RT Journal
A1 Ayyagari, R
A1 Nestorowicz, A
A1 Li, Y
A1 Chandrasekharappa, S
A1 Chinault, C
A1 van Tuinen, P
A1 Smith, R J
A1 Hejtmancik, J F
A1 Permutt, M A
T1 Construction of a YAC contig encompassing the Usher syndrome type 1C and familial hyperinsulinism loci on chromosome 11p14-15.1.
JF Genome Research 
JO Genome Research 
YR 1996 
FD June 01 
VO 6 
IS 6 
SP 504 
OP 514 
DO 10.1101/gr.6.6.504 
UL http://genome.cshlp.org/content/6/6/504.abstract 
AB The Usher syndrome type 1C (USH1C) and familial hyperinsulinism (HI) loci have been assigned to chromosome 11p14-15.1, within the interval D11S419-D11S1310. We have constructed a yeast artificial chromosome (YAC) contig, extending from D11S926 to D11S899, which encompasses the critical regions for both USH1C and HI and spans an estimated genetic distance of approximately 4 cM. A minimal set of six YAC clones constitute the contig, with another 22 YACs confirming the order of sequence-tagged sites (STSs) and position of YACs on the contig. A total of 40 STSs, including 10 new STSs generated from YAC insert-end sequences and inter-Alu PCR products, were used to order the clones within the contig. This physical map provides a resource for identification of gene transcripts associated with USH1C, HI, and other genetic disorders that map to the D11S926-D11S899 interval.