@article{Ayyagari01061996, author = {Ayyagari, R and Nestorowicz, A and Li, Y and Chandrasekharappa, S and Chinault, C and van Tuinen, P and Smith, R J and Hejtmancik, J F and Permutt, M A}, title = {Construction of a YAC contig encompassing the Usher syndrome type 1C and familial hyperinsulinism loci on chromosome 11p14-15.1.}, volume = {6}, number = {6}, pages = {504-514}, year = {1996}, doi = {10.1101/gr.6.6.504}, abstract ={The Usher syndrome type 1C (USH1C) and familial hyperinsulinism (HI) loci have been assigned to chromosome 11p14-15.1, within the interval D11S419-D11S1310. We have constructed a yeast artificial chromosome (YAC) contig, extending from D11S926 to D11S899, which encompasses the critical regions for both USH1C and HI and spans an estimated genetic distance of approximately 4 cM. A minimal set of six YAC clones constitute the contig, with another 22 YACs confirming the order of sequence-tagged sites (STSs) and position of YACs on the contig. A total of 40 STSs, including 10 new STSs generated from YAC insert-end sequences and inter-Alu PCR products, were used to order the clones within the contig. This physical map provides a resource for identification of gene transcripts associated with USH1C, HI, and other genetic disorders that map to the D11S926-D11S899 interval.}, URL = {http://genome.cshlp.org/content/6/6/504.abstract}, eprint = {http://genome.cshlp.org/content/6/6/504.full.pdf+html}, journal = {Genome Research} }