectasia ATM on chromosome 11q22-23. We have determined the complete amino acid sequence of the human Hs-VACM-1 protein, which is 780 amino acids long. The human and rabbit sequences are highly conserved, differing at only seven amino acids. Northern analysis of the human gene showed expression in a wide range of human tissues. The Hs-VACM-1 gene has homology with the Caenorhabditis elegans gene Ce-cul-5, a member of a family of cullin genes that are involved in cell cycle regulation and that might, when mutated, contribute to tumor progression. ER -